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Maternal hyperventilation and foetal hypocapnia in sheep.

1. In anaesthetized foetal lambs near term, hypocapnia induced by maternal hyperventilation abolished the rise of arterial pressure and femoral vasoconstriction caused by hypoxaemia. This is consistent with interaction of P(CO2) and P(O2) on the foetal aortic bodies.2. In immature lambs (0.6-0.77 of term) maternal hyperventilation caused a fall in foetal carotid P(CO2) commensurate with that in the maternal blood. In mature lambs (at 0.9 or more of term) the fall in foetal carotid P(CO2) was less than that in maternal blood, whether the foetus was exteriorized or in utero.3. The mean transplac