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[Surveillance of resistance in the intensive care units using a cumulative antibiogram].

Empiric treatment with broad-spectrum antibiotics exerts condensed pressure in intensive care units (ICUs) for the selection of multidrug-re … hough E.coli was the most commonly isolated species among urinary enteric bacilli, K.pneumoniae and Proteus mirabilis were the most resistant isolates. A statistically significant decrease in susceptibility rates against all antibiotics was observed in P.mirabilis isolates between the years 2015-2016. Carbapenem susceptibility rates decreased below 70%. E …

Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections.

IMPORTANCE: Management of gram-negative bloodstream infections (GN-BSIs) with oral antibiotics is highly variable. OBJECTIVE: To examine the transition from intravenous (IV) to oral antibiotics, including selection, timing, and associated clinical and microbial characteristics, among hospitalized patients with GN-BSIs. DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort study was conducted of 4581 hospitalized adults with GN-BSIs at 24 US hospitals between January 1 and December 31, 2019. Patients were excluded if they died within 72 hours. Patients were excluded from the oral therapy

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… Of patients transitioned to oral therapy by day 7, commonly isolated organisms were E coli (60.4% [1189 of 1969]), Klebsiella species (18.8% [371 of 1969]), Pseudomonas species (5.8% [115 of 1969]), Enterobacter species (4.1% [80 of 1969]), Proteus species (3.9% [76 of 1969]), and Serratia species (2.0% … Several other organisms were more prevalent in the IV group than the oral therapy group, including Enterobacter species (6.4% [167 of 2612] vs 4.1% [80 of 1969]; P < .001), Morganella morganii (1.3% [35 of 2612] vs 0.3% [6 of 1969]; P < .001), Proteus species (6.1% [160 of 2612] vs 3.9% [76 of 1969]; …

Usability testing of an electronic patient-reported outcome system linked to an electronic chemotherapy prescribing and patient management system for patients with cancer.

BackgroundPeople affected by cancer experience a wide range of symptoms which have a major impact on their functioning and health-related quality of life (HRQoL). One way to measure the impact of cancer symptoms is through the use of patient-reported outcomes.MethodsAn electronic patient-reported outcome (ePRO) application (ChemoPRO®) was designed to be used by cancer patients to report their symptoms and communicate with their clinical team. Usability testing sessions were conducted with people with lived experience of cancer to understand how real users interact with the ChemoPRO® system. On

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… It is recommended that developers follow PROTEUS Consortium's existing guidance on presentation of PRO data [ 32 , 33 ]. Strengths and limitations The main strength of our study is its methodology which includes a ‘think aloud’ technique which provides real-time feedback. … PROTEUS Consortium. 14/12/2022]; Available from: https://theproteusconsortium.org/proteus-trials/study-reporting/displaying-results/ . 34. Bennett A.V., et al. Mode equivalence and acceptability of tablet computer-, interactive voice response system-, and paper-based administration of the U.S. …

Impact of Adding a Rapid PCR-Based Blood Culture Identification Panel to the Antimicrobial Stewardship Program of Patients with Febrile Neutropenia in a Peruvian Referral Hospital.

The addition of Biofire® FilmArray® Blood Culture Identification panel 2 (BCID2) to the antimicrobial stewardship program (ASP) could improve outcomes in bloodstream infections (BSI) of patients with febrile neutropenia (FN). A pre- and post-quasi-experimental single-center study was conducted at a reference hospital in Peru. Three groups were considered: patients with BSI before ASP intervention (control group), patients with BSI after ASP intervention (group 1), and patients with BSI after ASP intervention plus BCID2 PCR Panel implementation (group 2). Overall, 93 patients were identified (3

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… Patient #31 was changed from piperacillin/tazobactam to meropenem after the detection of the CTX-M gene, however Proteus could not be isolated, unlike E. coli and Serratia marcescens . … The panel can identify within the gram-negative bacteria Acinetobacter calcoaceticus baumannii complex, Bacteroides fragilis , Enterobacteriaceae: Enterobacter cloacae complex, Escherichia coli , Klebsiella aerogenes , Klebsiella oxytoca , Klebsiella pneumoniae group, Proteus , Salmonella , Serratia …

Neisseria meningitidis Induced Fatal Waterhouse-Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure.

Neisseria meningitidis-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse-Friderichsen syndrome (WFS). Here, we describe a rare case of a patient with a fulminant Neisseria meningitidis-induced acute systemic meningococcal disease presenting with high-grade fever without meningitis symptoms. Fatal septicemia with DIC

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… It could also be caused by other bacteria, such as Proteus Mirabilis, Pseudomonas aeruginosa , Streptococcus pneumoniae , Mycobacterium tuberculosis , and Haemophilus influenzae [ 10 , 11 ]. … A unique fatal case of Waterhouse–Friderichsen syndrome caused by Proteus mirabilis in an immunocompetent subject. Medicine. 2019;98:e16664. doi: 10.1097/MD.0000000000016664. 12. Verzeletti A., Bonfanti C., Leide A., Azzalini E., De Francesco M.A., Piccinelli G., De Ferrari F. …

The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study.

This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020-15 August 2021. A total of 170 cases (58 female, aged 59 ± 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.63

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… Infection Microorganism n (%) Bacteraemia (n:34) E.coli 9 (26.4%) Acinetobacter spp. 4 (11.7%) S. aureus 4 (11.7%) Enterococcus spp. 5 (14.7%) S. pneumoniae 4 (11.7%) CoNS 4 (13.5%) Pseudomonas spp 3 (8.8%) Proteus mirabilis 1 (2.9%) Urinary tract infection (n:23) Candida spp. 12 (46.1%) E. coli 5 (19.2% … Infection | Microorganism | n (%) Bacteraemia (n:34) | E.coli | 9 (26.4%) Acinetobacter spp. | 4 (11.7%) S. aureus | 4 (11.7%) Enterococcus spp. | 5 (14.7%) S. pneumoniae | 4 (11.7%) CoNS | 4 (13.5%) Pseudomonas spp | 3 (8.8%) Proteus mirabilis | 1 (2.9%) Urinary tract infection (n:23) | Candida spp. …

Infections and Their Outcomes in Cancer Patients With and Without Neutropenia: A Single-Center Experience.

Background Patients with cancer are at a high risk of developing infections due to immunosuppression resulting from cancer treatment. Infections may occur both during neutropenic and non-neutropenic episodes and negatively impact outcomes both in terms of hospital stay and mortality. In this study, we aimed to determine the infection types, microbiological picture of infections, their outcomes, and associated factors in cancer patients during neutropenic and non-neutropenic episodes. Methods This is a retrospective cross-sectional study conducted at the Department of Medical Oncology, Geetanja

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… Klebsiella pneumoniae | 0 | 7 | 7 Pseudomonas aeruginosa | 0 | 2 | 2 Bronchial aspirate | Candida albicans | 0 | 1 | 1 Escherichia coli | 0 | 1 | 1 Pus | Staphylococcus aureus | 0 | 1 | 1 Citrobacter freundii | 0 | 1 | 1 Escherichia coli | 0 | 4 | 4 Enterobacter cloacae | 0 | 1 | 1 K.pneumoniae | 0 | 1 | 1 Proteus … mirabilis | 0 | 1 | 1 Pseudomonas aeruginosa | 0 | 1 | 1 Urine | Candida albicans | 0 | 2 | 2 Candida tropicalis | 0 | 1 | 1 Citrobacter koseri | 0 | 1 | 1 Escherichia coli | 5 | 14 | 19 Enterococcus spp . | 3 | 0 | 3 Klebsiella pneumoniae | 1 | 5 | 6 Proteus mirabilis | 0 | 1 | 1 Pseudomonas aeruginosa …

What's New in Genetic Skin Diseases.

The discoveries of new genes underlying genetic skin diseases have occurred at a rapid pace, supported by advances in DNA sequencing technologies. These discoveries have translated to an improved understanding of disease mechanisms at a molecular level and identified new therapeutic options based on molecular targets. This article highlights just a few of these recent discoveries for a diverse group of skin diseases, including tuberous sclerosis complex, ichthyoses, overgrowth syndromes, interferonopathies, and basal cell nevus syndrome, and how this has translated into novel targeted therapie

Risk factors and characteristics of blood stream infections in patients with newly diagnosed multiple myeloma.

BackgroundPatients with multiple myeloma are generally immune-compromised either due to pronounced depression in primary antibody responses or because of anti-myeloma therapy. Infection is a major risk factor for early deaths among these patients. The impact of blood stream infections (BSI) on newly diagnosed myeloma patients has been less studied. We aimed to study the incidence and risk factors of BSI within 3 months after diagnosis of multiple myeloma in a tertiary referral center.MethodsBetween November 2002 and December 2008, consecutive patients with multiple myeloma in Taipei Veterans G

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… coli Imipenem/vancomycin/amikin Y 9 (175) Y VAD - - Escherichia coli Cefuroxime/metronidazole - 10 (150) Y VAD - - Enterobacter gergoviae Oxacillin - 11 (14) Y VAD Implanted port - Enterobacter cloacae - 12 (94) - VAD Non-tunneled CVC - Pseudomonas Aeruginosa Cefepime Y 13 (115) Y VAD Implanted port - Proteus … Escherichia coli | Cefuroxime/metronidazole | - 10 (150) | Y | VAD | - | - | Enterobacter gergoviae | Oxacillin | - 11 (14) | Y | VAD | Implanted port | - | Enterobacter cloacae | | - 12 (94) | - | VAD | Non-tunneled CVC | - | Pseudomonas Aeruginosa | Cefepime | Y 13 (115) | Y | VAD | Implanted port | - | Proteus …

Characteristics of infections after BCMA-directed CAR T-cell therapy for multiple myeloma: a real-world analysis.

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… 65.5%) 36 (63.2%) Fungal 2 (7.1%) 1 (3.4%) 3 (5.3%) Pathogens: bacterial Escherichia coli 1 (3.6%) 4 (13.8%) 5 (8.8%) Enterobacter cloacae 0 (0%) 1 (3.4%) 1 (1.8%) Enterococcus spp. 1 (3.6%) 0 (0%) 1 (1.8%) Haemophilus influenzae 0 (0%) 1 (3.4%) 1 (1.8%) Klebsiella pneumoniae 2 (7.1%) 0 (0%) 2 (3.5%) Proteus … | 3 (5.3%) Pathogens: bacterial | | | Escherichia coli | 1 (3.6%) | 4 (13.8%) | 5 (8.8%) Enterobacter cloacae | 0 (0%) | 1 (3.4%) | 1 (1.8%) Enterococcus spp. | 1 (3.6%) | 0 (0%) | 1 (1.8%) Haemophilus influenzae | 0 (0%) | 1 (3.4%) | 1 (1.8%) Klebsiella pneumoniae | 2 (7.1%) | 0 (0%) | 2 (3.5%) Proteus …

Deciphering the Potentials of Cardamom in Cancer Prevention and Therapy: From Kitchen to Clinic.

Cardamom (cardamum) is a spice produced from the seeds of several Elettaria and Amomum plants of the Zingiberaceae family. Cardamom has been demonstrated to offer numerous benefits, including its antioxidant, antimicrobial, anti-inflammatory, and other metabolic (anti-diabetic) properties, and its potential to reduce cancer risk. Recently, researchers have extracted and tested multiple phytochemicals from cardamom to assess their potential effectiveness against various types of human malignancy. These studies have indicated that cardamom can help overcome drug resistance to standard chemothera

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… typhi , Shigella dysenteriae , Shigella sonnei , Staphylococcus aureus , Streptococcus-β-haemolytica , Bacillus subtilis , B. megaterium , and Sarcina lutea | [ 136 ] Staphylococcus aureus , Streptococcus pneumonia , S.epidermidis , P. aeroginosa , K. pneumonia , Proteus mirabilis , Enterobacter spp … Antibacterial Effect of Seed Extracts of Cardamom (Elettaria cardamomum) against Staphylococcus aureus and Proteus mirabilis. Tikrit J. Pure Sci. 2012;17:14–18. 136. Islam M., Rahman M., Sheikh M.M.I., Rahman, Jamal M.A., Firoz A. …

(68)Ga-radiopharmaceuticals for PET imaging of infection and inflammation.

Infection imaging has been challenging over the past four decades, which provided an excellent playing field for researchers working in this … wed it is capable of detecting both Gram-positive Staphylococcus aureus (Staph A) and Gram-negative Proteus mirobilis. This is an incidental finding but gives an insight into the potential of this agent to detect more than one bacterial infection.

THE CULTIVATION OF AMOEBAE IN PURE CULTURE UPON AUTOLYZED TISSUES.

Since the purpose of this paper is to record the cultivation of amoebae upon autolyzed tissue without bacterial association, the morphologic … ess strong hydrolyzing properties, e. g., Vibrio cholerae, Bacillus coli, Bacillus subtilis, Vibrio proteus (Finkler-Prior), etc., furnish the best symbionts to the amoebae. It is well known that these bacteria growing upon gelatin or blood serum liquify the medium and alter its reaction to a marked degree of acidity. This acidity, for the most part, resu …

Hyperammonemic Encephalopathy in Multiple Myeloma: A Case Report.

Multiple myeloma (MM) typically presents as lytic bony lesions, hypercalcemia, anemia, and renal failure. Only a few cases of hyperammonemic encephalopathy (HE) attributed to multiple myeloma have been reported. We report a case of a 68-year-old Hispanic female diagnosed with multiple myeloma and presented with altered mental status and elevated ammonia levels found to have HE. The pathology behind HE is associated with higher ammonia levels produced by myeloma cell lines in the absence of liver disease. Due to the wide range of differentials for altered mental status (AMS), HE often gets miss

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… Certain urase-producing organisms, such as proteus mirabilis, Escherichia (E.) coli, Klebsiella pneumonia, Pseudomonas, and Helicobacter (H.) pylori were also known to cause elevated ammonia levels and HE, which had not been seen in our patient [ 10 ]. …

Представление результатов анализа диабетических осложнений с головы до ног: всеобъемлющий радиологический обзор.

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… The most commonly identified organisms are Proteus mirabilis and Escherichia coli [ 46 ]. It is frequently associated with long-standing urinary tract obstruction, nephrolithiasis (often staghorn calculus), and DM, which predispose patients to persistent infection and impaired host defense. … The most commonly identified organisms are Proteus mirabilis , Escherichia coli , and Klebsiella pneumonia [ 46 ]. The symptoms may be nonspecific; however, fever, flank pain, dysuria, and nausea are common [ 12 ]. …

Evaluation of bloodstream infections in febrile neutropenic patients with hematological malignancy: a retrospective cohort study.

BACKGROUND: Patients with hematological malignancies (HMs) are at high risk of bloodstream infections (BSIs) during episodes of febrile neutropenia (FN). However, empirical treatment initiated before isolation of the causative agent from blood cultures is crucial. The aim of this study was to determine the distribution and antimicrobial resistance profile of microorganisms isolated from BSIs in patients with HMs, and to evaluate the association with the need for intensive care unit (ICU) and mortality at 30 days. METHODS: Single-centre data from patients with HMs who were admitted to the hema

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… Other Gram-negative bacteria include Stenotrophomonas maltophilia , Enterobacter spp., Serratia spp., Proteus mirabilis , Morganella morganii , Salmonella spp., and Sphingomonas paucimobilis . Other Gram-positive bacteria include Streptococcus pneumoniae and alpha-hemolytic streptococci. … Other Gram-negative bacteria include Stenotrophomonas maltophilia , Enterobacter spp., Serratia spp., Proteus mirabilis , Morganella morganii , Salmonella spp., and Sphingomonas paucimobilis . Other Gram-positive bacteria include Streptococcus pneumoniae and alpha-hemolytic streptococci. …

The PRO-CAR-T™ study: achieving excellence in patient and public involvement and engagement.

BackgroundPatient and Public Involvement and Engagement (PPIE) is advocated in Patient Reported Outcome (PRO) research, but implementation remains inconsistent and often suboptimal. Many barriers exist, including a lack of understanding about how to apply the principles of PPIE in practice. This paper offers an example of how PPIE can be meaningfully integrated into the development of a digital PRO system within the complex and rapidly evolving field of advanced therapies. The aims are to offer practical insights about how PPIE was conceptualised and operationalised in the context of this stud

Infectious Diseases

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… ), TB, fungi CONTIGUOUS SPREAD FROM SOFT TISSUE OR JOINTS (polymicrobial)— S. aureus , coagulase-negative Staphylococci, S. pyogenes, Enterococcus , Gram-negative bacilli, anaerobes CONTIGUOUS SPREAD WITH GENERALIZED VASCULAR INSUFFICIENCY (polymicrobial)— S. aureus, Streptococcus, Enterococcus, Proteus … See p. 148 for further information URINARY TRACT INFECTION ( E. coli, Klebsiella, Enterococcus, Proteus, S. saprophyticus )—nitrofurantoin, trimethoprim–sulfamethoxazole, ciprofloxacin. Duration of treatment is 3 days if uncomplicated UTI, otherwise 14–21 days. …

Multiple cystic lung disease.

Multiple cystic lung disease represents a diverse group of uncommon disorders that can present a diagnostic challenge due to the increasing number of diseases associated with this presentation. High-resolution computed tomography of the chest helps to define the morphological aspects and distribution of lung cysts, as well as associated findings. The combination of appearance upon imaging and clinical features, together with extrapulmonary manifestations, when present, permits confident and accurate diagnosis of the majority of these diseases without recourse to open-lung biopsy. The main dise

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… Several hereditary syndromes other than TSC, including Marfan syndrome, neurofibromatosis 1, Ehlers–Danlos syndrome and Proteus syndrome, have been associated with cystic lung disease. In all of these conditions, the number of pulmonary cysts is limited [ 97 – 101 ]. … Proteus syndrome: high-resolution CT and CT pulmonary densitovolumetry findings . J Thorac Imaging 2009 ; 24 : 45 – 48 . 19242304 10.1097/RTI.0b013e31818b20cd 102 Thompson GR 3rd . Pulmonary coccidioidomycosis . …

Регенеративная терапия на основе коллагена в критическом ишемическом диабиотическом ульце: доклад по делу о лимб-алкоголе.

58-летний мужчина с диабетом, конечной стадией почечных заболеваний и тяжелой периферической артерией страдал от хронической ишемической язвы ступни до одного года традиционной терапии. Инъекционная регенеративная терапия на основе коллагена привела к полной эпителиализации в течение трех месяцев и к долговременному спасению конечностей даже после техногенного рецидива, требующего реваскуляции.

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… (with later isolation of an extended‐spectrum β‐lactamase [ESBL]–producing strain), Pseudomonas aeruginosa , Acinetobacter species, Enterococcus species, coagulase‐negative Staphylococcus , methicillin‐resistant Staphylococcus epidermidis (MRSE), Enterobacter cloacae , and Proteus …