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What is the Reason That the Pharmacological Future of Chemotherapeutics in the Treatment of Lung Cancer Could Be Most Closely Related to Nanostructures? Platinum Drugs in Therapy of Non-Small and Small Cell Lung Cancer and Their Unexpected, Possible Interactions. The Review.

Over the course of several decades, anticancer treatment with chemotherapy drugs for lung cancer has not changed significantly. Unfortunately, this treatment prolongs the patient's life only by a few months, causing many side effects in the human body. It has also been proven that drugs such as Cisplatin, Carboplatin, Oxaliplatin and others can react with other substances containing an aromatic ring in which the nitrogen atom has a free electron group in its structure. Thus, such structures may have a competitive effect on the nucleobases of DNA. Therefore, scientists are looking not only for

Tumor microenvironment signaling and therapeutics in cancer progression.

Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors. Stromal cells can adopt new phenotypes to promote tumor cell invasion. A deep understanding of the signaling pathways involved in cell-to-cell and cell-to-ECM interactions is needed to design effective intervention strategies that might interrupt these interactions. In this review, we describe the tumor microenvironment (TME) components and associated therapeutics. We discuss t

Burden and temporal trends of non-communicable diseases from 1990 to 2021 and prediction to 2035 in the group of twenty countries: a systematic analysis of the Global Burden of Disease Study 2021.

BackgroundNon-communicable diseases (NCDs) represent a major global public health threat, closely linked to disruptions in host-microbe symbiosis and metabolic homeostasis. The Group of Twenty (G20) comprises the world's major economic powers with diverse developmental stages, yet the NCD burden and its potential implications for host and ecosystem resilience remain poorly characterized across these nations. This study aimed to systematically estimate the burden, temporal trends, and future projections of NCDs from 1990 to 2021 and up to 2035 in G20 countries.MethodsUsing data from the Global

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… Public Health Res. 10:2404. 10.4081/jphr.2021.2402 Liu H., Yin P., Qi J., Zhou M. (2024). Burden of non-communicable diseases in China and its provinces, 1990-2021: Results from the global burden of disease study 2021. Chin. Med. …

ADMET-Guided Design and In Silico Planning of Boron Delivery Systems for BNCT: From Transport and Biodistribution to PBPK-Informed Irradiation Windows.

BNCT (Boron Neutron Capture Therapy) is a binary radiotherapeutic modality in which high LET (Linear Energy Transfer) particles are generated from 10B(n,α)7Li reaction, ideally within boron-loaded tumour cells, so the therapeutic outcome depends critically on the pharmacokinetics and biodistribution of boron carriers. In this review, boron-containing agents for BNCT, with a focus on ADMET (absorption, distribution, metabolism, excretion and toxicity) and model-informed design, were examined. Low-MW (low-molecular-weight) compounds, peptide conjugates, polymeric and nanostructured platforms and

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… Qi Y. Huang Y. Near-Infrared 10 B-BODIPY for Precise Guidance of Tracer Imaging and Treatment in Boron Neutron Capture Therapy Chem. Commun. 2025 61 9079 9082 10.1039/D5CC01671A 40401390 75. Shao C. Lian G. Jin G. …

Second primary cancers following hematologic malignancies: Epidemiology, pathobiology and clinical management.

Second primary cancers (SPCs) pose an increasingly significant clinical challenge for survivors of hematologic malignancies, attributed to improved therapeutic outcomes and prolonged survival. The development of SPCs is influenced by a complex interplay of treatment-related factors, genetic susceptibility, immune dysregulation, and microenvironmental remodeling. This narrative review summarizes the epidemiological patterns of SPCs in survivors of hematologic malignancies and discusses the underlying biological mechanisms, including therapy-induced genomic instability, clonal hematopoiesis, inf

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… Liang R , Qi X , Cai Q , Niu L , Huang X , Zhang D , Ling J , Wu Y , Chen Y , Yang P , et al . The role of NLRP3 inflammasome in aging and age-related diseases . Immun Ageing . 2024 ; 21 ( 1 ): 14 . doi: 10.1186/s12979-023-00395-z . 38317229 PMC10840156 41. Shalapour S , Karin M . …

Contemporary Challenges in Venous Thromboembolism: Evolving Populations and Implications for Management and Risk Stratification.

Venous thromboembolism (VTE) remains a major cause of morbidity and mortality globally. The incidence of VTE continues to increase over time, contributed to by demographic shifts and emerging risk factors, such as novel cancer treatments and exposure to gender-affirming hormonal therapies. While the introduction of direct oral anticoagulants (DOACs) revolutionized VTE management, increasing complexity in select patient cohorts has driven the need for alternative treatment strategies, including pharmacological and interventional approaches. Concurrently, contemporary patient populations have ex

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… Qi Y. Li X. Development and validation of a machine learning model to predict venous thromboembolism among hospitalized cancer patients Asia Pac. J. Oncol. Nurs. 2022 9 100128 10.1016/j.apjon.2022.100128 36276886 PMC9583033 159. Chen C. Hu Z. Xu Q. Yuan L. Yuan Y. Zheng X. Lei H. …

Механистическая взаимосвязь между множественной миеломой и тяжелой SARS-CoV-2 Инфекция: терапевтическое обещание месенхимальных стволовых ячеек с внешней клеткой.

Пациенты с множественной миеломой (ММ) демонстрируют глубокое иммунное регулирование, предвосхищая их до тяжелых результатов после SARS-CoV-2 инфекция. Текущие данные свидетельствуют о наличии общих иммунопатологических механизмов, связывающих ММ и COVID-19, с уделением особого внимания interleukin-6 (В тыс.IL-6) ось как общий усилитель воспаления, а не как единственный движитель болезни. Для ММ характерна исходная провоспалительная среда, частично обусловленная: IL-6, которая еще больше усиливается в течение SARS-CoV-2 Инфекция, приводящая к эскалации цитокина, дополняет активацию, коагулопат

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… Wang Y., Li C., Xia J., Li P., Cao J., Pan B., Tan X., Li H., Qi K., Wang X., et al. Humoral Immune Reconstitution after Anti-BCMA CAR T-Cell Therapy in Relapsed/Refractory Multiple Myeloma. Blood Adv. 2021;5:5290–5299. doi: 10.1182/bloodadvances.2021004603. 14. …

Кардиотоксичность, вызванная множественными миэломатерапиями: механистическая конвергенция между протеиновыми ингибиторами, CAR-T и биконкретными антителами.

Сердечно-сосудистая токсичность стала важным препятствием на пути реализации полного клинического потенциала современной терапии для множественных миэломы (ММ), включая протеазонные ингибиторы (ИП), химерика антигенного рецептора Т-клеток (CAR-T) и CD3-engaging Биотипные антитела. Здесь мы обсуждаем эпидемиологию, лежащую в основе механистических путей, и новые стратегии предотвращения кардиотоксичности, вызванной терапией, в MM. На основе данных, полученных в ходе исследований по изучению мультиомики, доклинических моделей и данных наблюдений в реальном мире, мы синтезируем вклад митохондриал

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… Qi K, Yan Z, Cheng H, Chen W, Wang Y, Wang X, et al. An analysis of cardiac disorders associated with chimeric antigen receptor T cell therapy in 126 patients: a single-centre retrospective study. Front Oncol. 2021;11:691064. 10.3389/fonc.2021.691064. 14. …

Breaking the Resistance: Photodynamic Therapy in Cancer Stem Cell-Driven Tumorigenesis.

Cancer stem cells (CSCs) are essential for the growth of malignancies because they encourage resistance to cancer therapy and make metastasis and relapse easier. To effectively tackle the obstacles presented by CSCs, novel therapeutic approaches are required. Photodynamic therapy (PDT) is a promising treatment option for cancer cells, which uses light-sensitive medications that are activated by light wavelengths. This review investigates the use of PDT to overcome malignancies driven by CSCs that have innate resistance mechanisms. PDT works by causing tumor cells to accumulate photosensitizers

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… Qi Z. Dual-Functional NIR AIEgens for High-Fidelity Imaging of Lysosomes in Cells and Photodynamic Therapy ACS Sens. 2020 5 225 233 10.1021/acssensors.9b02090 31854187 133. Chen Y. Ren J. Tian D. Li Y. Jiang H. Zhu J. …

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential.

Single-cell sequencing (SCS) techniques have the potential to offer precise insights into cellular diversity by revealing unique genetic and transcriptomic profiles at the single-cell level. This advanced technology has been used extensively in research, but it has still not translated to clinical diagnostics, despite its potential. SCS provides more accurate granular information about heterogeneous cell populations and the creation of personalized treatment strategies. However, the integration of SCS into clinical practice is challenging. This review discusses the potential of SCS technologie

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… Adv. 1, 6–16. 10.14218/OnA.2023.00039 Zou D., Qi J., Wu W., Xu D., Tu Y., Liu T., et al. (2021a). Applications of single-cell sequencing in dermatology. Med. Sci. Monit. 27, e931862. 10.12659/MSM.931862 Zou A., Ramanathan S., Dale R. C., Brilot F. (2021b). …

Global first-in-class drugs approved in 2023-2024: Breakthroughs and insights.

First-in-class (FIC) drugs are considered the main drivers of new drug discovery and have novel targets and mechanisms. The proportion of FIC drugs among new drugs provides fundamental guidance for both academic and pharmaceutical research. From a global perspective, 81 FIC drugs were approved in 2023 and 2024. Among them, small-molecule drugs account for a greater percentage (51.9%), illustrating the discovery of new chemical entities. Macromolecule drugs (48.1%), which mainly consist of antibody analogs, represent a growing trend as new biotechnology techniques have emerged. In terms of FIC

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… Qi C. Chen Y. Claudin 18.2 as a novel therapeutic target Nat. Rev. Clin. Oncol. 21 2024 354 369 38503878 10.1038/s41571-024-00874-2 7 Gu J. Wu Q. Zhang Q. A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives Eur. J. Med. …

Exploring the role of Transcranial magnetic stimulation in cognitive impairment and sarcopenia: a narrative review.

Sarcopenia and cognitive impairment (CI) are major contributors to disability among the elderly, diminishing their quality of life and placing also a significant burden on healthcare systems and societies. There are currently no effective treatments for sarcopenia and CI. Interestingly, recent research has revealed a strong connection between these two conditions. Although the exact mechanisms of this relationship remain unclear, factors such as chronic inflammation, mitochondrial oxidative stress, and impaired communication through the muscle-brain axis have been put forward. Transcranial mag

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… Neurol Sci . 398 184–191. 10.1016/j.jns.2019.01.038 Liu S., Fan M., Xu J., Yang L., Qi C., Xia Q., et al. (2022). Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology. J. …

The role of the PD-1/PD-L1 immune checkpoint pathway in myocardial infarction: a review from pathophysiological mechanisms to therapeutic strategies.

Programmed cell death protein 1 (PD-1) and its ligand, programmed death-ligand 1 (PD-L1), are vital molecules in immune checkpoints, significantly impacting cancer treatment. Recent studies have increasingly highlighted the complex roles of the PD-1/PD-L1 pathway in cardiovascular diseases, particularly in myocardial infarction (MI). In addition to being involved in immune modulation and the inflammatory response post-myocardial ischemia, this pathway is also crucial for myocardial repair and regeneration. Additionally, the clinical application of PD-1/PD-L1 immune checkpoint inhibitors has le

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… Li T, Yan Z, Fan Y, Fan X, Li A, Qi Z, et al. Cardiac repair after myocardial infarction: a two-sided role of inflammation-mediated. Front Cardiovasc Med. (2022) 9:1077290. 10.3389/fcvm.2022.1077290 4. Shao L, Shen Y, Ren C, Kobayashi S, Asahara T, Yang J. …

Recent advancement in the anticancer efficacy of the natural flavonoid scutellarin: a comprehensive review.

Scutellarin (SC), a natural flavonoid, has been expansively employed in treating innumerable inflammation-related diseases due to its antitumor, antiinflammatory, anticancer, and antioxidant potential. Scutellarin can inhibit significant inflammatory cell signaling pathways, comprisingPI3K/Akt, NF-κB, and MAPK, and while activating antioxidant-related pathways such as Nrf2 and ARE. Numerous reviews have outlined scutellarin's pharmacological effects and associated mechanisms in inflammation-related diseases. Several studies have elucidated the mechanisms of anticancer activity by inhibiting va

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… Qi X. Li H. Ye P. Wang Z. ( 2017 ). Research progress in reversal of tumor multi-drug resistance via natural products . Anti-Cancer Agents Med. Chem. Former. Curr. Med. Chemistry-Anti-Cancer Agents 17 ( 11 ), 1466 – 1476 . 10.2174/1871520617666171016105704 29034843 Guo Y. Y. Zhou Y. Li Y. J. …

Endothelial dysfunction and hemostatic imbalance in CAR T-cell-associated toxicities: pathophysiological insights and the role of circulating biomarkers.

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed or refractory hematologic malignancies. While its clinical efficacy is well established, CAR T-cell therapy is frequently associated with severe immune-mediated toxicities, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), coagulopathy, and hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS). Increasing evidence suggests that endothelial dysfunction, hemostatic imbalance, and complement activation are key contributors to the pathogenesis of

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… Blood advances . ( 2021 ) 5 : 593 – 601 . doi: 10.1182/bloodadvances.2020002757 , PMID: 33496754 PMC7839371 83 Wang Y Qi K Cheng H Cao J Shi M Qiao J . …

Mechanistic Insights into the Metabolic Pathways and Neuroprotective Potential of Pentacyclic Triterpenoids: In-Depth Analysis of Betulin, Betulinic, and Ursolic Acids.

Due to their complexity, both genotypic and phenotypic, neurodegenerative diseases are one of the main causes of death globally nowadays. Among phytochemicals of high scientific interest, based on experimental studies, pentacyclic triterpenoids (TTs), including mainly betulin, betulinic, and ursolic acid, became targets of scientific research in recent years, especially in terms of their biological activity and pharmacological potential. Due to their anti-inflammatory and antioxidant properties, as well as their involvement in cellular signal transductions, they have been observed to act as an

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… Qi Y. Wang M. Liao P. Natural products attenuate PI3k/AKT/mtor signaling pathway: A promising strategy in regulating neurodegeneration Phytomedicine 2021 91 153664 10.1016/j.phymed.2021.153664 34391082 122. Chakraborty B. Mukerjee N. Maitra S. Zehravi M. Mukherjee D. Ghosh A. Massoud E.E.S. …

Phosphodiesterase 7: a potential novel therapeutic target in ovarian cancer.

INTRODUCTION: Chemoresistance and disease relapses in epithelial ovarian cancer (EOC) highlight the need for novel therapeutic strategies. Here, we investigated phosphodiesterase 7A (PDE7A) as a potential target in ovarian cancer treatment. METHODS: Gene expression was performed by RNA sequencing data comparing high-grade serous ovarian carcinoma (HGSOC) and fallopian tube samples. The PDE7 inhibitor BRL 50481, alone or combined with paclitaxel (PTX), was tested in drug-sensitive A2780 and multi-resistant OVCAR3 cells by Diphenyltetrazolium bromide (MTT) assay. To validate data from the high

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… Qi J. White S. W. ( 2009 ). Validation of molecular docking programs for virtual screening against dihydropteroate synthase . J. Chem. Inf. Model 49 ( 2 ), 444 – 460 . 10.1021/ci800293n 19434845 PMC2788795 Hibi M. Murakami M. Saito M. Hirano T. Taga T. Kishimoto T. ( 1990 ). …

Anticancer peptides as novel immunomodulatory therapeutic candidates for cancer treatment.

Cancer remains a concern after years of research in this field. Conventional therapies such as chemotherapy, radiation, and surgery are available for cancer treatment, but they are characterized by various side effects. There are several immunological challenges that make it difficult for the immune system and conventional therapies to treat cancer. Some of these challenges include heterogeneity, resistance to medicines, and cancer relapse. Even advanced treatments like immune checkpoint inhibitors (ICIs), which revolutionized cancer treatment, have associated toxicity and resistance further n

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… Chen X, Zou X, Qi G, Tang Y, Guo Y, Si J, et al. Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer. Cell Physiol Biochem. 2018;47:1060–73. doi: 10.1159/000490183. 119. Matsuzaki K. Magainins as paradigm for the mode of action of pore forming polypeptides. …

Monitoring concentration and lipid signature of plasma extracellular vesicles from HR+ metastatic breast cancer patients under CDK4/6 inhibitors treatment.

Extracellular vesicles (EVs) are cell-derived small membrane structures that transport various molecules. They have emerged as potential circulating biomarkers for monitoring responses to cancer therapies. This study aimed to comprehensively characterize plasma-carried EVs in hormone receptor-positive (HR+) metastatic breast cancer (MBC) patients treated with first-line CDK4/6 inhibitors (iCDK4/6) combined with endocrine therapy. MBC patients were classified into three groups based on their response to therapy: resistant, intermediate or sensitive. In a prospective cohort, we monitored the con

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… CA: A Cancer Journal for Clinicians , 69 ( 5 ), 363 – 385 . 10.3322/caac.21565 31184787 Moro , K. , Kawaguchi , T. , Tsuchida , J. , Gabriel , E. , Qi , Q. , Yan , L. , Wakai , T. , Takabe , K. , & Nagahashi , M. ( 2018 ). …

Sex- and Gender-Related Differences in Obesity: From Pathophysiological Mechanisms to Clinical Implications.

Obesity, primarily characterized by excessive fat accumulation, is a multifactorial chronic disease with an increasing global prevalence. Despite the well-documented epidemiology and significant advances in understanding its pathophysiology and clinical implications, the impact of sex is typically overlooked in obesity research. Worldwide, women have a higher likelihood to become obese compared to men. Although women are offered weight loss interventions more often and at earlier stages than men, they are more vulnerable to psychopathology. Men, on the other hand, are less likely to pursue wei

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… Heid I.M., Jackson A.U., Randall J.C., Winkler T.W., Qi L., Steinthorsdottir V., Thorleifsson G., Zillikens M.C., Speliotes E.K., Mägi R., et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat. …