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Best of Both Worlds? Fixation of Distal Femur Fractures with the Nail-Plate Construct.

OBJECTIVES: Distal femoral fractures are a significant injury sustained by low- and high-energy trauma. Common treatment practices are lateral locking plate or intramedullary nail fixation, with disadvantages including risk of non and malunion and limited post-operative weightbearing status. Combining both techniques as a nail-plate construct (NPC) theoretically achieves enhanced fixation to allow immediate weightbearing. The aim of this study is to examine radiographic union, malunion and patient-reported outcomes in distal femur NPC fixation. METHODS: Single-center retrospective study inclu

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… “Open box” design in a TKA refers to a femoral prosthesis with cancellous bone uncovered at the intercondylar fossa, thereby allowing insertion of a retrograde IMN. In comparison, a “closed box” prosthesis covers this area of cancellous bone and therefore precludes insertion of a retrograde IMN. …

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects.

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety of surgical techniques, current clinical strategies for bone defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient bone volume, bone graft resorption, and rejection. Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical

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… Kneser et al. reported the use of the AVL including artery, vein and vein graft, for bovine cancellous bone blocks axial vascularization in rats. … Beier et al. presented results of the bovine cancellous bone block axial vascularization via AVL in a sheep model. AVL was microsurgically created in an isolation chamber. …

Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice.

Chemotherapy is frequently accompanied by several side effects, including nausea, diarrhea, anorexia and fatigue. Evidence from ours and other groups suggests that chemotherapy can also play a major role in causing not only cachexia, but also bone loss. This complicates prognosis and survival among cancer patients, affects quality of life, and can increase morbidity and mortality rates. Recent findings suggest that soluble factors released from resorbing bone directly contribute to loss of muscle mass and function secondary to metastatic cancer. However, it remains unknown whether similar mech

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… Cisplatin Treatment Leads to Severe Bone Loss MicroCT assessment of the microarchitecture of femurs excised from mice treated with cisplatin displayed severe loss of cancellous bone ( Figures 3A,B ), as demonstrated by decreased trabecular bone volume ratio (BV/TV; −41%, p < 0.001 vs. … Trabecular Bone Is Preserved in the Mice Receiving the Combination C+ZA microCT analysis of femoral bone from animals exposed to cisplatin revealed marked loss of cancellous bone ( Figures 7A,B ). We observed reduced BV/TV (−35%, p < 0.05 vs. V) and Tb.N (−28%, p < 0.05 vs. …

Denosumab induction and Zoledronic acid maintenance therapy for recurrent unresectable giant cell tumour of the distal tibia: A case report with sustained tumour control after drug withdrawal.

A 31-year-old woman was diagnosed with a recurrent and rapidly growing giant cell tumour of distal tibia with skin ulceration after intralesional curettage. The patient started on Denosumab 120 mg subcutaneously, once per month with additional loading doses on Days 8 and 15 attempting to avoid below-knee amputation. Twelve doses of Denosumab were administered in 9 months, resulting in resolution of pain, reduction of tumour size and calcification. Hence, the local surgical treatment was delayed and bisphosphonate maintenance therapy was initiated as skin healing was incomplete. The patient was

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… bone formation within the lesion (ten months without antiresorptive treatment). … Fortunately, throughout the period of maintenance treatment, which lasted 31 months after DM withdrawal and over 10 additional months after ZA discontinuation, no progression and increasingly cancellous bone formation was observed on radiographic images. …

От фей к гигантам: Развенчание влияния размера тела, филогении и экологии на костную микроструктуру ксенарнских млекопитающих.

Трабковая кость — губчатая костная ткань, которая служит в качестве опоры, как решётка, внутри многих элементов скелета. Предыдущие исследования выявили аллометрические вариации в некоторых аспектах трабекулярной архитектуры костей (ТБА) и костной микроструктуры, в то время как другие - изометрически. Однако в большинстве из этих исследований были изучены весьма широкие размеры и диапазоны филогенетики или они были сосредоточены исключительно на приматах или лабораторных мышах. Мы изучили воздействие размера тела на ТБА по меньшему диапазону в млекопитающем клеще Ксенартра (плохи, бронежилиры

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… Three-dimensional methods for quantification of cancellous bone architecture. Bone 20:315–28. Odgaard A, Gundersen HJ. 1993. Quantification of connectivity with special emphasis on 3D reconstructions. Bone 14:173–82. Oliver JD, Jones KE, Hautier L, Loughry WJ, Pierce SE. 2016. … Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone 46:314–21. Swartz SM, Parker A, Huo C. 1998. Theoretical and empirical scaling patterns and topological homology in bone trabeculae. …

Oncology Nursing During a Pandemic: Critical Reflections in the Context of COVID-19.

ObjectivesTo provide a critical reflection of COVID-19 in the context of oncology nursing and provide recommendations for caring for people affected by cancer during this pandemic.Data sourcesElectronic databases, including CINAHL, MEDLINE, PsychINFO, Scopus, professional web sites, and grey literature were searched using Google Scholar.ConclusionNurses are key stakeholders in developing and implementing policies regarding standards of care during the COVID-19 pandemic. This pandemic poses several challenges for oncology services. Oncology nurses are providing a pivotal role in the care and ma

Витамин К: Инфекция, воспаление и автоиммунитет.

Витамин К (VK) состоит из группы веществ с биоактивностью хлорофилла квинона и существует в природе в виде VK1 и VK2. Так как его первоначальное распознавание было основано на способности поощрять коагуляцию крови, он известен как витамин коагуляции. Однако, основываясь на обширных исследованиях, VK продемонстрировал потенциал в области профилактики и лечения различных заболеваний. В последние годы растет интерес к исследованиям, демонстрирующим благотворное воздействие ВК на иммунитет, способность к антиоксидантам, регулирование кишечника микробиота, развитие эпителии и защиту костей. В этой

Radiomics-based classification of medication-related osteonecrosis of the jaw using panoramic radiographs.

OBJECTIVES: Medication-related osteonecrosis of the jaw (MRONJ) caused by bone resorption inhibitors is difficult to treat and reduces the patient's quality of life. We aimed to classify the likelihood of MRONJ development using panoramic radiographs taken prior to bone resorption inhibitor administration. METHODS: We included patients who underwent panoramic radiographic evaluation at Hiroshima University Hospital prior to bone resorption inhibitor administration. Thirty-two patients with MRON of the mandible (16 men and 16 women) and 57 without MRONJ (23 men and 34 women) were selected. The

Pertrochanteric fracture of an ankylosed hip with protrusio acetabuli treated by PFNA nail: A case report of a rare case.

INTRODUCTION: Hip fractures are the cause of significant morbidity and mortality, aggravated by the existence of an underlying hip pathology. The association of a pertrochanteric fracture with an ankylosed hip and acetabular protrusion is extremely rare. It has not been reported in the literature and the optimal management remains unknown. The surgical treatment indicated for trochanteric fractures allows patients to restore their autonomy quickly while avoiding complications. CASE PRESENTATION: We present the case of a 45-year-old patient who was followed for multiple myeloma and treated wit

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… Next, we chose a cervical blade ( Fig. 4 (c)), which recruits the cancellous bone during insertion to provide better anchorage while taking fixation on the calcar ( Fig. 4 (d)). …

Detection of potential complications in cancer survivors after chemotherapy and development of a regional care network: the PASCA feasibility study.

Complications are often poorly identified and managed in cancer survivors after treatment and restoring their initial quality of life remains a challenge, particularly in a context of unequal access to care nationwide. The PASCA "Parcours de Santé au cours du Cancer [in English: healthcare pathways with cancer]" feasibility study was conducted in the Léon Bérard Comprehensive Cancer Center (Lyon, France) to assess the feasibility of a complications detection program, in cancer survivors who have received intensive chemotherapy. An initial network of physicians and healthcare professionals was

Weekly teriparatide injections successfully treated advanced bisphosphonate-related osteonecrosis of the jaws.

This study investigated whether weekly teriparatide (TPTD) injections are as effective as daily teriparatide injections for the treatment of stage 3 bisphosphonate-related osteonecrosis of the jaws (BRONJ) and compared serum markers of bone turnover between the two treatment regimens. Daily TPTD treatment has recently been reported to be effective for BRONJ, but there are no reports describing the effectiveness of weekly TPTD injections. We report two patients with stage 3 BRONJ. One patient was successfully treated with weekly TPTD injections and the other with daily TPTD injections. Changes

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… Recombinant human parathyroid hormone (1–34) [teriparatide] improves both cortical and cancellous bone structure. J Bone Miner Res. 2003;18:1932–1941. doi: 10.1359/jbmr.2003.18.11.1932. …

Cement venogram as a harbinger of methacrylate embolism after kyphoplasty: A case series.

Vertebral compression fractures remain an important cause of pain and debility. Intractable pain may be approached with vertebral kyphoplasty. We herein present a case of symptomatic pulmonary cement embolism following kyphoplasty. Discovery of a paravertebral cement venogram at the time of this procedure prompted a case series review of our institutional experience with kyphoplasty. We found that cement embolization, whether symptomatic or discovered incidentally, was universally associated with a cement venogram at the site of vertebroplasty. We propose that a cement venogram be viewed as a

A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers.

This single-center retrospective observational study aimed to identify risk factors for developing denosumab-related osteonecrosis of the jaw (DRONJ) in stage IV solid cancer patients with bone metastases. In total, 123 consecutive patients who had received 120 mg of denosumab every 4 weeks at least twice between July 2014 and October 2018 were included. We surveyed their demographics, medical history, blood test, underlying disease, and intraoral findings. Fourteen patients (11.4%) developed DRONJ within a mean denosumab administration period of 4 months (range: 2-52 months). Univariate analy

The PI3K inhibitor buparlisib suppresses osteoclast formation and tumour cell growth in bone metastasis of lung cancer, as evidenced by multimodality molecular imaging.

Non‑small cell lung cancer (NSCLC) metastasis commonly occurs in bone, which often results in pathological fractures. Sustained phosphoinositide‑3‑kinase (PI3K) signalling promotes the growth of PI3K‑dependent NSCLC and elevates osteoclastogenic potential. The present study investigated the effects of a PI3K inhibitor on NSCLC growth in bone and osteoclast formation, and aimed to determine whether it could control symptoms associated with bone metastasis. A bone metastasis xenograft model was established by implanting NCI‑H460‑luc2 lung cancer cells, which contain a phosphatidylinositol‑​4,5‑b

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… Along the direction of the lateral border of the tibia, the needle was injected through the tibial cancellous bone into the marrow cavity from the centre of the tibial plateau using an empty BD insulin syringe (U40; 1 ml; 29 g × 12.7 mm; diameter, 0.30 mm; BD Biosciences, Franklin Lakes, NJ, USA). … The cancellous bone region of the femoral head was used as a region of interest for quantitative calculations. Bone volume/total volume, trabecular thickness, trabecular number and trabecular separation were calculated using the Inveon analysis workstation. …

MASCC/ISOO Clinical Practice Statement: imaging and clinical laboratory tests in the diagnosis and management of medication-related osteonecrosis of the jaw.

PURPOSE: A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise resource for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS focuses on the use of imaging and clinical laboratory tests for the diagnosis, staging, monitoring, treatment decision, and prediction of medication-related osteonecrosis of the jaw (MRONJ) in cancer patients. METHODS: This CPS was developed based on a critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of

Outcomes in dogs undergoing surgical stabilization and non-stereotactic radiation therapy for axial and appendicular bone tumors.

BackgroundInformation on dogs that undergo radiation therapy (RT) with non-stereotactic protocols in addition to surgical stabilization with implant placement for treatment of bone tumors is limited.ObjectiveOur primary objectives were to describe the clinical characteristics as well as short- and long-term outcomes, including complications, function, and disease progression, in dogs that underwent both surgical stabilization with implant placement and non-stereotactic RT for local treatment of a bone tumor.MethodsA bi-institutional retrospective case series was performed.AnimalsEight client-o

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… Fracture repair involved cancellous bone graft instillation into a 1.5 cm bone defect and fixation of a complete, simple, transverse fracture with a broad locking compression plate with multiple cortical and locking screws. …

Оценка в реальном мире физиотерапевтических упражнений в процессе предварительной абилитации и реабилитации во время аутологической трансплантации стволовых клеток в миэломе: опыт работы в одном центре.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Имеются новые данные, свидетельствующие о роли упражнений в оптимизации функций, качестве жизни (QoL) и сокращении продолжительности пребывания в больнице, если они начались до пересадки аутологических стволовых клеток (ASCT). Проведенное на местном уровне экспериментальное исследование в области предабилитации и реабилитации пациентов миломы в ходе АОПП показало обнадеживающие результаты и было адаптировано к местным медицинским услугам. Цель настоящего доклада состоит в том, чтобы дать общее представление о недавно внедренной физиотерапевтической службе предварительной

The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis.

Extracellular vesicles (EVs) are complex phospholipidic structures actively released by cells. EVs are recognized as powerful means of intercellular communication since they contain many signaling molecules (including lipids, proteins, and nucleic acids). In parallel, changes in epigenetic processes can lead to changes in gene function and finally lead to disease onset and progression. Recent breakthroughs have revealed the complex roles of non-coding RNAs (microRNAs (miRNAs) and long non-coding RNAs (lncRNAs)) in epigenetic regulation. Moreover, a substantial body of evidence demonstrates tha

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… In women, the increase in the bone remodeling rate in both cortical and cancellous bone, combined with a negative remodeling balance, results in bone loss and collapse of bone microarchitecture. … Indeed, cortical bone peculiarly shows an increase in cortical porosity and a reduction in cortical thickness, while cancellous bone is mainly affected by thinning and loss of trabeculae [ 5 , 6 , 7 ]. In men, a reduction in bone formation and bone turnover occurs during aging. …

Osteoporosis in Men: A Review of an Underestimated Bone Condition.

Osteoporosis is called the 'silent disease' because, although it does not give significant symptoms when it is not complicated, can cause fragility fractures, with serious consequences and death. Furthermore, the consequences of osteoporosis have been calculated to weigh heavily on the costs of health systems in all the countries. Osteoporosis is considered a female disease. Actually, the hormonal changes that occur after menopause certainly determine a significant increase in osteoporosis and the risk of fractures in women. However, while there is no doubt that women are more exposed to osteo

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… From the table, it can be seen that the ratio between bone volume and total volume does not change differently between men and women, but the total number of trabeculae decreases significantly in women and not in men, while trabecular thinning is lower in women in the cancellous bone. … Bone mineral densitometric indexes of the lumbar spine (cancellous bone) and distal radius (cortical bone) were consistent with osteoporosis; the distal radius was −4.7 SD below the mean value for age- and sex-matched normal men; indexes of bone turnover were increased. …

Colorectal cancer with first known case of simultaneous bilateral tibial metastases.

The most common osseous metastatic regions for colorectal cancer are the lumbar and sacral vertebrae and the pelvis. There are few reported cases of isolated solitary tibial metastasis, and simultaneous bilateral solitary tibial metastases in colorectal cancer are even rarer. A 62-year-old female patient was admitted to our inpatient clinic 3 years after receiving initial chemotherapy for a rectosigmoid adenocarcinoma with liver metastasis. The patient complained of left leg pain. Radiographs and magnetic resonance imaging revealed a 3- × 3-cm mass in the right proximal tibia and a 2- × 7-cm m

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… Metastatic colorectal cancer is usually osteolytic or mixed osteolytic/osteoblastic. 14 The tumor may be deposited on cortical or cancellous bone. 3 Clinically, in the early stages, patients are sometimes asymptomatic. …