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Shengma Biejia Decoction Inhibits Cell Growth in Multiple Myeloma by Inducing Autophagy-Mediated Apoptosis Through the ERK/mTOR Pathway.

Shengma Biejia decoction (SMBJD), a traditional Chinese formula recorded in the Golden Chamber, has been widely used for the treatment of malignant tumors. However, its underlying molecular targets and mechanisms are still unclear. This study showed that SMBJD inhibited tumor growth and stimulated hemogram recovery significantly in a multiple myeloma xenograft model. Western blot and immunohistochemistry assays of tumor tissues showed that SMBJD reduced the ratio of autophagy-related proteins LC3-II/LC3-I, while P62 and apoptosis-related proteins cleaved caspase-3/caspase-3 and Bax/Bcl-2 were

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… Finally, the sections were dehydrated with an alcohol gradient and permeabilized with xylene (Servicebio, Wuhan, China); the slides were sealed and then scanned using a Pannoramic 250 Flash III (3dhistech, Budapest, Hungary). …

Access to novel cancer medicines in Europe: inequities across countries and their drivers.

BackgroundAn increasing number of cancer medicines are being developed and approved. Access to these medicines is important for improving patient outcomes and overall quality of care, yet achieving equitable access across countries in Europe is challenging.MethodThis study reviews inequities in access to novel cancer medicines in countries of the European Union (EU) and European Economic Area (EEA), and neighboring countries, at three critical stages: regulatory approval, reimbursement approval, and use in clinical practice. It also examines reasons contributing to these inequities. The analys

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… with Malta. 14 , 22 Yet considerable differences exist even across CEE countries with similar GDP per capita, with the reimbursed proportion of EMA-approved indications ranging from 19% in Slovakia to 64% in Czechia and the median time to reimbursement ranging from 27 months in Poland to 37 months in Hungary …

Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk.

Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely that many true risk loci are missed. Functional annotation of GWAS polymorphisms is a proven strategy to identify additional risk loci. We aimed to investigate single-nucleotide polymorphisms (SNP) in regulatory regions [transcription factor binding sites (TFBSs) and enhancers] that could change the expre

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… It is a multicentric consortium consisting of 11 European countries (Greece, Italy, Germany, the Netherlands, Denmark, the Czech Republic, Hungary, Poland, Ukraine, Lithuania, and the UK), whose samples and data have been collected at the German Cancer Research Center (DKFZ, Heidelberg, Germany), where …

Epidemiology and source of infection in cancer patients with febrile neutropenia: an experience from a developing country.

BackgroundFebrile neutropenia (FN) is a life-threatening complication that predisposes cancer patients to serious infections. This study aims to describe the epidemiology and source of infection in cancer patients with FN in a tertiary care hospital.MethodsA hospital-based retrospective study was conducted in a large tertiary care hospital from January 2020 to December 2021. Data on cancer patients with FN were collected from the hospital information system.Results150 cancer patients with FN were identified during the study period. Most patients were males (98; 65.3%), and the mean age of part

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… Epidemiological trends and resistance associated with Stenotrophomonas maltophilia Bacteremia: a 10-year retrospective cohort study in a tertiary-care hospital in Hungary. Diseases. 2019;7(2):41. doi: 10.3390/diseases7020041. 27. Gajdács M. …

Oncological Diseases and Social Costs Considerations on Undertaken Health Policy Interventions.

The growing incidence and prevalence of civilization diseases is prompting national and transnational entities to seek instruments that would reverse epidemiological trends. Not without significance is the need to design such solutions that are going to provide an improved relation between the costs incurred to maintain health or recovery and the profit for citizens of continuing to function in good health. In its strategic documents, the European Union indicates the most important development goals in each financial perspective and the tools necessary to achieve them. In the Europe 2020 strat

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… The highest rates of cancer incidence among women were recorded in Australia (363/100,000), New Zealand (358.3), and Hungary (330.6/100,000) [ 7 ]. In 2018, there were about 18 million cancer cases worldwide, of which about 9.5 million were male and 8.5 million were female. …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

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… P1246: Clinical characteristics of rotavirus, enteric adenovirus and astrovirus infections among hospitalised children in Hungary F. Jakab, L. Varga, Z. Nyul, D. Mitchell, J. Walter, T. Berke, D. Matson, G. … Based on the epidemiological and clinical data we can conclude that these enteric viruses are a significant burden of disease based upon hospitalizations for childhood gastroenteritis in Baranya County, Hungary. …

Identification and validation of CKAP2 as a novel biomarker in the development and progression of rheumatoid arthritis.

BACKGROUND: Rheumatoid arthritis (RA) is a common chronic joint disease. However, many patients exhibit inadequate responses to treatment due to disease heterogeneity. Identifying novel biomarkers for RA is crucial for advancing molecular diagnosis and identifying potential therapeutic targets. METHODS: Synovial tissue transcriptome data from RA patients and healthy controls were obtained from the GEO database. Differentially expressed gene (DEG) analysis, functional enrichment analysis, and weighted gene co-expression network analysis (WGCNA) identified key gene modules in RA. Machine learni

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… Neutral resin was applied to seal the sections, and slides were imaged in the Department of Pathology of Shantou Central Hospital using a digital slide scanner (Pannoramic SCAN, 3DHISTECH Ltd, Hungary). …

Oral health status and quality of life in female patients receiving low dose bone-modifying agents for cancer treatment-induced bone loss: a single-center exploratory study.

INTRODUCTION: Breast cancer patients, undergoing low-dose bone-modifying agent (LD-BMA) therapy for cancer treatment-induced bone loss (CTIBL), represent an emerging category at risk of Medication-Related (MRONJ) low (<1%) but not absent. However, data on their oral health status and quality of life related are currently limited. This single-center exploratory study aimed to assess oral health conditions, periodontal status, and oral health-related quality of life in non-metastatic breast cancer patients under LD-BMA therapy for CTIBL. MATERIALS AND METHODS: Forty patients were consecutively

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… Edited by: Luis Proença , Instituto Universitário Egas Moniz, Portugal Reviewed by: Kasidid Ruksakiet , Semmelweis University, Hungary Silvia D'Agostino , G. …

Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study.

BACKGROUND AND OBJECTIVES: Cladribine tablets (CladT) represent an effective immune reconstitution therapy, administered in short treatment courses over two consecutive years. To better understand the amplitude of immune changes, we performed a comprehensive analysis during the 2-year study period for the entire MAGNIFY-MS population (N=270). In addition to lymphocyte kinetics, we studied intracellular cytokines serum proteins, and their associations with clinical outcomes. To put these changes into perspective, we analyzed transcriptional changes in T and B cells and associated biological pat

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… Hungary: Medical Research Council, Ethics Committee for Clinical Pharmacology, Budapest. …

Retrospective analysis of the efficacy of adjuvant cytokine-induced killer cell immunotherapy combined with chemotherapy in colorectal cancer patients after surgery.

ObjectivesEven though postoperative chemotherapy can eliminate residual tumor cells in patients with colorectal cancer (CRC), severe adversity, weakened immunity and drug resistance are still problems. Adjuvant cytokine-induced killer (CIK) cell therapy is an alternative to CRC patients after surgery. The present study investigated the efficacy of adjuvant CIK cell therapy combined with chemotherapy in postoperative CRC patients.MethodsThis retrospective analysis included 137 postoperative CRC patients, including 71 who received adjuvant chemotherapy alone (control group) and 66 who received a

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… The slides were again washed three times with PBS, sealed with anti‐fluorescence quencher (Servicebio), digitised with a fluorescence pannoramic slide scanner (PANNORAMIC DESK/MIDI/250/1000, 3DHISTECH, Budapest, Hungary) and analysed with appropriate analytic software (Halo v3.0.311.314, Indica labs, …

Mapping Functions in Health-Related Quality of Life: Mapping from Two Cancer-Specific Health-Related Quality-of-Life Instruments to EQ-5D-3L.

BACKGROUND: Clinical trials in cancer frequently include cancer-specific measures of health but not preference-based measures such as the EQ-5D that are suitable for economic evaluation. Mapping functions have been developed to predict EQ-5D values from these measures, but there is considerable uncertainty about the most appropriate model to use, and many existing models are poor at predicting EQ-5D values. This study aims to investigate a range of potential models to develop mapping functions from 2 widely used cancer-specific measures (FACT-G and EORTC-QLQ-C30) and to identify the best model

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… Footnotes This work has been presented at the following meetings: International Society of Quality of Life Research (ISOQOL), Budapest, Hungary, October 2012; Health Economic Study Group (HESG), Exeter, UK, January 2013; 9th World Congress on Health Economics (iHEA), Sydney, Australia, July 2013; and …

Some Aspects and Convergence of Human and Veterinary Drug Repositioning.

Drug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter, cheaper, and less risky. This review provides an overview of drug innovation in both human and veterinary medicine, with a focus on drug repositioning. The evolution of drug repositioning and the effectiveness of this approach are presented, including the growing role of data science and computational modeling methods in identifying drugs with po

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… National authorization date indicates the date of the first authorization in Hungary. * Tepoxalin was withdrawn by the EMA in 2012 but remains on the market in the USA under FDA approval. H: Active substance taken from human medicine; V: active substance authorized only in veterinary medicine. … Conflicts of Interest This study was sponsored by the National Research, Development and Innovation Office (Hungary) and the E-GROUP ICT SOFTWARE Information Technology Private Limited Company. There is no conflicts of interest between the authors and the sponsors. Funding Statement Project no. …

Emerging Therapies in the Management of Advanced-Stage Gastric Cancer.

Globally, gastric malignancy contributes to significant cancer-related morbidity and mortality. Despite a recent approval of two targeted agents, trastuzumab and ramucirumab, the treatment options for advanced-stage gastric cancer are limited. Consequently, the overall clinical outcomes for patients with advanced-stage gastric cancer remain poor. Numerous agents that are active against novel targets have been evaluated in the course of randomized trials; however, most have produced disappointing results because of the molecular heterogeneity of gastric cancer. The Cancer Genome Atlas (TCGA) pr

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… Patients with advanced GC/GEC in the U.S., Australia, Poland, Hungary, Spain, and Turkey are currently being recruited for a phase III randomized, double-blind, placebo-controlled trial (Bendell et al., 2017a ) that aims to compare the efficacy of andecaliximab vs. placebo in combination with mFOLFOX … Another phase II trial is planned to evaluate the safety and efficacy of the combination of nivolumab (3 mg/kg) and andecaliximab (800 mg, IV) vs. nivolumab (3 mg/kg alone) for recurrent or advanced GC; this trial aims to enroll 120 patients in the U.S., Hungary, and Australia (Shah et al., 2017a ) [ …

UEG Week 2017 Oral Presentations

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Population health impacts from the taxation of salt and sugar in the United Kingdom.

ObjectiveTo estimate the potential health benefits from the reduction in consumption of salt and sugar following the introduction of a proposed tax on salt and sugar in the United Kingdom (UK).DesignEpidemiological modelling study. Life table modelling was used to estimate the expected population health benefits from the reduction in consumption of salt and sugar for four scenarios, each reflecting different manufacturer and consumer responses the proposed tax. Relative risks for twenty-four disease-risk pairs were applied, exploring different pathways between salt and sugar consumption, and m

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… The recommendation is based on findings from countries such as Mexico ( 40 ) , Hungary ( 41 ) and Denmark ( 42 ) , which have all suggested decreased purchases of taxed foods from food categories such as confectionery and ice cream. …

Isatuximab in combination with cemiplimab in patients with relapsed/refractory multiple myeloma: A phase 1/2 study.

BACKGROUND: Given the incurable nature of multiple myeloma (MM), efforts are made to improve the efficacy of anti-CD38 monoclonal antibodies via combinations with other potentially synergistic therapies. This Phase 1/2 trial (NCT03194867) was designed to determine whether cemiplimab (anti-PD-1) enhances the anti-myeloma activity of isatuximab (anti-CD38) in patients with relapsed and refractory multiple myeloma (RRMM), to confirm the feasibility of the combination, determine its efficacy, and further evaluate its safety. METHODS: Patients received isatuximab 10 mg/kg once weekly for 4 weeks f

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… Patients were enrolled at 29 sites in 10 countries (Australia, Brazil, Canada, Czech Republic, France, Greece, Hungary, Italy, Spain, and the United States). The study employed an independent Data Monitoring Committee to monitor the safety of patients enrolled in the study. …

A Pilot Clinical Study of Hyperacute Serum Treatment in Osteoarthritic Knee Joint: Cytokine Changes and Clinical Effects.

The serum fraction of platelet-rich fibrin (hyperacute serum) has been shown to improve cartilage cell proliferation in in vitro osteoarthritic knee joint models. We hypothesize that hyperacute serum may be a potential regenerative therapeutic for osteoarthritic knees. In this study, the cytokine milieu at the synovial fluid of osteoarthritic knee joints exposed to hyperacute serum intraarticular injections was investigated. Patients with knee osteoarthritis received three injections of autologous hyperacute serum; synovial fluid was harvested before each injection and clinical monitoring was

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… Eighteen ml venous blood was taken by venipuncture from the patients with the hypACT Inject device (OrthoSera Kft, Budapest, Hungary), which was immediately centrifugated at 1710× g for 8 min [ 64 ]. …

Pre-Engraftment Syndrome After Autologous Stem Cell Transplantation in Relapsed or Refractory Hodgkin Lymphoma: An Association with Prior PD-1 Inhibitor Exposure.

Background and Objectives: Autologous stem cell transplantation (ASCT) remains the standard of care for relapsed or refractory Hodgkin lymphoma (R/R HL), and an increasing proportion of patients receive programmed cell death protein 1 (PD-1) inhibitors prior to transplantation. Engraftment syndrome (ES) is a noninfectious inflammatory complication classically associated with neutrophil recovery; however, early peri-transplant inflammatory manifestations remain poorly characterized and may mimic infectious complications. We aimed to evaluate peri-transplant inflammatory events after ASCT, with

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… Improved survival of autologous stem cell transplantation in primary refractory and relapsed Hodgkin lymphoma in the brentuximab vedotin era—Real-world data from Hungary Ann. Hematol. 2023 102 2555 2563 10.1007/s00277-023-05354-8 37428200 PMC10444678 2. Chung S. White J. Toze C.L. Sutherland H.J. …

Global welfare burden of hematologic malignancies from 2015 to 2023.

Hematologic malignancies cause premature mortality and disability across the life course, but their welfare burden is difficult to compare across countries. We monetized global burden of disease (GBD) 2023 disability-adjusted life years (DALYs) for major hematologic malignancies in 188 countries from 2015 to 2023 using a value of lost welfare framework incorporating purchasing power parity adjusted gross domestic product (GDP), income transfer, age-specific valuation, and discounting. Global leukemia-related value of lost welfare (VLW) increased from US$1.40 trillion to US$1.70 trillion, while

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… Tunisia (+1.83 percentage points), Iran (+1.37 percentage points), and Turkiye (+1.05 percentage points), whereas the largest downward shifts occurred in Ukraine (−4.84 percentage points), Bulgaria (−3.59 percentage points), Lithuania (−2.46 percentage points), Moldova (−2.30 percentage points), and Hungary …

Radiocopper in BCMA-targeted immunotheranostics of myeloma.

BACKGROUND: The theranostic potential of copper-64 (PET imaging) and copper-67 (SPECT imaging and therapy) is increasingly recognized. This work investigates the performance of this 'true' matched pair in a preclinical radioimmunotheranostic setting that utilizes experimental monoclonal antibodies (mAbs) directed against B cell maturation antigen (BCMA), a transmembrane glycoprotein that has emerged as a critical target for the treatment of multiple myeloma (MM). METHODS: The commercially available BCMA-directed mAbs MAB193 and Vicky-1 were modified with the bispidine N2py4 enabling chelation

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… Positron emission tomography Small-animal positron emission tomography (PET) was performed using the nanoScan PET/CT (Mediso Medical Imaging Systems, Budapest, Hungary). …