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Impact of Antibiotic Time-Outs in Multidisciplinary ICU Rounds for Antimicrobial Stewardship Program on Patient Survival: A Controlled Before-and-After Study.

The antimicrobial stewardship program (ASP) is an important quality improvement initiative that is recommended in the ICU. However, the shortage of infectious disease physicians in Japan has led to the need for simpler methods for implementing ASPs. We investigated whether antibiotic time-outs (ATOs) during multidisciplinary rounds as part of an ASP can improve patient survival and reduce the number of days of therapy (DOT) with antibiotics.DesignSingle-center controlled before-and-after study.SettingMedical/surgical ICU in a tertiary university medical center in Tokyo, Japan.PatientsAll patie

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… D , DOT with anti-methicillin-resistant Staphylococcus aureus (MRSA) antibiotics, including vancomycin, teicoplanin, linezolid, and daptomycin. TABLE 3. Parameters Estimated From the Interrupted Time-Series Analysis for Changes in Days of Therapy ATO = antibiotic time-out. …

Bloodstream Infections in Patients with Hematologic Diseases: Causative Organisms and Factors Associated with Resistance.

BackgroundPatients with hematologic diseases are at high risk of bloodstream infections (BSIs). This study aimed to analyze clinical features and distributions of microorganisms in patients with hematologic diseases presenting at a tertiary care university-affiliated hospital in Korea.Materials and methodsWe retrospectively reviewed all BSI episodes recorded in patient medical records at two hematologic wards of the Catholic Hematology Hospital from January to December 2020. Our aim was to analyze demographic and clinical characteristics relevant to BSIs. We also described the antimicrobial re

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… OXA, oxacillin; TMP/ SMX, trimethoprim-sulfamethoxazole; AMP, ampicillin; CTX, cefotaxime; CRO, ceftriaxone; VAN, vancomycin; TEC, teicoplanin; LZD, linezolid; spp., species; CoNS, coagulase-negative staphylococci. …

Bloodstream infections in patients with hematological malignancies: which is more fatal - cancer or resistant pathogens?

BackgroundThe primary objective of this study was to report the incidence of bloodstream infections (BSIs) and clinically or microbiologically proven bacterial or fungal BSIs during neutropenic episodes in patients with hematological malignancies.MethodsIn this retrospective observational study, all patients in the hematology department older than 14 years who developed febrile neutropenia during chemotherapy for hematological cancers were evaluated. Patients were included if they had experienced at least one neutropenic episode between November 2010 and November 2012 due to chemotherapy in th

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… Patients with VRE bacteremia were treated with linezolid 2×600 mg/day for at least 14 days. Patients with vancomycin-sensitive enterococci (VSE) were treated with ampicillin-sulbactam 8–12 g/day plus gentamicin 160–240 mg/day for at least 14 days. …

Mining the FAERS database reveals new safety signals for 120 mg denosumab in oncology practice.

OBJECTIVE: To detect and quantify adverse drug event (ADE) signals linked to 120 mg denosumab in the real world. METHODS: We queried the US Food and Drug Administration Adverse Event Reporting System (FAERS) for reports on 120 mg denosumab, standardized, and categorized these events with Preferred Terms (PT) and System Organ Classes (SOC) from MedDRA version 27.1. Disproportionality analysis was performed using the reporting odds ratio (ROR) and Bayesian confidence propagation neural network (BCPNN). RESULTS: We identified 10,963 ADE reports for 120 mg of denosumab. Among 10 963 reports, 41.

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… Adverse drug events associated with linezolid administration: a real-world pharmacovigilance study from 2004 to 2023 using the FAERS database. Front Pharmacol. 2024;15:1338902. doi: 10.3389/fphar.2024.1338902 25. Peng Y, Zhou Y, Shu K, Jia X, Zhong Y. …

Epidemiology and source of infection in cancer patients with febrile neutropenia: an experience from a developing country.

BackgroundFebrile neutropenia (FN) is a life-threatening complication that predisposes cancer patients to serious infections. This study aims to describe the epidemiology and source of infection in cancer patients with FN in a tertiary care hospital.MethodsA hospital-based retrospective study was conducted in a large tertiary care hospital from January 2020 to December 2021. Data on cancer patients with FN were collected from the hospital information system.Results150 cancer patients with FN were identified during the study period. Most patients were males (98; 65.3%), and the mean age of part

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… | – | – | – | 0 | – | – | – | 0 | 0 | 0 S. oralis | 2 | – | – | – | – | – | – | – | 0 | 0 | – | – | 2 (100) | 1 (100) TMP/SMX | Gentamicin | Streptomycin | Amikacin | Benzylpenicillin | Oxacillin | Erythromycin | Quinupristin/Dalfopristin | Vancomycin | Tetracycline | Tigecycline | Nitrofurantoin | Linezolid …

Нетуберкулезные микобактерные инфекции в Центре комплексного рака Национального института рака во Флориде.

Нетуберкулезная микобактерия (НТМ) - это экологические организмы, которые становятся оппортунистическими патогенами в некоторых популяциях. Показатель распространенности НТМ возрос во всем мире, что, вероятно, объясняется расширением диагностических тестов и наличием демографических исследований. Нынешняя литература по онкологическим пациентам минимальна и представляет собой уникальную область исследований. Здесь мы представляем эпидемиологию и лечение случаев заражения НТМ в созданном Национальным институтом раковых заболеваний Центре комплексного лечения раковых заболеваний. Мы провели ретро

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… ethambutol, and rifabutin/rifampin | 15/23 (65) M abscessus group | Azithromycin, ceftaroline, meropenem, and tigecycline | 2/19 (11) M kansasii | Azithromycin, ethambutol, and rifabutin | 1/1 (100) M chelonae | NA c M fortuitum | Ciprofloxacin and sulfamethoxazole-trimethoprim | 1/3 (33) Doxycycline and linezolid …

Muscle cramps and neuropathies in patients with allogeneic hematopoietic stem cell transplantation and graft-versus-host disease.

OBJECTIVE: Graft-versus-host disease (GVHD) is an immune-mediated multisystemic disorder and the leading cause of morbidity after allogeneic hematopoietic stem cell transplantation. Peripheral nervous system manifestations of GVHD are rare but often disabling. Whereas immune-mediated neuropathies are an established feature of GVHD, muscle cramps are not well characterized. METHODS: In a single-centre retrospective cohort we studied 27 patients (age 23 to 69 years) with GVHD (acute n = 6, chronic n = 21) who complained of symptoms suggestive of peripheral nervous system complications. Clinical

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… Previous treatment of the hematological malignancy, opportunistic infections, or GVHD included at least one potentially neurotoxic therapy in all patients (cyclosporin, n = 26; tacrolimus, n = 13; spinal or total body radiation, n = 11; voriconazol, n = 10; lenalidomid, n = 4; vincristin, n = 4; linezolid …

Infectious Diseases

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… For MRSA-associated skin infections, consider vancomycin 1–2 g IV q12 h, clindamycin 600 mg IV TID or 300 mg PO QID, daptomycin 4–6 mg/kg IV daily, tigecycline 100 mg loading dose, then 50 mg IV q12 h, doxycycline 100 mg PO BID, linezolid 600 mg PO/IV q12 h or quinupristin–dalfopristin 7.5 mg/kg IV q8 … breakage | | G. vaginalis | +++C. diff | ++protozoa | No Glycopeptides | | | | | | Vancomycin 15 mg/kg IV q12h | Bactericidal, interferes with peptidoglycan and RNA synthesis | +++ | | | | | | S. epidermidis , MRSA, Entero | | ++C. diff | | Yes (interval) Oxazolidinones | | | | | | Linezolid …

Anti-Infective-Associated AKI: A Narrative Review of the Epidemiology, Mechanisms, Risk Factors, Biomarkers, Clinical Course, Monitoring, Prevention, and Therapeutic Strategies.

Acute kidney injury (AKI) occurs commonly in hospitalized patients, especially patients in intensive care units (ICUs). Medications are among the major causative factors of AKI. This narrative review addressed and updated different aspects of anti-infective-associated AKI, including amphotericin B, cidofovir, foscarnet, polymyxins, vancomycin, and aminoglycosides. There is no standard definition or operational criteria to describe anti-infective-associated AKI. Characteristically, it usually occurs during the first two weeks of treatment and is typically dose dependent. Functional resolution o

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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PNEUMONIA | Community Acquired Pneumonia, Bacterial and Other Common Pathogens

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… For those with pseudomonal risk factors, use an antipseudomonal beta-lactam (above) plus either ciprofloxacin/high-dose levofloxacin or the combination of an aminoglycoside with either a macrolide or antipneumococcal quinolone (above) Vancomyin and linezolid should be used rarely and only in those with …

Antidepressant Drug Sertraline against Human Cancer Cells.

The use of FDA-approved drugs for new indications represents a faster and more economical way to find novel therapeutic agents for cancer therapy, compared to the development of new drugs. Repurposing drugs is advantageous in a pharmacological context since these drugs already have extensive data related to their pharmacokinetics, facilitating their approval process for different diseases. Several studies have reported the promising anticancer effects of sertraline, both alone and combined, in different types of cancer cell lines. Here, we performed a literature review on the anticancer potent

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… Care must also be taken regarding drug–drug interactions: sertraline interacts with monoamine oxidase inhibitors including isocarboxazid, linezolid, methylene blue, phenelzine, selegiline, tranylcypromine, and pimozide. …

Infectious Complications of Cancer Therapy

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… Linezolid vs. vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. Chest. 2003;124:1789–1797. 35. Tunkel A.R., Sepkowitz K.A. Infections caused by viridans streptococci in patients with neutropenia. …

Onco-Hem Connectome-Network-Based Phenotyping of Polypharmacy and Drug-Drug Interactions in Onco-Hematological Inpatients.

We introduce the Onco-Hem Connectome (OHC), a patient similarity network (PSN) designed to organize real-world hemato-oncology inpatients by exploratory phenotypes with potential clinical utility. Background: Polypharmacy and drug-drug interactions (DDIs) are pervasive in hemato-oncology and vary with comorbidity and treatment intensity. Methods: We retrospectively analyzed a 2023 single-center cohort of 298 patients (1158 hospital episodes). Standardized feature vectors combined demographics, comorbidity (Charlson, Elixhauser), comorbidity polypharmacy score (CPS), aggregate DDI severity scor

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… Effectiveness and Safety of Linezolid as Continuous Infusion Versus Intermittent Infusion in Critically Ill Patients: A Pilot Study Future Pharmacol. 2025 5 61 10.3390/futurepharmacol5040061 81. Herrmann J. Lenihan D. Armenian S. Barac A. Blaes A. Cardinale D. Carver J. Dent S. Ky B. Lyon A.R. …

Как готовить пациентов, получающих антирезортивную терапию, к извлечению зубов: обзор.

Бифосфонаты (БП) и Деносумаб (ДМБ) являются антирепрессивными агентами (АА), обычно используемыми для лечения остеопороза, множественной миеломы (8,0%), рака груди (3,3%), рака простаты (2,9 процента) и других магнелез (0,7 процента), метастаза кости и гиперкальцемии, вызванной раком. Однако эта терапия связана со значительным риском связанного с лекарствами остеонекроза челюсти (MRONJ), особенно после выведения зубов. Цель этого описательного обзора заключалась в обобщении текущих данных о мерах, направленных на снижение риска ДРОНЖ после извлечения зубов, и в критическом обсуждении достоверн

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… Another recent development is the concept of antibiotic-loaded PRF (AL-PRF) in which antibiotics (e.g., amoxicillin, clindamycin, metronidazole, or gentamycin, linezolid, vancomycin) are incorporated into the fibrin matrix at the time of preparation. …

Current landscape of innovative drug development and regulatory support in China.

The global pharmaceutical landscape remains dynamic and competitive, shaped by advancements in first-in-class therapies and breakthrough technologies. The United States has maintained its leadership in first-in-class therapies and breakthrough technologies, driven by advanced regulatory pathways, significant multinational corporation investments, a robust Research and Development (R&D) workforce, and continuous technological innovation. Additionally, global impact of the Food and Drug Administration (FDA) is further amplified through collaborations like Project Orbis, which facilitates simulta

The Role of Platelet Dysfunctions in the Pathogenesis of the Hemostatic-Coagulant System Imbalances.

Platelet dysfunction plays a critical role in the pathogenesis of various disorders affecting the hemostatic-coagulant system. This review aims to explore the mechanisms by which platelet dysfunctions contribute to the disruption of hemostasis, leading to an increased risk of both thrombosis and bleeding. Platelets, traditionally known for their role in clot formation, can exhibit altered functionality under pathological conditions such as cardiovascular diseases, metabolic disorders, and autoimmune diseases, impacting their interaction with coagulation factors and vascular endothelium. The re

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… This is commonly observed with antineoplastic agents, which are toxic to hematopoietic stem cells, and with the antibiotic linezolid, which has been associated with myelosuppression. …

Inpatient Medicine

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P941 – P1197

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Экстренные ситуации в гематологии: Почему, когда и как я лечусь?

Гематологические чрезвычайные ситуации являются критическими медицинскими условиями, требующими неотложного внимания в силу их быстрого развития и опасного для жизни характера. В качестве примера можно привести гиперкальцемию, которая часто ассоциируется с раком, таким как множественная миелома, что может привести к серьезной неврологической и сердечной дисфункции. Гиперлейкоцитоз, распространенный в острой миэлоидной лейкемии, повышает риск лейкостаза и многоорганического отказа. Кислородный кризис, обычное осложнение серповидноклеточной болезни, является результатом вазооккуляции, приводящей

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… The antimicrobial regimen should include linezolid, teicoplanin, daptomycin, and tigecycline. Antimicrobials for Gram-positive microorganisms are used empirically only in specific situations and should be discontinued 48 h after initiation if not confirmed [ 55 ]. …