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FSHB -211 G>T is a major genetic modulator of reproductive physiology and health in childbearing age women.

STUDY QUESTION: Are the genetic variants FSHB -211 G>T (rs10835638), FSHR c.2039 A>G (Asn680Ser, rs6166) and FSHR -29 G>A (rs1394205) associ … id not reach significant associations with serum AMH measurements, menstrual cycle length or age at menarche. LIMITATIONS, REASONS FOR CAUTION: Small sample size and the design involving two clinical groups with different reproductive histories may have limited the capacity to replicate the associations with the age at menarche and length of menstrual cyc …

Adolescence and the next generation.

Adolescent growth and social development shape the early development of offspring from preconception through to the post-partum period through distinct processes in males and females. At a time of great change in the forces shaping adolescence, including the timing of parenthood, investments in today's adolescents, the largest cohort in human history, will yield great dividends for future generations.

Mammographic patterns and breast cancer risk factors among women having elective screening.

We assessed the association between Wolfe mammographic patterns and breast cancer risk factors among 239 women who attended the Breast Evaluation Unit screening program of the Comprehensive Cancer Center of Alabama, University of Alabama at Birmingham, from November 1984 through April 1986. Evaluation consisted of a breast cancer risk assessment based on a questionnaire concerning commonly accepted breast cancer risk factors, along with a physical breast examination and mammogram. Increased age, weight, and parity were associated with a low-risk pattern; late age at first birth, alcohol consum

Existing and emerging strategies for fertility preservation in female patients with leukemia.

Leukemia, the most common malignancy in childhood, affects individuals from prepubertal girl to women of reproductive age. It originates from immature hematopoietic cells in the bone marrow and disseminates systemically via the blood and lymphatic circulations. Although survival rates have improved substantially, standard treatments, including intensive chemotherapy and hematopoietic stem cell transplantation, often combined with total body irradiation, are highly gonadotoxic. Consequently, a significant proportion of survivors experience long-term endocrine dysfunction and infertility, with f

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… The mean age at menarche was defined as 12.2 years, and participants were categorized into pre-menarche and post-menarche groups. … The results demonstrated that the pre-menarche group yielded significantly fewer mature oocytes after the in-vitro maturation (IVM) period compared with the post-menarche group. …

[Predictive value of a combined prediction model for pathologic upgrade to endometrial carcinoma after hysterectomy in patients with endometrial hyperplasia].

Objective: To explore the predictive value of combined prediction model for pathological upgrading to endometrial carcinoma (EC) after hyste … ared with the EH group, the EC group had a higher proportion of diabetes mellitus, a younger age at menarche, a longer duration of irregular menstruation, and a higher proportion of nulliparous and non-pregnant patients (all P<0.05). Under hysteroscopy, the proportion of endometrial polypoid change, irregular polypoid change, tumor necrosis and rupture, br …

The Impact of Abnormal Uterine Bleeding on Adolescents' Quality of Life: Results of the Adolescent Menstrual Bleeding Questionnaire.

OBJECTIVE: To determine the extent to which abnormal uterine bleeding affects the quality of life in adolescents. MATERIALS AND METHODS: Th … an age of the 69 patients included in the study was 14.95 years (range: 11-18), and the mean age at menarche was 12.2 years (range: 9-16). Of the patients, 28.9% (n = 20) had been admitted to the hospital for the first time due to bleeding, and 71.1% (n = 49) had been admitted before and had used some treatments. During menstruation, 23.2% (n = 16) of the …

Evaluation of folliculogenesis and oxidative stress parameters in type 1 diabetes mellitus women with different glycemic profiles.

BACKGROUND: Despite enormous advances in diabetes treatment, women with type 1 diabetes mellitus (DM) still experience delayed menarche, menstrual irregularities, fewer pregnancies, and a higher rate of stillbirths compared to women without the disease. Due to the fact that type 1 DM occurs at a young age, the preservation of reproductive health is one of the most important goals of treatment. AIMS: The aim of this study was to evaluate the relationship between different glycemic profiles and changes in the pro-oxidant-antioxidant balance and ovarian follicular apparatus in reproductive-age p…

Prenatal phthalate exposure and pubertal development in 16-year-old daughters: reproductive hormones and number of ovarian follicles.

STUDY QUESTION: Is there a possible association between prenatal phthalate exposure and late effects in teenage daughters with respect to re … delling associations of combined prenatal phthalate exposure with the reproductive outcomes in post-menarcheal females. MAIN RESULTS AND THE ROLE OF CHANCE: In bivariate correlation analyses, negative significant associations were found between several prenatal phthalate metabolite concentrations and serum hormone concentrations (testosterone, 17-OH-proge …

Rare combination of simple virilizing form of 21-hydroxylase deficiency, Graves' disease and 47, XXX in a woman: A case report.

RATIONALE: Coexistence of congenital adrenal hyperplasia due to 21-hydroxylase deficiency, Graves' disease and 47, XXX is rare. We report a … s for half a year. The patient didn't noticed her enlarged clitoris until she was 17 years old. Her menarche was 16 years old and the final height was 163 centimeter. She was diagnosed with GD 2 months before admission to our hospital due to palpitation, heat intolerance, muscle weakness. DIAGNOSES: The patient was diagnosed with SV 21-OHD, Graves disease …

Musculoskeletal Injuries Among Females in the Military: A Scoping Review.

INTRODUCTION: Musculoskeletal injuries (MSKi) are a common challenge for those in military careers. Compared to their male peers, reports in … s. For physiological risk factors for both female military groups, being less physically fit, later menarche, and having no/irregular menses were predictors of MSKi and stress fractures. For biomechanical risk factors, among female recruits, longer tibial length and femoral neck diameter increased the risk of stress fractures, and low foot arch increased r …

From adjuvant therapy to breast cancer prevention: BCPT and STAR.

The continued widespread prevalence of breast cancer supports placing a high priority on research aimed at its primary prevention, particula … ail model risk factors [family history, age, and personal history (i.e., age at first birth, age at menarche, previous breast biopsies)] were randomized to tamoxifen 20 mg/day or placebo for 5 years. Through 69 months of follow-up tamoxifen reduced the risk of invasive breast cancer, primarily estrogen receptor-positive tumors, by 49% (two-sided p < 0.0000 …

[Artificial insemination by donor/in vitro fertilization by donor and quality of the embryo. Federation of CECOS].

OBJECTIVE: To assess pregnancies and conceptus after artificial insemination (IAD) or IVF with frozen semen donor (IVFD) on sufficiently large study population in order to distinguished minor variations. STUDY DESIGN: From 1987 to 1994 all pregnancies obtained after AID or IVFD where registered prospectively in the French CECOS Federation data base. Different factors were recorded for this study: first menarch age of the recipient women, cycle length, insemination date in the conception cycle, maternal age at delivery, hormonal treatments, donor age, sperm conservation length and follow up of

[Clinical characteristics and management status of Turner syndrome in 1 089 children].

Objective: To investigate the clinical characteristics and management status of children with Turner syndrome (TS) in China. Methods: As a c … %) showed spontaneous sexual development (mean bone age (11.0±1.7) years), 10 cases had spontaneous menarche (mean bone age (12.0±2.2) years), and 2 cases had regular menstrual cycles. Common physical features included cubitus valgus (311 cases (28.5%)), neck webbing (188 cases (17.2%)), low posterior hairline (185 cases (17.0%)), shield chest (153 cases ( …

Menstrual cups and cash transfer to reduce sexual and reproductive harm and school dropout in adolescent schoolgirls in western Kenya: a cluster randomised controlled trial.

BACKGROUND: High rates of sexual and reproductive health (SRH) harms and interrupted schooling are global challenges for adolescent girls, r … eceived puberty and hygiene training. Assenting girls with parent or guardian consent who were post-menarche, not pregnant, area residents, not boarding, and had no disabilities precluding participation were eligible. Socio-behavioural risk factors and incidence of HIV and herpes simplex virus type 2 (HSV-2) were measured annually. School retainment and ad …

Effect of core strengthening exercises on pain and quality of life in females with primary dysmenorrhea: a scoping review.

BACKGROUND: Dysmenorrhea is characterized by recurrent lower abdomen or pelvic pain that may radiate to the legs, inner thighs, and lower back. It is divided into two categories: primary dysmenorrhea (PD) and secondary dysmenorrhea (SD). When the ovulatory cycle is established, which usually happens in the first two years following menarche, PD is defined as menstrual discomfort without any visible pelvic disease. Many teenage girls suffer from primary dysmenorrhea, or excruciating period cramps, which can seriously interfere with their everyday activities, social contacts, and attendance at s…

Prenatal maternal stress is associated with alterations in the structural integrity of the hypothalamic-pituitary-gonadal axis 20 years later: Project Ice Storm.

STUDY QUESTION: Is prenatal maternal stress (PNMS) in humans associated with alterations in the sexually differentiated reproductive axis structures in the offspring? SUMMARY ANSWER: PNMS, experienced by pregnant mothers exposed to a natural disaster in 1998, was associated with structural changes in hypothalamic-pituitary-axis (HPG) structures of 18.5-year-old offspring. WHAT IS KNOWN ALREADY: In a human prospective study, PNMS was associated with higher childhood BMI, which in turn predicted earlier menarche. Epidemiological studies have shown that maternal life event stress is associated …

"Homo informatio".

A phylogenetic split ∼7.5 Ma (million years ago) separated paninan ancestors that were unlike today's chimpanzees, from homininan ancestors that were unlike Homo sapiens today; neither had evolved into their modern physical and behavioural forms. Those paninans gave rise to the mainly frugivorous woodland-dwelling chimpanzees (Pan troglodytes), whose multifemale-multimale troops have social hierarchies where prominent parts are played by promiscuous males whose female offspring have little choice after menarche but to seek sexual partners in other troops, hostility between troops notwithstandi…

Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques.

STUDY QUESTION: What is the impact of prolonged exposure to hyperandrogenemia (T), Western-style diet (WSD) and the combination on metabolic … emale nonhuman primates. STUDY DESIGN, SIZE, DURATION: Female rhesus macaques began treatment near menarche (roughly 2.5 years of age) consisting of either cholesterol (control; C) or testosterone (T) implants (average serum levels 1.4 ng/ml) and exposure to standard monkey chow or a WSD (15 vs 36% of calories from fat, respectively). The four groups were …

Reproductive and hormonal factors and risk of cognitive impairment among Singapore Chinese women.

BACKGROUND: Epidemiologic studies suggest that declining estrogen levels in menopause may play an important role in the pathogenesis of deme … rs of age, and after 54 years, respectively. Compared with women with 35-39 reproductive years from menarche to menopause, the odds ratios (95% confidence interval) were 1.28 (1.11-1.48) for women with <35 reproductive years. Furthermore, compared with women who had 1-2 children, the odds ratios (95% confidence interval) were 1.27 (1.04-1.55) for women who …

Changes in Clavicle Length and Maturation in Americans: 1840-1980.

Secular changes refer to short-term biological changes ostensibly due to environmental factors. Two well-documented secular trends in many populations are earlier age of menarche and increasing stature. This study synthesizes data on maximum clavicle length and fusion of the medial epiphysis in 1840-1980 American birth cohorts to provide a comprehensive assessment of developmental and morphological change in the clavicle. Clavicles from the Hamann-Todd Human Osteological Collection (n = 354), McKern and Stewart Korean War males (n = 341), Forensic Anthropology Data Bank (n = 1,239), and the Mc…