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Bilateral Knee Effusions Secondary to Zoledronic Acid Infusion.

Intravenous zoledronic acid is an established and generally well tolerated form of antiresorptive therapy for osteoporosis. Although mild arthralgias are a well-documented manifestation of the acute phase response to intravenous bisphosphonates, more severe musculoskeletal reactions manifesting as debilitating pain and joint effusions have been rarely documented in the current literature. In this case report, we discuss the case of a 55-year-old woman who developed severe painful bilateral knee effusions within 1 week of her first zoledronic acid infusion for osteoporosis. Prescribing physicia

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… It is generally well tolerated by most patients, with a common adverse effect being a well-described acute phase response characterized by fever, chills, myalgias, arthralgias, and fatigue, which is normally benign and self-limiting in nature [ 4 ]. … No imaging performed. | Therapeutic bilateral knee arthrocentesis Werner de Castro et al (2010) [ 6 ] | 64-year-old woman with osteoporosis and no other comorbidities | Developed subjective chills and pain and swelling in interphalangeal and trapezio-metacarpal joints of both hands within 24 hours of …

Isatuximab with pomalidomide-dexamethasone in relapsed/refractory multiple myeloma: post-marketing surveillance in Japan.

This post-marketing surveillance assessed the safety and effectiveness of isatuximab plus pomalidomide and dexamethasone (Isa-Pd) for relapsed or refractory multiple myeloma (RRMM) during real-world use in Japan. Data from 211 individuals with RRMM treated with Isa-Pd in Japan between October 2020 and October 2021 were collected, with follow-up for up to 12 months after initiation of Isa-Pd or until treatment discontinuation. The incidence of adverse drug reactions (ADRs), ADRs of special interest (infusion reactions, bone marrow suppression, infections, cardiac disorders, other ADRs of Grade

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… 0.8) 0 0 Nausea 1 (0.8) 0 1 (0.8) 0 Vomiting 1 (0.8) 0 0 1 (0.8) Hepatobiliary disorders 1 (0.8) 1 (0.8) 0 1 (0.8) Hepatic function abnormal 1 (0.8) 1 (0.8) 0 1 (0.8) General and systemic disorders and administration site conditions 7 (5.8) 1 (0.8) 4 (3.3) 1 (0.8) Chest discomfort 1 (0.8) 0 1 (0.8) 0 Chills … Vomiting | 1 (0.8) | 0 | 0 | 1 (0.8) Hepatobiliary disorders | 1 (0.8) | 1 (0.8) | 0 | 1 (0.8) Hepatic function abnormal | 1 (0.8) | 1 (0.8) | 0 | 1 (0.8) General and systemic disorders and administration site conditions | 7 (5.8) | 1 (0.8) | 4 (3.3) | 1 (0.8) Chest discomfort | 1 (0.8) | 0 | 1 (0.8) | 0 Chills …

A Review of Interstitial Pneumonitis Caused by Elotuzumab Through Case Discussions and Academic Writings.

Patients with relapsed or refractory multiple myeloma have undergone two or three previous therapies are now being treated with a humanized IgG1 monoclonal antibody elotuzumab (HuLuc63) that targets F7 signalling lymphocytic activation molecule F7 (SLAMF7)- a signalling lymphocytic activation molecule. It is combined with dexamethasone and lenalidomide/pomalidomide for therapy. Adverse effects associated with elotuzumab consists of peripheral neuropathy, fever, constitutional symptoms (fatigue, headache, decreased appetite), and infections. A rare side effect of interstitial lung disease has o

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… He denied having fever, chills, night sweats, chest pain, abdominal pain, nausea, vomiting, diarrhoea, urinary changes and lower extremity swelling. The patient was diagnosed with pulmonary embolism a month back. Compliance of the patient with therapeutic dose enoxaparin was documented. … Patient endorsed diffuse weakness, chills and sweats for the past couple of days and a 1-day history of cough with progressively worsening shortness of breath. She was uncertain about fever: denied headache, chest pain, abdominal pain, diarrhoea, dysuria. …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… In the case of pulmonary disease, symptoms include fever, chills, cough, malaise, sleep hyperhidrosis, dyspnea, weight loss, and hemoptysis [ 211 ]. … The primary symptoms include chest pain, chills, fever, myalgia, sleep hyperhidrosis, dyspnea, cough (productive or non-productive), hemoptysis, fatigue, anorexia, and weight loss [ 223 ]. …

Amphotericin B Colloidal Dispersion Is Effective and Safe for the Treatment of Invasive Aspergillosis in Chinese Patients with Hematologic Disease: A Multicenter, Prospective, Observational, Real-World Study.

PURPOSE: Invasive aspergillosis (IA) causes significant morbidity and mortality in hematologic patients. This study aimed to evaluate the efficacy and safety profile of amphotericin B colloidal dispersion (ABCD) for IA in this high-risk population. PATIENTS AND METHODS: This multicenter, prospective, observational study enrolled hematologic patients with IA. Eligible patients received ABCD for up to 28 days or until investigator-assessed clinical response or intolerance. The primary outcome was clinical response rate, and the secondary outcome was 28-day all-cause mortality following the last

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… Infusion-related reactions mainly manifested as post-infusion fever (14/65, 21.54%) and chills (13/65, 20.00%). Notably, no severe nephrotoxicity was observed; elevated creatinine occurred in 8 patients (12.31%), all of which were grade 1–2. … AEs, n (%) | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Total Fever | 6 (9.23) | 7 (10.77) | 1 (1.54) | 0 | 14 (21.54) Chill | 10 (15.38) | 3 (4.62) | 0 | 0 | 13 (20.00) Headache | 2 (3.08) | 2 (3.08) | 0 | 0 | 4 (6.15) Hypokalemia | 9 (13.85) | 9 (13.85) | 3 (4.62) | 0 | 21 (32.31) Anoxia | 0 | 3 (4.62 …

Распространение и идентификация типа 1 диабет у взрослых китайцев с недавно диагностированным диабетом.

АИМ: Цель этого исследования заключалась в оценке распространенности скрытого аутоиммунного диабета среди взрослых (ЛАДА) и классического типа 1 Диагноз сахарного диабета (T1DM) у недавно диагностировавшегося взрослого диабета в Китае. МЕТОД: Это перекрестное исследование 17,349 вновь диагностированный диабет у взрослых ≥30 лет с 46 Больницы 31 месяцев. Демографические характеристики, клинические особенности и медицинская история были собраны квалифицированными исследователями. T1DM в целом состояли из классических T1DM и ЛАДА. Классический T1DM был определен на основе клинического фенотипа ин

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… At the time of admission, 90.5% (19/21) presented with fever, with the highest temperature of 39.8° C. 71.4% (15/21) had cough; 38.1%(8/21) had chills; 19.0% (4/21) had sputum; 42.8% (9/21) had shortness of breath; 66.7% (14/21) had myalgia; 14.3% (3/21) patients had chest pain, and nausea was found … 38.4-39.2) | 38.0(37.8-39.0) | 38.2 | 37.9(38.5-39.0) Respiratory rate, median (IQR) | 22(20-22.5) | 20(19-21) | 20 | 20(20-22) Pulse, median (IQR) | 101(91-106.5) | 84(76-100) | 80 | 92(76-101.5) Fever, n(%) | 5(100) | 13(86.6) | 1(100) | 19(90.5) Cough, n(%) | 3(60) | 11(73.3) | 1(100) | 15(71.4) Chills …

Missed Until Critical: Unravelling the Mystery of Persistent Hemolysis With a Definitive Diagnosis of Babesiosis.

Babesiosis is a parasitic protozoan infection caused primarily by Babesia microti in the United States. Its presentation can imitate that of malaria, which often leads to misdiagnosis. We present here a case of a 54-year-old female with multiple comorbidities, such as hypertension and hyperlipidemia, who was initially diagnosed with malaria but, with further investigation, was found to have babesiosis. The patient initially presented with anemia and thrombocytopenia, prompting an extensive and meticulous workup including a peripheral blood smear and autoimmune studies. From these tests, we wer

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… These parasitic diseases present with overlapping clinical symptoms, including fever, chills, fatigue, and hemolytic anemia [ 2 ]. Microscopically, both infections reveal intraerythrocytic parasites on peripheral blood smears (PBS), presenting further opportunity for potential diagnostic pitfalls. … She reported experiencing runny stools for the past three days and chills the day before. She denied having a fever, chest pain, vomiting, dysuria, or lightheadedness. During the physical examination, severe tenderness was noted in the right upper quadrant and epigastric area. …

Efficacy and safety profile of COVID-19 mRNA vaccine in patients with hematological malignancies: Systematic review and meta-analysis.

Patient populations, including those with hematological malignancies, have different responses to COVID-19 vaccines. This study aimed to quantitatively analyze the efficacy and safety of COVID-19 mRNA vaccines in patients with hematological malignancies. Studies reporting on the efficacy and safety of COVID-19 mRNA vaccines in cohorts with hematological malignancies compared to healthy controls were systematically searched in four databases. Meta-analysis and subgroup analyses were performed to generate quantitative synthesis. Fifteen studies with 2,055 cohorts with hematological malignancies

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… HC)=HC 353.3 AU/mL, MM 106.7 AU/mL (P=0.003), MPM 172.9 AU/mL (P=0.049) | After the first dose=mild (20% pain, 10% tenderness, 1% headache, 3% malaise, 1% myalgia) and moderate (2% malaise); after the second dose=mild (13% pain, 7% tenderness, 3% fever, 2% headache, 1% malaise, 1% chills), moderate ( … 3% pain, 1% tenderness, 1% fever, 1% myalgia, 1% chills), and severe (2% pain) | No sex effect (P=0.913); there was a significant trend to a lower response according to age increase in age (P<0.001) and for the disease cohort (both MM and MPM P<0.001); in MM cohort, patients on active treatment with …

COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network.

Patients with multiple myeloma frequently present with substantial immune impairment and an increased risk for infections and infection-related mortality. The risk for infection with SARS-CoV-2 virus and resulting mortality is also increased, emphasising the importance of protecting patients by vaccination. Available data in patients with multiple myeloma suggest a suboptimal anti-SARS-CoV-2 immune response, meaning a proportion of patients are unprotected. Factors associated with poor response are uncontrolled disease, immunosuppression, concomitant therapy, more lines of therapy, and CD38 an

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… , fever | Swelling in the underarm, headache, nausea vomiting, muscle ache, joint aches, and stiffness, injection site pain or swelling, feeling very tired, chills, fever | Injection site tenderness, pain, warmth, itching, or bruising, feeling tired (fatigue) or generally feeling unwell, chills or feeling … , nausea, muscle aches, injection site pain, feeling very tired Common (up to 1 in 10) | Injection site redness, nausea | Rash, rash, redness, or hives at the injection site | Injection site swelling or redness, fever (>38°C), being sick (vomiting) or diarrhea | Injection site redness and swelling, chills …

Safety of Rapid Daratumumab Infusion: A Retrospective, Multicenter, Real-Life Analysis on 134 Patients With Multiple Myeloma.

BackgroundThe anti-CD38 monoclonal antibody daratumumab is the backbone of most anti-multiple myeloma (MM) regimens. To mitigate the risk of infusion-related reactions (IRRs), intravenous daratumumab administration requires 7 hours for the first infusion and 3.5-4 hours thereafter, thus making daratumumab-containing regimens burdensome for patients and health care resources. Preliminary data suggest that a rapid (90-minute) infusion of daratumumab is safe and does not increase IRRs. The rapid schedule was adopted by our centers since 2019.MethodsWe conducted an observational multi-center, real

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… Similarly to other monoclonal antibodies, infusion-related reactions (IRRs) are the most frequent adverse events (AEs) experienced by patients receiving daratumumab and consist of upper respiratory tract symptoms (cough, throat irritation, nasal congestion, wheezing, or shortness of breath), chills, … IRRs/AEs*, n (%) Barr et al. ( 9 ) | Prospective, single center | 28 | 90 minutes: 20% of the dose in 30 minutes (200 mL/hr), 80% in 60 minutes (450 mL/hr) after >2 infusions | - No IRRs - 1 (3%) G2 hypertension Hamadeh et al. ( 10 ) | Retrospective, single center | 53 | Same as above | - 1 (2%) G2 chills …

План осуществления амбулаторного управления биконкретными антителами в множестве миеломы.

Удельные антитела (BsAbs) являются новыми иммунотерапевтическими агентами для лечения повторной/охлажденной множественной миеломы (RRMM). В настоящее время 3 БСАБ (теклистамб, талькетамаб и эль-Ранатамаб) утверждены для обработки РУМ. Для улучшения доступа к лечению и результатов лечения пациентов решающее значение имеет управление БСАБ в различных практических условиях. В настоящем докладе содержатся практические рекомендации по обеспечению безопасного и эффективного управления БСАБ для пациентов, имеющих ОРМ в амбулаторных и общинных условиях. В Соединенных Штатах, Европе и Латинской Америке

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… Patients were sent home with instructions to contact the MDT or the hematologist on call if they experienced fever >100.4°F (38°C), breathing issues, or any clinical issue (eg, chills, cough, chest or abdominal pain) and to go to the ED in case of serious complications. … For emergent symptoms (persistent mild fever, nausea, chills, blood pressure drop) the patient should go to the hospital within 2 hours, and staff should follow AE management protocols. …

Immediate adverse events to intravenous immunoglobulin in pediatric patients with inborn errors of immunity: A longitudinal study with a pre-infusion protocol.

INTRODUCTION: Immunoglobulin represents the main therapy for patients with inborn errors of immunity (IEI) and it is a safe procedure, but adverse events (AEs) can occur with variable frequencies. OBJECTIVE: To evaluate the frequency of immediate AEs to intravenous immunoglobulin (IVIG) regular therapy in a pediatric cohort with IEI after a pre-IVIG infusion protocol. METHODS: This was a longitudinal study from 2011 to 2019 at a tertiary pediatric hospital in Brazil. RESULTS: A total of 1736 infusions were studied in 70 patients with IEI, 46 (65.7%) of whom were males and whose median age w

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… In this particular case, after recurrent episodes of skin rash/chills, 6 out of 8 infusions, the intravenous route was changed to subcutaneous with the resolution of reactions. No significant association was observed in the distribution of latency by severity of the AE, p > 0.05 ( Figure 2 ). … Mild symptoms are predominant in patients with IEI, especially chills, fever and headache and usually have resolution with temporary infusion and symptomatic medication. 12 , 13 , 14 , 18 , 27 Severe AEs are more frequent in patients with autoimmunity and neurological disorders and hematological diseases …

Chronic granulomatous disease secondary to a rare compound heterozygote mutation in an adolescent cured by hematopoietic stem cell transplantation: a case report.

BackgroundChronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency characterized by recurrent infections and aberrant inflammation due to defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex.Case presentationWe report a case of recurrent pneumonia and significantly elevated IgE levels in an adolescent. Metagenomic next-generation (mNGS) sequencing contributed to the identification of Burkholderia multivorans in bronchoalveolar lavage fluid and the initiation of appropriate treatment. Whole exome sequencing (WES) revealed two point mutations

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… Case presentation A 16-year-old boy was referred to this hospital with a two-week history of persistent fever, chills, cough and scant sticky phlegm despite intravenous azithromycin and cefuroxime. … | Meropenem | Recovered 2 | 2005 | UK | 40/F | Sputum | Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis | Chronic cough | Acute bronchitis, mild asthma, mannose binding lectin deficiency | Tobramycin and ceftazidime | Recovered 3 | 2018 | USA | 55/M | CSF | None | Fever, chills …

Indwelling time of peripherally inserted central catheters and incidence of bloodstream infections in haematology patients: a cohort study.

BackgroundWe aimed to assess whether longer indwelling time of peripherally inserted central catheters (PICC) increases risk of central line associated bloodstream infections (CLABSI) in haematology patients.MethodsMulticentre retrospective cohort study among haematology patients receiving PICCs between 2013 and 2015. Occurrence of CLABSI based on CDC definitions was assessed. We calculated incidence rates, determined risk factors for CLABSI and used Poisson regression models to assess the risk of developing CLABSI as a function of PICC dwell time. We compared diagnoses and treatment character

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… This module defines CLABSI as a laboratory-confirmed bloodstream infection (LCBI), with either a recognized pathogen (LCBI 1) or a common commensal in the presence of one or more clinical signs or symptoms (temperature > 38.0 °C, chills or systolic blood pressure < 90 mmHg) (LCBI 2, see also Fig. 1 ) … However, this is less likely with the crude CLABSI definitions, in which positive blood cultures with common commensal bacteria (such as CNS) are only considered CLABSI if clinical symptoms (fever, chills, and/or hypotension) are present. …

Adjuvant immunotherapy of dendritic cells and cytokine-induced killer cells is safe and enhances chemotherapy efficacy for multiple myeloma in China: a meta-analysis of clinical trials.

ObjectiveThe aim of this study was to systematically evaluate the efficacy and safety of the combination of dendritic cells and cytokine-induced killer cells (DC-CIK) adjuvant immunotherapy and chemotherapy in the treatment of multiple myeloma (MM).MethodsClinical trials were gathered by searching Web of Science, PubMed, Embase, Cochrane Library, Wanfang, and CNKI database. Outcome measurements including therapeutic efficacy, prognosis, immune function, and adverse events were extracted and evaluated.ResultsA total of 12 trials including 594 MM patients were involved in this study for statisti

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… The most common side effects include chills and fever, which subsided naturally within 24 h without any medical treatment. No serious adverse events or death was reported after DC–CIK therapy ( Table 6 ). … Chills and fever were the most common side effects during DC–CIK therapy but were well tolerated, and no serious adverse events or death occurred during therapy. There are some limitations in our analysis. …

Safety and Tolerability of Antibody-Drug Conjugates in Cancer.

Antibody-drug conjugates are monoclonal antibodies attached to biologically active drugs through chemical linkers that deliver and release cytotoxic agents at the tumor site, reducing the likelihood of systemic exposure and therefore toxicity. Currently, there are about 110 ongoing studies implementing antibody-drug conjugates in the treatment of multiple human malignancies. Antibody-drug conjugates carry a feature of the specificity of a monoclonal antibody and the anti-neoplastic potential of a cytotoxin. The first antibody-drug conjugate was approved in 2001, and the field of antibody-drug

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… Approximately 60 min after the start of the infusion, the patient developed severe chills, fever, and moderate dyspnea. The patient also became oliguric and hypotensive. … The most frequent (≥ 20%), regardless of cause, were nausea (42%), fatigue (38%), anemia (29%), chills (29%), pyrexia (29%), thrombocytopenia (29%), dry eye (21%), and hypercalcemia (21%). Grade 3/4 AEs reported in ≥ 10% of patients were thrombocytopenia, anemia, and neutropenia. …

Smallpox vaccination and adverse reactions. Guidance for clinicians.

The guidance in this report is for evaluation and treatment of patients with complications from smallpox vaccination in the preoutbreak sett … ve care. Adverse reactions that are usually self-limited include fever, headache, fatigue, myalgia, chills, local skin reactions, nonspecific rashes, erythema multiforme, lymphadenopathy, and pain at the vaccination site. Other reactions are most often diagnosed through a complete history and physical and might require additional therapies (e.g., VIG, a …

Monoclonal Antibodies Approved for Cancer Therapy

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… Others : hepatitis B virus reactivation, infections, cardiac arrhythmias, bowel obstruction and perforation | Systemic : pulmonary events, renal toxicity, neutropenias, serum sickness, anaphylaxis, fever, lymphopenia, chills, asthenia. … Infusion reactions to alemtuzumab, manifesting as pyrexia, chills, nausea, emesis, dyspnea, rash, and urticaria, predictably occur most commonly during the first week of treatment. Serious reactions that can be fatal are known. …

Evaluating the safety and feasibility of allogeneic NK cell infusion in high-risk lymphoma patients post-autologous stem cell transplantation.

Lymphoma, a cancer with poor prognosis is a growing global health challenge that encompasses two primary types, Hodgkin (HL) and non-Hodgkin lymphoma (NHL), each further divided into various subtypes with distinct biological behaviors. Conventional therapeutic strategies include chemotherapy, radiation, surgery, and autologous hematopoietic stem cell transplantation (auto-HSCT). Natural killer (NK) cells exhibit intrinsic cytotoxicity against tumor cells without the need for prior immunization or activation. In this prospective clinical trial, we evaluated the feasibility of allogeneic NK cell

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… Table 2 Safety evaluation according to NCI Common Terminology Criteria for Adverse Events CTCAE guideline Fever | Tachycardia | Headacke | Chill | Dyspnea P-3, P-8, P-4 | P-4 | P-1 | – | P-4 Bearman scale CNS toxicity | Cardiac toxicity | GI toxicity | Bladder/renal toxicity | Pulmonary toxicity – | … After each PB-NK cell injection, four patients experienced grade 1 transitory chills, headaches, nausea, and bone pain; these side effects did not require hospitalization [ 35 ]. …

Гематологические маньяки маскируются как ревматологические заболевания: серия дел и обзор.

RATALE: Гематологическая недостаточность может имитировать ревматологические заболевания, создавая серьезную диагностическую проблему из-за перекрывающихся клинических особенностей. В настоящем исследовании подчеркивается 5 - случаи гематологических маньяков, представляющих собой ревматологические расстройства, и обсуждаются связанные с этим диагностические сложности. БОЛЕЕ ТРУДЯЩИЕСЯ: 64 в адрес 78, с различными рематологическими симптомами, включая полиартрит, васкулит, явление Рейно, и такими систематическими симптомами, как потеря веса, усталость и ночной пот. В ходе первоначальной эксперт

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… SSA antibody A 74-year-old Caucasian female with a remote history of breast cancer presented to the emergency department in July 2022 with acute hemoptysis, on a background of 1 month of polyarthritis, subjective lower extremity weakness, petechial rash to her lower legs, and intermittent fever and chills … One year later in August 2023, the patient re-presented to the emergency department with progressive night sweats, chills, and shortness of breath. Repeat chest imaging revealed worsening lymphadenopathy and new findings of intra-abdominal lymphadenopathy and splenomegaly. …