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Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria.

Sulopenem (formerly known as CP-70,429, and CP-65,207 when a component of a racemic mixture with its R isomer) is an intravenous and oral pe … ter calcoaceticus, B. fragilis, Citrobacter freundii, Enterobacter cloacae, E. coli, K. pneumoniae, Proteus vulgaris, and Serratia marcescens. These studies reported that overall, sulopenem was non-inferior to carbapenems but appeared to be superior to cephalosporins. A phase III clinical trial (SURE-1) reported that sulopenem was not non-inferior to cipr …

Systematic review of patient-reported outcome item libraries in cancer research: an EORTC Quality of Life Group study.

BackgroundPatient-reported outcome (PRO) item libraries support flexible PRO assessment in cancer research by facilitating the development of customized item lists. However, little is known about the use of item lists in clinical research. This systematic review addresses this by assessing utilization of PRO item libraries and lists in oncology research.MethodsA systematic review of MEDLINE, Embase, and CINAHL identified cancer studies using PRO item libraries to develop item lists, regardless of study design, published between October 2021 and September 2025. Key features of item library usag

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… Alexandra Gilbert: PROTEUS consortium steering committee personal consultancy fees. Data availability The data underlying this article are available in the article and in its online supplementary material. References 1. Basch E, Barbera L, Kerrigan CL, Velikova G. … The PROTEUS Guide to Implementing Patient-Reported Outcomes in Clinical Practice: A Synthesis of Resources . 2023. Accessed July 14, 2025. https://theproteusconsortium.org/ 25. U.S. Food & Drug Administration. …

Pneumonia in the Cancer Patient

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… Gram-negative bacilli (GNB) including Enterobacteriaceae ( Klebsiella, Escherichia coli, Entero­bacter, Citrobacter, Serretia ) and Proteus spp., [ 10 ] are the predominant source of pneumonias associated with neutropenic fever. …

Декодирование связи между микроорганизмами и автоиммунизацией: многоаспектный обзор данных по конкретным патогенам, которые вызывают аутоиммунные заболевания.

Происхождение и прогрессирование аутоиммунных заболеваний (АИД) являются результатом совокупного воздействия генетической восприимчивости, дефектов иммунной реакции и экологических факторов. Среди них микроорганизмы, являющиеся ключевыми экологическими факторами, широко гипотезуют для того, чтобы сыграть свою роль в инициировании АИД, однако точная причинно-следственная связь еще не доказана. Цель этого обзора заключается в глубоком изучении ключевой роли конкретных микробных инфекций в инициировании АИД путем интеграции данных, полученных с помощью three - измерения: эпидемиологические исслед

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… Clinical and experimental studies have highlighted the role of microorganisms in RA development, with the most important including EBV, Porphyromonas gingivalis ( P.gingivalis ), Proteus mirabilis ( P. mirabilis ) and Escherichia coli ( E. coli ) [ 29 ]. …

Bloodstream Infections in Patients with Hematologic Diseases: Causative Organisms and Factors Associated with Resistance.

BackgroundPatients with hematologic diseases are at high risk of bloodstream infections (BSIs). This study aimed to analyze clinical features and distributions of microorganisms in patients with hematologic diseases presenting at a tertiary care university-affiliated hospital in Korea.Materials and methodsWe retrospectively reviewed all BSI episodes recorded in patient medical records at two hematologic wards of the Catholic Hematology Hospital from January to December 2020. Our aim was to analyze demographic and clinical characteristics relevant to BSIs. We also described the antimicrobial re

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… Table 2 Microorganisms isolated from bloodstream infections a Capnocytophaga sputigena (n = 2), Serratia marcescens (n = 2), Proteus mirabilis (n = 1), Haemophilus parainfluenza (n = 2), Campylobacter jejuni (n = 2), Raoultella planticola (n = 1), Pantoea spp. …

Late-occurring infections in a contemporary cohort of hematopoietic cell transplantation survivors.

BackgroundThere is a paucity of studies describing the incidence and risk factors for late-occurring (≥1 year) infectious complications in contemporary survivors of hematopoietic cell transplantation (HCT).MethodsThis was a retrospective cohort study of 641 1-year survivors of HCT, transplanted between 2010 and 2013 as adults, and in remission from their primary disease. Standardized definitions were used to characterize viral, fungal, and bacterial infections. Cumulative incidence of infections was calculated, with relapse/progression considered as a competing risk event. Fine-Gray subdistrib

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… .: Acinetobacter , Stenotrophomonas , Actinomyces , Alcaligenes , Xylosus , Bacillus , Clostridium , Corynebacterium , Gardnerella , Haemophilus influenzae , Hafnia alvei , Serratia , Leuconostoc mesenteroides , Lysinibacillus , Moraxella , Mycobacterium , Mycoplasma , Propionibacterium , Proteus , Rhizobium …

Host impairments in patients with neoplastic diseases.

Healthy individuals possess an immune system comprising physical barriers, innate and acquired immunity as well as the indigenous microflora that populate the body surfaces. The immune system maintains constant vigilance over the body at the cellular level as well as at the interface between the host integument and the resident microflora. However, neoplastic diseases and their treatment often lead to impaired immunity resulting in an increased risk of infections due to viruses, bacteria, fungi, and protozoa. This chapter explores the various aspects of host impairment focusing on the componen

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… M. morganii Proteus spp. P. mirabilis Gram-positive facultatively Lactobacillus spp. L. rhamnosus Anaerobic bacilli Gram-positive anaerobic bacilli Bifidobacterium spp. Clostridium spp. C. tertium , C. difficile , C. sporogenes Eubacterium spp. Lachnospira spp. Propionibacterium spp. … Fusobacterium spp. | F. nucleatum | Butyrvibrio spp. | | Sucinimonas spp. | | Vibrio spp. | Gram-negative facultatively | Escherichia spp. | E. coli Anaerobic bacilli | Citrobacter spp. | C. freundii | Klebsiella spp. | K. pneumoniae | Enterobacter spp. | E. cloacae | Morganella spp. | M. morganii | Proteus …

Primary causes of hospital admission in HTLV-1 infected patients: infectious complications, predictors of mortality and long-term survival outcomes.

BACKGROUND: Human T-cell lymphotropic virus type 1 (HTLV-1) is a globally prevalent retrovirus associated with adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Despite substantial research, the high mortality risk among HTLV-1 carriers remains poorly understood. OBJECTIVE: This study aimed to identify primary causes of hospital admission, predictors of mortality, and long-term survival outcomes in HTLV-1-infected patients. METHODS: A retrospective cohort study was conducted in two referral hospitals in Mashhad, Iran, from 2011 to 2

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… chemotherapy, myelopathy Enterobacter species | 1 | Bacteremia, | HB CoNS | 1 | Bacteremia, | ATL, chemotherapy, myelopathy Salmonella typhi | 1 | Bacteremia, | ATL NTM | 1 | pneumonia | S. aureus | 1 | Infected pressure ulcer | ATL, chemotherapy, myelopathy Pseudomonas species | 1 | UTI | DM, myelopathy Proteus …

A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period.

For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter study in 28 Argentinian hospitals between 2007 and 2012. We included 515 episodes of febrile neutropenia from 346 patients, median age 49 years. Neutropenia followed chemotherapy in 77% of cases, half of the cases due to hematological malignancies. Most episodes were classified as high-risk accordi

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… , Enterococcus faecalis (1) , Methicillin-resistant Staphylococcus aureus (1) Total | 33 Urine culture | Isolated microbe (n) Urine cultures at the onset (n = 515) | Gram-negative bacilli | 40 Escherichia coli (31) , Klebsiella pneumonia (4) , Enterobacter cloacae(2) , Acinetobacter baumannii (1) , Proteus …

Экспериментальные и клинические исследования фармакологических действий рода ахиллия: всеобъемлющий и обновленный обзор.

ЦЕЛЬ: Виды рода Ахиллеа (от семейства Compositae или Asteraceae) широко используются для их многочисленных фармакологических свойств. В настоящем документе рассматриваются фармакологические действия и их возможные основополагающие молекулярные механизмы, о которых сообщается в отношении различных видов ахиллы. МАТЕРИАЛЫ И МЕТОДЫ: использовались различные базы данных, включая PubMed, Science Direct и Scopus. Результаты: Для этих растений были продемонстрированы эффекты иммуноспрепрессии, против воспламенения и против окислителей. Кроме того, было продемонстрировано, что эти растения оказывают н

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… Antimicrobial effects A. damascena methanolic extract showed inhibitory effect against Proteus species, Candida albicans , Staphylococcus aureus , Shigella dysenteriae , Salmonella enteritidis , and Streptococcus faecalis (Barbour et al., 2004). …

Preventive Healthcare and Management for Acute Lymphoblastic Leukaemia in Adults: Case Report and Literature Review.

Acute lymphoblastic leukaemia (ALL) is diagnosed by the presence of at least 20% lymphoblasts in the bone marrow. ALL may be aggressive and include the lymph nodes, liver, spleen, central nervous system (CNS), and other organs. Without early recognition and timely treatment, ALL will progress quickly and may have poor prognosis in clinical scenarios. ALL is a rare type of leukaemia in adults but is the most common type in children. Precipitating factors such as environmental radiation or chemical exposure, viral infection, and genetic factors can be associated with ALL. We report a rare case o

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… Her sputum culture yielded Carbapenem -resistant Acinetobacter baumannii , and urine culture yielded extensively drug-resistant Proteus mirabilis and Escherichia coli . The patient died due to septic shock. 3. Discussion 3.1. …

Actinium-225 targeted alpha particle therapy for prostate cancer.

Targeted alpha particle therapy (TAT) has emerged as a promising strategy for the treatment of prostate cancer (PCa). Actinium-225 (225Ac), a potent alpha-emitting radionuclide, may be incorporated into targeting vectors, causing robust and in some cases sustained antitumor responses. The development of radiolabeling techniques involving EDTA, DOTA, DOTPA, and Macropa chelators has laid the groundwork for advancements in this field. At the forefront of clinical trials with 225Ac in PCa are PSMA-targeted TAT agents, notably [225Ac]Ac-PSMA-617, [225Ac]Ac-PSMA-I&T and [225Ac]Ac-J591. Ongoing inve

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… Similar to this, a theranostic pair, using proteus-DOTA as a carrier for 225 Ac and 111 In was developed 112 . This carrier was captured in vivo by a single-chain variable fragment (scFv) attached to the cell surface. …

Associations of body mass index and waist circumference with incidence of overall and of 27 site-specific cancers: a population-based retrospective cohort study.

BackgroundOverweight and obesity are known risk factors for cancer. The aim of this study was to investigate associations of body mass index (BMI) and waist circumference (WC) with incidence of 27 site-specific cancers stratified by sex and menopausal status accounting for non-linearity.MethodsWe performed a population-based retrospective cohort study using the Korean National Health Insurance Service (KNHIS 2009-2020) database. We included 3,986,155 participants (aged ≥ 20 years), and the mean follow-up duration was 9.0 ± 1.6 years. The primary outcome was the incidence of cancer.ResultsThere

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… General and abdominal obesity trajectories across adulthood, and risk of prostate cancer: results from the PROtEuS study , Montreal, Canada . …

Nanopore-based metagenomic sequencing for the rapid and precise detection of pathogens among immunocompromised cancer patients with suspected infections.

Cancer patients are at high risk of infections and infection-related mortality; thereby, prompt diagnosis and precise anti-infectives treatment are critical. This study aimed to evaluate the performance of nanopore amplicon sequencing in identifying microbial agents among immunocompromised cancer patients with suspected infections. This prospective study enlisted 56 immunocompromised cancer patients with suspected infections. Their body fluid samples such as sputum and blood were collected, and potential microbial agents were detected in parallel by nanopore amplicon sequencing and the convent

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… In two samples (No. 17 and No. 33), findings from culture showed the presence of Candida krusei and Proteus mirabilis . …

Infectious complications distribution following CLL1 CAR-T cell therapy for acute myeloid leukemiass.

The CLL1-targeted chimeric antigen receptor T (CAR-T) cell therapy offers a novel therapeutic approach for refractory or relapsed acute myeloid leukemia (AML).The targeted elimination of tumor cells by CLL1 CAR-T therapy also induces cytotoxic effects on neutrophils, leading to a severe granulocytopenia, thereby significantly increasing the risk of infectious complications during CAR-T therapy. However, the infectious complications associated with this strategy have not been comprehensively investigated. The objective of this study was to evaluate the incidence rate of infectious complications

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… Among the identified pathogens, there were 25 cases of Gram-negative bacteria (including Acinetobacter baumannii [ n = 6], Enterobacter cloacae [ n = 1], Pseudomonas aeruginosa [ n = 4], Klebsiella pneumoniae [ n = 5], Proteus mirabilis [ n = 2], Escherichia coli [ n = 2], and Smmaltophilia [ n = 5]) …

A review on clinical cases of rare mold infections and their antifungal treatment strategies.

In recent years, with the growing population of immunocompromised individuals, infections caused by rare environmental molds have become increasingly prevalent and clinically significant. Due to frequent misdiagnosis and difficult clinical management, the overall disease burden of such infections poses a major challenge in clinical practice. This article aims to fill the knowledge gap by reviewing cases of rare mold infections from January 2020 to February 2026, analyzing the susceptible populations, identification techniques, antifungal susceptibility testing, and antifungal treatment strateg

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… Nails and skin co-infection by Fusarium verticillioides and Proteus vulgaris secondary to arterial occlusion of lower extremity. Rev. Iberoam. Micol . 41, 37–42. doi: 10.1016/j.riam.2021.07.003 , Mhmoud, N. A., Siddig, E. E., Nyuykonge, B., Bakhiet, S. M., van de Sande, W. W. J., Fahal, A. …

Critically Ill Immunosuppressed Host

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… Response Neutropenia Hematologic malignancies, cytotoxic chemotherapy, aplastic anemia Gram-negative bacilli, Staphylococcus aureus, Candida species, Aspergillus species Complement System C3 Congenital liver disease S. aureus, Staphylococcus pneumoniae Systemic lupus erythematosus Pseudomonas species, Proteus … Neutropenia | Hematologic malignancies, cytotoxic chemotherapy, aplastic anemia | Gram-negative bacilli, Staphylococcus aureus, Candida species, Aspergillus species Complement System C3 | Congenital liver disease | S. aureus, Staphylococcus pneumoniae Systemic lupus erythematosus | Pseudomonas species, Proteus …

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review.

BackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and approachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key findings and conclusionsThe literature

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… ; A. ascalonicum ; edible portion | ( 18 ) | | UAE : 2.3 mm; dd = 0 mm | A. sativum | UAE (Water; SLR = 1:10; 30°C; 15 min; 20 kHz) >> C (3,000 × g; 15 min; 4°C) >> F | Nha Trang, Vietnam | Shallot; A. ascalonicum ; bulb | ( 19 ) Proteus | | UAE : MIC = 7.33 μg/ml | NA | UAE (Water; SLR 1:4; 10 min … ; 200 watts) >> F >> C (4,000 rpm;10 min) >> FD | Hamadan city, Iran | Shallot; A. ascalonicum; bulb | ( 16 ) Proteus mirabilis | | E : MIC = 10,000; MBC = 20,000 | NA | E (Water; SLR 2:1, 5 h) >> F | Zagros mountains, Iran | Shallot/red onion; A. ascalonicum; bulb | ( 26 ) Pseudomonas | | UAE : MIC …

Abstracts cont.

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… Results : Most frequent pathogen of UTI was: E. coli -58%, Staphylococcus aureus -10%, Proteus mirrabilis -10%, Pseudomonas aeruginosa -3%. … Proteus mirabilis sensitivity for: Amoxicilin/clavulonic acid-86%, Gentamicin-86%, Cefalotine-83% and resistance for: Azlocilin-64%, Nitrofurantoin-54%, Neomicin-52% were found. …

Proceedings to the 2020 Online Conference of the Particle Therapy Cooperative Group (PTCOG2020Online): 13-14 September 2020Organized by the Particle Therapy Cooperative Group (PTCOG), this special online meeting featured abstracts and programs that enabled the communication and cross fertilization for which PTCOG meetings are known.

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… O 04 Developing FLASH Treatment Planning for IBA Proteus System Using the RayStation TPS E. Traneus 1 , R. Labarbe 2 , L. … Treatment plans for FLASH delivery were generated by interfacing a research version of the RayStation TPS (RaySearch Laboratories AB) with a software simulator of the IBA Proteus system (IBA S.A.). …