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Evaluating the Impact of Insurer-Sponsored Health Coaching on Hospitalization and Costs in India: A Retrospective Cohort Study.

Health coaching programs are emerging as a promising intervention to improve disease management and reduce healthcare costs, particularly in the context of insurer-sponsored wellness initiatives. While such programs have shown positive outcomes in Western healthcare settings, their effectiveness in India remains underexplored. This study examines the impact of a health coaching program implemented by a prominent Indian health insurer (Aditya Birla Health Insurance), focusing on hospitalization rates and claims paid among high-risk policyholders. To assess the intervention's effectiveness, a re

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collect

Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

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… Qualitative responses were coded thematically by two researchers using grounded theory. Associations were examined between face-to-face interactions and the frequency of each major learning theme category. … METHODS : We drew upon existing principles of SDL and used constructivist grounded theory to explore the effects of context on SDL during residency training. We conducted 7 focus groups (FG) with 46 internal medicine residents. FG guides were developed from literature and expert review. …

Психометрическая оценка шкалы восприятия искусственного интеллекта для больных раком: подход к структурному уравнению.

РАЦИОНАЛЬ, ЦЕЛИ И ЗАДАЧИ: Искусственный интеллект (ИИ) всё более интегрируется в онкологическую помощь, и онкологические сестры играют ключевую роль в образовании пациентов, коммуникации и восприятии этих технологий. Несмотря на то, что ИИ всё более интегрируется в здравоохранение, существующие шкалы восприятия ИИ и принятия технологий в основном были разработаны для общих здравоохранительных условий и не достаточно отражают уникальные клинические, этические и связанные с рабочим процессом аспекты онкологической практики. Целью этой работы было разработка и психометрическая валидация шкалы, из

Validity of evidence-based recommendations by a large language model for interdisciplinary board decisions in neurooncology: An explorative study and critical evaluation.

ObjectivesThis study aims to evaluate the stylistic and structural equivalence of Artificial Intelligence (AI)-generated summaries, particularly those by Large Language Models (LLMs) like ChatGPT, compared to traditional human-generated case summaries in neuro-oncological board decisions. The primary goal is to explore the stylistic alignment between AI-generated and human-authored summaries from board meeting audio recordings.MethodsThe study compares 30 traditional human-generated case summaries with 30 AI-generated summaries based on board meeting audio recordings. Two expert raters, blinde

Combined spatial metabolomics and 4D-DIA quantitative proteomics approaches to explore the relationship between lung cancer and the heart.

Lung cancer and cardiovascular disease pose persistent threats to human health, despite advancements in targeted therapy, percutaneous coronary intervention, and drug treatments. Challenges such as side effects, drug resistance, hospitalization rates, and mortality remain high. These diseases are closely linked, sharing common risk factors and intricately influencing each other. This study aims to investigate the interplay between lung disease and cardiovascular disease by examining changes in cardiac metabolites and protein expression using spatial metabolomics and 4D-DIA quantitative proteom

Joint AI-driven event prediction and longitudinal modeling in newly diagnosed and relapsed multiple myeloma.

Multiple myeloma management requires a balance between maximizing survival, minimizing adverse events to therapy, and monitoring disease progression. While previous work has proposed data-driven models for individual tasks, these approaches fail to provide a holistic view of a patient's disease state, limiting their utility to assist physician decision-making. To address this limitation, we developed a transformer-based machine learning model that jointly (1) predicts progression-free survival (PFS), overall survival (OS), and adverse events (AE), (2) forecasts key disease biomarkers, and (3)

Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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… Interviews were professionally transcribed and data was analyzed using a grounded theory approach. Transcript data were coded by two independent researchers using NVivo 10 software and analyzed in an iterative process to identify emergent themes. … From these 6603 written comments, we randomly selected 500 and coded them using grounded theory methods. An initial coding tree was developed by two raters (CK, JLJ). Once the tree was saturated, 25 % of utterances were double coded with good inter-rater reliability (Spearman: 0.94). …

Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology.

Technological advancements in cell-free DNA (cfDNA) liquid biopsy have triggered exponential growth in numerous clinical applications. While cfDNA-based liquid biopsy has made significant strides in personalizing cancer treatment, the exploration and translation of epigenetics in liquid biopsy to clinical practice is still nascent. This comprehensive review seeks to provide a broad yet in-depth narrative of the present status of epigenetics in cfDNA liquid biopsy and its associated challenges. It highlights the potential of epigenetics in cfDNA liquid biopsy technologies with the hopes of enha

Нейронный вклад в управление химически активным балансом: обзор ЭЭГ, ФНИРС, МРТ и ПЕТ.

Справочная информация/задачи: Для предотвращения падений решающее значение имеют быстрые посттуральные реакции, однако нейронные системы, поддерживающие эти ответные действия, не в полной мере понимаются, особенно в том, что касается старения и неврологических расстройств. Понимание того, как мозг обнаруживает, интерпретирует и реагирует на нарушения равновесия, крайне важно для разработки новых мер вмешательства. Цель этого аналитического обзора заключалась в обобщении данных, полученных в ходе исследований нейроимации, с целью выявления кортикальных и субкортических механизмов, лежащих в осн

В центре внимания пользователей находятся проектирование и формальная оценка приборной панели для многомерной оценки ходьбы при множественном склерозе.

Цифровой анализ походов с использованием изношенных датчиков и приборов все чаще проводится в рамках обычного ухода за людьми с множественным склерозом. Однако многоаспектные оценки ходьбы приводят к получению продольных и разнородных результатов, которые часто представляются в разрозненных, трудно интерпретируемых докладах, ограничивая их полезность для клинической коммуникации и совместного принятия решений. Цель этого исследования заключалась в разработке ориентированной на пациента приборной панели, которая включает многоплановые данные о походах в последовательный и интуитивный обзор, в п

Иммунитет в нейромодуляции: исследование нейронных и иммунных путей в расстройствах мозга.

Иммунитет четко регулирует функцию мозга. Она непосредственно участвует в патологических процессах таких нейродегенеративных заболеваний, как болезнь Паркинсона и Альцгеймера, посттравматические заболевания, множественный склероз, травма головного мозга и психические расстройства (большое расстройство организма, серьезное депрессивное расстройство (МДС), расстройства тревожности, расстройства психоза и шизофрения, а также расстройства нервного развития (НРД). Нейромодулирование в настоящее время является одной из ведущих терапевтических стратегий лечения этих расстройств, однако пока мало что

Health literacy, eHealth literacy and their association with burden, distress, and self-efficacy among cancer caregivers.

PurposeHealth literacy skills are vital for cancer caregivers in helping cancer survivors to navigate their diagnosis, treatment, and recovery but little is known. This study explored health literacy and eHealth literacy among cancer caregivers and the relationship between health literacy/eHealth literacy and potential associated factors.MethodsInformal caregivers who had cared for an individual with cancer completed a survey which collected demographic data and measured caregiver health literacy, eHealth literacy, self-efficacy, burden, and distress.ResultsSeven percent of caregivers had inad

Mesenchymal stem cells lineage and their role in disease development.

BackgroundMesenchymal stem cells (MSCs) are widely dispersed in vivo and are isolated from several tissues, including bone marrow, heart, body fluids, skin, and perinatal tissues. Bone marrow MSCs have a multidirectional differentiation potential, which can be induced to differentiate the medium in a specific direction or by adding specific regulatory factors. MSCs repair damaged tissues through lineage differentiation, and the ex vivo transplantation of bone marrow MSCs can heal injured sites. MSCs have different propensities for lineage differentiation and pathological evolution for differen

Forgoing life-sustaining treatment - a comparative analysis of regulations in Japan, Korea, Taiwan, and England.

BackgroundRegulations on forgoing life-sustaining treatment (LST) have developed in Asian countries including Japan, Korea and Taiwan. However, other countries are relatively unaware of these due to the language barrier. This article aims to describe and compare the relevant regulatory frameworks, using the (more familiar) situation in England as a point of reference. We undertook literature reviews to ascertain the legal and regulatory positions on forgoing LST in Japan, Korea, Taiwan, and England.Main textFindings from a literature review are first presented to describe the development of th

Understanding CAM Natural Health Products: Implications of Use Among Cancer Patients and Survivors.

Herbs, vitamins, and other natural health products are being used by cancer patients and survivors with increasing prevalence in the United States. These complementary and alternative medicine (CAM) products, which are also referred to as natural health products in Canada and abroad, are used during cancer treatment and the survivorship period to ease the burden of symptoms such as pain, fatigue, insomnia, anxiety, and depression and hence improve overall quality of life. Data indicate that while patients choose these products for self-treatment, they often do not inform their health-care prov

Heterogeneous tissue-specific macrophages orchestrate metastatic organotropism of breast cancer: implications for promising therapeutics.

Compelling evidences have manifested that breast cancer cells prefer to metastasize to certain distant organs, including brain, lung, bone and liver. According to the canonical "seed and soil" theory, this prominent biological behavior, termed as metastatic organotropism, involves intricate interactions between breast cancer cells (the "seeds") and specific residents in the tumor microenvironment (the "soil"), initiating from pre-metastatic niche formation to metastatic outgrowth. Recently, multifaceted heterogeneity of tissue-specific macrophages (TSMs) and their roles played in organotropic

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol.

Celastrol (CEL) is a natural pentacyclic triterpenoid demonstrating significant therapeutic properties against various diseases. However, the ambiguity of target information poses a significant challenge in transitioning CEL from a traditional remedy to a modern pharmaceutical agent. Recently, the emerging target discovery approaches of natural products have broadened extensive avenues for uncovering comprehensive target information of CEL and promoting its drug development. Herein, diverse target discovery strategies are overviewed for the pharmacological and toxicological studies of CEL, inc

Amyloid Proteins and Peripheral Neuropathy.

Painful peripheral neuropathy affects millions of people worldwide. Peripheral neuropathy develops in patients with various diseases, including rare familial or acquired amyloid polyneuropathies, as well as some common diseases, including type 2 diabetes mellitus and several chronic inflammatory diseases. Intriguingly, these diseases share a histopathological feature-deposits of amyloid-forming proteins in tissues. Amyloid-forming proteins may cause tissue dysregulation and damage, including damage to nerves, and may be a common cause of neuropathy in these, and potentially other, diseases. He

Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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… We analyzed questionnaires using standard grounded theory principles and conducted in-depth interviews with 9 participants to ensure that questionnaires were interpreted accurately. …