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Trial watch: Immunostimulatory cytokines in cancer therapy.

Tumor-targeting immune responses provide a significant contribution to (when they do not entirely account for) the clinical activity of diverse antineoplastic regimens, encompassing not only a large panel of immunotherapeutic strategies but also conventional cytotoxic molecules, targeted anticancer agents and irradiation. In line with this notion, several approaches have been devised to elicit novel or boost existing anticancer immune responses, including the administration of immunomodulatory cytokines. Such a relatively unspecific intervention suffices to mediate clinical effects in (at leas

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… Common side effects included fever, chills, hypotension, nausea/emesis, and elevations in circulating hepatic enzymes. … Common side effects were chills, fever, headache and nausea, while abnormal laboratory findings included transient asymptomatic lymphopenia, hyperglycemia, anemia, hypoalbuminemia as well as temporary elevations in circulating bilirubin and hepatic enzymes. …

Different Therapeutic Paths (Colchicine vs. Anakinra) in Two Patients With Schnitzler's Syndrome.

Schnitzler's syndrome is a rare autoinflammatory syndrome with unidentified mechanism of disease and etiology with unknown definitive treatment algorithm. The two obligatory criteria for the diagnosis of Schnitzler's syndrome include chronic urticarial rash and monoclonal gammopathy (immunoglobulin M or immunoglobulin G). In this article, we describe two patients with different courses of disease with different average lengths of time between initial symptoms and the final diagnosis (6 months to 8 years). Exclusion of more common conditions is needed to ensure the correct diagnosis. Treatment

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… CASE REPORT Case 1- A 50-year-old female patient with unremarkable medical history had an eight-year history of intermittent urticarial rash (localized, later on generalized) and periodic high fevers with chills and shivering, accompanied by generalized myalgia and malaise. …

Inpatient Medicine

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… Legionella pneumonia presents with the common symptoms of fever, chills, and cough. Distinguishing features are loss of appetite, loss of coordination, and occasionally diarrhea and vomiting. Relative bradycardia has traditionally been considered a symptom. … A 40-year-old male is admitted to the hospital for new-onset fever and chills. He denies any other symptoms. He was recently diagnosed with non-Hodgkin’s lymphoma, for which he received his first cycle of chemotherapy 10 days ago. He currently does not have an indwelling venous catheter. …

Antibody-based drug delivery systems for cancer therapy: Mechanisms, challenges, and prospects.

In recent years, antibody-based cancer therapy has emerged as one of the efficient therapeutic strategies, such as immune checkpoint inhibitors (ICIs), angiogenesis inhibitors, antibody-drug conjugates (ADCs), multi-specific antibodies, and chimeric antigen receptor T (CAR-T) cells, among others. To date, various drug delivery platforms have been developed to improve the bioavailability, delivery convenience, and reduced toxicity towards increased therapeutic efficacy of antibodies. Herein, we emphasize the clinical manifestations of various antibody-based tumor therapies, highlighting their m

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… Across the clinical trials, severe infusion-related reactions, such as chills, dizziness, fever, itching, and wheezing, occurred in 2.9%-12%, so it is necessary to interrupt the administration or slow down the infusion rate to moderate the reactions. … | IRR, CRS, infections, fever, diarrhea, nausea, fatigue, hypotension, edema, bleeding episodes, dyspnea, headache | Brexucabtagene autoleucel; Tecartus® | MCL | For autologous use only, intravenous infusion | CRS, pyrexia, hypotension, encephalopathy, fatigue, tachycardia, arrhythmia, infections, chills …

Peritoneal Carcinomatosis in an Adult With Sjögren's Syndrome: A Diagnostic Dilemma Revealing a Rare Association With Primary Gastric Adenocarcinoma.

Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly affects middle-aged women. It is rarely associated with solid neoplasms. We report a 60-year-old woman with a past medical history relevant for SS who was diagnosed with advanced-stage gastric adenocarcinoma upon evaluating for peritoneal carcinomatosis and succumbed two months after her original diagnosis. This case highlights the significance of considering gastrointestinal (GI) malignancy as an essential differential, particularly when evaluating patients with SS who fail conservative treatment for their GI symptoms.

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… Upon her ED presentation, she relates that her condition was associated with fatigue, nausea, anorexia, and denied any fever, chills, night sweats, change in weight, or bowel habits. She reports only taking levothyroxine and occasional diclofenac sodium. She denied any family history of cancers. …

Incidental Discovery of Multiorgan Extramedullary Plasmacytomas in the Setting of Newly Diagnosed Multiple Myeloma and Delayed Hemolytic Transfusion Reaction.

Extramedullary plasmacytomas (EMPs) are defined by the presence of clonal plasma cell proliferation outside of the bone marrow, portending an overall poor prognosis. This case highlights extramedullary plasmacytomas as an unusual presenting manifestation of multiple myeloma. Through incidental discovery during a delayed hemolytic transfusion reaction workup, EMPs were found in the liver, spleen, and possibly the lung. Though rare at presentation, this case emphasizes that the presence of EMPs should be considered at the outset as it not only impacts the treatment regimen for such patients but

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… She denied fever, chills, unintentional weight loss, abdominal pain, diarrhea, constipation, and cardiopulmonary or neurological symptoms. Routine lab work demonstrated anemia (hemoglobin: 8 mg/dL), hypercalcemia (13.8 mg/dL), and renal impairment (creatinine: 2.83 mg/dL). …

Seasonal clustering of sinopulmonary mucormycosis in patients with hematologic malignancies at a large comprehensive cancer center.

BackgroundInvasive Mucorales infections (IMI) lead to significant morbidity and mortality in immunocompromised hosts. The role of season and climatic conditions in case clustering of IMI remain poorly understood.MethodsFollowing detection of a cluster of sinopulmonary IMIs in patients with hematologic malignancies, we reviewed center-based medical records of all patients with IMIs and other invasive fungal infections (IFIs) between January of 2012 and August of 2015 to assess for case clustering in relation to seasonality.ResultsA cluster of 7 patients were identified with sinopulmonary IMIs (

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… months) LAMB, then posa Hospice 63/F AML Fever, Palatal lesions Nodules w/cavitation; Diffuse sinus mucosal thickening Rhizopus microsporus or azygosporus; Mucor circinelloides Palate biopsy culture & histopath +; BAL culture, Mucorales & pan-fungal PCRs+ Proven Sinopulmonary Flu LAMB Hospice 73/M AML Chills … Hospice 63/F | AML | Fever, Palatal lesions | Nodules w/cavitation; Diffuse sinus mucosal thickening | Rhizopus microsporus or azygosporus; Mucor circinelloides | Palate biopsy culture & histopath +; BAL culture, Mucorales & pan-fungal PCRs+ | Proven | Sinopulmonary | Flu | LAMB | Hospice 73/M | AML | Chills …

Cytokine-induced killer (CIK) cells: from basic research to clinical translation.

The accumulation of basic researches and clinical studies related to cytokine-induced killer (CIK) cells has confirmed their safety and feasibility in treating malignant diseases. This review summarizes the available published literature related to the biological characteristics and clinical applications of CIK cells in recent years. A number of clinical trials with CIK cells have been implemented during the progressive phases of cancer, presenting potential widespread applications of CIK cells for the future. Furthermore, this review briefly compares clinical applications of CIK cells with th

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… On the basis of animal studies, a large number of clinical trials have indicated that adverse events seldom occurred after the infusion of CIK cells; most of the adverse events were minor, including mild fever, chills, fatigue, and GVHD. … After receiving autologous or allogeneic CIK cells, minimal adverse events, such as mild fever (37.5°C-40°C), transient ventricular arrhythmias, chills, fatigue, and GVHD, developed and were easily treated with symptomatic regimens [ 34 ]. …

Rack1-mediated ferroptosis affects hindgut development in rats with anorectal malformations: Spatial transcriptome insights.

Anorectal malformation (ARM), a common congenital anomaly of the digestive tract, is a result of insufficient elongation of the urorectal septum. The cytoplasmic protein Receptor of Activated C-Kinase 1 (Rack1) is involved in embryonic neural development; however, its role in embryonic digestive tract development and ARM formation is unexplored. Our study explored the hindgut development and cell death mechanisms in ARM-affected rats using spatial transcriptome analysis. We induced ARM in rats by administering ethylenethiourea via gavage on gestational day (GD) 10. On GDs 14-16, embryos from b

Clinical Treatment Guidelines for Tafasitamab Plus Lenalidomide in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma.

Diffuse large B-cell lymphoma (DLBCL) accounts for approximately 24% of new cases of B-cell non-Hodgkin lymphoma in the US each year. Up to 50% of patients relapse or are refractory (R/R) to the standard first-line treatment option, R-CHOP. The anti-CD19 monoclonal antibody tafasitamab, in combination with lenalidomide (LEN), is an NCCN preferred regimen for transplant-ineligible patients with R/R DLBCL and received accelerated approval in the US (July 2020) and conditional marketing authorization in Europe (August 2021) and other countries, based on data from the L-MIND study. The recommended

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… In L-MIND, IRRs (all grade 1) occurred in 6% of patients, 80% of which occurred during cycle 1 and 2, with reported symptoms of fever, chills, rash, flushing, dyspnea, and hypertension. 9-11 Discontinuation of tafasitamab was not required. … infusions in patients not experiencing an IRR during the first 3 infusions • Additional supportive care including but not limited to, epinephrine, IV fluids, vasopressors, oxygen, bronchodilators, may be used to manage infusion reactions • Meperidine 25 mg may also be included as an option for rigors or chills …

Small-Cell Lung Cancer Presenting as Hypercalcemia.

Hypercalcemia of malignancy is a common and life-threatening complication in cancer patients, typically seen in advanced breast cancer, multiple myeloma, and non-small-cell lung cancer. In contrast, it is rare in small-cell lung carcinoma (SCLC), where parathyroid hormone levels remain mostly within the normal range despite elevated calcium. We present a case of hypercalcemia in a patient with SCLC and discuss its clinical implications. A 67-year-old male with a significant smoking history and a history of hypertension and atrial fibrillation presented with symptoms, including nausea, vomiting

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… presentation A 67-year-old man with a 50-pack-year smoking history, hypertension, and atrial fibrillation on rivaroxaban presented with worsening nausea, vomiting, fatigue, constipation, poor appetite, weight loss, excessive thirst, wheezing, hemoptysis, shortness of breath, pleuritic chest pain, fevers, chills …

Conference Proceedings - 6th International Conference on Molecular Diagnostics and Biomarker Discovery (MDBD 2022): Building Resilience in Biomedical Research : Penang, Malaysia. 11-13 October 2022.

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Длинный процесс у пациентов с множественным склерозом, обработанных с помощью Rituximab: доклад о двух случаях.

Симптомы COVID-19 могут сохраняться в течение более 12 недель у некоторых инфицированных пациентов, причем в этих случаях это состояние характеризуется как продолжительность COVID-19. У этих пациентов есть симптомы, связанные с повреждением нескольких органов. Ученые обнаружили длительную этиологию COVID-19, факторы риска и лечение. Было отмечено, что иммунодепрессия может приводить к затягиванию симптомов COVID-19. Пациенты с множественным склерозом (PwMS), как правило, лечатся с помощью методов, позволяющих модифицировать заболевания, которые подавляют иммунную систему и предрасположены к ин

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… ng/mL | | 800 | 1370 ALT, U/L | | 38 | 14 AST, U/L | | 29 | 32 LDH, U/L | | 315 | 496 Ferritin, ng/ml | | 283 | 2150 ESR, mm/hr | | 52 | 70 Case 2 A 26-year-old female with a prior history of relapsing-remitting MS, diagnosed four years ago, had initially visited a hospital due to fever and chills …

Intraventricular topotecan for the treatment of neoplastic meningitis: five case studies.

Many systemic cytotoxic agents cannot penetrate the blood-brain barrier. Because of this, in approximately 5% of cancer cases, metastatic disease is seen in the leptomeninges. Without treatment, patients with neoplastic meningitis (NM) generally survive for only a matter of weeks. In the treatment of NM, intraventricular (IVT) topotecan results in progression-free and overall survival outcomes similar to those seen with other IVT chemotherapies, while being particularly well tolerated by most patients. In this article, we present the case studies of five patients with NM, with various primary

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… The patient experienced arachnoiditis symptoms during treatment with IVT topotecan, including headache, fever, chills, and stiff neck. She received no special intervention for any of these symptoms. …

Delayed gastric emptying in critical illness: is enhanced enterogastric inhibition with cholecystokinin and peptide YY involved?

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… The most common clinical sign of hemolysis is fever, with or without chills. 71 Other common signs and symptoms include back or flank pain, anxiety, nausea, lightheadedness, dyspnea, and hemodynamic instability. … Clinical signs include fever, with or without chills, usually beginning 1 to 2 hours after the start of the transfusion but occasionally delayed up to 4 to 6 hours. Multiparous women and patients who are multiply transfused are particularly prone to FNHRs. …

Дело Plasma Cell Leukemia Arising De Novo: Редкое и смертельное заболевание.

Плазменная лейкемия (ПХЛ) является агрессивной формой множественной миэломы, характеризующейся растущим количеством циркулирующих плазменных клеток в периферической (циркуляционной) крови. Первичный ПХЛ (PPCL) представляет собой одну из форм моноклонной гаммопатии, которая является наиболее острой при высоком уровне смертности. С учетом ожидаемых изменений в клинических критериях диагностики его распространенность будет возрастать. Мы приводим пример для того, чтобы помочь более глубоко понять это заболевание и предлагаемые изменения критериев, поскольку потребуются дополнительные исследования

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… He denied fever, chills, chest pain, wheezing, coughing, nausea and vomiting, abdominal pain, hematuria, melena, or hematochezia. He had smoked a pack a day since the age of 13 but quit five years before presentation. He drank alcohol heavily, almost 15-18 drinks daily. …

Acute Hepatitis C After Penile Stem Cell Injection.

Hepatitis C is a viral infection that is transmitted via blood or other bodily fluids and usually manifests as a chronic infection. We present a unique case of acute hepatitis C from a penile stem cell injection. Although previous cases have reported the reactivation of chronic hepatitis C after hematopoietic stem cell transplantation, it is uncommon for hepatitis C to present acutely, especially in an immunocompetent patient. To our knowledge, this is the first case of acute hepatitis C after a penile stem cell injection.

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… Although these symptoms subsided, he began to have chills and general malaise lasting 14 days before the patient presented to his doctor for evaluation. …

Trametinib: A Targeted Therapy in Metastatic Melanoma.

Trametinib is a MEK inhibitor approved both as a single agent and in combination with dabrafenib for the treatment of BRAF V600E or V600K mutated melanoma. It is a once-daily oral medication that was approved based on progression-free survival and overall survival advantage compared to chemotherapy. Most common side effects include rash, diarrhea, peripheral edema, and fatigue. When used in combination with dabrafenib, pyrexia and nausea are also common. Most side effects can be managed effectively with dose interruptions, supportive care, and/or dose reductions. Ongoing trials are investigati

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… The most common side effects reported in the phase III open-label COMBI-v trial investigating dabrafenib plus trametinib vs. vemurafenib (Zelboraf) were pyrexia, nausea, diarrhea, chills, fatigue, headache, and vomiting. …

Acute Liver Failure due to Disseminated Varicella Zoster Infection.

Acute liver failure (ALF) can be due to numerous causes and result in fatality or necessitate liver transplantation if left untreated. Possible etiologies of ALF include ischemia, venous obstruction, medications, toxins, autoimmune hepatitis, metabolic and infectious causes including hepatitis A-E, varicella-zoster virus (VZV), cytomegalovirus (CMV), herpes simplex virus (HSV), Epstein-Barr virus (EBV), and adenovirus with VZV being the most rarely reported. Pathognomonic skin lesions facilitate diagnosis of VZV hepatitis, but definitive diagnosis is secured with liver biopsy, tissue histopath

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… She reported nausea, constipation, and worsened dysphagia, but denied vomiting, weight change, night sweats, fever, chills, chest pain, cough, and shortness of breath. She also denied pertinent past surgeries, family history, recent travel, sexual activity, drug use, and alcohol and tobacco use. …

II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies.

In the last few years, new primary immunodeficiencies and genetic defects have been described. Recently, immunoglobulin products with improved compositions and for subcutaneous use have become available in Brazil. In order to guide physicians on the use of human immunoglobulin to treat primary immunodeficiencies, based on a narrative literature review and their professional experience, the members of the Primary Immunodeficiency Group of the Brazilian Society of Allergy and Immunology prepared an updated document of the 1st Brazilian Consensus, published in 2010. The document presents new know

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… However, this mode of administration is painful, reaches serum concentrations in about 24 hours, and has low bioavailability and less than 50% recovery. 18 With the use of higher doses, side effects, such as chills, fever or even anaphylaxis, occur more frequently. 15 Since the 1960’s, different preparations … Symptoms and signs | Frequency Related to infusion rate Chills | Frequent Headache | Frequent Dyspnea | Frequent Chest pain or tightness | Frequent Back pain | Frequent Fatigue and malaise | Frequent Fever | Frequent Hypotension or hypertension | Frequent Myalgia | Frequent Nausea and vomiting | Frequent …