Результаты поиска

Одинокий квантовый Sodium MRI на 3T для разделения сигналов Sodium и Mono и B-T2.

Из-за десятикратной разницы в концентрации натрия на мембранах, которая активно поддерживается насосом с натрием-потассием (Na+-K+), клеточный ионный баланс очень чувствительн. Разрывы в этом насосе или мембранной целостности, наблюдаемые в таких неврологических расстройствах, как эпилепсия, множественный склероз, биполярное заболевание и легкая травма головного мозга, приводят к увеличению внутриклеточного натрия. Однако это изменение клеточного уровня часто маскируется доминирующим внеклеточным сигналом натрия, что затрудняет проведение различия между популяциями натрия с моно- и биэкспонент

Myeloma Patient Value Mapping: A Discrete Choice Experiment on Myeloma Treatment Preferences in the UK.

BackgroundMyeloma is an incurable life-threatening hematological cancer. Recent treatment developments have seen improvements in survival; however, while patients are living longer, they are living with symptoms and treatment side effects.ObjectiveTo evaluate myeloma patients' preferences for treatment using a discrete choice experiment (DCE). This study set out to define the relative importance of key treatment attributes, characterize the risk-benefit trade-offs in patients' decision-making, and to analyze the predictive power of basic demographic factors.MethodsFour hundred seventy-five mye

The causal relationship between multiple cardiovascular diseases and glioblastoma: A Mendelian randomization study.

Observational studies suggest an association between glioblastoma (GBM) and cardiovascular diseases (CVDs), but a causal relationship remains unestablished. This study aimed to investigate the causal link between multiple CVDs and GBM risk. The inverse variance weighted method indicated that all 18 CVDs had significant causal associations with GBM (P < .05). Genetically predicted CVDs were uniformly associated with a lower risk of GBM (odds ratio < 1), identifying them as potential protective factors. Sensitivity analyses confirmed the absence of significant heterogeneity or horizontal pleiotr

Correlation between anemia-related red blood cell parameters and pulmonary function severity in patients with AECOPD.

AimThis study aimed to investigate the prevalence of anemia and the correlation between specific red blood cell (RBC) parameters-particularly red cell distribution width (RDW) and mean corpuscular hemoglobin (MCH)-and pulmonary function severity in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).MethodsA retrospective, single-center cohort study was conducted involving 120 hospitalized AECOPD patients. Participants were stratified by lung function grade (GOLD 1-4) and anemia status. Data on demographics, RBC parameters (Hb, RDW, MCH, MCV), and clinical outcom

Временная изменчивость результатов одинаковых режимов в ходе недавно диагностированных испытаний миэломы: систематический обзор.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Межсудебные сопоставления в области онкологии по своей сути являются проблематичными, но обычно проводятся. Диагностические изменения 2014 Это привело к тому, что ранее пациенты с задушенной миэломой были реклассифицированы как больные миэломой. Информационная цензура может также влиять на результаты. Мы стремились оценить изменчивость беспрогрессивных результатов выживаемости для идентичных терапевтических режимов в ходе многочисленных испытаний миэломы, в ходе которых борцезомиб, линалидомид и дексаметасон (VRd) или линалидомид/дексаметасон (Rd) без трансплантации служ

Real-World Outcomes of Tisagenlecleucel Versus Standard-of-Care Salvage Chemotherapy in Relapsed or Refractory Diffuse Large B-Cell Lymphoma: A Propensity Score-Matched Analysis From Korea.

BACKGROUND: Tisagenlecleucel, a CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy, has shown durable efficacy in relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL). However, comparative real-world data against standard-of-care (SOC) therapies remain scarce in Asian populations. METHODS: We performed a retrospective, propensity score-matched cohort study at two tertiary hospitals in Korea. Adult patients with R/R DLBCL treated in the third-line (3L) or later setting received either tisagenlecleucel (CAR-T cohort) or SOC salvage chemoimmunotherapy. Propensity score

Barriers to Mobility in the ICU: Insights from Severe COVID-19 and Implications for Improving Patient Outcomes.

ObjectiveTo evaluate mobility outcomes of patients with severe COVID-19 during their intensive care unit (ICU) stay compared to non-COVID-19 critically ill counterparts and assess factors impacting mobility status.DesignA retrospective, single-center case-control study.SettingThis investigation was conducted at a large tertiary care center at the epicenter of the COVID-19 pandemic between April 2019 and July 2020 to capture a prepandemic baseline and the initial surge.ParticipantsA total of 3275 ICU cases were analyzed. Analysis was conducted at the ICU visit level rather than the patient leve

Продольная графика физических функций, сообщаемых пациентами, лечащимися гематологическими микроорганизмами.

Управление США по контролю за продуктами питания и лекарствами (УПП) выпустило проект руководящего документа, в котором подробно излагаются основные результаты, сообщенные пациентами при клинических испытаниях на рак, включая физическую функцию (ПФ). Цели этого исследования заключались в разработке аналитических методов и визуализации зарегистрированных пациентов с раком. МЕТОДЫ: Мы использовали оценочные рамки для определения конечных точек приемлемости данных о пациентах в целях подготовки резюме данных в поперечном разрезе и с течением времени наряду с визуализацией. Мы добились этого благо

Изучение вопроса о том, имеет ли распространение информации во времени существенное значение для повторного выявления множественных склерозов.

Диагноз множественных склерозов (MS) требует как распространения в космосе (DIS), так и во времени (DIT); олиголональные полосы (OCB) в CSF могут заменить DIT на MRI. Мы изучили вопрос о том, необходим ли DIT (или положительный CSF) для диагностики MS у пациентов, отвечающих большому числу критериев СОП. Мы вероятно наняли пациентов с первым демиелинизирующим событием, которое оценивалось с помощью MRI мозга и спинного мозга. 3 месяцев начала. За пациентами следили клинически и с МРТ. Мы ретроспективно применяли критерии СОП, требующие нанесения повреждений ≥2/4, ≥3/4, или 4/4 регионов, обычно

Автоматическое отслеживание активного движения в многоразовом склерозе с использованием неконтролируемого машинного обучения

Справочная информация: Выявление активных повреждений в магнитно-резонансной съемке (MRI) имеет решающее значение для диагностики и планирования лечения множественных склерозов (MS). Активные повреждения МРТ выявляются после применения противопоказательных агентов на основе гадолиния (ГБЦА). Однако недавние исследования показали, что неоднократное применение ГБЦН приводит к накоплению ГД в тканях. Кроме того, администрация ГБКА увеличивает расходы на медицинское обслуживание. Таким образом, для повышения безопасности пациентов и снижения расходов на медицинское обслуживание важное значение име

Exploring cellular diversity in lung adenocarcinoma epithelium: Advancing prognostic methods and immunotherapeutic strategies.

Immunotherapy has brought significant advancements in the treatment of lung adenocarcinoma (LUAD), but identifying suitable candidates remains challenging. In this study, we investigated tumour cell heterogeneity using extensive single-cell data and explored the impact of different tumour cell cluster abundances on immunotherapy in the POPLAR and OAK immunotherapy cohorts. Notably, we found a significant correlation between CKS1B+ tumour cell abundance and treatment response, as well as stemness potential. Leveraging marker genes from the CKS1B+ tumour cell cluster, we employed machine learnin

Symptom experiences and self-management strategies of patients with haematological malignancy undergoing chemotherapy: A qualitative study.

ObjectiveTo explore symptom experiences and self-management strategies from the haematological malignancy patient's perspective.MethodsA qualitative descriptive approach was used to provide a direct and comprehensive understanding of the symptoms experienced and self-management strategies during treatment among patients with haematological malignancy. Fourteen patients with haematologic malignancies who received chemotherapy at a Chinese tertiary hospital were selected using purposeful sampling. Data were collected via semi-structured interviews and one-on-one patient sessions. The collected d

Different expression patterns of VISTA concurrent with PD-1, Tim-3, and TIGIT on T cell subsets in peripheral blood and bone marrow from patients with multiple myeloma.

V-type immunoglobulin domain-containing suppressor of T cell activation (VISTA) is considered as an immunosuppressive factor and potential therapeutic target for anticancer therapy. However, little is known about VISTA expression and its role in immunosuppression in multiple myeloma (MM). In this study, VISTA expression and co-expression with programmed cell death receptor-1 (PD-1), T cell immunoglobulin mucin-domain-containing-3 (Tim-3), and T cell immunoglobulin and ITIM domain (TIGIT) in CD3+, CD4+, CD8+, and regulatory T (Treg) cells were analyzed in patients with MM by multi-color fluores

Indirect Treatment Comparison of Daratumumab, Pomalidomide, and Dexamethasone Versus Standard of Care in Patients with Difficult-to-Treat Relapsed/Refractory Multiple Myeloma.

IntroductionThe phase 3 APOLLO study demonstrated significantly better progression-free survival (PFS) and clinical responses with daratumumab, pomalidomide, and dexamethasone (D-Pd) versus pomalidomide and dexamethasone (Pd) in patients with relapsed/refractory multiple myeloma (RRMM). On the basis of these results and those from the phase 1b EQUULEUS trial, D-Pd was approved in this patient population. In the absence of head-to-head data comparing D-Pd with further standard of care (SOC) therapies, indirect treatment comparisons (ITCs) can provide important information to help optimize treat

Fetal hemoglobin induction during decitabine treatment of elderly patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: a potential dynamic biomarker of outcome.

Hematologic responses to hypomethylating agents are often delayed in patients with myelodysplastic syndrome or acute myeloid leukemia. Fetal hemoglobin is a potential novel bio-marker of response: recently, we demonstrated that a high fetal hemoglobin level prior to decitabine treatment was associated with superior outcome. Here we investigated whether early fetal hemoglobin induction during decitabine treatment also had prognostic value, and studied the potential of decitabine to induce erythroid differentiation and fetal hemoglobin expression in vitro Fetal hemoglobin levels were measured by

Local control and vertebral compression fractures following stereotactic body radiotherapy for spine metastases.

PURPOSE: We aimed to retrospectively assess the incidence of vertebral compression fractures (VCF), examine clinicopathologic factors potentially associated with VCF, and evaluate treatment response in patients who received stereotactic body radiotherapy (SBRT) for spine metastases (spMets). METHODS AND MATERIALS: We identified 78 patients with 125 spMets at baseline and subsequent assessments. Patients received SBRT doses of 16 or 18 Gy. Patients with pre-existing VCF and co-existing local progression were excluded. Spine instability neoplastic score (SINS) was used for spMets categorization

Action of Phytochemicals on Insulin Signaling Pathways Accelerating Glucose Transporter (GLUT4) Protein Translocation.

Diabetes is associated with obesity, generally accompanied by a chronic state of oxidative stress and redox imbalances which are implicated in the progression of micro- and macro-complications like heart disease, stroke, dementia, cancer, kidney failure and blindness. All these complications rise primarily due to consistent high blood glucose levels. Insulin and glucagon help to maintain the homeostasis of glucose and lipids through signaling cascades. Pancreatic hormones stimulate translocation of the glucose transporter isoform 4 (GLUT4) from an intracellular location to the cell surface and

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… The experimentation for AKT targets in muscle and adipocytes continue, probably gives further intuition into the definite phases of GLUT4 trafficking which is regulating by this kinase. 3.3. …

Dose-Dependent Effect of Granulocyte Transfusions in Hematological Patients with Febrile Neutropenia.

It is still under debate whether granulocyte transfusions (GTs) substantially increase survival in patients with febrile neutropenia. We retrospectively examined data relative to 96 patients with hematological malignancies receiving 491 GTs during 114 infectious episodes (IE). Patients were grouped according to the median doses of granulocytes transfused during the infectious episode (low-dose group: 3.0x108 cells/Kg). The impact of clinical, microbiological and GT-related variables on the infection-related mortality (IRM) was investigated. The IRM was not influenced by the number of GTs or by

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… Although the intuition to transfuse granulocytes from allogeneic donors in neutropenic patients dates back several decades [ 7 ], only the introduction of granulocyte-colony stimulating factor (G-CSF) as a mobilizing protocol has yielded adequate granulocyte apheresis products [ 8 ]. …

A practical guide for using registry data to inform decisions about the cost effectiveness of new cancer drugs: lessons learned from the PHAROS registry.

Decision makers increasingly request evidence on the real-world cost effectiveness of a new treatment. There is, however, a lack of practical guidance on how to conduct an economic evaluation based on registry data and how this evidence can be used in actual decision making. This paper explains the required steps on how to perform a sound economic evaluation using examples from an economic evaluation conducted with real-world data from the Dutch Population based HAematological Registry for Observational Studies. There are three main issues related to using registry data: confounding by indicat

Psychometric properties of two physical activity questionnaires, the AQuAA and the PASE, in cancer patients.

BackgroundThis study aimed to evaluate the reliability and validity of two self-report physical activity (PA) questionnaires - the AQuAA (Activity Questionnaire for Adults and Adolescents) and PASE (Physical Activity Scale for the Elderly) - in cancer patients.MethodsTest-retest reliability was determined by administering the questionnaires twice within 5 days. Intraclass correlation coefficient (ICC), standard error of measurement (SEM) and smallest detectable difference (SDD) were calculated. Construct validity was determined by comparing the questionnaire results with ActiGraph acceleromete

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… It does however require more effort to fill in the AQuAA compared to the PASE because you really have to think about how much time you spent on the activities in the last week...The PASE is much easier because you can pick an answer which suits you best, you use your intuition to give an answer compared …