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Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs.

Cancer prevention is a serious global challenge. We aimed to investigate the relationship between lipid-lowering drugs and cancers. We included participants based on the UK Biobank. Lipid-lowering drug use was defined as new users before enrollment and the primary outcome was cancer incidence. The Cox proportional hazards regression model was used to evaluate the association between drug use and outcome. We also performed a meta-analysis. We found that lipid-lowering drugs were associated with decreased risk of 21 types of cancers, including melanoma, skin cancer, and reproductive, hematologic

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… : mmHg]), history of bowel cancer screening (yes or no), prostate specific antigen (PSA) test (yes or no), breast cancer screening/mammogram (yes or no), cervical smear test (yes or no), oral contraceptive pill (yes or no), hormone-replacement therapy (HRT) (yes or no) and age when periods started (menarche … Cancer-specific confounders adjusted in Model 4: PSA test for prostate cancer; age when periods started (menarche), oral contraceptive pill, and HRT for ovarian and uterus cancers; cervical smear test (yes or no), age when periods started (menarche), oral contraceptive pill, and HRT for cervical cancer …

Development and pilot testing of a personalised decision aid for decision-making regarding fertility preservation in young female patients with cancer: a study protocol.

INTRODUCTION: Infertility resulting from cancer treatment is known to be a major factor that reduces the quality of life of young cancer sur … the patient's characteristics, which are essential for determining the appropriate option, such as menarche status and desire for pregnancy. The value communication module provides information on the extent to which each fertility preservation option satisfies the patient's values and preferences. After the development of the DA, a small group of young pa …

Glanzmann's thrombasthenia: pathogenesis, diagnosis, and current and emerging treatment options.

Glanzmann's thrombasthenia (GT) is a genetic platelet surface receptor disorder of GPIIb/IIIa (ITG αIIbβ3), either qualitative or quantitative, which results in faulty platelet aggregation and diminished clot retraction. Spontaneous mucocutaneous bleeding is common and can lead to fatal bleeding episodes. Control and prevention of bleeding among patients with GT is imperative, and remains challenging. Local measures, including anti-fibrinolytic therapy, with or without platelet transfusions, used to be the mainstay of therapy. However, in recent years the use of recombinant factor VIIa (rFVIIa

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… In some cases, women have not been diagnosed until menarche, when severe blood loss due to menorrhagia has required transfusion, as reported in a study by George et al. … Hormonal intrauterine devices have also been used to reduce bleeding, with or without the use of an anti-fibrinolytic agent. 3 Severe menorrhagia, which plagues many women with GT and can be seen with menarche, can be treated with high-dose conjugated estrogen intravenously for 24–48 hours, followed …

Bone Health for Gynaecologists.

Osteoporosis, the most common bone disorder, profoundly impacts women's health, especially during postmenopausal phases. Characterised by diminished bone mineral density (BMD), it increases the risk of fractures, affecting mobility, quality of life, and potentially mortality. The present review analyses the intricate interactions among physiological alterations, diseases, and medications that lead to bone mineral density reduction in women. It underscores the importance of gynaecologists in the prevention, diagnosis, and management of osteoporosis via early risk assessment, suitable hormone tr

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… Evidence indicates that the use of combined oral contraceptives (COCs) in teenagers results in diminished bone mineral accumulation, particularly when utilised within the initial three years following menarche [ 33 ]. … To assess the risk to bone health in young women receiving hormone therapy for gynecological conditions, particularly in adolescents utilizing oral contraceptives within three years post-menarche. …

Associations of childhood adiposity with menstrual irregularity and polycystic ovary syndrome in adulthood: the Childhood Determinants of Adult Health Study and the Bogalusa Heart Study.

STUDY QUESTION: Is high adiposity in childhood associated with menstrual irregularity and polycystic ovary syndrome (PCOS) in later life? S … ted relative risks (RRs) adjusting for childhood age, highest parental and own education and age at menarche. MAIN RESULTS AND THE ROLE OF CHANCE: The prevalence of childhood obesity was 1.1% in CDAH and 7.5% in BBS. At follow-up, menstrual irregularity was reported by 16.7% of CDAH and 24.5% of BBS participants. The prevalence of PCOS was 7.4% in CDAH an …

Intermittent iron supplementation for reducing anaemia and its associated impairments in menstruating women.

BACKGROUND: Daily iron supplementation has been traditionally a standard practice for preventing and treating anaemia but its long term use … her individual or cluster randomisation. Participants were menstruating women, that is women beyond menarche and prior to menopause who were not pregnant or lactating and did not have a known condition that impeded the presence of menstrual periods. The intervention was the use of iron supplements intermittently (one, two or three times a week on non-conse …

Aqueous vaginal contrast and scheduled hematocolpos with magnetic resonance imaging to delineate complex müllerian anomalies.

OBJECTIVE: To demonstrate the advantage of using aqueous vaginal contrast and scheduled hematocolpos with magnetic resonance imaging (MRI) t … INTERVENTION(S): OHVIRA is a unilateral obstructed müllerian anomaly that presents typically after menarche with progressively worsening dysmenorrhea caused by progressive distension of the obstructed hemivagina and uterine horn. The definitive treatment for this anomaly is resection of the unilateral obstruction. When the obstructed hemivagina is within …

Oral prolonged-release dienogest 2 mg and ethinylestradiol 0.02 mg in a 24/4-day regimen for polycystic ovary syndrome-associated hirsutism: a double-blind, randomised, placebo-controlled trial.

BACKGROUND: Current guidelines for polycystic ovary syndrome (PCOS) recommend combined oral hormonal contraceptives as first-line pharmacolo … ary, Lithuania, Poland, Serbia, Slovakia, Spain and Ukraine. Eligible participants were 2-year-post-menarche women (14-40 years old) with a body mass index (BMI) of 18 to <35 kg/m2 who were diagnosed with clinical hyperandrogenism (adapted modified Ferriman-Gallwey [mFG] score ≥7) plus oligomenorrhea of ≤6 menses per year and/or polycystic ovary morphology …

[Molecular action of insulin-sensitizing agents].

Atypical endometrial hyperplasia has been associated with progression to endometrial cancer, the most common genital malignancy. There are multiple risk factors for endometrial cancer, such as early menarche, exogenous estrogen exposure, obesity and diabetes. Diabetics have a 3-4 fold relative risk of endometrial cancer. Also, several studies have demonstrated an association between insulin resistance and endometrial cancer. There is known the first description of atypical endometrial hyperplasia resistant to progestogen therapy, which was subsequently treated with an insulin-sensitizng agent,…

Uterine Extramedullary Plasmacytoma as a Primary Manifestation of Multiple Myeloma.

The association between plasmacytomas and multiple myeloma (MM) is well-described, and in about one third of the cases of plasmacytoma the additional study will lead to the diagnosis of MM. The finding of plasmacytomas in the genital tract is extremely rare, with sparse cases described in the literature, and these cases pose a challenge regarding the optimal guidance and treatment. This paper describes a case of uterine extramedullary plasmacytoma in a 79-year-old woman with complaints of postmenopausal abnormal uterine bleeding. The complementary study led to the diagnosis of uterine plasmacy

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… Her menarche occurred at 11 years old, and she had regular cycles and 1 pregnancy (with a vaginal delivery at 27 years old). There was no history of use of hormonal contraceptives, and she had spontaneous menopause at 41 years without hormonal therapy. …

Predicting which patients with cancer will see a psychiatrist or counsellor from their initial oncology consultation document using natural language processing.

BackgroundPatients with cancer often have unmet psychosocial needs. Early detection of who requires referral to a counsellor or psychiatrist may improve their care. This work used natural language processing to predict which patients will see a counsellor or psychiatrist from a patient's initial oncology consultation document. We believe this is the first use of artificial intelligence to predict psychiatric outcomes from non-psychiatric medical documents.MethodsThis retrospective prognostic study used data from 47,625 patients at BC Cancer. We analyzed initial oncology consultation documents

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… current, current medications, medications include, include, takes, medications current, taking, daily 11 | 1111 | Patient Family Counseling Referral | patient family, patient, family, counseling, family counseling, referral, discussion, understand, today, counselling 12 | 1009 | Menstrual History | menarche … , age, menarche age, menopause, menopause age, history menarche, gynecological, gynecological history, history, menstrual 13 | 669 | Clear Lungs Auscultation | lungs, clear, lungs clear, auscultation, clear auscultation, auscultation lungs, bilaterally, clear lungs, bilaterally lungs, entry 14 | 495 …

Chained Risk Assessment for Life-Long Disease Burden of Early Exposures - Demonstration of Concept Using Prenatal Maternal Smoking.

Traditional risk factors and environmental exposures only explain less than half of the disease burden. The developmental origin of the health and disease (DOHaD) concept proposes that prenatal and early postnatal exposures increase disease susceptibility throughout life. The aim of this work is to demonstrate the application of the DOHaD concept in a chained risk assessment and to provide an estimate of later in life burden of disease related to maternal smoking. We conducted three systematic literature searches for meta-analysis and reviewed the literature reporting meta-analyses of long-ter

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… 45 , 46 ] | Decreased lung function (FEF75, FEV1, FVC) | | [ 47 ] | [ 47 , 48 ] | Metabolic | | | | Cortisol secretion | [ 49 ] | | [ 50 ] | Metabolic syndrome | | | [ 32 ] | [ 51 ] Total cholesterol | | | [ 52 ] | [ 53 ] Other | | | | Congenital anomalies | [ 54 ] | | | Age at menarche … A meta-analysis provides evidence that prenatal smoking exposure decreases age at menarche. Reprod. Toxicol. 2015;58:222–228. doi: 10.1016/j.reprotox.2015.10.019. 56. Van Leeuwen J., Koes B.W., Paulis W.D., van Middelkoop M. …

Нацеливаюсь на гормональное лечение мозга в менопаузе.

Эстрогены являются нейрозащитными, и менопауза может способствовать нейродегенерации. Эстриол преимущественно связывает бета-рецептор эстрогена (ERβ) в мозге для обеспечения нейрозащиты. Ранее пероральный эстриол повышал скорость когнитивной обработки и уменьшил атрофию коры головного мозга в месяц лечения twelve в случае женщин с множественным склерозом (МС). В данном случае лечение с помощью волдыря, предназначенного для здоровых менопаузальных женщин, содержащих эстриол и прогестерон (Pearlpak), оценивалось с точки зрения его воздействия на когнитивные симптомы, характерные для домена, в ря

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… Conversely, regional brain protection has been reported in women with more years of estrogen exposure (more time between menarche and menopause) or more exposure to high levels of estrogen during pregnancy (multiparity) 15 , 16 . … Conversely, regional brain protection has been reported in women with more years of estrogen exposure (more time between menarche and menopause) or more exposure to high levels of estrogen during pregnancy (multiparity). …

Racial divergence in adiposity during adolescence: The NHLBI Growth and Health Study.

BACKGROUND: Black women are particularly vulnerable to obesity, with a prevalence rate of >50%. The higher mortality and morbidity from card … es with Holtain calipers. Sexual maturation was assessed by trained registered nurses. The onset of menarche was ascertained annually by questionnaire. All clinical assessments were conducted using a common protocol by centrally trained staff. Longitudinal regression (generalized estimating equations) models were used to examine the relationship between ad …

Optimizing treatment efficacy and fertility preservation in patients undergoing hematopoietic stem cell transplantation: A narrative review of ovarian shielding with total-body irradiation or treosulfan-based conditioning regimens.

BackgroundPediatric and adolescent/young adult (AYA) patients with hematologic malignancies often require hematopoietic stem cell transplantation (HSCT) using conditioning regimens that pose high risks for gonadal toxicity. Traditional protocols, including total body irradiation (TBI) and busulfan-based regimens, can impair fertility. This review explores the potential of gonadal shielding during TBI and treosulfan-based conditioning as strategies to optimize treatment efficacy while preserving fertility.MethodsA PubMed search up to February 2025 was performed for English, peer-reviewed articl

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… Faraci et al. 12 performed a multicenter study involving 137 patients, including those with malignant cases, to evaluate spontaneous puberty achievement in prepubertal children and spontaneous menarche in both prepubertal and postpubertal girls, with quantitative hormone level assessments. … The results were as follows: For spontaneous puberty in prepubertal children, 38% versus 100% in females and 85% versus 100% in males; for spontaneous menarche, 10% versus 100% in prepubertal girls and 65% versus 75% in postpubertal girls. …

Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial.

OBJECTIVES: The aim of this randomised GCP-controlled trial is to clarify whether combination therapy with the antibiotic azithromycin and h … ancy test must be available at inclusion • Informed consent signed by the patient *Defined as after menarche and until postmenopausal (no menstruation for 12 months) Exclusion criteria: • At the time of recruitment, the patient uses >5 LO2/min (equivalent to 40% FiO2 if measured) • Known intolerance/allergy to azithromycin or hydroxychloroquine or hypersen …

Assessment of TSPAN Expression Profile and Their Role in the VSCC Prognosis.

The role and prognostic value of tetraspanins (TSPANs) in vulvar squamous cell carcinoma (VSCC) remain poorly understood. We sought to primarily determine, at both the molecular and tissue level, the expression profile of the TSPANs CD9, CD63, CD81, and CD82 in archived VSCC samples (n = 117) and further investigate their clinical relevance as prognostic markers. Our studies led us to identify CD63 as the most highly expressed TSPAN, at the gene and protein levels. Multicomparison studies also revealed that the expression of CD9 was associated with tumor size, whereas CD63 upregulation was ass

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… As depicted in Table 1 , the median age of the patients selected for our studies was 67.22 years (ranging from 14 to 98 years old), where the median age for patients in the menopause was 50 years (ranging from 35 to 64 years old), in menarche was 14 (ranging from 11 to 19 years old), and in sexarche … Variables | Categories | Overall Population by Medical Record/Percentage Frequencies Age | ≤50 | 12 (10.5%) >50 | 102 (89.5%) Menarche | 11 to 14 years old | 41 (68.3%) 15 to 19 years old | 19 (31.7%) Menopause | No | 3 (4.6%) Yes | 62 (95.4%) Sexarche | 15 to 18 years old | 16 (51.6%) ≥19 years old …

[Homozygous Variant of FANCM of the Fanconi Anemia Pathway Causes Premature Ovarian Insufficiency: Investigation of the Pathogenic Mechanism].

OBJECTIVE: Infertility affects approximately one-sixth of the people of childbearing age worldwide, causing not only economic burdens of tre … Valfs*10. The patient presented with primary infertility, experiencing irregular menstruation since menarche at the age of 16. Hormonal evaluation revealed an FSH level of 26.79 IU/L and an anti-Müllerian hormone (AMH) level of 0.07 ng/mL. Vaginal ultrasound indicated unsatisfactory visualization of the ovaries on both sides and uterine dysplasia. The pati …

Gynaecological and obstetric management of women with inherited bleeding disorders.

OBJECTIVE: The prevalence of bleeding disorders, notably von Willebrand disease (vWD), among adult women with objectively documented menorrhagia is consistently reported to be 10% to 20% and is even higher in adolescents presenting with menorrhagia. This consensus document has been developed by a multidisciplinary committee consisting of an anesthesiologist, 2 hematologists, and an obstetrician/gynaecologist and has been endorsed by their relevant specialty bodies. It has been prepared with the express purpose of providing guidelines for both women with inherited bleeding disorders and for the