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The Expanding Field of Secondary Antibody Deficiency: Causes, Diagnosis, and Management.

Antibody deficiency or hypogammaglobulinemia can have primary or secondary etiologies. Primary antibody deficiency (PAD) is the result of intrinsic genetic defects, whereas secondary antibody deficiency may arise as a consequence of underlying conditions or medication use. On a global level, malnutrition, HIV, and malaria are major causes of secondary immunodeficiency. In this review we consider secondary antibody deficiency, for which common causes include hematological malignancies, such as chronic lymphocytic leukemia or multiple myeloma, and their treatment, protein-losing states, and side

The crosstalk network of non-coding RNAs: Emerging opportunities for the clinical application of osteoporosis.

Current methods for testing bone density lack the capability to detect patients with early bone loss, and existing osteoporosis therapies have limitations in their efficacy and safety. Therefore, the development of more precise and convenient diagnostic technologies and novel treatments is of paramount importance. Extracellular vesicle (EV)-mediated non-coding RNA (ncRNA) interaction networks enable both the detection of early bone loss and targeted therapy for enhanced treatment outcomes. In this review, we highlight the utility of EVs for carrying various ncRNAs (e.g., miRNAs, lncRNAs, and c

From Early Diagnoses to New Treatments for Liver, Pancreatic, Gastric, and Colorectal Cancers Using Carbon Nanotubes: New Chances Still Underexplored.

Pancreatic, liver, gastric, colorectal, and rectal cancers (PC, LC, GC, CRC, and RC) are highly lethal tumours, with a 5-year survival rate of 10.5% (PC) and <20% (LC), and of 5%, 12%, and 13% for IV-stage GC, CRC, and RC, respectively. Currently, PC and LC represent the third leading cause of cancer-related death, while GCs and CRCs account for 4.8 million cancer cases and 4.4 million cancer deaths worldwide. Poor prognoses are mainly due to late diagnosis, limited efficacy of available treatments, tumour recurrence, as well as therapy-induced secondary tumorigenesis and drug resistance. In r

FDA-Approved Drugs Containing Amide Functionality in the Last Five Years (2021-2025): Pharmaceutical Use, Trends and Synthetic Approaches.

The amide functional group remains a cornerstone of medicinal chemistry, serving as an indispensable scaffold in the design of modern therapeutics. This review presents an analysis of FDA-approved drugs (small molecules and peptides with MW ®), amides form the structural backbone of peptidomimetics, enabling high-affinity binding to a viral protease. In precision oncology, as seen with adagrasib (Krazati®), the amide acts as a critical, metabolically stable linker that positions a covalent warhead for selective inhibition of a mutant kinase. This analysis underscores that amide's unique combin

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… Food and Drug Administration approved on 25 October 2024 for the treatment of uncomplicated urinary tract infections (uUTIs) caused by Escherichia coli , Klebsiella pneumoniae , or Proteus mirabilis in adult women who have limited or no alternative oral antibacterial treatment options [ 204 , 205 ]. …

P941 – P1197

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The Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer.

Chronic inflammation is now recognized as one of the major risk factors and molecular hallmarks of chronic prostatitis, benign prostatic hyperplasia (BPH), and prostate tumorigenesis. However, the molecular mechanisms by which chronic inflammation signaling contributes to the pathogenesis of these prostate diseases are poorly understood. Previous efforts to therapeutically target the upstream (e.g., TLRs and IL1-Rs) and downstream (e.g., NF-κB subunits and cytokines) inflammatory signaling molecules in people with these conditions have been clinically ambiguous and unsatisfactory, hence foster

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… However, the list is not limited to those two bacteria, as many other bacteria such as Pseudomonas spp., Proteus mirabilis , Klebsiella spp., and Serratia spp. have also been identified and isolated from the prostate during bacterial prostatitis [ 10 , 11 ]. 2. …

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents.

The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Children and Adolescents was developed by dietitians, physicians, and pediatric hematologists from 10 Brazilian reference centers in hematopoietic stem cell transplantation. The aim was to emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to patient´s nutritional assessment. This consensus is intended to improve and standardize nutrition therapy during hematopoietic stem cell transplantation. The consensus was approved by the Brazilian

Proceedings of Réanimation 2020, the French Intensive Care Society International Congress.

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Acute Pneumonia

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… Pasteurella multocida Proteus spp. Burkholderia pseudomallei Salmonella spp. Enterococcus faecalis Streptococcus pyogenes TABLE 69-1B Causative Agents of Acute Pneumonia: Viruses MERS-CoV, Middle East respiratory syndrome coronavirus; SARS, severe acute respiratory syndrome. …

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives.

Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compoun

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… 2020a , b ) Antiviral | Ability on the immune system or/and its inhibitory effects on major virus proteins | Ma et al. ( 2018 , 2020a , b ), Li et al. ( 2020d ) Ethanol exract | The antimicrobial activities of seed and roots | Against Bacillus subtilis , Escherichia coli , Micrococcus tetragenus and Proteus …

ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts

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Chest and Mediastinum

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СРП 2013

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Oral Presentations

Introduction: As robotic-guidance and minimally invasive approaches become more prevalent in spine surgery, there is a growing interest in h … le for 37% of the SSIs, followed by Propionibacterium acnes (17%), Enterococcus faecalis (14%), and Proteus mirabilis respectively Staph. aureus accounting for 6% each. Staph. epidermidis, Enterococcus faecalis, Proteus mirabilis and Stap aureus could be cultivated from wound swabs and used for the subsequent evaluation. In vitroevaluation: The efficacy o …

Р

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Emergency Care

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RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS.

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Proceedings of Reanimation 2021, the French Intensive Care Society International Congress.

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Research Communications of the 26th ECVIM‐CA Congress

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… Among 125 Enterobacteriaceae , E . coli ( 52%) was the most frequently isolated, followed by Enterobacter spp. (16%), Proteus spp. (10.4%) and Citrobacter spp. (9.6%). …

Integumentary System

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