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The Immuno-oncology-Induced Cytokine Release Syndrome Patient Diary: A Content-Valid, Patient-Reported Outcome Measure.

INTRODUCTION: Cytokine release syndrome (CRS) occurs when the immune system reacts excessively to infections or certain immunotherapies, leading to a systemic inflammatory response. The clinical presentation of CRS is highly variable, ranging from mild symptoms, such as fever and fatigue, to severe, life-threatening conditions. Currently, there is no standardized method for collecting patient-reported data on CRS experiences. This study aims to develop a novel patient-reported outcome measure (PROM) to capture patients' experience with CRS. METHODS: A comprehensive, multistep evidence-generat

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… Its clinical presentation is heterogeneous: it can manifest as mild, with fever, nausea, fatigue, headache, rash, arthralgia, myalgia, and chills; or severe, with vascular leakage, disseminated intravascular coagulation, shock, and respiratory compromise, which may lead to multisystem organ failure or … Refinement and Finalization of the Patient-Reported Outcome Measure Cognitive Debriefing Interviews with Clinical Oncologists Clinical oncologists proposed adding headache to the draft PROM, and to separate chills and shaking. …

Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study.

BackgroundPatients with cancer are a high-risk population in the COVID-19 pandemic. We aimed to describe clinical characteristics and outcomes of patients with cancer and COVID-19, and examined risk factors for mortality in this population.MethodsWe did a retrospective, multicentre, cohort study of 205 patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and with a pathological diagnosis of a malignant tumour in nine hospitals within Hubei, China, from Jan 13 to March 18, 2020. All patients were either discharged from hospitals or had died b

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… malignancies (Eastern Cooperative Oncology Group [ECOG] performance status, cancer type, cancer stage, time since cancer diagnosis, and treatments), vital signs (temperature, breathing rate, heart rate, and blood oxygen saturation), symptoms (fever, cough, sputum, chest congestion, shortness of breath, chills … Symptoms | Fever | 159 (78%) | 126 (76%) | 33 (83%) | 0·53 | Chills | 17 (8%) | 15 (9%) | 2 (5%) | 0·60 | Cough | 151 (74%) | 119 (72%) | 32 (80%) | 0·42 | Sputum | 70 (34%) | 51 (31%) | 19 (48%) | 0·072 | Chest congestion | 67 (33%) | 49 (30%) | 18 (45%) | 0·096 | Shortness of breath | 71 (35% …

A Preliminary Investigation towards the Risk Stratification of Allogeneic Stem Cell Recipients with Respect to the Potential for Development of GVHD via Their Pre-Transplant Plasma Lipid and Metabolic Signature.

The clinical outcome of allogeneic hematopoietic stem cell transplantation (SCT) may be influenced by the metabolic status of the recipient following conditioning, which in turn may enable risk stratification with respect to the development of transplant-associated complications such as graft vs. host disease (GVHD). To better understand the impact of the metabolic profile of transplant recipients on post-transplant alloreactivity, we investigated the metabolic signature of 14 patients undergoing myeloablative conditioning followed by either human leukocyte antigen (HLA)-matched related or unr

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense.

In the present study, we evaluated the potential of the plant E. arvense against the cytotoxic and mutagenic effects induced by cyclophosphamide (chemotherapeutic agent) in the bone marrow cells of mice using the Chromosome assay (CA) and Mitotic index (MI) in vivo as the biomarkers. The study was performed following 3 protocols: pre-treatment, simultaneous treatment and post-treatment with the ethanolic extract of the plant. The results demonstrated that the plant extract was not cytotoxic and mutagenic and has a protective effect against the mutagenicity induced by cyclophosphamide in pre, s

Role of denosumab in the management of skeletal complications in patients with bone metastases from solid tumors.

Skeletal-related events (SREs) including pain, fractures, and hypercalcemia are a major source of morbidity for cancer patients with bone metastases. The receptor activator of NF-κB ligand (RANKL) is a key mediator of osteoclast formation and activity in normal bone physiology as well as cancer-induced bone resorption. The first commercially available drug that specifically targets and inhibits the RANKL pathway is denosumab, a fully human monoclonal antibody that binds and neutralizes RANKL, thereby inhibiting osteoclast function. In this review, we summarize the major studies leading to the

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… Intravenous infusion of zoledronic acid can be associated with an acute-phase reaction, including bone pain, fever, and chills in up to 30% of patients following their first infusion. … No patient treated with denosumab and 10 patients (1%) treated with zoledronic acid experienced serious adverse events associated with acute-phase reactions during the first 3 days after treatment. 29 These events included pyrexia (n = 7), bone pain (n = 2), and asthenia, back pain, chest pain, chills …

Одинокая плазмоцитома ребер: доклад о рейдовом деле.

Одинарная плазмоцитома кости (СБ) — редко злокачественная плазма, состоящая из неоплазмы. 6% из всех опухолей плазменных клеток. Для него характерно одиночное остеолитическое повреждение. В настоящем докладе содержится описание асимптомного СПБ в ребре 66-year-old Чувак. Рентгеновское излучение и вычисленная томография (CT) первоначально показали локализованную ресорбцию костей и разрушение правого пятого заднего ребра с помощью а 4.0×2.4×2.8 масса мягких тканей. Одинокие фотовыбросы, рассчитанные на томографию (SPECT), подтвердили наличие изолированных ребер без множественных повреждений скел

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… Case Report A 66-year-old male patient presented with occasional cough, without sputum production, dyspnea, chills, or fever. …

Major approaches in early diagnostics of common variable immunodeficiency in adults in Moscow.

Common variable immunodeficiency (CVID) is a primary immunological disease characterized predominantly by hypogammaglobulinemia. The main clinical manifestations are severe recurrent infections that often lead to structural damage of affected organs. The early start of adequate intravenous immunoglobulin therapy has significantly improved the prognosis of this serious disorder. Patients with CVID are also predisposed to autoimmune and lymphoproliferative complications. This article deals with the features of this primary immunodeficiency in adults. Clinical manifestations, immunological featur

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… Additionally, chills, headache, dizziness and general weakness were observed. These symptoms characterize a reaction to the introduction of a large dose of protein, which is not an indication to stop administering the drug. …

Диагностика множественных склерозов: из материалов Конференции Национального общества по проблемам множественных склерозов.

28-летняя чернокожая женщина имела как типичные, так и нетипичные особенности множественного склероза в условиях многоженства, включая психиатрическую историю, осложняющие диагностику и лечение. Этот случай иллюстрирует важность дифференциального диагноза и продольного контроля, прежде чем брать на себя обязательство по профилактике заболеваний. Особое внимание уделяется принятию решений в отношении индивидуального лечения.

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… Two months before, she had a presumed self-limited viral illness characterized by fevers, chills, nausea, and nonintractable, nonbilious emesis lasting 7–10 days. She tested negative for common respiratory viruses including coronavirus disease 2019 (COVID-19). …

An Unusual Case of Primary Plasma Cell Leukemia Presenting As Pericardial Effusion.

Plasma cell leukemia represents the rarest form of plasma cell dyscrasias arising from monoclonal proliferation of plasma cells in peripheral blood. Its aggressive natural history raises a significant therapeutic challenge. We present a case of a 58-year-old female who presented with a cough accompanied by exertional dyspnea. Further radiological investigations revealed a circumferential pericardial effusion. A pericardiocentesis was performed, resulting in the drainage of 650 cc of hemorrhagic pericardial fluid. Cytology revealed monoclonal plasma cells expressing CD38 and CD138 with cytoplas

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… She denied any history of orthopnea, fevers, chills, nausea, vomiting, diarrhea, or recent illness or contact with sick individuals. Objectively, the patient had a blood pressure of 147/89 mmHg, a heart rate of 82 bpm, and a respiratory rate of 20 breaths per minute. …

A Case Report on Solitary Extramedullary Plasmacytoma of the Pleura.

Solitary plasmacytoma is an extremely rare form of plasma cell malignancy that presents as a single mass of monoclonal plasma cells located either intraosseous or extramedullary (extraosseous). Extramedullary plasmacytoma can affect any part of the body, but the most common sites of origin are the head and neck region. The involvement of pleura is very rare. Here, we are enlightening this rare presentation and making readers aware of the clinical presentation and management of this rare malignancy.

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… He otherwise denied any episodes of fever, chills, nausea, or emesis. He states that he was initially doing well at the short-term rehab facility, however, because of the Clostridium difficile infection in the rehab he noted a significant decline in his overall health. …

Elotuzumab: The First Monoclonal Antibody for the Treatment of Multiple Myeloma.

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… Adverse Effects The primary adverse effects noted in phase I and II trials were infusion reactions, including pyrexia, chills, hypertension, nausea, and/or vomiting ( Liu et al., 2014 ; van de Donk et al., 2016 ). …

Хроническая нейтрофическая лейкемия у пациента с множественной миеломой.

Высокодозированная химиотерапия, применяемая для аутологической трансплантации стволовых клеток (ASCT), часто связана с распространением клеток с неопластическими способностями. В результате может быть расширена одна конкретная линия клеток, т.е. клональная гематомоизис (CH). Частота CH в множестве миеломы (ММ) была зарегистрирована как ~21,6%. Хотя нейтрофия в MM может быть лейкемоидной реакцией, нельзя забывать о таких гематоологических новообразованиях, как хроническая нейтрофильная лейкемия (CNL), которая характеризуется мутации CSF3R и отсутствием цитопении и/или значительного морфологиче

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… Both can present with constitutional symptoms, such as fevers, chills, fatigue, and weight loss; however, patients could be asymptomatic in either case. Thus, it is important to distinguish the two in order to guide treatment and prognostication. …

Brown Tumor From Secondary Hyperparathyroidism Mimicking Metastatic Renal Cell Carcinoma in a Patient With End-Stage Renal Disease.

Brown tumors (also known as osteitis fibrosa cystica) are rare complications of end-stage renal disease (ESRD) and secondary hyperparathyroidism (HPT), characterized by focal bone lesions that resemble neoplasms. They are often misdiagnosed as metastatic bone disease, especially in patients with a history of malignancy. We present a case of a 60-year-old man with a history of renal cell carcinoma (RCC), and ESRD on hemodialysis (HD), who developed diffuse bone lesions on imaging with osteolytic/osteoblastic appearance concerning metastases, but on further workup was found to have brown tumors.

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… Of note, the patient denied any prior injuries or trauma, numbness or tingling in his hands, fever, or chills. He reported swelling of the left wrist and focal pain which was worsened with movement. …

Incidence, Risk Factors and Outcome of Bloodstream Infections in Patients After Hematopoietic Stem-Cell Transplantation: A Single Center Study.

The bloodstream infections (BSIs) are among the most common infectious complications after hematopoietic stem-cell transplantation (HSCT), often associated with high mortality rates. The aim of this study was to evaluate the incidence, risk factors and outcome of BSIs in HSCT recipients from the Transplantation Center of the University Hospital in Varna, Bulgaria during the period January 2019-December 2021. The role of patient- and transplantation-related variables was studied as potential risk factors for BSIs and survival after HSCT. Seventy-four patients were included in the study. The cum

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… colonization Yes | 2 (4.1) | 2 (8.0) No | 47 (95.9) | 23 (92.0) Donor type HLA MUD | NA | 14 (56.0) HLA MRD | NA | 5 (20.0) Haplo | NA | 6 (24.0) Stem-cell source Bone marrow | 0 | 2 (8.0) Peripheral blood | 49 (100.0) | 23 (92.0) Microbiological Investigation In case of suspected infectious complication (chills …

Metformin-Associated Functional Vitamin B12 Deficiency Presenting as Subacute Combined Degeneration in a 57-Year-Old Man With Diabetes Mellitus.

BACKGROUND Functional vitamin B12 deficiency, also known as metformin-associated cobalamin deficiency, can occur in patients receiving metformin due to impaired gastrointestinal absorption of vitamin B12. This condition can coexist with diabetic neuropathy and may result in impaired myelin formation in the spinal cord and peripheral nerves, leading to subacute combined degeneration of the spinal cord. This report describes a patient with diabetes mellitus and metformin-associated functional vitamin B12 deficiency who presented with subacute combined degeneration of the spinal cord and gastroin

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… He also reported complete cessation of bowel movements, with only occasional passage of flatus; he did not experience fever, chills, palpitations, or chest pain. Worsening of these symptoms over the week prior to presentation prompted his hospital visit. …

Current Status of Gene Engineering Cell Therapeutics.

Ex vivo manipulations of autologous patient's cells or gene-engineered cell therapeutics have allowed the development of cell and gene therapy approaches to treat otherwise incurable diseases. These modalities of personalized medicine have already shown great promises including product commercialization for some rare diseases. The transfer of a chimeric antigen receptor or T cell receptor genes into autologous T cells has led to very promising outcomes for some cancers, and particularly for hematological malignancies. In addition, gene-engineered cell therapeutics are also being explored to in

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… CAR T cells specific for CD19 | Patients with chemotherapy-refractory CLL or relapsed B-cell ALL | CLL PR 1/8, SD 2/8, ALL B-cell aplasia 1/1 | Well tolerated, most patients had rigors, chills, and transient fevers. 1 death from sepsis ( 5 ) | MSKCC | NCT01044069 | Autol. … ) (N = 4/12) that subsided with symptomatic management ( 76 ) | UPMC | Phase I, NCT00900809 | Allogeneic NK92 cell line | Refractory/relapsed AML ( n = 7) | Transient activity seen in 3 of 6 evaluable patients | One patient developed grade 2 fever and chills following each aNK cell infusion that required …

Продвижение многомерной миеломной терапии: систематический анализ кортикостероидов и моноклонных антител в качестве двух терапевтических агентов.

Множественная миелома (ММ) — неизлечимая гематопоэтическая порча, которая определяется клональным расширением неопластических плазменных клеток костного мозга. Кортикостероиды и моноклонные антитела (mAbs) были утверждены для обработки MM в прошлом 20 годы и в настоящее время являются ключевыми компонентами режима лечения, повышая клинические результаты. Кортикостероиды (дексаметазон и преднизон) часто используются в сочетании с другими агентами [протеозными ингибиторами и иммуномодулятивными препаратами (ИМИД)], в то время как mAbs (daratumumumab, elotuzumab и isatuximab) изменили парадигмы л

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… While mAbs are generally well-tolerated, they can also cause infusion-related reactions such as fever, chills, and nausea, mainly with daratumumab or isatuximab agents[ 20 ]. … Infusion reactions such as fever, chills, and hypotension are common when administering mAbs and can delay the continuation of therapy. Although these reactions are mild, they can affect treatment time and the patient's comfort. …

Anti-BCMA/CD19 CAR T cell therapy in patients with refractory generalized myasthenia gravis: a single-arm, phase 1 trial.

BACKGROUND: Treating refractory generalized myasthenia gravis is still a big challenge, so new treatments are needed. Several studies have shown the potential of chimeric antigen receptor (CAR) T cell therapy in the treatment of autoimmune diseases. However, no clinical trial of bispecific CAR T cells targeting refractory myasthenia gravis has been done. We developed autologous anti-B-cell maturation antigen (BCMA) and CD19 bispecific CAR T cells to evaluate the safety and efficacy in refractory myasthenia gravis. METHODS: This single-arm, phase 1 trial (ChiCTR2200061267) was conducted at the

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… alanine aminotransferase 1 (6) 0 0 0 0 0 0 0 Increased aspartate aminotransferase 0 0 0 0 0 0 0 0 Increased creatinine 0 0 0 0 0 0 0 0 Increased total bilirubin 0 0 0 0 0 0 0 0 Headache 9 (50) 1 (6) 0 0 2 (12) 0 0 0 Hand numbness 10 (56) 0 0 0 7 (41) 0 0 0 Muscle soreness 15 (83) 1 (6) 0 0 13 (76) 0 0 0 Chills … | 0 | 0 | 0 Increased creatinine | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 Increased total bilirubin | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 Headache | 9 (50) | 1 (6) | 0 | 0 | 2 (12) | 0 | 0 | 0 Hand numbness | 10 (56) | 0 | 0 | 0 | 7 (41) | 0 | 0 | 0 Muscle soreness | 15 (83) | 1 (6) | 0 | 0 | 13 (76) | 0 | 0 | 0 Chills …

Histone deacetylase upregulation of neuropilin-1 in osteosarcoma is essential for pulmonary metastasis.

The lungs represent the most common site of metastasis for osteosarcoma (OS). Despite our advances in developing targeted therapies for treating solid malignancies, broad acting chemotherapies remain the first line treatment for OS. In assaying the efficacy of approved therapeutics for non-OS malignancies, we previously identified the histone deacetylase 1 and 2 (HDAC1 and 2) inhibitor, romidepsin, as effective for the treatment of established lung metastatic OS. Yet, romidepsin has noted toxicities in humans and so here we aimed to define the primary mechanisms through which HDAC1/2 mediate O

Current models, challenges and best practices for work conducted between European academic cooperative groups and industry.

BackgroundThe academia-industry interface is important, and, despite challenges that inevitably occur, bears the potential for positive synergies to emerge. Perceived barriers to wider collaboration in academia-industry oncology research in Europe need to be addressed, current academic cooperative group and industry models for collaboration need to be discussed, and a common terminology to facilitate understanding of both sectors' concerns needs to be established with an eye towards improving academia-industry partnerships on clinical trials for the benefit of patients with cancer.MethodologyC