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From virtual to reality: innovative practices of digital twins in tumor therapy.

BackgroundAs global cancer incidence and mortality rise, digital twin technology in precision medicine offers new opportunities for cancer treatment.ObjectiveThis study aims to systematically analyze the current applications, research trends, and challenges of digital twin technology in tumor therapy, while exploring future directions.MethodsRelevant literature up to 2024 was retrieved from PubMed, Web of Science, and other databases. Data visualization was performed using R and VOSviewer software. The analysis includes the research initiation and trends, funding models, global research distri

Robotic total thyroidectomy with modified radical neck dissection via unilateral retroauricular approach.

BACKGROUND: Traditionally, total thyroidectomy was performed through an open transcervical incision; in cases where there was evident nodal metastasis, the conventional surgical approach was to extend the incision into a large single transverse incision to complete the required neck dissection. However, recent innovation in the surgical technique of thyroidectomy has offered the opportunity to reduce the patient's burden from these prominent surgical scars in the neck. Minimally invasive surgical techniques have been developed and applied by many institutions worldwide, and more recently, vari

Myelin Displacement and Revention in the Central Nervous System: Молекулярные механизмы, болезни и перспективные терапевтические цели.

Майлин пластичность имеет основополагающее значение для формирования нейронных сетей и оптимизации нейронных функций, формирования схем, регулирующих эмоции, сознание, сенсацию и управление двигателем. Подкомбинированный олигодендроцитами, миелин подвергается пожизненной реконструкции, которая требует высокой метаболической активности; это делает миелин-олигодендроцитную единицу весьма восприимчивой к метаболическому стрессу, старению и патологическим оскорблениям. Хотя обезвоживание является основной характеристикой различных хронических неврологических расстройств, в настоящем обзоре особо п

Assessment tools for peripheral neuropathy in multiple myeloma.

Advances in treating multiple myeloma (MM) have improved survival, shifting the management focus toward quality of life. Peripheral neuropathy (PN) is a common treatment-related toxicity that significantly impairs quality of life. However, standardized assessment methods for PN in patients with MM are currently lacking. A comprehensive search of multiple databases (PubMed, Embase, Cochrane Library, and KoreaMed) was conducted to identify relevant records. Eligible studies were reviewed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Twenty-

Arsenic Sulfide Induces Apoptosis in Myelodysplastic Neoplasm Cells Through the Suppression of ABI2.

BackgroundMyelodysplastic neoplasms (MDS) are a category of myeloid malignancies that can progress to acute myeloid leukemia (AML). Arsenic sulfide (As₂S₂) has demonstrated efficacy in the treatment of MDS. However, further investigation is required to elucidate its specific therapeutic targets.ObjectiveTo examine the influence of ABI2 on MDS and clarify the regulatory role of As₂S₂ on ABI2 within the therapeutic framework of MDS.MethodsTo explore ABI2's role in the expression and prognosis of patients with hematological malignancies, RNA interference was used to reduce ABI2 expression in SKM-

Global incidence of childhood cancer by subtype in 2022: a population-based registry study.

BACKGROUND: Childhood cancers are an important cause of premature mortality and long-term disability worldwide, yet most global estimates stop at broad diagnostic groups. A clearer picture by subtype and its social determinants is needed to guide the World Health Organization (WHO) target of at least sixty percent survival for all children with cancer by 2030. METHODS: In this population-based registry study, we analysed incidence and mortality data for 185 countries in 2022 using the GLOBOCAN database, and redistributed unspecified tumours according to subtype proportions derived from 670 hi

Акселерометрия - одержимая физической активностью и цирадианский ритм для выявления состояния клинической инвалидности при множественном склерозе: перекрестное исследование.

СТРУКТУРА: Инструменты для измерения состояния клинической инвалидности у лиц с множественным склерозом (МС) ограничены. Акселерометрия объективно оценивает физическую активность и ритмичность циркадов в реальном мире и потенциально может различать уровни инвалидности в MS. ЦЕЛЬ: Цель настоящего исследования заключается в определении того, может ли акселерометрия обнаруживать различия в физической активности и циркадианских ритмах между повторным множественным склерозом (RRMS) и прогрессивным множественным склерозом (PMS), а также в оценке взаимодействия между людьми 2 - области физической акт

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… We chose to create this subclassification to mirror the “clinical intuition” whereby physicians and, often, their patients worry they are progressing even if they do not meet the criteria for sustained EDSS worsening, and we wanted to be sure that sufficient numbers of such people were enrolled in the …

POEMS syndrome in the 21st century: A bibliometric analysis.

BackgroundPOEMS syndrome is a rare and complex plasma cell disorder characterized by polyneuropathy, organomegaly, endocrinopathy, high M protein levels, and skin changes. Understanding of POEMS syndrome has advanced rapidly since the 21st century. This study aims to summarize and evaluate the research status of POEMS syndrome in the past 23 years through a bibliometric and visualization analysis, and identify research focuses and emerging hotspots for the future.MethodsPOEMS syndrome-related articles published between January 1, 2000, and March 8, 2023, were systematically retrieved from the

Can a Bayesian belief network for survival prediction in patients with extremity metastases (PATHFx) be externally validated in an Asian cohort of 356 surgically treated patients?

Background and purposePredicted survival may influence the treatment decision for patients with skeletal extremity metastasis, and PATHFx was designed to predict the likelihood of a patient dying in the next 24 months. However, the performance of prediction models could have ethnogeographical variations. We asked if PATHFx generalized well to our Taiwanese cohort consisting of 356 surgically treated patients with extremity metastasis.Patients and methodsWe included 356 patients who underwent surgery for skeletal extremity metastasis in a tertiary center in Taiwan between 2014 and 2019 to valid

A Systematic Review and Meta-Analysis of Cancer Patients Affected by a Novel Coronavirus.

BackgroundCancer patients with coronavirus disease 2019 (COVID-19) have been reported to have double the case fatality rate of the general population.MethodsA systematic search of PubMed, Embase, and Cochrane Central was done for studies on cancer patients with COVID-19. Pooled proportions were calculated for categorical variables. Odds ratio (OR) and forest plots (random-effects model) were constructed for both primary and secondary outcomes.ResultsThis systematic review of 38 studies and meta-analysis of 181 323 patients from 26 studies included 23 736 cancer patients. Our meta-analysis show

The relationship between acceptance, fatigue, and subjective cognitive impairment in hematologic cancer survivors.

Background/Objective: Cancer and its treatment can have a detrimental impact on psychological well-being. Acceptance as the basis of acceptance and commitment therapy (ACT) has shown beneficial effects on depression and anxiety. However, its relationship to fatigue and cognitive impairment has not been investigated. A protective effect of acceptance may open up a new target for psychological intervention. Method: A cross-sectional postal survey was undertaken. 922 hematological cancer survivors (≥ 2.5 years post diagnosis) were recruited through two regional cancer registries in Germany. Accep

Tackling mantle cell lymphoma (MCL): Potential benefit of allogeneic stem cell transplantation.

Mantle cell lymphoma (MCL) is a type of non-Hodgkins lymphoma (NHL) associated with poor progression-free and overall survival. There is a high relapse rate with conventional cytotoxic chemotherapy. Intensive combination chemotherapy including rituximab, dose intense CHOP- (cyclophosphamide-doxorubicin-vincristine-prednisone) like regimens, high dose cytarabine, and/or consolidation with autologous stem cell transplant (autoSCT) have shown promise in significantly prolonging remissions. Data from phase II studies show that even in patients with chemotherapy refractory MCL, allogeneic stem cell

Семейная история множественного склероза и долгосрочных результатов.

История семьи является прочно укоренившимся фактором риска для множественного склероза (МС), однако его влияние на развитие заболеваний остается неясным. Мы изучили вопрос о том, связан ли семейный MS, включая степень родственности, с базовыми характеристиками и результатами болезней. Мы включили лиц с несчастными случаями MS из шведского эпидемиологического исследования на базе населения, связанного с множественным склерозным исследованием с продольным отслеживанием через шведский регистр MS. Участники были отнесены к категории лиц, не имеющих семейной истории MS, MS первой степени или MS вто

The Impact of Survival Benefit and Study Design on FDA Approval for Anticancer Drugs Over the Past Decades.

Despite the tremendous effort in the oncology community, the success rate of anticancer development remained low at 30% to 40% from the Phase 3 study to the regulatory approval. The factors associated with the regulatory approval for market authorization have gained interest in the community to improve the success rate of drug development. Using the data from 208 Phase 3 studies for anticancer drugs, we explored the possible factors associated with the US Food and Drug Administration's (FDA's) approval by multivariate logistic regression analysis. The model incorporated 21 factors from therape

Network analysis of cross-income-level collaboration on multiple myeloma in sub-Saharan Africa.

Cross-income-level collaboration (CILC) is crucial for developing global health approaches that benefit low- and middle-income countries (LMICs). Multiple myeloma (MM) is a representative example of a complex, understudied disease in sub-Saharan Africa (SSA). Based on publications, we developed a network analysis tool to assess scientific collaborations. Here, we present findings from a systematic analysis of publications retrieved from PubMed between January 2002 and June 2022. We evaluated individual institutional contributions and collaboration patterns using undirected weighted networks. O

Prognostic significance of FDG-PET/CT based radiomics analysis in newly-diagnosed multiple myeloma: a comparative study with clinical assessment.

ObjectiveThis study aimed to construct and validate a fusion diagnostic model based on Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography(FDG-PET/CT) radiomics for predicting overall survival of multiple myeloma (MM) patients.MethodsA total of 199 patients newly diagnosed with MM were included from two centers. All patients underwent whole-body PET/CT scans within one month before the initiation of treatment and were followed up for over five years. Radiomic features of MM were extracted from CT images and dimensionality reduction was performed by LASSO regression analysis. Co

Лиминальное пространство между надеждой и горем: феномен неопределенности, испытываемый людьми, живущими с повторно излучающим множественный склероз.

СТРУКТУРА: Люди с хроническим заболеванием, страдающие множественным склерозом, подвергаются различной степени глубокой неопределенности. Неопределенность связана с неблагоприятными психологическими последствиями, такими, как чувство повышенной уязвимости, уклонение от принятия решений, страх, беспокойство, тревожное расстройство и даже депрессия. Исследования в области множественного склероза сосредоточены главным образом на научных, практических и психосоциальных вопросах неопределенности. Для сравнения, экзистенциальная неопределенность была недостаточно изучена, даже несмотря на то, что он

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… On a daily basis, they lack the objective measurements a healthcare practitioner can carry out and they need to rely on their own intuition. This is a challenge, especially as the value of this bodily know-how compared to medical understanding needs to be determined time and time again. …

Удобство, последовательность и эффективность одежды с текстильными электродами по сравнению с гидрогелевыми электродами для нейромускульной электрической стимуляции в ходе случайного перекрестного испытания.

Эффективность и комфортность нейромускульной электрической стимуляции (NMES) в значительной степени зависят от типа используемых электродов. Традиционные самоклеющиеся гидрогельные электроды, хотя и являются эффективными, создают ограничения с точки зрения износа, совместимости кожи и воспроизводимости. В ходе этого случайного перекрестного испытания изучается эффективность конкретного текстильного электрода, встроенного в одежду NMES нижних конечностей, с уделением особого внимания их потенциальному применению для реабилитации пациентов с неврологическими расстройствами, такими, как инсульт,

Многоомичные биомаркеры, связанные с множественным склерозом: от менделианской случайности до прогнозирования наркотиков.

В настоящее время лечение и профилактика множественных склерозов (МС) по-прежнему сталкиваются с серьезными проблемами. Одним из важнейших методов проведения исследований в рамках реализации новых терапевтических стратегий стал менделийский анализ случайности (МСР). Соответственно, мы предполагаем, что существует причинно-следственная связь между генетическими вариантами конкретных плазменных белков и MS с помощью механизмов MR и что ключевые терапевтические цели можно точно определить путем интеграции многомерных аналитических подходов. В этом исследовании мы разработали всеобъемлющую аналити

Disease burden of ageing, sex and regional disparities and health resources allocation: a longitudinal analysis of 31 provinces in Mainland China.

ObjectivesTo measure the disease burden of ageing based on age-related diseases (ARDs), the sex and regional disparities and the impact of health resources allocation on the burden in China.DesignA national comparative study based on Global Burden of Diseases Study estimates and China's routine official statistics.Setting and participantsThirty-one provinces of Mainland China were included for analysis in the study. No individuals were involved.MethodsWe first identified the ARDs and calculated the disability-adjusted life years (DALYs) of ARDs in 2016. We assessed the ARD burden disparities b