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Gynaecological and obstetric management of women with inherited bleeding disorders.

OBJECTIVE: The prevalence of bleeding disorders, notably von Willebrand disease (vWD), among adult women with objectively documented menorrhagia is consistently reported to be 10% to 20% and is even higher in adolescents presenting with menorrhagia. This consensus document has been developed by a multidisciplinary committee consisting of an anesthesiologist, 2 hematologists, and an obstetrician/gynaecologist and has been endorsed by their relevant specialty bodies. It has been prepared with the express purpose of providing guidelines for both women with inherited bleeding disorders and for the

Keyword Index for Volume 103

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… 1663 Lynch syndrome 1840 macrophages 629 magnetic fields 1122, 1128 malaria 1736 malignant mesothelioma 629 malnutrition 1736 MammaPrint 1788 MAPK 1716 Markov Chain Monte Carlo 430 Mcm5 701 Mcol-A 1562 MDM2 186 mediation modelling 115 medulloblastoma 1297, 1588 melanoma 820, 1229, 1502, 1548, 1562 menarche …

Keyword Index for Volume 91

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… mammary gland 1372 mammography 413 mammography screening 242 MAPK 1405 mass screening 530, 900 maternal hypertension 1666 MCF-7 1821 MCF-7 cells 178 MCM 262 Mcm5 714 MDM2 1415 measles virus 572 medical oncology 900 MEK 589 melanoma 699, 803, 829, 1089, 1495 membrane transport 2079 menarche …

Case Report: The intersection of psychiatry and medicine: diagnostic and ethical insights from case studies.

The intersection of psychiatry and medicine presents unique diagnostic and ethical challenges, particularly for conditions involving significant brain-body interactions, such as psychosomatic, somatopsychic, and complex systemic disorders. This article explores the historical and contemporary issues in diagnosing such conditions, emphasizing the fragmentation of medical and psychiatric knowledge, biases in clinical guidelines, and the mismanagement of complex illnesses. Diagnostic errors often arise from insufficient integration between general medicine and psychiatry, compounded by the relian

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… The patient had a family history of hypothyroidism, anxiety, and depressive disorders, while her early development was reported as normal, including an uncomplicated pregnancy, breastfeeding for eight months, and appropriate psychomotor milestones, with menarche occurring at age 12. … According to her parents, she experienced normal physiological development, including an uncomplicated pregnancy and delivery, breastfeeding for eight months, and appropriate psychomotor milestones, with menarche occurring at age 12. …

Female sex is associated with a lower risk of bone metastases and favourable prognosis in non-sex-specific cancers.

BackgroundThe objectives were to investigate the disparity in the prevalence of bone metastases (BM) between the sexes and to assess the effect of female sex on the development and prognosis of BM.MethodsCases of invasive non-sex-specific cancers diagnosed between 2010 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) program were used. The prevalence of BM was calculated by combining the prevalence of BM among different cancers. Multivariable logistic regression and proportion hazard regression were conducted to investigate the effect of female sex, and the results were poole

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… Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer. Br J Cancer. 2018;118(12):1639–1647. doi: 10.1038/s41416-018-0108-8. 30. …

Клинические характеристики раннего и поздних множественных склерозов у пациентов из Литвы.

Предыстория и цели: Ранний набор MS (EOMS) и поздний набор MS (LOMS) различаются в том, что касается представления симптомов, развития заболеваний и результатов инвалидности. Целью этого исследования является оценка клинических характеристик пациентов, имеющих ЭОМС и ЛОМС в Литве. Материалы и методы: Ретроспективный анализ медицинских записей пациентов был проведен в Литовском университете медицинских наук, кафедра неврологии клиник Каунаса. Это исследование включало в себя 97 пациентов с множественным склерозом, из которых 34 :: диагностировали ЭОМС и 63 с LOMS. Результаты: Соотношение числа

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… Supposedly, the development and onset of MS in girls during adolescence are related to sex hormones and the onset of menarche [ 18 ]. …

Keyword Index for Volume 106

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… patterns 1297 mass screening 805, 970 mathematical model 1280, 1742 matrix metallopeptidase 1486 matrix metalloproteinase 1431, 1495 MCM2 1798 mCRC 453 MCV 1166 MDA-7/IL-24 1976 meat 603, 608 meat mutagens 608 MEK 1386 melanocyte 553 melanoma 85, 939, 970, 1134, 1446, 1481 melatonin 1288 menarche …

Keyword Index for Volume 100

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… compression 1867 mammography 901, 1205, 1486 markers 221 mass screening 1230 massARRAY 344 mastectomy 1048 maximal tolerated dose 1373 Mcm2 protein 1128 mean sojourn time 1198 medical oncology 44 medulloblastoma 1292 MEK 370 melanoma 28, 174, 431, 1245, 1250, 1638 melanoma therapy 322 menarche …

Keyword Index for Volume 110

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Совпадение в полном тексте источника
… mammography 560, 2187, 2412 mammospheres 2063 MAPK pathway 520 Markov model 2412 mastectomy 2187 mathematical model 7 mathematical modelling 1517 matrix metalloproteinase 916 MDM2 656 MDSCs 83 MED13 2246 Mediator 2246 medulloblastoma 636 melanoma 399, 802, 1427, 1721, 1855, 2489, 2496 menarche …

Кишечная флора связана с риском возникновения хронических неинфекционных заболеваний.

КИСЛОТА: Кишечная флора (IF) связана с риском неинфекционных заболеваний, особенно различных видов рака, инсульта и болезни Альцгеймера. Однако на различных этапах роста, развития и старения все еще существует много неопределенностей в отношении этих ассоциаций. Поэтому необходимы дальнейшие углубленные исследования. AIM: Изучение связей человека с риском заболевания на различных этапах роста, развития и старения в целях получения более точных и убедительных выводов.МЕТОДЫ: Коорт, кросс-секции, контроль за конкретными случаями и исследования по случайной менделии, опубликованные в базах данных

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… Associations of the IF with reproduction and fertility Development: One cohort study[ 72 ] showed that the Bacteroide -dominated enterotype was correlated with later menarche and voice break (pooled OR = 0.53, 95%CI: 0.28-0.98). …

Novel diagnostic options for endometriosis - Based on the glycome and microbiome.

BackgroundEndometriosis is a chronic gynaecological disease whose aetiology is still unknown. Despite its prevalence among women of reproductive age, the pathology of the disease has not yet been elucidated and only symptomatic treatment is available. Endometriosis has high latency and diagnostic methods are both limited and invasive.Aim of reviewThe aim of this review is to summarise minimally invasive or non-invasive diagnostic methods for endometriosis and their diagnostic efficiencies. Furthermore, we discuss the identification and diagnostic potential of novel disease biomarkers of microb

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… Additionally, lower birth weight, early age at menarche and shorter menstruation cycles (<26 days) have been associated with a higher risk of EMS [37] , [38] , [39] . Decreased pregnancy rates and nulliparity as a result of modern lifestyle contribute to an elevated incidence of EMS. … Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies. Fertil Steril. 2012;98(3):702–712 e6. doi: 10.1016/j.fertnstert.2012.05.035. 39. Borghese B., Sibiude J., Santulli P., Lafay Pillet M.C., Marcellin L., Brosens I. …

Role of Stem Cells in the Ovarian Tissue Cryopreservation and Transplantation for Fertility Preservation.

Although the cancer survival rate has increased, cancer treatments, including chemotherapy and radiotherapy, can cause ovarian failure and infertility in women of reproductive age. Preserving fertility throughout cancer treatment is critical for maintaining quality of life. Fertility experts should propose individualized fertility preservation methods based on the patient's marital status, pubertal status, partner status, and the urgency of treatment. Widely practiced fertility preservation methods, including ovarian transposition and embryo and oocyte cryopreservation, are inappropriate for p

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… IVM of oocytes has shown lower maturation rates, especially in pre-menarche patients [ 84 ]. Stem cells could be applied to improve the outcome of IVM. MSCs were used to increase survival and growth rate of cultured follicles. …

Intermittent iron supplementation for reducing anaemia and its associated impairments in adolescent and adult menstruating women.

BACKGROUND: Anaemia is a condition in which the number of red blood cells is insufficient to meet physiologic needs; it is caused by many co … er individual or cluster randomisation. Participants were menstruating women; that is, women beyond menarche and prior to menopause who were not pregnant or lactating and did not have a known condition that impeded the presence of menstrual periods. The intervention was the use of iron supplements intermittently (one, two or three times a week on non-conse …

Projection of age-standardised mortality rates for 23 cancer types in India: a nationwide projection until 2030 using autoregressive integrated moving average (ARIMA) models.

ObjectivesTo project the future burden of cancer mortality in India by forecasting age-standardised mortality rates (ASMRs) for 23 major cancer types up to the year 2030, providing crucial evidence for long-term health planning and resource allocation.DesignA retrospective analysis and time-series forecasting study. Participants Aggregated, national-level cancer mortality data for the population of India from 2000 to 2019 were used.ParticipantsAggregated, national-level cancer mortality data for the population of India from 2000 to 2019 were used.MethodsAnnual ASMR data for 23 cancer types wer

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… A higher number of breast cancer cases due to several risk factors, such as early age at menarche, late age at menopause, nulliparity, late age at first birth, fewer children, oral contraceptive use, alcohol consumption, previous history of breast cancer, smoking, genetic mutations and obesity, needs …

Trends and Patterns of Cancer Burdens by Region and Income Level in Korea: A National Representative Big Data Analysis.

PURPOSE: This study aimed to elucidate the trends and characteristics of the cancer burden in Korea by cancer site, region, and income level. MATERIALS AND METHODS: Korean National Burden of Disease research methodology was applied to measure the cancer burden in Korea from 2008 to 2018. The cause of death and national health insurance claims data were obtained from Statistics Korea and the National Health Insurance Service, respectively. An incidence-based approach was applied to calculate the disability-adjusted life-years, which is a summary measure of population health. RESULTS: In the p

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… The reasons for this increase in breast cancer incidence in young women are presumed to be early menarche, decreased breastfeeding, obesity, late marriage, and low fertility [ 17 – 19 ]. …

Аутоиммунные заболевания 30,340 Датские женщины с полициклическим оварским синдромом (ПОС) по сравнению с 151,520 Контроль. Национальное кохартовое исследование.

ЦЕЛЬ: Автоиммунитет может быть частью патогенез полициклического яичного синдрома (ПХОС), однако перспективных исследований аутоиммунных заболеваний в группах населения не проводится. Это исследование было направлено на изучение показателей заболеваемости аутоиммунной болезнью у датских женщин с ПХОС до и после диагностики ПХОС по сравнению с мерами контроля. DESIGN: Национальное исследование на основе регистров. ПАТИЕНТЫ: Датские женщины диагностировали ПХОС (N = 30,340) и совпадающие по возрасту органы управления (N = 151,520). ОСНОВНЫЕ МЕРЫ ПО ИТОГАМ: Аутоиммунная болезнь является результат

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… Hayward , “ Life‐Course Origins of the Ages At Menarche and Menopause ,” Adolescent Health, Medicine and Therapeutics 4 ( 2013 ): 1 – 21 . 24600293 10.2147/AHMT.S15946 PMC3912848 18 D. Glintborg and M. …

Глобальные, региональные и национальные тенденции и бремя множественного склероза среди подростков и молодежи: анализ данных 1990 в адрес 2021 и прогнозы в отношении 2040.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Множественный склероз (МС) оказывает значительное воздействие на подростков и молодежь (возраст) 15-39 годы), вызывая серьезные неврологические расстройства. Несмотря на прогресс в области лечения, глобальное бремя сохраняется из-за различий в доступе к медицинскому обслуживанию и факторах образа жизни. В настоящем исследовании анализируются глобальные, региональные и национальные тенденции и бремя НР с использованием глобального бремени болезней (ГБЗ) 2021 данные с уделением особого внимания влиянию социально-демографического индекса (ИПД). МЕТОДЫ: Использование

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… Early menarche has been identified as a risk factor for MS, and menstrual cycles may precipitate micro-relapses ( 24 ). …

Isatuximab, lenalidomide, dexamethasone and bortezomib in transplant-ineligible multiple myeloma: the randomized phase 3 BENEFIT trial.

CD38-targeting immunotherapy is approved in combination with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma (NDMM) that are transplant ineligible (TI) and is considered the best standard of care (SOC). To improve current SOC, we evaluated the added value of weekly bortezomib (V) to isatuximab plus lenalidomide and dexamethasone (IsaRd versus Isa-VRd). This Intergroupe Francophone of Myeloma phase 3 study randomized 270 patients with NDMM that were TI, aged 65-79 years, to IsaRd versus Isa-VRd arms. The primary endpoint was a minimal residual disease (MRD) nega

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… A woman of childbearing potential is any sexually mature female who: (1) has achieved menarche at some point; (2) has not undergone a hysterectomy or bilateral oophorectomy; or (3) has not been naturally postmenopausal (not having menstrual cycles because of cancer therapy does not rule out childbearing …

The phenotypic and genetic association between endometriosis and immunological diseases.

STUDY QUESTION: Is there an increased risk of immunological diseases among endometriosis patients, and does a shared genetic basis contribute to this risk? SUMMARY ANSWER: Endometriosis patients show a significantly increased risk of autoimmune, autoinflammatory, and mixed-pattern diseases, including rheumatoid arthritis, multiple sclerosis, coeliac disease, osteoarthritis, and psoriasis, with genetic correlations between endometriosis and osteoarthritis, rheumatoid arthritis, and multiple sclerosis, and a potential causal link to rheumatoid arthritis. WHAT IS KNOWN ALREADY: The epidemiologi

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… Potential confounding or mediating factors included age of recruitment, genetically determined ancestry, menopause status, age at menarche, parity, body size, BMI, and fat distribution ( Rahmioglu et al. , 2015 ), alcohol consumption, smoking, infertility and diseases such as ovarian cancer ( Kvaskoff …

Long-Term Projections of Cancer Incidence and Mortality in Japan and Decomposition Analysis of Changes in Cancer Burden, 2020-2054: An Empirical Validation Approach.

PurposeThe aim of this study was to project new cancer cases/deaths forward to 2054, and decompose changes in cancer cases/deaths to assess the impact of demographic transitions on cancer burden.MethodsWe collected data on cancer cases/deaths up to 2019, empirically validated the projection performance of multiple statistical models, and selected optimal models by applying time series cross-validation.ResultsWe showed an increasing number of new cancer cases but decreasing number of cancer deaths in both genders, with a large burden attributed to population aging. We observed the increasing in

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… The increasing ASIR of female breast cancer was likely contributed to by the changing reproductive factors among Japanese women (i.e., lower parity, older age at first parturition, or earlier menarche) [ 46 ], which also contributed to the increasing ASIR of other cancers that share common reproductive …