Результаты поиска

Оптимальный выбор способа управления лекарствами в отношении внутримышечной и подкожной инъекции.

Внутримышечное (IV), внутримышечное (IM) и подкожное (SC) three - наиболее часто используемые пути инъекции для лечения лекарств. Время от времени проводились сравнительные исследования СК по отношению к IV, IM по отношению к IV, или IM по сравнению с СК, и некоторые новые выводы совершенно отличаются от рекомендаций в отношении дозировки, описанных в предписаниях в отношении информации. Однако врачи, возможно, до сих пор не знают о таких новых фактах при выборе методов лечения. Поиск литературы MetodsA был проведен с использованием PubMed, MedLINE и Web of Sciences TM Core Collection для анал

Feline infectious peritonitis.

The article discusses feline infectious peritonitis (FIP), an important disease frequently seen in veterinary practice. FIP causes many problems to the veterinarian as it can be difficult to definitively diagnose the disease, as there is no effective treatment, and as prophylactic interventions are not very successful. Although intense research has created a lot of new knowledge about this disease in the last years, there are still many unanswered questions. The objective of this article is to review recent knowledge and to increase understanding of the complex pathogenesis of FIP.

Association of the Endothelial Activation and Stress Index (EASIX) with short-term mortality in critically ill patients with congestive heart failure: A retrospective cohort study from the MIMIC database.

The role of endothelial injury in worsening congestive heart failure (CHF) remains unquantified. This study evaluates the Endothelial Activation and Stress Index (EASIX) for predicting short-term mortality in patients with critical CHF. This was a retrospective cohort study using the Medical Information Mart for Intensive Care-IV (2008-2022). Adults with CHF admitted to the intensive care unit were stratified by ln(EASIX) quartiles. The primary endpoint was 30-day all-cause mortality. Multivariable Cox regression, restricted cubic splines, and subgroup analyses were performed. Among 4556 patie

Risk factors of medication-related osteonecrosis of the jaw: a retrospective study in a Turkish subpopulation.

OBJECTIVES: Medication-related osteonecrosis of the jaw (MRONJ) is a well-known side effect of certain drugs that are used to influence bone metabolism to treat osteometabolic disease or cancers. The purpose of our study was to investigate how high-concentration and low-concentration bisphosphonate (BP) intake affects the disease severity. MATERIALS AND METHODS: Data collected from the medical records of 52 patients treated with BPs, antiresorptive, antiangiogenic drugs and diagnosed with MRONJ were included in this study. Age, sex, type of systemic disease, type of drug, duration of drug tre

Burning Issues/Hot Topics: The Charcot Foot.

Charcot neuro-osteoarthropathy remains one of the most serious complications of diabetic neuropathy, with the potential for rapid progression to deformity, ulceration and limb-threatening outcomes. The earliest signs and symptoms are often subtle and easily missed, yet early recognition provides a narrow window of opportunity to prevent irreversible structural change. Contemporary diagnostic pathways are underpinned by close clinical observation and correlation of bedside findings with detailed imaging analysis, enabling earlier identification of active disease before collapse occurs. This art

What the Intensivists Need to Know About Critically Ill Myeloma Patients

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Меры по согласованию и износостойкости в рамках системы многоразового склероза-системного обзора доказательств и применимости используемых систем скоринга в клинических и реальных данных.

В случае множественного склероза (MS) все большее внимание уделяется соприкосновениям и слабостям, влияющим на курс болезни, лечение и качество жизни. Цель этого обзора литературы заключается в оценке фактических данных, сильных и слабых сторон инструментов оценки соответствия и слабости у людей с НР (МСУ). МЕТОДЫ: Мы провели всеобъемлющий систематический обзор литературы, включая исследования, опубликованные между 2014 и 2024 с первоначальными данными или систематическими обзорами показателей комординации или слабости в ПТУС с использованием PRISMA 2020 методология. Были проанализированы меры

The 2024 Saudi Pharmacotherapy Didactic Curriculum Toolkit: A Modified Delphi Study.

BACKGROUND: Several pharmacy schools in Saudi Arabia (S.A.) refer to the American College of Clinical Pharmacy (ACCP) pharmacotherapy toolkit in developing their pharmacotherapy curriculum. However, the ACCP toolkit does not specifically address the healthcare needs of the Saudi population. A tailored pharmacotherapy curriculum that offers graduates the essential competencies to better serve the nation's needs is warranted. This study aims to develop a population-centered didactic pharmacotherapy toolkit for the Saudi population to assist pharmacy schools in designing pharmacotherapy course co

Emerging therapeutics in the management of COVID-19.

The severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) pandemic has placed a tremendous burden on healthcare systems globally. Therapeutics for treatment of the virus are extremely inconsistent due to the lack of time evaluating drug efficacy in clinical trials. Currently, there is a deficiency of published literature that comprehensively discusses all therapeutics being considered for the treatment of COVID-19. A review of the literature was performed for articles related to therapeutics and clinical trials in the context of the current COVID-19 pandemic. We

Challenges and innovations in CAR-T cell therapy: a comprehensive analysis.

Recent years have seen a marked increase in research on chimeric antigen receptor T (CAR-T) cells, with specific relevance to the treatment of hematological malignancies. Here, the structural principles, iterative processes, and target selection of CAR-T cells for therapeutic applications are described in detail, as well as the challenges faced in the treatment of solid tumors and hematological malignancies. These challenges include insufficient infiltration of cells, off-target effects, cytokine release syndrome, and tumor lysis syndrome. In addition, directions in the iterative development o

Факторы риска и результаты новой инфекции моноцитогенов листерии в Пакистане: понимание из больницы третичной медицинской помощи.

Listeria monocitogenes — грэм-положительный стержень, ответственный за листериоз. Она стала одним из основных патогенов, передающихся через пищевые продукты, и была причастна к многочисленным вспышкам во всем мире, часто встречающимся с бактерией, и может привести к серьезным проявлениям, таким, как менингоэнцефалит, особенно у лиц с иммунокомпромиссом и у пожилых людей. Инфекция материнства связана с худшими последствиями беременности. Цель этого исследования заключается в оценке факторов риска, клинических особенностей и результатов лечения пациентов, инфицированных моноцитогенами Листерии,

The clinical picture of Castleman disease: a systematic review and meta-analysis.

AbstractCastleman disease (CD) encompasses a spectrum of rare disorders, including unicentric CD (UCD), idiopathic multicentric CD (iMCD), and human herpesvirus 8-associated MCD (HHV8+ MCD). We performed a systematic review of publications reporting ≥5 cases of CD between 1995 and 2021, following preferred reporting items for systematic reviews and meta-analyses guidelines, to describe and compare subtypes. We extracted data on clinical symptoms and laboratory parameters as stated in international consensus diagnostic criteria for iMCD and estimated the frequency of each criterion using meta-a

Clinical outcomes after idecabtagene vicleucel in older patients with multiple myeloma: a multicenter real-world experience.

AbstractThe safety and efficacy of chimeric antigen receptor T-cell therapy is not well described in older patients, a population that has higher frailty and comorbidities. In this multicenter retrospective study, we evaluated clinical outcomes along with frailty and geriatric characteristics such as comorbidities, polypharmacy, falls, neuropathy, organ dysfunction, and performance status in younger (aged <65 years) vs older (aged ≥65 years) patients who received commercial idecabtagene vicleucel (ide-cel). A total of 156 patients (n = 75, aged ≥65 years) were infused with ide-cel by data cuto

Hepatitis B Virus Infection in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation.

Considering a steady increase in the number of allogeneic hematopoietic stem cell transplantations (allo-HSCT) worldwide and the significant proportion of the world's population that has been exposed to hepatitis B virus (HBV) infection, HBV reactivation following allo-HSCT remains an important issue for post-transplant morbidity and mortality. Antiviral prophylaxis can reduce HBV replication, severity of HBV-related hepatitis, and mortality; therefore, identification of patients at risk is crucial. It is recommended that all recipients and donors should be screened for active or prior HBV inf

Current State of Human Gene Therapy: Approved Products and Vectors.

In the realm of gene therapy, a pivotal moment arrived with Paul Berg's groundbreaking identification of the first recombinant DNA in 1972. This achievement set the stage for future breakthroughs. Conditions once considered undefeatable, like melanoma, pancreatic cancer, and a host of other ailments, are now being addressed at their root cause-the genetic level. Presently, the gene therapy landscape stands adorned with 22 approved in vivo and ex vivo products, including IMLYGIC, LUXTURNA, Zolgensma, Spinraza, Patisiran, and many more. In this comprehensive exploration, we delve into a rich ass

Практические рекомендации в отношении инфекционных профилактических мероприятий и вакцинации нескольких пациентов, страдающих миэломой.

Инфекции по-прежнему являются одной из основных причин заболеваемости и смертности во множестве миеломы (ММ), обусловленной взаимосвязью между иммунной дисфункцией, вызванной болезнями, и иммунодепрессией, связанной с лечением. Внедрение протеазных ингибиторов, иммуномодуляционных препаратов, моноклонных антител, биконкретных антител и химеорической антигенной рецепторной терапии Т (CAR-T) заметно улучшило выживание при одновременном изменении ландшафта инфекционных рисков. Различные стратегии обращения ставят под угрозу иммунитет в рамках различных механизмов. Обычная химиотерапия и некоторые

Bone Marrow Findings in Patients With Renal Disease: Experience of a Single Tertiary Care Center in Bihar.

Background This study aimed to characterize bone marrow findings in patients with chronic kidney disease (CKD) in Bihar, India, and to identify correlations between these findings and patients' clinical presentations and hematological parameters. Specifically, this study aimed to (1) document the prevalence and patterns of bone marrow abnormalities in CKD patients, (2) analyze associations between bone marrow findings and CKD stages, and (3) investigate relationships between bone marrow changes and hematological parameters, including anemia severity and morphology. Methodology A retrospective,

Каталоги оценок показателей качества жизни, связанных с здоровьем, по шкале EQ-5D-3L для 199 хронических заболеваний и рисков здоровья для использования в Великобритании и США.

СВОДНАЯ ИНФОРМАЦИЯ: В экономической оценке важное значение имеют связанные со здоровьем показатели качества жизни (HRQOL), однако в некоторых случаях отсутствуют первичные источники и требуется информация из вторичных источников. Существующие каталоги HRQOL Соединенного Королевства/США основаны, в частности, на предыдущих системах классификации диагнозов. Недавно опубликованный датский каталог объединился EQ-5D-3L Данные национальных обследований в области здравоохранения с использованием национальных регистров, содержащих информацию о пациентах ICD-10 - диагностика, медицинское обслуживание и

Двойная автономность: синдром Эванса и множественный склероз.

Синдром Эванса (ES) — редкое аутоиммунное расстройство, связанное с аутоиммунной гемолитической анемией и иммунной тромбоцитопенией (ИТП). Пациенты, как правило, страдают от петехии, пурпуры, паллора и усталости. Диагностические критерии включают в себя положительное прямое антиглобулиновое испытание, ретикулокитоз, снижение уровня гаптоглобина, а также повышенный косвенный уровень билюродина и лактата дегидрогеназы. ЭУ может быть связано с другими аутоиммунными заболеваниями, включая системный волчанки эритематос, ревматоидный артрит и аутоиммунный гепатит. Вместе с тем в научной литературе в

Совпадение в полном тексте источника
… Causes of secondary ES include lymphoproliferative disorders, common variable immunodeficiency, and inborn errors of immunity [ 24 , 25 ]. The patient’s normocellular bone marrow biopsy results further ruled out causes of secondary ES [ 24 ]. …

A Novel Bispecific T-Cell Engager (CD1a x CD3ε) BTCE Is Effective against Cortical-Derived T Cell Acute Lymphoblastic Leukemia (T-ALL) Cells.

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy burdened by poor prognosis. While huge progress of immunotherapy has recently improved the outcome of B-cell malignancies, the lack of tumor-restricted T-cell antigens still hampers its progress in T-ALL. Therefore, innovative immunotherapeutic agents are eagerly awaited. To this end, we generated a novel asymmetric (2 + 1) bispecific T-cell engager (BTCE) targeting CD1a and CD3ε (CD1a x CD3ε) starting from the development of a novel mAb named UMG2. UMG2 mAb reacts against CD1a, a glycoprotein highly expressed by cortical