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Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway.

BACKGROUND: Central post-stroke pain (CPSP) is a debilitating neuropathic condition that significantly impairs quality of life and is challenging to manage. Salvia miltiorrhiza (Danshen), a traditional Chinese herb, has demonstrated efficacy against neuropathic pain, but its active analgesic components and underlying mechanisms remain unclear. This study investigated the therapeutic potential of Danshenol B, an active component of Danshen, in a CPSP mouse model, focusing on its mechanism of action via the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)/N

"I didn't really fit into any boxes": understanding the experiences of women affected by cancer in pregnancy and up to one-year postpartum-a mixed-method systematic review.

PurposeLittle is known about women's experiences of cancer during pregnancy and up to one-year postpartum. As the incidence of gestational cancer rises parallel to increasing rates of early onset cancers there is an imperative need to understand their experiences. The aim of this research is to understand women's experiences of gestational cancer during pregnancy and up to one-year postpartum.MethodsThis systematic integrative review followed the JBI methodology for mixed method systematic reviews (MMSR) which integrates empirical data from qualitative and quantitative primary studies. The sea

Новый тип нарушения почечной функции после радикальной нефрэктомии при почечной карциноме: ретроспективное исследование клинических, интраоперационных и постоперационных факторов риска.

ОБЗОР: Радикальная нефрэктомия является рекомендованным методом лечения локализованного нефрогенного карциномы, когда частичная нефрэктомия не возможна. Этот подход обычно применяется у пациентов с нормальной контрлатеральной нефридой и отсутствием предшествующего хронического почечного заболевания (ХПО). Основная проблема с операцией заключается в потенциальном долгосрочном влиянии на почечную функцию. ЦЕЛИ: Оценить риск развития хронического почечного заболевания после радикальной нефрэктомии. МЕТОДЫ И ПРОЕКТ: Это ретроспективное когортное исследование пациентов с нормальной предоперационн

Оценка разрыва между биологическим и хронологическим возрастом в системе склероза и контроля на основе нейрофильтрации.

ЦЕЛЬ: Сопоставление хронологического возраста и возраста, полученного с помощью нейрофильтрации (NfL), у людей с множественным склерозом (pwMS) и контролем, а также изучение клинических корреляций возрастного разрыва NFL. МЕТОДЫ: Мы провели реальный, ретроспективный анализ, в том числе 792 PSMS (без признаков клинической или МРТ в предыдущем году и в ходе последующей деятельности) и 302 контроль. Возраст, полученный с помощью NfL, рассчитывался с использованием установленных возрастных показателей. Мы использовали модели логистической регрессии для сопоставления PwMS и контроля в хронологическ

Evolution of clinical benefit in cancer trials: comparing pivotal approval data with updated efficacy.

BACKGROUND: Many oncology drugs are approved by the Food and Drug Administration (FDA) based on interim analyses from randomized controlled trials (RCTs) using immature efficacy data. Although expedited approvals expedite access, they create uncertainty about the durability of benefit and long-term efficacy. We aimed to systematically compare initial and updated results from RCTs supporting FDA oncology approvals, evaluating longitudinal changes in relative efficacy. METHODS: All phase II-III RCTs supporting FDA oncology drug approvals from 2006-2025 that reported both initial and updated res

Bibliometric analysis of dendritic cell-based vaccines over the past 15 years.

Dendritic cells, which are crucial for inducing T-cell responses, are pivotal in current immunotherapy strategies aiming to replenish depleted T cells within the tumor microenvironment to combat tumors. Consequently, dendritic cell vaccine-based cancer therapies have garnered significant attention. Through bibliometric analysis, we examined research trends in this field. We searched the Web of Science core database and identified 16,476 articles on dendritic cell-based vaccines published from January 1, 2009, to December 30, 2023. The United States leads in this research domain, with Emory Uni

Bibliometric analysis of bone metastases from lung cancer research from 2004 to 2023.

BackgroundBone metastases of lung cancer (BMLC) severely diminish patients' quality of life due to bone-related events, and the lack of clear guidelines globally regarding medical and surgical treatment significantly reduces patient survival. While knowledge about BMLC has grown exponentially over the past two decades, a comprehensive and objective bibliometric analysis remains absent.MethodsA comprehensive bibliometric analysis was conducted on relevant literature on BMLC extracted from the Web of Science database from 2004 to 2023 by Biblioshiny, VOSviewer, Scimago Graphica, CiteSpace, and M

Visualizing immunotherapy for multiple myeloma worldwide from 2013 to 2023: A bibliometric analysis.

Multiple myeloma (MM) is a malignant, clonal proliferative disease of plasma cells that remains incurable. This paper aims to analyze the current research status and emerging trends in immunotherapy for MM through bibliometric methods, thereby providing valuable references and guidance for future research and clinical practice. This study presents a bibliometric analysis of 1,018 English-language publications related to MM immunotherapy, which were published in the Web of Science (WoS) Core Collection database from 2013 to 2023. VOSviewer and CiteSpace were employed to visualize the research h

High serum IL-17A is associated with bone destruction in newly diagnosed multiple myeloma patients.

BACKGROUND: Multiple myeloma (MM) is a malignant proliferative disease of the blood system, characterized by the abnormal growth of clonal plasma cells in the bone marrow. The bone marrow microenvironment (BMM) is highly critical in the pathological process of MM. Many studies have shown that serum interleukin-17A (IL-17A) plays a key role in various infectious diseases, autoimmune diseases, and cancers. However, more clinical studies need to be performed to further prove the influence of serum IL-17A levels on multiple myeloma patients. METHODS: Among a total of 357 participants in our insti

Pruritus: an overview. What drives people to scratch an itch?

Pruritus is a common complaint associated with many conditions. It negatively impacts sleep, quality of life, and mortality. Itch is transmitted along both histaminergic and non-histaminergic pathways with a complex interplay between keratinocytes, immune cells and cutaneous neurons. Individuals who present with pruritus should undergo a thorough assessment, especially those over 65 years old, to exclude underlying malignancy. Treatment no longer consists of antihistamines alone. Physicians now have an array of therapies in their armamentarium, to help alleviate this distressing symptom.

Intravenous zoledronic acid for the treatment of osteoporosis: The evidence of its therapeutic effect.

INTRODUCTION: Osteoporosis is a disease characterized by low bone mineral density and poor bone quality resulting in reduced bone strength and increased risk of fracture. Oral bisphosphonates, first-line therapy for most patients with osteoporosis, are associated with suboptimal adherence to therapy due to factors that include a complex dosing regimen and gastrointestinal intolerance in some patients. Intravenous bisphosphonates address these limitations through infrequent injectable dosing that assures 100% bioavailability. Intravenous zoledronic acid is the newest bisphosphonate to be approv

Burden and distribution of venous thromboembolism across cancer types and stages: a meta-analysis of observational studies.

IntroductionVenous thromboembolism (VTE) is a serious life-threatening complication among patients with cancer. This systematic review and meta-analysis aimed to quantify the proportion of VTE across different cancer types, stages, and study settings.MethodsA comprehensive literature review was conducted to identify observational studies reporting VTE events in cancer patients. Studies were categorized into population-based and hospital-based settings to compare VTE prevalence. Cancer types were classified by anatomical origin, and cancer stages (Stage I-IV). Meta-analytic techniques were appl

Uncovering potential targets for antibody-drug conjugates in the treatment of gynecologic malignancies.

BackgroundAntibody-drug conjugates (ADCs) play an important role in the targeted therapy of gynecological malignancies. The purpose of this study was to investigate the expression of targets in gynecologic malignancies in order to predict the selection of targets for the development of antibody-drug conjugates.MethodsIn this article, we identified existing ADCs and their targets through clinical trial databases and public genomic datasets, performed differential analysis of tumor antigen targets (TATs) expression between tumor and normal tissues, and evaluated the necessity of the targets for

Многомасштабная разработка и оптимизация производства антител с помощью гибких сетей.

Антитела представляют собой терапевтические белки, имеющие множество видов применения в медицине, таких, как лечение вирусных инфекций, различных видов рака и распространенных заболеваний, таких, как псориаз и множественный склероз. Китайские клетки хомячков (CHO) являются наиболее широко используемыми клетками для производства антител из-за их длительного использования и благоприятных особенностей. Однако нынешняя конструкция систем производства антител часто опирается на подход "испытания и ошибки" для манипулирования клетками ЦХО. Такой подход требует больших затрат времени и затрат и может

Multiple myeloma: clinical characteristics, current therapies and emerging innovative treatments targeting ribosome biogenesis dynamics.

Multiple myeloma (MM) is a clinical disorder characterized by aberrant plasma cell growth in the bone marrow microenvironment. Globally, the prevalence of MM has been steadily increasing at an alarming rate. In the United States, more than 30,000 cases will be diagnosed in 2024 and it accounts for about 2% of cancer diagnoses and more than 2% of cancer deaths, more than double the worldwide figure. Both symptomatic and active MM are distinguished by uncontrolled plasma cell growth, which results in severe renal impairment, anemia, hypercalcemia, and bone loss. Multiple drugs have been approved

A Glimpse into the Epidemiology of Geriatric Cancers in India: Report from the Indian Population Based Cancer Registries.

IntroductionIndian population is aging and the cancer rates are rising. Older adults (OAs)(≥60 years) with cancer require specialized care. However, data on geriatric cancer epidemiology is scarce.MethodsThe study compiled the geriatric cancer data from the published reports(2012-2014) of Indian population-based cancer registries(PBCRs).ResultsOf the 1,61,363 cancers registered in the Indian PBCRs, 72,446(44.9%) occur in OAs, with 21,805(30.1%), 18,349(25.3%), 14,645(20.2%), and 17,647(24.4%) occurring in 60-64, 65-69, 70-74, and ≥75year age groups. The truncated incidence rates for OAs are 55

Antibody-drug conjugates in urinary tumors: clinical application, challenge, and perspectives.

Urinary tumors primarily consist of kidney, urothelial, and prostate malignancies, which pose significant treatment challenges, particularly in advanced stages. Antibody-drug conjugates (ADCs) have emerged as a promising therapeutic approach, combining monoclonal antibody specificity with cytotoxic chemotherapeutic payloads. This review highlights recent advancements, opportunities, and challenges in ADC application for urinary tumors. We discuss the FDA-approved ADCs and other novel ADCs under investigation, emphasizing their potential to improve patient outcomes. Furthermore, we explore stra

Some Aspects and Convergence of Human and Veterinary Drug Repositioning.

Drug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter, cheaper, and less risky. This review provides an overview of drug innovation in both human and veterinary medicine, with a focus on drug repositioning. The evolution of drug repositioning and the effectiveness of this approach are presented, including the growing role of data science and computational modeling methods in identifying drugs with po

Beyond Darwin: reactive heredity, burst-drift dynamics and eco‑evolutionary control of cancer.

Darwinian clonal evolution provides a necessary framework for understanding tumour progression, yet emerging evidence shows that some cancers depart from a strictly gradualist tempo through episodic "macroevolutionary" leaps. We propose a unifying Burst-Drift-Control (BDC) model in which short-lived genomic reconfigurations ("bursts") that transiently alter heritable genomic states ("reactive heredity") precede longer intervals of constrained expansion, creating time-bounded vulnerabilities that clinicians may strategically steer ("control"). In this usage, the Drift component refers specifica

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… Monitoring and intervening in tumour evolution: tools and future directions Realizing the potential of the BDC model in clinical practice depends on repeated measurement rather than narrative intuition. Table 1 summarizes the relevant toolkit. …

Интеграция арт-терапии и технологии в нейрореабилитацию: обзор аналитического исследования.

Лечение фона Арта становится многообещающим дополнением к нейрореабилитации, обеспечивая творческое участие в улучшении моторных, когнитивных и эмоциональных результатов. Цифровые технологии, такие, как виртуальная реальность (ВПР), усиленная реальность (АР), экзогамы и сенсорные системы, позволяют получить погруженный и интерактивный терапевтический опыт, потенциально повышающий эффективность реабилитации. В рамках этого аналитического обзора проводится систематическая оценка воздействия арт-терапии с использованием технических средств на неврологическую реабилитацию и выявляются эффективные