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Long-term efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses.

BACKGROUND: Few studies have examined the long-term efficacy of fluorouracil (FU) or chemical peels for the treatment of actinic keratoses ( … mical peel or with 5% FU should be reevaluated yearly or every 1.5 years for reappearance of AK and retreatment.

[Combination chemo-endocrine therapy of metastatic and stage IV breast cancer with cyclophosphamide, adriamycin, prednisolone and tamoxifen (CAPT)--with special reference to management of brain and liver metastasis].

Sixty-three evaluable patients with metastatic and stage IV breast cancer who had not previously undergone chemo-endocrine therapy were trea … are usually viewed as a sign of grim prognosis, was obtained similar to other sites of metastasis. Retreatment with CAPT, which was attempted in patients with secondary brain metastasis who responded to CAPT for initial brain metastasis, was uniformly effective. High ration of androgen to corticosteroid, positive estrogen receptors, long disease-free surviva …

5-Aminosalicylic acid enemas in refractory distal ulcerative colitis: long-term results.

In this trial, we examined the role of 4-g 5-aminosalicylic acid (5-ASA) enema in the long-term management of patients with previously refra … symptoms). Six other patients relapsed when the enemas were tapered to every two nights, and after retreatment on a nightly regimen, four could be maintained on an every third night regimen while two have required every second night administration. One patient has required nightly administration from the outset. Currently, one patient is off all medication, …

Management of High Jugular Bulb in Retrosigmoid Surgery for Vestibular Schwannoma: Analysis of 590 Consecutive Cases.

BACKGROUND AND OBJECTIVES: High jugular bulb (HJB) is an obstacle when performing retrosigmoid intradural temporal drilling for resection of … distance was 3.3 mm. There were no statistically significant differences in tumor removal rates or retreatment rates, and the sigmoid-jugular venous system remained patent in all 3 groups. CONCLUSION: The HJB management should be considered when the HJB apex is located at a high position, and the distance between the HJB apex and the surface of the petrous …

Association between bacterial load and volumetric bone loss in teeth with persistent apical periodontitis: A cone-beam computed tomography segmentation-based observational study.

AIM: To quantitatively compare the bacterial DNA load in root apices and periapical lesions surgically retrieved from teeth with failed root … entation using Blue Sky Bio software. Demographic and clinical data including gender, age, previous retreatment, tenderness to percussion, tooth position, and periapical healing after 1 year were preliminarily associated with the lesion volume. Normality of the variables was analyzed by the Shapiro Wilk test, and global comparisons were explored by ANOVA when …

Aquablation as salvage therapy for benign prostatic hyperplasia: an international multicentre study.

OBJECTIVE: Our objective was to evaluate the safety and effectiveness of Aquablation® as a salvage therapy in patients who underwent prior i … were no significant differences in perioperative complications, 30-day readmission rates, surgical retreatment rates, or sexual function outcome scores (all P > 0.05). There were also similar improvements in maximum urinary flow rates, post-void residuals, International Prostate Symptom Scores, and quality of life scores (all P > 0.05). When comparing outcom …

Thulium fiber laser enucleation of the prostate with SOLTIVE™ SuperPulsed laser systems: a prospective evaluation of early outcomes in an Asian cohort.

INTRODUCTION: Thulium fiber laser (TFL) technology, with its shorter wavelength and higher water absorption coefficient compared to Holmium: … s 21.9 ml/s (IQR 15.2-26.8 ml/s), median IPSS was 2 (IQR 1-5), and there was no surgical or medical retreatment. CONCLUSION: ThuFLEP demonstrates early safety and feasibility in this Asian cohort, including catheter-dependent patients. Larger, multicenter studies with longer follow-up are warranted to confirm its safety and efficacy. CLINICAL TRIAL REGISTRA …

Short-Term Results of Dexamethasone Intravitreal Implant in Patients with Persistent Diabetic Macular Edema.

PURPOSE: To evaluate the effectiveness and safety of combining intravitreal dexamethasone implant (IVDI) and ranibizumab in patients with pe … P < 0.001). DME recurred in 16-17 eyes between months 3 and 5, requiring additional IVRB. Following retreatment, BCVA remained stable (0.50-0.54 logMAR, P ≤ 0.029) and CMT persisted between 353 and 382 µm (P ≤ 0.001) through month 6. IOP increased significantly during the first 2 months but returned to baseline thereafter. CONCLUSIONS: IVDI demonstrated subs …

Long-term external validation of the Japan Achalasia Multicenter Study Peroral Endoscopic Myotomy score reveals dynamic risk trajectories in achalasia patients after peroral endoscopic myotomy.

BACKGROUND AND AIMS: The Japan Achalasia Multicenter Study Peroral Endoscopic Myotomy (JAMS POEM) score is a preoperative tool for predictin … OEM at a single tertiary center between 2012 and 2017. The JAMS POEM score was calculated from the pretreatment Eckardt score, prior treatment history, and manometric subtype. Clinical failure was defined as an Eckardt score of ≥4 or retreatment. Predictive performance was assessed using the area under the receiver operating characteristic curve (AUROC) at sh …

Silver diamine fluoride versus conventional restorative treatment for dental caries in primary teeth of children: a meta-analysis.

BACKGROUND: Early childhood caries remains a major public health burden, and silver diamine fluoride (SDF) has emerged as a minimally invasi … ent selection should also consider esthetic staining, child cooperation, caregiver preferences, and retreatment needs.

Exploratory Cross-Trial Non-Inferiority Analysis of 2% Versus 1% Sodium Hyaluronate in Knee Osteoarthritis.

Objectives: Our primary objective was to compare the 12-month efficacy of two dosing regimens of intra-articular sodium hyaluronate (SH) in patients with knee osteoarthritis (OA) using a cross-study analysis within a non-inferiority framework. Methods: This study combined individual patient data from two prospective multicenter trials with similar outcome measures: the Trueba Davalillo study (five injections of 1% SH) and the SOYA Trial (single injection of 2% SH, with the possibility of retreatment after 6 months). The primary endpoint of this cross-study analysis was the relative change in p…

Flow diversion versus conventional endovascular treatment for ruptured basilar artery dissecting aneurysms: a single-center cohort study.

BACKGROUND: Ruptured basilar artery dissecting aneurysms (BADAs) are rare and associated with high risks of rebleeding, brainstem ischemia, … avorable functional outcome (mRS 0-2) at the last follow-up. Secondary outcomes included mortality, retreatment, complications, and descriptive radiological outcomes. RESULTS: Twenty-two patients were included: 5 received FD-based treatment as the index strategy and 17 received conventional endovascular treatment. Fusiform morphology was more frequent in the …

Case Report: Unexpected HBV reactivation upon nucleos(t)ide analogue discontinuation despite 17 years of sustained HBsAg loss post-liver transplantation.

Long-term administration of nucleos(t)ide analogues (NAs) has substantially mitigated the risk of post-transplant hepatitis B virus (HBV) re … mical normalization. HBV DNA fell below the lower limit of detection (<20 IU/mL) within 9 months of retreatment (December 2023) and has remained fully suppressed through April 2026. This case emphasizes that fulminant HBV reactivation may transpire following NA cessation in LT recipients, irrespective of protracted virological suppression and stable HBsAg ser …

Бремя лечения, секвенирования и использования ресурсов здравоохранения в множестве миеломы в Латинской Америке: обзор целевой литературы.

Утверждение основных классов лекарственных препаратов позволило улучшить выживание пациентов с множественной миеломой (ММ). В то же время большинство пациентов сталкиваются с рецидивом или становятся противниками этих методов лечения, причем повторное лечение имеет ограниченную эффективность. Доступ к этим основным методам лечения в разных странах Латинской Америки (ЛАТАМ), что может привести к неоптимальным клиническим результатам. Цель этого целевого обзора литературы заключалась в том, чтобы понять эпидемиологию, бремя лечения, последовательность лечения и наличие MM в Аргентине, Бразилии,

Совпадение в аннотации оригинала
Approval of key drug classes has improved survival for patients with multiple myeloma (MM). However, most patients experience relapse or become refractory to these treatments, with retreatment having limited efficacy. Access to these key treatments varies widely across countries in Latin America (LATAM), which can lead to suboptimal clinical outcomes. This t…

Short Perioperative Antiviral Prophylaxis for Hepatitis C Viremic Donor Kidney Transplantation: Outcomes in 204 Recipients.

BACKGROUND: Kidney transplantation using hepatitis C virus (HCV) nucleic acid test-positive donors for HCV-negative recipients (D+/R-) has e … resistance-associated substitutions were identified in 4 of 8 tested breakthrough cases. First-line retreatment achieved sustained virologic response (SVR) at 12 wk in 14 of 15 (93.3%); 1 patient required salvage therapy, yielding overall SVR at 12 wk of 15 of 15 (100%), although 93% required insurance prior authorization (median delay 36 d). One-year patient …

Incidence and Outcomes of Flow Diverter Braid Deformation following Treatment with Non-DFT Wire Devices.

Flow diverter braid deformation is occasionally observed after flow diverter placement. However, the frequency and clinical significance of … ion group, whereas the rates of in-stent stenosis, aneurysm occlusion (O'Kelly-Marotta grades C-D), retreatment, and favorable functional outcomes (modified Rankin Scale, 0-2) did not differ significantly between the groups. Younger age and proximal stent oversizing were independent predictors of flow diverter braid deformation. Given the rarity of the high-r …

[Image-Guided Irreversible Electroporation for the Treatment of Localized Prostate Cancer].

Focal treatment has emerged as a precision-oriented alternative to whole-gland treatment approaches for localized prostate cancer. It aims t … ng early and intermediate-term oncologic outcomes, although patterns of recurrence and the need for retreatment vary between cohorts and depend on the respective follow-up protocols. Functional outcomes are consistently excellent: continence is preserved in the vast majority of patients, and potency preservation is often high, typically ranging from approxima …

Stent-Assisted Coil Embolization for Ruptured Wide-Neck Aneurysms in the Acute Phase of Subarachnoid Hemorrhage: A Single-Center Experience in Japan.

OBJECTIVE: Stent-assisted coil embolization (SAC) has expanded the treatment options for ruptured wide-neck aneurysms; however, SAC during t … y outcomes included angiographic outcomes, clinical outcomes at discharge and 1-year follow-up, and retreatment rates. RESULTS: A total of 140 patients were included (SAC group, n = 24; non-SAC group, n = 116). Aneurysms in the SAC group demonstrated more complex morphology, particularly lower aneurysm height and smaller dome-to-neck ratios. The rates of per …

Anti-TNF withdrawal or long-term treatment in ulcerative colitis (BIOSTOP): a multicentre open label, randomized controlled trial.

BACKGROUND AND AIMS: Anti-tumour necrosis factor (anti-TNF) treatment is effective in ulcerative colitis (UC). Optimal treatment duration is … . UC flares occurred in 52% (45/86) of withdrawal and 12% (10/86) of maintenance patients. Anti-TNF retreatment was successful in 74% (20/27). CONCLUSION: Two years after anti-TNF withdrawal in UC patients in deep remission, endoscopically confirmed remission rate was significantly lower compared to maintenance treatment. Non-inferiority could not be proven. …

Intermittent phototherapy in neonatal hyperbilirubinemia: A pilot randomized controlled trial in Taiwan.

BACKGROUND: Continuous phototherapy (CPT) is standard for neonatal hyperbilirubinemia, but intermittent phototherapy (IPT) regimens may prod … hreshold on Day 3 (-3.92 vs. -2.98 mg/dL; p = 0.047). Notably, rebound hyperbilirubinemia requiring retreatment occurred only in the CPT group (n = 2, 5.9%), while the IPT group remained stable. Adverse events were infrequent and similar. CONCLUSION: Our findings suggest that a 12-h IPT regimen may be comparable to CPT, exhibiting potential advantages in the …