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DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review.

As an important nutrient in the human body, cholesterol can not only provide structural components for the body's cells, but also can be transformed into a variety of active substances to regulate cell signaling pathways. As an important cholesterol synthase, DHCR24 participates in important regulatory processes in the body. The application of DHCR24 in tumor clinical diagnosis and treatment also attracts much attention. This article reviews the structure and regulatory characteristics of DHCR24, and the research of DHCR24 on tumor progression. We summarize the possible mechanisms of DHCR24 pr

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… Qi J, Li M, Wang L, et al. National and subnational trends in cancer burden in China, 2005-20: An analysis of national mortality surveillance data. Lancet Public Health. 2023;8(12):e943-e955. doi: 10.1016/S2468-2667(23)00211-6 175. Kini AS, Vengrenyuk Y, Shameer K, et al. …

The emerging role of osteoclasts in the treatment of bone metastases: rationale and recent clinical evidence.

The occurrence of bone metastasis is a grave medical concern that substantially impacts the quality of life in patients with cancer. The precise mechanisms underlying bone metastasis remain unclear despite extensive research efforts, and efficacious therapeutic interventions are currently lacking. The ability of osteoclasts to degrade the bone matrix makes them a crucial factor in the development of bone metastasis. Osteoclasts are implicated in several aspects of bone metastasis, encompassing the formation of premetastatic microenvironment, suppression of the immune system, and reactivation o

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… Nat Med . ( 2019 ) 25 : 656–66 . doi: 10.1038/s41591-019-0374-x PMC7175920 30833750 114 Jiang K-Y Qi L-L Liu X-B Wang Y Wang L . Prognostic value of siglec-15 expression in patients with solid tumors: A meta-analysis . …

Cold atmospheric plasma sensitizes head and neck cancer to chemotherapy and immune checkpoint blockade therapy.

Head and neck cancer (HNC) is the seventh most prevalent cancer globally, often characterized by chemo-resistance and immunosuppression, which significantly hampers treatment efficacy. Cold atmospheric plasma (CAP) has recently emerged as a promising adjuvant oncotherapy with substantial potential and advantages. In this study, Piezobrush® PZ2, a handheld CAP unit based on the piezoelectric direct discharge technology, was used to generate and deliver non-thermal plasma. We aimed to investigate the effects of CAPPZ2 on various types of HNC cells and elucidate the underlying mechanisms. In addi

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… Guo B., Pomicter A.D., Li F., Bhatt S., Chen C., Li W., Qi M., Huang C., Deininger M.W., Kong M.G., Chen H.L. Trident cold atmospheric plasma blocks three cancer survival pathways to overcome therapy resistance. Proc. Natl. Acad. Sci. U.S.A. 2021;118(51) doi: 10.1073/pnas.2107220118. 20. …

Cancer Therapy and Exercise Intolerance: The Heart Is But a Part: JACC: CardioOncology State-of-the-Art Review.

The landscape of cancer therapeutics is continually evolving, with successes in improved survivorship and reduced disease progression for many patients with cancer. Improved cancer outcomes expose competing comorbidities, some of which may be exacerbated by cancer therapies. The leading cause of disability and death for many early-stage cancers is cardiovascular disease (CVD), which is often attributed to direct or indirect cardiac injury from cancer therapy. In this review, the authors propose that toxicities related to conventional and novel cancer therapeutics should be considered beyond th

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… Qi W.X., Lin F., Sun Y.J., Tang L.N., Shen Z., Yao Y. Risk of venous and arterial thromboembolic events in cancer patients treated with gemcitabine: a systematic review and meta-analysis. Br J Clin Pharmacol. 2013;76:338–347. doi: 10.1111/bcp.12203. 108. West M.A., Loughney L., Lythgoe D., et al. …

Chinese expert consensus on the diagnosis and clinical management of medication-related osteonecrosis of the jaw.

Medication-related osteonecrosis of the jaw (MRONJ) is a side effect that occurs after treatment for systemic diseases. However, most institutions currently rely on empirical methods to make diagnosis and treatment plans, and there is a lack of consensus or guidelines for the classification, staging and treatment of MRONJ in China. To address this gap and improve prognosis, an expert panel representing 11 renowned domestic medical colleges and affiliated hospitals in China was convened. The panel made a comprehensive literature review of previous treatment experiences and research findings to

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… Surg. 41 2012 1397 1403 10.1016/j.ijom.2012.06.020 22840716 74 Qi W.X. Tang L.N. He A.N. Yao Y. Shen Z. Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: a meta-analysis of seven randomized controlled trials Int. J. Clin. …

Эффективность транскраниального прямого тока (tDCS) на нейропсихиатрических Симптомах в множестве склерозов (MS) - обзор и понимание возможных механизмов действий.

Введение: Нейропсихиатрические симптомы, такие, как депрессия и беспокойство, являются значительным бременем для пациентов с множественным склерозом (МС). Их патофизиология сложна и еще не до конца понятна. Существует срочная потребность в неинвазивных методах лечения, которые непосредственно нацелены на мозг и помогают пациентам с склерозом. Одним из таких возможных способов лечения является транскраниальная стимуляция прямого тока (TDCS) - популярный и эффективный метод неинвазивной стимуляции мозга. Методы: В рамках этого механистического обзора изучается эффективность ТДСС в лечении депрес

Роль Гут Микробиота в неврологических, психиатрических и неевроразвитых расстройствах.

АИМ: Эта статья направлена на изучение роли человеческого кишечного микробиота (ГМ) в патогенезе неврологических, психиатрических и нейроразвитых расстройств, с уделением особого внимания его влиянию на здоровье и болезни и изучением потенциальных терапевтических стратегий, ориентированных на модификацию ГМ. МАТЕРИАЛЫ И МЕТОДЫ: Предусмотрен всеобъемлющий анализ состава кишечного микробиота и его взаимодействия с человеческим телом, в частности его роли в неврологических и психиатрических условиях. В обзоре обсуждаются факторы, влияющие на состав ГМ, включая родовой режим, грудное вскармливание

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… Qi Q. Comparison of Fecal Collection Methods for Microbiome and Metabolomics Studies Front. Cell. Infect. Microbiol. 2018 8 301 10.3389/fcimb.2018.00301 30234027 PMC6127643 47. Flores R. Shi J. Yu G. Ma B. Ravel J. Goedert J.J. Sinha R. …

Clinical outcomes of antimicrobial resistance in cancer patients: a systematic review of multivariable models.

BackgroundInfections are major causes of disease in cancer patients and pose a major obstacle to the success of cancer care. The global rise of antimicrobial resistance threatens to make these obstacles even greater and hinder continuing progress in cancer care. To prevent and handle such infections, better models of clinical outcomes building on current knowledge are needed. This internally funded systematic review (PROSPERO registration: CRD42021282769) aimed to review multivariable models of resistant infections/colonisations and corresponding mortality, what risk factors have been investig

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… Zhang Q Gao H-Y Li D Li Z Qi S-S Zheng S Clinical outcome of Escherichia coli bloodstream infection in cancer patients with/without biofilm formation: a single-center retrospective study Infect Drug Resist 2019 12 359 371 10.2147/IDR.S192072 30809097 PMC6377049 157. …

Senescent T cells: Beneficial and detrimental roles.

As the thymus involutes during aging, the T-cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward replicative senescence, due to telomere erosion. This review discusses mechanisms that regulate the end-stage differentiation (senescence) of T cells. Although these cells, within both CD4 and CD8 compartments, lose proliferative activity after antigen-specific challenge, they acquire innate-like immune function. While this may confer broad i

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… Goronzy JJ, Fang F, Cavanagh MM, Qi Q, Weyand CM. Naive T cell maintenance and function in human aging. J Immunol. 2015;194(9):4073‐4080. doi: 10.4049/jimmunol.1500046 63. Hu B, Jadhav RR, Gustafson CE, et al. Distinct age‐related epigenetic signatures in CD4 and CD8 T cells. …

Recent Advances in CAR-Based Solid Tumor Immunotherapy.

Adoptive cell therapy using chimeric antigen receptor (CAR) technology is one of the most advanced engineering platforms for cancer immunotherapy. CAR-T cells have shown remarkable efficacy in the treatment of hematological malignancies. However, their limitations in solid tumors include an immunosuppressive tumor microenvironment (TME), insufficient tumor infiltration, toxicity, and the absence of tumor-specific antigens. Although recent advances in CAR-T cell design-such as the incorporation of co-stimulatory domains and the development of armored CAR-T cells-have shown promising results in

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… Qi C., Gong J., Li J., Liu D., Qin Y., Ge S., Zhang M., Peng Z., Zhou J., Cao Y., et al. Claudin18.2-specific CAR T cells in gastrointestinal cancers: Phase 1 trial interim results. Nat. Med. 2022;28:1189–1198. doi: 10.1038/s41591-022-01800-8. 80. …

Cardiotoxicity of anti-cancer drugs: cellular mechanisms and clinical implications.

Cardio-oncology is an emerging field that seeks to enhance quality of life and longevity of cancer survivors. It is pertinent for clinicians to understand the cellular mechanisms of prescribed therapies, as this contributes to robust understanding of complex treatments and off-target effects, improved communication with patients, and guides long term care with the goal to minimise or prevent cardiovascular complications. Our aim is to review the cellular mechanisms of cardiotoxicity involved in commonly used anti-cancer treatments and identify gaps in literature and strategies to mitigate card

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… Latifi Y, Moccetti F, Wu M, Xie A, Packwood W, Qi Y, et al. Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib. Blood. (2019) 133(14):1597–606. 10.1182/blood-2018-10-881557 162. Siegel RL, Miller KD, Jemal A. …

Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies.

Chimeric antigen receptor (CAR)-T cell therapies have been approved by FDA to treat relapsed or refractory hematological malignancies. However, the adverse effects of CAR-T cell therapies are complex and can be challenging to diagnose and treat. In this review, we summarize the major adverse events, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and CAR T-cell associated HLH (carHLH), and discuss their pathophysiology, symptoms, grading, and diagnosis systems, as well as management. In a future outlook, we also provide an overview of

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… Jiang M Qi L Li L Li Y The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer Cell Death Discov. 2020 6 112 10.1038/s41420-020-00349-0 33133646 PMC7595122 52. …

Management and Prevention of Cellular-Therapy-Related Toxicity: Early and Late Complications.

Chimeric Antigen Receptor T (CAR-T) cell therapy has dramatically changed prognosis and treatment of relapsed and refractory hematologic malignancies. Currently the 6 FDA approved products target various surface antigens. While CAR-T therapy achieves good response, life-threatening toxicities have been reported. Mechanistically, can be divided into two categories: (1) toxicities related to T-cell activation and release of high levels of cytokines: or (2) toxicities resulting from interaction between CAR and CAR targeted antigen expressed on non-malignant cells (i.e., on-target, off-tumor effec

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… Yang H., Hao Y., Chai X., Qi C.Z., Wu E.Q. Estimation of total costs in patients with relapsed or refractory diffuse large B-cell lymphoma receiving tisagenlecleucel from a US hospital’s perspective. J. Med. Econ. 2020;23:1016–1024. doi: 10.1080/13696998.2020.1769109. 117. …

Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy.

Despite the great advancements made in cancer treatment, there are still many unsatisfied aspects, such as the wide palette of side effects and the drug resistance. There is an obvious increasing scientific attention towards nature and what it can offer the human race. Natural products can be used to treat many diseases, of which some plant products are currently used to treat cancer. Plants produce secondary metabolites for their signaling mechanisms and natural defense. A variety of plant-derived products have shown promising anticancer properties in vitro and in vivo. Rather than recreating

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… Qi X. Zhao Y. Liu H. Wang J. Mei X. MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma Oncotarget 2017 8 73938 73946 10.18632/oncotarget.17881 29088758 PMC5650313 129. Kang N. Wang M.M. Wang Y.H. Zhang Z.N. Cao H.R. Lv Y.H. Yang Y. Fan P.H. Qiu F. Gao X.M. …

Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer.

Traditional Chinese medicine (TCM) usually acts in the form of compound prescriptions in the treatment of complex diseases. The herbs contained in each prescription have the dual nature of efficiency and toxicity due to their complex chemical component, and the principle of prescription is usually to increase efficiency and reduce toxicity. At present, the studies on prescriptions have mainly focused on the consideration of the material basis and possible mechanism of the action mode, but the quantitative research on the compatibility rule of increasing efficiency and reducing toxicity is stil

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… In addition, in clinical trials, Yiqi Yangyin Jiedu Decoction has been proved to be ameliorate the qi-yin deficiency syndrome evidently in advance lung cancer patients, and the Karnofsky score is significantly higher than that of chemotherapy group, improving the quality of life of lung cancer patients …

Approaches to the Management of Metastatic Adenoid Cystic Carcinoma.

High rates of recurrence and distant metastasis are a foremost challenge in the management of adenoid cystic carcinoma (ACC), occurring in approximately 40% of all ACC patients. Despite the morbidity and mortality resulting from recurrent/metastatic (R/M) disease, there are no FDA-approved systemic agents for these patients. In this review, we summarize pertinent ACC pathophysiology and its implications for different systemic treatment regimens in R/M ACC. We review the evidence for the most widely used systemic agents - cytotoxic chemotherapy and tyrosine kinase inhibitors (TKIs) targeting VE

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… Qi F. Dong M. Survival and Prognosis of Metastatic Head and Neck Adenoid Cystic Carcinoma Head Neck 2022 44 2407 2416 10.1002/hed.27143 35822446 115. Shingaki S. Kanemaru S. Oda Y. Niimi K. Mikami T. Funayama A. Saito C. …

Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer.

Cancer constitutes a severe threat to human health and quality of life and is one of the most significant causes of morbidity and mortality worldwide. Natural dietary products have drawn substantial attention in cancer treatment and prevention due to their availability and absence of toxicity. Rosmarinic acid (RA) is known for its excellent antioxidant properties and is safe and effective in preventing and inhibiting tumors. This review summarizes recent publications on culture techniques, extraction processes, and anti-tumor applications of RA-enriched dietary supplements. We discuss techniqu

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… Qi H. Cheng Z. Chen L. Anticancer effects of rosmarinic acid in human oral cancer cells is mediated via endoplasmic reticulum stress, apoptosis, G2/M cell cycle arrest and inhibition of cell migration J. BU ON. Off. J. Balk. Union Oncol. 2020 25 1245 1250 32521932 101. Huang L. Chen J. Quan J. …

Human γδ T Cell Subsets and Their Clinical Applications for Cancer Immunotherapy.

Gamma delta (γδ) T cells are a minor population of T cells that share adaptive and innate immune properties. In contrast to MHC-restricted alpha beta (αβ) T cells, γδ T cells are activated in an MHC-independent manner, making them ideal candidates for developing allogeneic, off-the-shelf cell-based immunotherapies. As the field of cancer immunotherapy progresses rapidly, different subsets of γδ T cells have been explored. In addition, γδ T cells can be engineered using different gene editing technologies that augment their tumor recognition abilities and antitumor functions. In this review, we

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… Qi C. Wang Y. Li P. Zhao J. Gamma Delta T Cells and Their Pathogenic Role in Psoriasis Front. Immunol. 2021 12 627139 10.3389/fimmu.2021.627139 33732249 PMC7959710 18. Davey M.S. Willcox C.R. Hunter S. Kasatskaya S.A. Remmerswaal E.B.M. Salim M. Mohammed F. Bemelman F.J. Chudakov D.M. Oo Y.H. …

Cancer Immunotherapy Beyond Checkpoint Blockade: JACC: CardioOncology State-of-the-Art Review.

Avoidance of immune destruction is recognized as one of the hallmarks of cancer development. Although first predicted as a potential antitumor treatment modality more than 50 years ago, the widespread clinical use of cancer immunotherapies has only recently become a reality. Cancer immunotherapy works by reactivation of a stalled pre-existing immune response or by eliciting a de novo immune response, and its toolkit comprises antibodies, vaccines, cytokines, and cell-based therapies. The treatment paradigm in some malignancies has completely changed over the past 10 to 15 years. Massive effort

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… Successful anti-CLL1 CAR T-cell therapy in secondary acute myeloid leukemia Front Oncol 10 2020 685 32528876 10.3389/fonc.2020.00685 PMC7266936 82 Qi C. Gong J. Li J. …

Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets.

Curcuma longa is very well-known medicinal plant not only in the Asian hemisphere but also known across the globe for its therapeutic and medicinal benefits. The active moiety of Curcuma longa is curcumin and has gained importance in various treatments of various disorders such as antibacterial, antiprotozoal, cancer, obesity, diabetics and wound healing applications. Several techniques had been exploited as reported by researchers for increasing the therapeutic potential and its pharmacological activity. Here, the dictum is the new room for the development of physicochemical, as well as biolo

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… Qi C. Huang N.-P. Xiao Z.-D. Lu Z.-H. Tannous B.A. Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy Biomaterials 2018 150 137 149 10.1016/j.biomaterials.2017.10.012 29040874 61. Abdolahi M. Jafarieh A. Sarraf P. Sedighiyan M. Yousefi A. Tafakhori A. …