Результаты поиска

Achieving dual emission of thermally activated delayed fluorescence and ultralong room-temperature phosphorescence by controlling excited state dynamics through metal coordination.

Controlling excited-state dynamics is crucial for achieving dual emissions of ultralong room-temperature phosphorescence (URTP) and thermally activated delayed fluorescence (TADF), but remains challenging in the exploration of transition-metal compounds. Herein, we propose a new strategy to develop highly efficient TADF and URTP dual-emission materials by modulating URTP organic molecules through metal ion coordination. Specifically, Ag+ ions narrow the singlet-triplet energy gap (ΔE ST) and enhance spin-orbit coupling (SOC), thereby accelerating intersystem crossing (ISC) and facilitating rev

Red-Emitting Cyclometalated Platinum(II) Complexes with Pyrrolide and Phenoxide-Based Ancillary Ligands.

Phosphorescent platinum(II) complexes often have low photoluminescence quantum yields (ΦPL) due to the less effective spin-orbit coupling (SOC) in square-planar geometries, leading to relatively small radiative rate constants (kr). In this work, seven new red-emitting heteroleptic cyclometalated Pt(II) complexes are described, with the goal of investigating ancillary ligands that promote fast kr values. The heteroleptic four-coordinate complexes include 1-phenylisoquinoline as the cyclometalating ligand, paired with an anionic chelating ancillary ligand with either N∧N, O∧O, or mixed N∧O coord

Effect of Donor and Acceptor on Improving the ROS Generation of Benzothiadiazole-Based Photosensitizers and Effective Photodynamic Therapy to Pancreatic Cancer Cells.

Photodynamic therapy (PDT) has emerged as a promising strategy for pancreatic cancer treatment, yet its efficacy is hindered by the limited reactive oxygen species (ROS) generation efficiency of conventional photosensitizers (PSs). Herein, we adopted a PS with a donor-acceptor structure as the researched object, which chose triphenylamine (TPA) and benzothiadiazole as an electronic donor and an acceptor. Another electronic donor of anisole and an electronic acceptor of nitrophenyl were introduced to the researched object to obtain two PSs of BLY-719 and BLY-720, which aimed to enhance PDT perf

Multiple effects of aromatic substituents on excited-state properties and singlet fission process in azaquinodimethane systems.

Singlet fission (SF) could offset the thermalization loss of high-energy photons via multiexciton generations, thus holding great potential in improving the power conversion efficiency of solar cells. However, the development of SF-based devices has basically remained stagnant so far owing to the limited scope of practical SF materials. Therefore, designing and developing practical SF material systems have been imperative, yet challenging so far. In this work, we comprehensively investigated the effects of aromatic substituents on excited-state properties and SF process of azaquinodimethane sy

Metal-Free Singlet Oxygen Generation via Excited-State Intramolecular Proton-Transfer-Driven Intersystem Crossing in 2D Covalent Organic Frameworks.

Singlet oxygen (1O2) is a key reactive species in photodynamic therapy and organic synthesis. Conventional generation of 1O2 relies on metal-containing sensitizers to promote intersystem crossing (ISC) and thereby activate molecular oxygen (3O2), which limits biocompatibility and scalability. Here, we report a metal-free strategy leveraging excited-state intramolecular-proton-transfer (ESIPT) to enhance 1O2 production. Two classes of ESIPT-active materials, 1D polymers and 2D covalent organic frameworks (COFs), were systematically compared. Interestingly, while the ESIPT transition in the 1D p

Aggregation-Induced Phosphorescence of a Trans-Bis(iminomethylpyrolato)Platinum Complex Bearing a Polymethylene Vaulted Structure: Chain Length-Dependent Solid-State Emissions.

Aggregation-induced emission (AIE) has recently attracted considerable attention. Although phosphorescent transition-metal complexes exhibit significant potential as aggregation-induced emission luminogens (AIEgens), their exploration and utilization have remained limited, partly due to the insufficient understanding of the underlying mechanisms. Here, we report a new series of platinum(II) complexes, trans-bis(2-iminomethylpyrrolato)platinum derivatives (1a-d), which feature vaulted polymethylene chains of varying lengths (n = 9-12) that bridge over the metal atom. Notably, racemic complexes

Coordination-Induced Supramolecular Assembly Enhances Singlet Oxygen Generation in Pt-BODIPY Photosensitizers for Synergistic Chemo-Photodynamic Therapy.

Organic dyes hold great potential as photosensitizers for tumor diagnosis and therapy. However, their practical application is hindered by two major limitations: aggregation-caused fluorescence quenching (ACQ) and inefficient reactive oxygen species (ROS) generation. To overcome these challenges, we developed a coordination-induced supramolecular assembly strategy aiming at enhancing their photophysical properties and therapeutic efficacy. Herein, two Pt(II)-BODIPY conjugates were designed by integrating platinum(II) moieties with a tailored boron-dipyrromethene derivative (py-BDP). Notably, t

Photoinduced charge-transfer dynamics in fluorescent electron donor-acceptor polymers.

Electron donor-acceptor (D-A) polymers are emerging as promising candidates for the development of solid materials with tunable emission. Herein, we investigate the excited-state dynamics of polymers consisting of a central naphthalenediimide (NDI) acceptor with two polystyrene donor chains and copolymers with various secondary donors incorporated. We find strong differences in the dynamics when going from diluted polymer solutions to pure polymer films. In liquids, ultrafast intrachain electron transfer from a styrenic donor to the excited NDI, followed by sub-nanosecond charge recombination

Is t(11;14) Always a Standard-Risk Cytogenetic Abnormality? Results From GEM05MENOS65 and GEM2012 PETHEMA/GEM Transplantation Trials.

PURPOSE: Recent studies describe inferior outcomes in newly diagnosed multiple myeloma (NDMM) patients with t(11;14) treated with novel agents. MATERIALS AND METHODS: We analyzed 240 NDMM transplant eligible (TE) patients who received triplet induction regimen in the GEM05MENOS65 (bortezomib, thalidomide and dexamethasone - VTD) and GEM2012 (bortezomib, lenalidomide and dexamethasone - VRD) clinical trials. RESULTS: t(11;14) and standard risk (SR) non-t(11;14) were prevalent in 51 (21%) and 189 (79%) patients, respectively. Patients with t(11;14) treated with VTD had a lower overall response

Current Treatment Strategies for Multiple Myeloma at First Relapse.

Multiple myeloma (MM), the second most common hematologic cancer, remains an incurable malignancy, characterized by an initial response to therapy followed by successive relapses. The upfront treatment typically involves induction therapy, autologous stem cell transplantation for eligible patients, and long-term maintenance therapy. It is important to note that the anticipated duration of myeloma response diminishes with each subsequent relapse. Therefore, the first relapse represents a critical juncture in treatment, where refractoriness to key drug classes emerges as a significant challenge.

Совпадение в полном тексте источника
… Other options include an IMiD-based triplet, pomalidomide, bortezomib, and dexamethasone (PVd), or a CAR T-cell therapy or belantamab mafodotin-based triplets (BPd or BVd), which have proven efficacy in clinical trials but are still pending regulatory approval for clinical use. … Currently approved triplet regimens at first relapse | 482 4. Conclusions The evolving treatment landscape for first-relapse MM underscores the need for an individualized approach to patient care. …

Emerging Real-World Treatment Patterns and Clinical Outcomes of Multiple Myeloma in Argentina and Brazil: Insights from the TOTEMM Study in the Private Healthcare Sector.

As treatments for multiple myeloma (MM) evolve, there is a need for real-world insights into treatment patterns and outcomes. The treatment practices and clinical outcomes in patients with MM (TOTEMM) was a database study (2018-2024) of newly diagnosed transplant-ineligible patients with MM in Argentina (TOTEMM-A) and Brazil (TOTEMM-B) in a private healthcare setting. In TOTEMM-A (n = 72) and TOTEMM-B (n = 892), 37 and 92 different drug regimens were reported, respectively. In each country, treatment duration reduced across lines of therapy (LOT) (TOTEMM-A: range, 6.2-3.4 months; TOTEMM-B: ran

Theoretical Exploration of the Effects of Conjugated Side Chains on the Photoelectric Properties of Y6-Based Nonfullerene Acceptors.

With the application of nonfullerene acceptors (NFAs) Y6 and its derivatives, the power conversion efficiencies (PCEs) of single-junction organic solar cells (OSCs) have exceeded 20%. Side-chain engineering has proven to be an important strategy for optimizing Y6-based NFAs. However, studies on the incorporation of conjugated side chains into Y6-based NFAs are still rare, and the corresponding underlying mechanisms are still not well understood. In this article, we systematically designed eight molecules based on modifications to the conjugated side chains of two reported Y6-based NFAs, involv

Regulating charge transfer of copper(i) coordination compounds via conformation engineering for highly efficient radioluminescence and 3D X-ray imaging.

Copper(i) coordination compounds have emerged as promising candidates for X-ray scintillators because of their superior X-ray absorption capacity and tunable radioluminescence. However, a strategy that realizes efficient radioluminescence by varying the competition between radiative ligand-related transitions and nonradiative cluster-centered charge transfer is yet to be clearly demonstrated. Here, via conformation engineering, a series of copper(i) iodide coordination clusters have been designed and synthesized, and named (POPy)4Cu2I2, (POPy)4Cu4I4-α and (POPy)4Cu4I4-β (POPy = 4-phenoxypyridi

Platinum Complexes of Tetradentate NCCN-Coordinating Ligands: Structures and Photophysical Properties of PtII, Pt2III and PtIV Compounds.

Tetradentate proligands based on biphenyl appended at the 3 and 3' positions with pyridin-2-yl rings (H2L1), quinoline-8-yl (H2L3) heterocycles, or one such pyridine and quinoline (H2L2), have been synthesized by palladium-catalyzed cross-coupling. These compounds were expected to undergo cyclometalation with K2PtCl4 to generate Pt(II) complexes, PtL1-3, featuring NCCN-coordinated ligands. For H2L2 and H2L3, the corresponding Pt(IV) compounds PtL2-3Cl2 were initially isolated, from which PtL2-3 could be obtained by reduction with zinc. In contrast, H2L1 gave an unusual Pt(III) dimer, Pt2L12Cl2

Premutation Females with preFXTAS.

Fragile-X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurodegenerative disorder associated with the FMR1 gene premutation, characterized by the presence of 55 to 200 CGG triplet repeat expansions. Although the initial symptoms of FXTAS typically manifest in males around the age of 60 with motor symptoms and cognitive deficits, the presentation and progression in females differ. Women, in fact, exhibit a higher prevalence of neuropsychiatric symptoms, with an earlier onset compared to the motor symptoms observed in men. The following article reports on ten cases of women with a

Modulating ultralong room-temperature phosphorescence through mechanical confinement of tailored polymer/MOF hybrid interfaces.

Achieving ultra-long room temperature phosphorescence (RTP) remains a significant challenge due to the inherent trade-off between excited-state lifetime and photoluminescence quantum yield (QY). Herein, we report the synthesis of polymer/metal-organic framework (MOF) hybrids via a bottom-up approach, enabling the formation of direct covalent integration between polymer matrices and MOF structures. By systematically optimizing the incorporation of long-chain alkyl amines during the synthesis process, the resultant hybrids demonstrate green RTP performance, achieving a lifetime of 359 millisecon

Multicenter dose de-escalation phase I trial of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel and cisplatin in combination with systemic nab-paclitaxel in recurrent ovarian cancer patients: trial in progress.

OBJECTIVES: Ovarian cancer (OC) often presents with peritoneal metastases (PM) which contribute significantly to morbidity and treatment resistance. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) has emerged as a promising modality for locoregional drug delivery in peritoneal surface malignancies. Historically, combined intraperitoneal (IP) and intravenous (IV) cisplatin and paclitaxel regimens have demonstrated activity in first-line OC treatment. PIPAC nab-paclitaxel and cisplatin with systemic nab-paclitaxel holds promise as a safe and effective therapy, but has not been explo

Green Light Activated Dual-Action Pt(IV) Prodrug with Enhanced PDT Activity.

Light induced release of cisplatin from Pt(IV) prodrugs is a promising tool for precise spatiotemporal control over the antiproliferative activity of Pt-based chemotherapeutic drugs. A combination of light-controlled chemotherapy (PACT) and photodynamic therapy (PDT) in one molecule has the potential to overcome crucial drawbacks of both Pt-based chemotherapy and PDT via a synergetic effect. Herein we report green-light-activated Pt(IV) prodrug GreenPt with BODIPY-based photosentitizer in the axial position with an incredible high light response and singlet oxygen generation ability. GreenPt d

Machine Learning Accelerates Discovery of High-Performance Corrole Photosensitizers for Optical Imaging Diagnosis and Photodynamic Therapeutics of Nasopharyngeal Carcinoma.

This study centers on corrole, an emerging photosensitizer with great application potential, and innovatively develops an intelligent machine learning-based screening strategy. Through integrating molecular descriptor generation, feature engineering, multiple predictive models, and SHapley Additive exPlanations (SHAP)-based feature analysis, we have predicted two key performances of corrole photosensitizers, involving absorption peak wavelength and singlet-triplet intersystem crossing rate (kISC). Among 10 tested models, XGBoost outperforms other models. After introducing descriptors such as e

Scyphophyllidium garshai n. sp. (Cestoda: Phyllobothriidea) from the Grey Sharpnose Shark, Rhizoprionodon oligolinx Springer, 1964, in the Persian Gulf.

PURPOSE: There is a single species in category 3 of the cestode genus Scyphophyllidium that possesses six bothridial facial loculi. For 19 years, this species was believed to parasitize only sharks of the genus Scoliodon. The purpose of this study was to evaluate whether members of Scyphophyllidium with this unique scolex morphology are also found in another shark genus, Rhizoprionodon. METHODS: The tapeworms belonging to a new species, isolated from several specimens of Rhizoprionodon oligolinx from the Persian Gulf, were stained, measured, drawn, and described. RESULTS: Scyphophyllidium ga