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Core Competencies for Serious Illness Conversations: An Integrative Systematic Review.

Objective: The Serious Illness Care Program was developed to support goals and values discussions between seriously ill patients and their clinicians. The core competencies, that is, the essential clinical conversation skills that are described as requisite for effective serious illness conversations (SICs) in practice, have not yet been explicated. This integrative systematic review aimed to identify core competencies for SICs in the context of the Serious Illness Care Program. Methods: Articles published between January 2014 and March 2023 were identified in MEDLINE, PsycINFO, CINAHL, and Pu

Intervention and application of drawing therapy in cancer patients: a scoping review.

BACKGROUND: Cancer itself and its treatment process cause a range of physical and psychological discomforts to patients. Drawing therapy, as a form of complementary alternative medicine, has been proven to be effective in alleviating the physical and psychological discomforts of cancer patients, such as chemotherapy-associated nausea and vomiting, and negative emotions such as anxiety and depression. OBJECTIVE: This scoping review aims to organize and describe the literature on drawing therapy in cancer patients, including implementers, intervention methods, and effects. It strives to provide

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… This theory [ 51 ] clarifies that the left hemisphere of the brain is mainly responsible for logical thinking, language, analysis, and rational processing, while the right hemisphere is more involved in creative thinking, intuition, art, and spatial perception. …

The Disruptive Impact of COVID-19 on the Utilization of Cancer Chemotherapy-Related Healthcare Assistance at the Principal Nationwide Referral Hospital in Kenya.

Background Lockdown measures to reduce the outbreak of COVID-19 negatively impacted the administration of cancer chemotherapy globally; however, data from Kenya are limited. Researchers strove to address this information gap and assess chemotherapy trends before and during the pandemic at Kenyatta National Hospital (KNH), the most wide-ranging referral infirmary in Kenya, along with associated factors to provide future guidance. Methods Time series analyses and patient interviews were undertaken at the KNH Cancer Treatment Centre. Patient data were analyzed descriptively and inferentially. The

Цифровая двойная модель для подкрепления клинического решения на основе фактических данных при многократном лечении миэломы.

За последнее десятилетие в области лечения миеломы (ММ) был достигнут значительный прогресс. Несмотря на эффективность новых веществ, реакция пациентов, как правило, остается весьма непредсказуемой. С ростом когнитивной нагрузки, создаваемой за счет сложного и меняющегося ландшафта лечения, инструменты оказания помощи, основанные на данных, становятся все более популярными. Подходы, основанные на модели, такие как цифровые близнецы (ДТ), позволяют имитировать возможные ответы на набор входных параметров, основанных на ретроспективных наблюдениях. В контексте поддержки принятия решений о лечени

Risk Assessment and Risk-Adapted Treatment Selection: A Case-Based Approach for Chronic Lymphocytic Leukemia.

Selected Patient Cases From the APSHO Regional Lecture Series INTRODUCTION As the official publication of the Advanced Practitioner Society for Hematology and Oncology (APSHO), JADPRO is pleased to offer Part 3 of an accredited educational activity based on the recently concluded APSHO Regional Lecture Series. Hosted in collaboration with major cancer centers around the country, the APSHO Regional Lecture Series brought case-based didactic presentations and skills workshops to advanced practitioners. In the spirit of JADPRO, three accredited Grand Rounds articles by Beth Eaby-Sandy, MSN, CRNP,

Managing anemia in lymphoma and multiple myeloma.

Anemia is common in cancer, and lymphoproliferative disease is no exception. Erythropoiesis-stimulating agents (ESA) have been used for renal anemia since 1986, and considerably later in cancer anemia. The first studies were published around 1993, but the use of ESA did not become common in cancer anemia until in the late 1990s. Cancer anemia is still under-treated. This review gives an overview of the use of ESA in hematologic malignancies. A background is given about this treatment in the cancer field generally. The pathophysiology of cancer anemia is described with special emphasis on the d

Exploring the applicability, combined strategies, and challenges of ablation in hematology based on its characteristics and immunomodulatory mechanisms.

Malignant hematological diseases, such as lymphoma, leukemia, and multiple myeloma, are frequently accompanied by clinical challenges including local progressive lesions, relapsed/refractory conditions, and poor tolerance to standard treatments in special populations. Systemic therapies represented by chemotherapy and targeted therapy have inherent limitations in addressing local tumor burden, relieving organ compression, and being suitable for frail patients. As a minimally invasive local treatment technology, ablation has been widely used in solid tumor therapy due to its advantages of preci

Electroretinographic dysfunction, insulin resistance, and childhood trauma in early-course psychosis: A case-control exploratory study.

BACKGROUND: Subarachnoid hemorrhage (SAH) is characterized by intense central inflammation, leading to substantial post-hemorrhagic complications such as vasospasm and delayed cerebral ischemia. Given the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation (taVNS) and its ability to promote brain plasticity, taVNS has emerged as a promising therapeutic option for SAH patients. However, the effects of taVNS on cardiovascular dynamics in critically ill patients, like those with SAH, have not yet been investigated. Given the association between cardiac complications and e

The Role of Monoclonal Antibodies in the Era of Bi-Specifics Antibodies and CAR T Cell Therapy in Multiple Myeloma.

Multiple myeloma (MM) remains largely incurable despite enormous improvement in the outcome of patients. Over the past decade, we have witnessed the "era of monoclonal antibody (moAb)", setting new benchmarks in clinical outcomes for relapsed and newly diagnosed MM. Due to their excellent efficacy and relative safe toxicity profile, moAbs in combination with immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs) have become the new backbone of upfront anti-MM therapy. Yet, most patients will eventually relapse and patients who become refractory to IMiDs, PIs and moAbs have a dismal out

Knowledge Mapping of Acupuncture for Cancer Pain: A Scientometric Analysis (2000-2019).

OBJECTIVE: This study aimed to demonstrate the state of the present situation and trends concerning the global use of acupuncture for cancer pain in the past 20 years. METHODS: Searched the Web of Science database from 2000 to 2019 related to acupuncture for cancer pain, and then used CiteSpace to conduct scientometric analysis to acquire the knowledge mapping. RESULTS: Yearly output has increased year by year, and the growth rate has become faster after 2012. According to the cluster analysis of institutions, authors, cited references, and keywords, 4, 4, 15, and 14 categories were obtained

Maintenance Therapy in AML.

Recent advances in therapeutics coupled with steady improvements in supportive care for patients with acute myeloid leukemia (AML) have led to improved outcomes. Despite these advances, even in patients that achieve a complete remission with initial therapy high rates of relapse remain a clinical dilemma. For decades, investigators have attempted strategies of maintenance therapy to prolong both remission duration and overall survival in patients with AML. These approaches have included cytotoxic chemotherapy, immunotherapy, hypomethylating agents, and targeted small molecule therapy. Overall,

Killing me softly--future challenges in apoptosis research.

The induction of apoptosis, a highly regulated and clearly defined mode of cell dying, is a vital tenet of modern cancer therapy. In this review we focus on three aspects of apoptosis research which we believe are the most crucial and most exciting areas currently investigated and that will need to be better understood in order to enhance the efficacy of therapeutic measures. First, we discuss which target to select for cancer therapy and argue that not the cancer cell as such, but its interaction with the microenvironment is a more promising and genetically stable site of attack. Second, the

Precision Medicine Through Network Language: Integrating Clinical Insight and Data Expertise.

Precision medicine is facing a critical transition driven by the growing complexity of biological data and the insufficient ability of current models to translate such data into clinically meaningful information. Linear, single-gene approaches are no longer adequate to explain the multifactorial nature of most modern diseases, whose phenotypes emerge from combinations of genetic, molecular, and environmental factors. Network-based precision medicine addresses this by providing a systemic framework capable of integrating heterogeneous omics data, interactomes, and clinical information to identi

Ручная обработка против методов извлечения глубоких признаков для диагностики множественной скlerоза на основе МРТ.

Фон: Несмотря на значительные продвижения в анализе медицинских изображений, автоматический диагноз множественной скlerоза (МС) на основе магнитно-резонансной томографии (МРТ) остается сложной задачей из-за сложности 3D-данных мозга и вариабельности вида плоскостей поражений. Цель: В этой работе мы предлагаем эффективную и оптимизированную систему извлечения признаков для автоматического диагноза МС с использованием МРТ с весом FLAIR, T1 и T2. Предложенный подход улучшает Декимальные Дескрипторные Паттерны (DDP) за счет интеграции локальной информации градиента, создавая 3D-представление текст

CAR-T cell therapy clinical trials: global progress, challenges, and future directions from ClinicalTrials.gov insights.

Chimeric antigen receptor T (CAR-T) cell therapy has undergone vigorous development in recent years, yet it still faces significant challenges and difficulties in its clinical application and further development. A systematic synthesis of global trends in CAR-T clinical trials is essential to identify knowledge gaps, optimize treatment strategies, and guide future research directions. This review analyzed 1,580 CAR-T clinical trials registered at ClinicalTrials.gov as of April 2024, and extracted characteristic data in multiple dimensions, including target specificity, treatment indication, an

Mobile health applications for supporting self-management of oral systemic anticancer therapy in haematological malignancies: A systematic review of acceptability and efficacy.

BACKGROUND: The acceptability and impact of mobile health (mHealth) applications on health outcomes in haemato-oncology remain unclear, particularly for patients undergoing long-term oral systematic anticancer therapy (SACT). PURPOSE: This systematic review investigated the acceptability and efficacy of mHealth applications in facilitating self-management of oral SACT in patients with haematological malignancies. METHODS: We conducted a comprehensive search of five electronic databases, PubMed, PsycINFO, CINAHL, Cochrane Library, and Web of Science, until October 2024, and extracted data, in

Применение телемедицины в лечении усталости пациентов с множественным склерозом: обзор аналитического исследования.

Усталость является распространенным симптомом у людей с множественным склерозом, однако доказательства эффективности телемедицины в лечении этого симптома остаются неполными. Несмотря на положительные результаты клинических испытаний, его учет в практической деятельности и систематическая оценка являются ограниченными. ЦЕЛЬ: Цель этого исследовательского проекта заключается в тщательной оценке того, насколько хорошо телемедицина помогает пациентам, страдающим от усталости. МЕТОДЫ: Этот аналитический обзор проводился в соответствии с методологической основой Института Джоанны Бриггс и с учетом

Текстурный анализ и искусственный интеллект как инструменты поддержки решений в диагностике множественного склероза - систематический обзор.

ВВЕДЕНИЕ: Магнитная резонансная визуализация (MRI) обычно используется для обнаружения и диагностики множественных склерозов (MS), часто дополняемых поясничными проколами - очень инвазивным методом для подтверждения диагноза. Кроме того, МРТ периодически повторяется для контроля за развитием и эффективностью лечения заболеваний. В ходе недавних исследований основное внимание уделялось применению искусственного интеллекта (АИ) и радиомики при обработке медицинских изображений, диагностике и планировании лечения. МЕТОДЫ: Был проведен обзор существующей литературы с анализом использования моделей

Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study.

BackgroundPatients with refractory or relapsed haematological malignancies have few treatment options and short survival times. Identification of effective therapies with genomic-based precision medicine is hampered by intratumour heterogeneity and incomplete understanding of the contribution of various mutations within specific cancer phenotypes. Ex-vivo drug-response profiling in patient biopsies might aid effective treatment identification; however, proof of its clinical utility is limited.MethodsWe investigated the feasibility and clinical impact of multiparametric, single-cell, drug-respo

From economic burden to patient-centered solutions: the evolving landscape of financial toxicity in oncology.

BackgroundFinancial burden has emerged as a significant challenge in oncology, adversely affecting patients' quality of life, treatment adherence, and long-term outcomes. While research on cancer-related financial toxicity (FT) has grown rapidly, a comprehensive bibliometric analysis of its knowledge structure, thematic evolution, and emerging trends remains scarce.MethodsPublications on FT among cancer patients, published from 2003 to January 19, 2026, were retrieved from the Web of Science Core Collection and Scopus databases. Bibliometric and science mapping analyses were conducted using Ci