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Blastic plasmacytoid dendritic cell neoplasm: a short review and update.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic neoplasm (less than 1% of primary cutaneous lymphomas and acute leukemia) with a highly aggressive clinical course and frequent skin, bone marrow and central nervous system involvement. Even though there is often an early response to chemotherapy, leukemic dissemination relapses are very common and result in poor outcomes, with a median overall survival of 8 to 14 months in the first-line setting using standard combination chemotherapy regimens. Almost 90% of patients experience skin involvement as their initial site of

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… MPDCP is associated with a poor outcome. 5 Beyond myeloid neoplasms, pDCs are also present in the reactive lymph nodes and skin of patients with Kikuchi lymphadenitis, Castleman hyaline vascular disease and lupus erythematosus. 5 Epidemiology, pathogenesis and genetic features BPDCN represents less …

Network pharmacology- and molecular docking-based investigation of the therapeutic potential and mechanism of daucosterol against multiple myeloma.

BackgroundSome studies have shown that daucosterol has potential anti-tumor activity, but its therapeutic effect on multiple myeloma (MM) has not been reported. This study aimed to evaluate the therapeutic effect daucosterol against MM and explore its possible mechanism through network pharmacology.MethodsWe collected daucosterol and approved drugs for MM, and their potential target profiles were obtained. We used 2 major methods to collect the gene sets related to the physiological process of MM. Based on the protein-protein interaction (PPI) network in the STRING database, the correlation be

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… Study on the mechanism of Ginseng-Gegen for mesenteric lymphadenitis based on network pharmacology. Transl Pediatr 2022;11:1534-43. 10.21037/tp-22-386 23. Song T, Wang G, Ding M, et al. Network-Based Approaches for Drug Repositioning. Mol Inform 2022;41:e2100200. 10.1002/minf.202100200 24. …

Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database).

Percutaneous coronary intervention (PCI) improves anginal chest pain in most, but not all, treated patients. PCI is associated with unplanned readmission for angina and non-specific chest pain within 30-days of index PCI. Patients with an index hospitalization for PCI between January-November in each of the years 2010-2014 were included from the United States Nationwide Readmissions Database. Of 2 723 455 included patients, the 30-day unplanned readmission rate was 7.2% (n = 196 581, 42.3% female). This included 9.8% (n = 19 183) with angina and 11.1% (n = 21 714) with non-specific chest pain.

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… connective tissue disorders 211 | Other connective tissue disease 212 | Other bone disease and musculoskeletal deformities 217 | Other congenital anomalies 237 | Complication of device; implant or graft 238 | Complications of surgical procedure or medical care 240 | Burns 246 | Fever of unknown origin 247 | Lymphadenitis …

Combinational Antitumor Strategies Based on the Active Ingredients of Toad Skin and Toad Venom.

A multidrug combination strategy is an important mean to improve the treatment of cancer and is the mainstream scheme of clinical cancer treatment. The active ingredients of traditional Chinese medicine, represented by toad skin and toad venom, have the advantages of high efficiency, low toxicity, wide action and multiple targets and have become ideal targets in combined treatment strategies for tumors in recent years. Toad skin and toad venom are traditional Chinese animal medicines derived from Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider that have shown excellent therapeutic

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… Wine Processed Trogopteri Faeces, Wine Processed Angelicae Sinensis Radix, Pini Ink, Momordicae Semen Dispersing knots and relieving swelling, dispersing stasis and relieving pain It is used for initial Yin gangrene, unchanged skin color, hard and painful swelling, multiple abscess, thyroid tumor, lymphadenitis … Drug Standards of the National State Food and Drug Administration, WS 3 -B-3919-98-1 Jiawei Xihuang pill (加味西黄丸) | Bovis Calculus Artifactus, Myrrha, Artificial Musk, Bufonis Venenum, Olibanum | Detoxifying and dispersing knots, relieving swelling and pain | For carbuncle and sore, multiple abscesses, lymphadenitis …

Viruses

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Multisystemic sarcoidosis-important lessons learnt from one of the great imitators.

We report a case of a woman who was admitted with a suspicion of metastatic malignancy of unknown primary origin. A few months prior to her admission, she presented to a rheumatologist with acute anterior uveitis, psoriasiform rashes and polyarthritis. A diagnosis of psoriatic arthropathy was made and she was treated accordingly. Soon after she presented with persistent back and right upper quadrant abdominal pain for which she had a CT scan done with evidence of hilar lymphadenopathy, liver hypodensities and lytic-sclerotic bone lesions. She was referred to our hospital for further investigat

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… This is then usually followed by a chronic suppurative phase during which patients develop lung involvement, subcutaneous abscesses, lymphadenitis, and possibly even suppurative parotitis and granulomatous osteomyelitis. 15–17 Histological findings of melioidosis vary widely, depending on the clinical …

Esid 2014 oral presentations.

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Plasmacytoid Dendritic Cells as a Novel Cell-Based Cancer Immunotherapy.

Plasmacytoid dendritic cells (pDCs) are multifaceted immune cells with a wide range of innate and adaptive immunological functions. They constitute the first line of defence against multiple viral infections and have also been reported to actively participate in antitumor immune responses. The clinical implication of the presence of pDCs in the tumor microenvironment (TME) is still ambiguous, but it is clear that pDCs possess the ability to modulate tumor-specific T cell responses and direct cytotoxic functions. Therapeutic strategies designed to exploit these qualities of pDCs to boost tumor-

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… Grade 3 adverse events (pain and lymphadenitis). | Antigen-specific T cells Recruitment of anti-vaccine T cells into the tumor bed | Stable disease for 16 to 48 weeks in 4 patients | Charles, Chaperot et al., 2020 [ 31 ] J Charles NCT02692976 | Completed | W R Gerritsen | Radboud University Nijmegen …

Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (rhu GM-CSF) as Adjuvant Therapy for Invasive Fungal Diseases.

BackgroundSargramostim (yeast-derived, glycosylated recombinant human granulocyte-macrophage colony-stimulating factor [rhu GM-CSF]) augments innate and adaptive immune responses and accelerates hematopoietic recovery of chemotherapy-induced neutropenia. However, considerably less is known about its efficacy as adjunctive immunotherapy against invasive fungal diseases (IFDs).MethodsThe clinical courses of 15 patients with pediatric malignancies and IFDs treated adjunctively with sargramostim at a single institution were analyzed in a retrospective cohort review. Further, a systematic review of

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… Development of purulent inguinal lymphadenitis on day 14 of cytokine therapy. …

A comprehensive update of extracutaneous involvement of mycosis fungoides: A narrative review of literature.

Mycosis fungoides, the most prevalent subtype of cutaneous T-cell lymphoma, primarily targets areas of the skin that of not exposed to sunlight. Nevertheless, it can involve extracutaneous tissues at any disease stage, especially during its advanced phases. Research suggests that all extracutaneous organs might be susceptible, though such cases are more commonly reported in autopsy studies and less so in clinical setting. The most recent comprehensive review of such extracutaneous manifestations in mycosis fungoides occurred almost a decade ago. With the aim of enhancing clinicians' understand

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… T-cell clonality analysis is a crucial tool for differentiating between benign dermatopathic lymphadenitis and early LN involvement. [ 22 ] The consistent identification of identical dominant T-cell clones in both skin and lymph node biopsies via Genescan analysis across various cases suggests that these …

A review of feline infectious peritonitis virus infection.

Feline infectious peritonitis (FIP) is an infectious disease characterized by non-specific laboratory changes and clinical signs. Clinical symptoms include anorexia, jaundice, fever, and weight loss. Moreover, some lesions are found in the digestive and respiratory systems. FIP, whose virulence varies, cannot be distinguished using several diagnostic methods. Moreover, feline coronaviruses (FCoVs) can be classified into two serotypes based on differences in their amino acid sequences, spike (S) protein sequences, and antibody (Ab) neutralization. There are two pathotypes, namely those caused b

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… The lesions include hepatitis/capsulitis, pancreatitis, ascites or abdominal effusion, serositis/leiomyositis, lymphadenitis, jaundice, perivasculitis, and uveitis. In addition, necrotizing interstitial nephritis has been noted in the kidneys [ 57 ]. …

New Insights Into the Role of Neutrophils in Lymphoma.

Under physiological conditions, neutrophils exhibit remarkable tissue surveillance capabilities, infiltrating interstitial spaces within secondary lymphoid organs such as lymph nodes and spleen, and even actively patrolling nodal tissues. These observations provide groundbreaking insight into the functional heterogeneity of neutrophils while offering new perspectives on the tumor microenvironment (TME) in lymphomas. A critical question arises: what roles might these specialized, lymphoid tissue-resident neutrophils play in lymphomagenesis through their unique phenotypic and functional adaptati

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… CD11b + CD15 + PMN‐MDSCs were significantly elevated in NHL patients compared with those with lymphadenitis and were identified as an independent prognostic factor [ 101 ]. …

Integumentary System

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Ход работы сессии 28th Европейский конгресс педиатрической ремуматологии (ПСР) 2022) Прага, Чешская Республика. 20-23 сентябрь 2022.

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Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

Proceedings of the 27th European Paediatric Rheumatology Congress (PReS 2021) : Virtual. 19-21 September 2021

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Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… Paracoccidioidomycosis symptoms resemble numerous other infections (e.g., tuberculosis) and noninfectious diseases (e.g., sarcoidosis) and include cough, dyspnea, fatigue, fever, hepatosplenomegaly, lesions in the mouth and throat, lymphadenitis, weight loss [ 239 ]. …

Сердечно-сосудистые заболевания

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… Obviously this requires differentiation from hypoproteinemic states, vasculitis, thrombophlebitis, lymphadenitis, or other less common diseases. …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

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… In three children out of eight, pathohistological diagnosis of lymphadenitis granulomatosa was obtained. In one of them PH diagnosis of Lymphadenitis tuberculosa caseoproductiva was excluded after serological confirmance by MAT (1:640). … The high per cent of persisted lymphadenopathy, recurrence of lymphadenitis and surgical approach (biopsy and incision), pointed out to greater resistance of F. tularesis on antibiotics. …