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A combination of Semen Cuscutae and Fructus Lycii improves testicular cell proliferation and inhibits their apoptosis in rats with spermatogenic dysfunction by regulating the SCF/c-kit--PI3K--Bcl-2 pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Semen Cuscutae is the seed of Cuscuta japonica Choisy, and Fructus Lycii is the mature fruit of Lycium barbarum L. (Solanaceae). Semen Cuscutae and Fructus Lycii (SC-FL) are well-known Chinese medicine which have been used to tonify the kidney and replenish the essence for thousands of years. Chinese physicians prefer to prescribe them for treating male infertility. Recent studies have found that SC-FL repair spermatogenic dysfunction, however, the therapeutic mechanism has yet to be clearly elucidated. AIM OF THE STUDY: This study aimed at evaluating the thera…

Traditional ethnobotanical knowledge of important local plants in Sudhnoti, Azad Kashmir, Pakistan.

This research purpose was focused to document the traditional ethnobotanical knowledge (TEK) associated with important wild plants and indig … the popularity of these plants used in various TEMs and among these Artemisia maritima and Berberis lycium were the most common. The DMR indicated that Pinus roxburghii was the most common species being used for multipurpose by the indigenous communities. The highest use value index was found for Indigofera linifolia. The relative frequency of citations …

Comparative study of alveolar bone height and implant survival rate between autogenous bone mixed with platelet rich plasma versus venous blood for maxillary sinus lift augmentation procedure.

Moderate exercise is beneficial to physical and mental health. When the amount of exercise and exercise intensity exceeds a certain limit and reaches the state of exhaustion, oxidative stress levels in the body increase, which can lead to oxidative stress‑associated damage. Lycium barbarum polysaccharide (LBP) is one of the primary active ingredients extracted from wolfberry. Following exhausting exercise in rats, LBP supplements decrease damage to the myocardium and blood vessels, indicating that LBP exerts a protective effect on the cardiovascular system. The Kelch‑like ECH‑associated protei…

Jiajian Shuyu Pills ameliorates cerebral ischemia-reperfusion injury by regulation hippo signaling and the lipid metabolism-ferroptosis axis.

ETHNOPHARMACOLOGICAL RELEVANCE: Ischemic stroke is a life-threatening cerebrovascular disease characterized by focal injury to the central n … icum chuanxiong Hort, Eucommia ulmoides Oliv, Polygala tenuifolia Willd, Acorus tatarinowii Schott, Lycium barbarum L, and Schisandra chinensis (Turcz.) Baill. JJSYP show therapeutic potential for ischemic stroke; however, their bioactive components and molecular mechanisms remain insufficiently defined. AIM OF THE STUDY: This study aimed to evaluate th …

Bridging traditional knowledge and modern discovery: The role of zebrafish in anti-aging research of medicinal and edible traditional Chinese medicine.

BACKGROUND: With the acceleration of global aging, anti-aging research has become a critical frontier in the life sciences. The zebrafish (D … enescence-related signaling pathways. Representative substances, including Astragalus membranaceus, Lycium barbarum, and Panax ginseng, were reported to improve aging-related phenotypes in zebrafish by increasing antioxidant enzyme activities, reducing lipid peroxidation, and modulating p53-/telomerase-associated pathways. These findings support the valu …

Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota.

BACKGROUND: The prevalence and incidence of type 2 diabetes mellitus (T2DM) have dramatically increased. The intestinal flora and its derived metabolites are demonstrated to play vital roles in the etiology and onset of T2DM. Shouhuitongbian (SHTB) is a traditional Chinese formula to treat constipation. SHTB is composed of seven herbs and components of Colla corii asini (CCA) that are obtained from the hide of Equus asinus L.. Some of herbs in SHTB such as Aloe vera (L.) Burm.f., Cassia obtusifolia L., fruits of Lycium barbarum L., and Citrus aurantium L. have shown to improve insulin resistan…

Ethnomedicinal and folklore inventory of wild plants used by rural communities of valley Samahni, District Bhimber Azad Jammu and Kashmir, Pakistan.

The current study describes ethnobotanical (EB) and traditional ethnomedicinal (TEMs) uses of medicinal plants (MPs) of Tehsil Samahni area … t RFC (0.95) was found for Acacia modesta, followed by Boerhavia procumbens (RFC:0.87) and Berberis lycium (RFC:0.85). The relative importance of MPs was calculated by using UVI and Moringa oleifera showed highest (1.38), followed by Zanthoxylum armatum (1.25) and Withania somnifera (1.24) use-values. High UVI of plants depicts that these species are pre …

First Report of Longidorus kuiperi and Rotylenchus eximius from Coastal Sand Dunes in Crete, Greece.

Plant-parasitic nematode species have been reported on several occasions from coastal sand dunes, including Longidorus and Rotylenchus species (Vovlas et al., 2008; De Luca et al., 2009; Mateille et al., 2014). In April 2016, 10 soil samples of 3 to 4 kg from the rhizosphere of Tamarix smyrnensis with different vegetation around (viz. Elymus farctus, Lycium schweinfurthii, Crithmum maritimum, and Arthrocnemum sp.) were collected for diagnosis of plant-parasitic nematodes. The area of sampling was a coastal sand dune near the archeological site of Komos, southwest of Crete, Greece. Low soil pop…

Contributions to the phytotherapies of digestive disorders: Traditional knowledge and cultural drivers of Manoor Valley, Northern Pakistan.

ETHNO PHARMACOLOGICAL RELEVANCE: Ethno medicinal traditional knowledge regarding the uses of indigenous medicinal plants used for various hu … most cited medicinal plant species by the traditional drivers were Ficus carica (0.43) and Berberis lycium (0.41), while most respondents percentage was noticed for same plant species calculated through consensus index (CI%=42.9% and 41.3%) respectively. The medicinal plant species with highest fidelity level was of Grewia optiva, Juglans regia and Sorba …

Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice.

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease featured by memory loss, neuroinflammation and oxidative stress. Overproduction or insufficient clearance of Aβ leads to its pathological aggregation and deposition, which is considered the predominant neuropathological hallmark of AD. Therefore, reducing Aβ levels and inhibiting Aβ-induced neurotoxicity are feasible therapeutic strategies for AD treatment. Wolfberry has been traditionally used as a natural antioxidant and anti-aging product. However, whether wolfberry species has therapeutic potential on AD remains unknown.

Potential of Lycii Radicis Cortex as an Ameliorative Agent for Skeletal Muscle Atrophy.

Lycii Radicis Cortex (LRC) is a traditional medicine in East Asia with various beneficial effects, including antioxidant, anti-inflammatory, anti-tumor, anti-diabetic, and anti-depressant properties. However, its potential effects on skeletal muscle atrophy have not been studied. In this study, the protective effects of LRC extract (LRCE) on dexamethasone (DEX)-induced muscle atrophy were investigated in C2C12 myotubes and mice. We evaluated the effect of LRCE on improving muscle atrophy using a variety of methods, including immunofluorescence staining, quantitative polymerase chain reaction (

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… Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller J. Ethnopharmacol. 2014 152 470 477 10.1016/j.jep.2014.01.029 24512737 21. Kim J.H. Kim E.Y. Lee B. Min J.H. Song D.U. Lim J.M. Eom J.W. Yeom M. Jung H.S. Sohn Y. … Kukoamine B. a spermine alkaloid from Lycium chinense Phytochemistry 1995 38 1529 1531 10.1016/0031-9422(94)00826-F 34. Zhao Q. Li L. Zhu Y. Hou D. Li Y. Guo X. Wang Y. Olatunji O.J. Wan P. Gong K. …

The Potential of Chronotherapy and Nanotherapy-Based Strategies for Glioblastoma Treatment.

Glioblastoma is the most common and aggressive brain tumour in adults, and despite ongoing efforts, effective treatment remains limited. Standard therapies often face challenges because of the tumour's specific biology, its aggressive nature, and the presence of certain physiological barriers in the brain that impede chemotherapeutics from reaching their target. Emerging research in circadian biology highlights the role of the internal circadian clock in tumour progression and treatment response. Evidence suggests that aligning therapy to patients' chronotypes could potentially improve treatme

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… Finally, natural compounds such as Lycium barbarum extract inhibited proliferation and lipogenesis through PER2 upregulation. … cancer cells HIF-1α | Hypoxia-inducible factor 1-alpha HSA | Human serum albumin HSVtk | Herpes simplex virus thymidine kinase ICI | Immune checkpoint inhibitors IDH-1 | Isocitrate dehydrogenase 1 IL-1β | Interleukin-1ß IL6-R | Interleukin 6 receptor INK | Cyclin-dependent kinase inhibitors LbGP | Lycium …

Research Progress on Chinese Herbal Medicine Components Targeting Ferroptosis for Cancer Therapy.

Recent studies indicate that ferroptosis shows unique advantages in oncotherapy, particularly in reversing multidrug resistance (MDR). Despite current therapeutic advancements, the treatment of high-incidence malignancies with dismal prognoses continues to face challenges, including limited clinical efficacy, significant side effects, and drug resistance. In recent years, Chinese herbal medicine (CHM) has gained increasing attention in anti-tumor therapy. CHM bioactive components are highly effective in inducing tumor cell ferroptosis, inhibiting tumor proliferation and migration, and reversin

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… Lycium barbarum polysaccharide (LBP) exerts dose-dependent cytotoxicity, thereby attenuating the proliferation of MCF-7 and MDA-MB-231 breast cancer cells. … Type of Material | Name | Modulation of Ferroptosis | Cell Line(s)/Model | Reference Extract | Tripterygium wilfordii | Inhibition of Nrf2/SLC7A11/ GPX4 pathway | 4T1 | [ 104 ] Extract | Lycium barbarum polysaccharide | Inhibition of xCT/GPX4 axis | MCF-7, MDA-MB-231 | [ 105 ] Extract | BCHE | Upregulation …

Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential.

Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing lo

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… In addition, the anti-pancreatic ductal carcinoma activity of pectin derived from Lycium ruthenicum Murr (LRP3-S1) was evaluated in AsPC-1, PANC-1, and BxPC-3 pancreatic cancer cell lines, finding it inhibited their development in a dose-dependent manner by altering signaling through the mitogen-activated … Isolation and structural characterization of a pectin from Lycium ruthenicum Murr and its anti-pancreatic ductal adenocarcinoma cell activity Carbohydr. Polym. 2019 223 115104 10.1016/j.carbpol.2019.115104 31426957 37. Lord R. Suddle A. Ross P.J. …

Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment.

Chemotherapeutic drugs are indispensable in cancer treatment, but their effectiveness is often lessened because of non-selective toxicity to healthy tissues, which triggers inflammatory pathways that are harmful to vital organs. In addition, tumors' resistance to drugs causes failures in treatment. Chlorogenic acid (5-caffeoylquinic acid, CGA), found in plants and vegetables, is promising in anticancer mechanisms. In vitro and animal studies have indicated that CGA can overcome resistance to conventional chemotherapeutics and alleviate chemotherapy-induced toxicity by scavenging free radicals

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… For example, Pollini et al. demonstrated that the microwave assistance of Lycium barbarum leaf extracts reduced the CGA yield [ 54 ], and that water with different mineralization levels produce different isomerization of CGA after microwave treatment [ 55 ]. … Is the household microwave recommended to obtain antioxidant-rich extracts from Lycium barbarum leaves? Processes. 2021;9:656. doi: 10.3390/pr9040656. 55. Ianni F., Barola C., Blasi F., Moretti S., Galarini R., Cossignani L. …

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines.

Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis is a process of programmed cell death and it plays a vital role in human development and tissue homeostasis. Mounting evidence indicates that apoptosis is closely related to the survival of cancer and it has emerged as a key target for the discovery and development of novel anticancer drugs. Various studies indicate that targeting the apoptotic signaling pathway by anticancer drugs is an important mechanism in cancer therapy. Therefore, numerous novel anticancer agents have been discovered and developed from traditional

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… Cortex lycii radicis, the root bark of Lycium chinense Miller (Solanaceae), has been used as a TCM for the treatment of inflammatory symptoms in China. … (Triptolide, Minnelide), Rubia yunnanensis (RA-XII, rubiarbonol G), Scutellaria baicalensis Georgi (wogonin, baicalein, baicalin), Lycium chinense Miller (Cortex lycii radices), Paeonia lactiflora Pall (paeoniflorin), Nigella sativa | NF-κB Curcuma longa Linn (Curcumin, B63, B19, EF24, WZ26, WZ35, L48H37 …

Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis.

Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the presence of harmful microorganisms in blood which could cause mortality. Complications associated with sepsis involve multiple organ dysfunction. The pathogenesis of sepsis remains intricate, with limited treatment options and high mortality rates. Traditional Chinese medicine (TCM) has consistently demonstrated to have a potential on various disease management. Its complements include reduction of oxidative stress, inhibiting inflammatory pathways, regulating immune responses, and improving microcirculation. Tra

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… . & Thomson) H.Ohba | CLP-induced male BALB/C mice | 5, 10, 20 mg/kg | ↓: α-SMA, FN, Vimentin, Col Ⅰ, p-JAK2, p-STAT3, iNOS, IL-6 ↑: IL-4, IL-10 | Lung | NA | Guo et al. (2022) Kukoamine B | Lycium chinense Mill. | LPS-induced KM mice | 1.25, 2.5, 5 mg/kg | ↓: TLR4, TLR9, iNOS, COX-2, NF-κB, TNF-α, IL … Kukoamine B is an alkaloid component primarily derived from the Chinese medicinal plant Lycium chinense Mill. …

Effects of three flavonoids from an ancient traditional Chinese medicine Radix puerariae on geriatric diseases.

As the worldwide population ages, the morbidity of neurodegenerative, cardiovascular, cerebrovascular, and endocrine diseases, such as diabetes and osteoporosis, continues to increase. The etiology of geriatric diseases is complex, involving the interaction of genes and the environment, which makes effective treatment challenging. Traditional Chinese medicine, unlike Western medicine, uses diverse bioactive ingredients to target multiple signaling pathways in geriatric diseases. Radix puerariae is one of the most widely used ancient traditional Chinese medicines and is also consumed as food. T

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… Zhao H Feng J Emerging roles of Ganoderma lucidum in anti-aging Aging Dis 2017 8 691 707 29344411 10.14336/AD.2017.0410 PMC5758346 4 Wang N Ji S Zhang H Mei S Qiao L Jin X Herba cistanches: Anti-aging Aging Dis 2017 8 740 59 29344414 10.14336/AD.2017.0720 PMC5758349 5 Gao Y Wei Y Wang Y Gao F Chen Z Lycium …

Терапевтическая способность монометилфумарата и иона алюминия к уменьшению воспаления и окислительного стресса в псориазе.

Псориаз представляет собой хроническое воспалительное состояние кожи, характеризующееся эритематическими досками с белыми чешуями. Его патогенез тесно связан с окислительным стрессом и дисбалансом в иммунной реакции Th1/TH2. Нынешние методы лечения псориаза, такие, как актуальные агенты, системная терапия и фототерапия, часто не достигают полной ремиссии в клинических условиях. Монометилфумарат (MMF), который был утвержден Администрацией США по продуктам питания и наркотикам в 2020 году в отношении множественного склероза, продемонстрировал свою эффективность в борьбе с псориазом. Кроме того,

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… Improvement of skin barrier dysfunction by phenolic-containing extracts of lycium barbarum via Nrf2/HO-1 regulation Photochem. Photobiol. 98 1 2022 262 271 34342370 10.1111/php.13498 41 Ma C. Gu C. Lian P. Wazir J. Lu R. Ruan B. Wei L. Li L. Pu W. Peng Z. Wang W. Zong Y. Huang Z. Wang H. Lu Y. …

Естественные соединения серы в состоянии психического здоровья и неврологических расстройств: наблюдения и исследования.

За прошедшие годы глобальное бремя неврологических и психических расстройств значительно возросло, в результате чего они стали одной из наиболее серьезных проблем и вызовов для здоровья человека. В рамках новых методов лечения от болезней и болезней все больше внимания уделяется вопросам питания и здравоохранения. Питание серы, главным образом полученное из различных природных источников, играет решающую роль в многочисленных физиологических процессах, включая функцию мозга. В настоящем обзоре содержится обзор химического состава ряда естественных источников таких богатых серой веществ, как из

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… A study by Zhou et al. proposed that polysaccharides sourced from Lycium barbarum could enhance cognitive functions in APP/PS1 transgenic mice while decreasing Aβ levels ( 141 ). …