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A secondary analysis of data from the OPTICARE randomized controlled trial investigating the effects of extended cardiac rehabilitation on functional capacity, fatigue, and participation in society.

OBJECTIVE: In this secondary analysis of data from the OPTICARE trial, we compared the effects of two behavioral interventions integrated into cardiac rehabilitation to standard rehabilitation with regard to functional capacity, fatigue, and participation in society. DESIGN: This is a randomized controlled trial. SETTING: This study was conducted in a cardiac rehabilitation setting. SUBJECTS: A total of 740 patients with acute coronary syndrome were recruited for this study. INTERVENTIONS: Patients were randomized to (1) three months of standard rehabilitation; (2) cardiac rehabilitation p

Determinants of timeliness in early childhood vaccination among mothers with vaccination cards in Sindh province, Pakistan: a secondary analysis of cross-sectional survey data.

OBJECTIVE: Untimely vaccination refers to receiving the given dose before (early) or after (delayed) the recommended time window. The purpose of this study was to assess the extent of timeliness of childhood vaccinations and examine the determinants of vaccination timeliness in Sindh province, Pakistan. DESIGN: Cross-sectional analysis of data from the 2013 and 2014 Maternal and Child Health Program Indicator Surveys. SETTING: Community-based maternal and child health surveys. PARTICIPANTS: Among 10 200 respondents of Maternal and Child Health Program Indicator Surveys, 1143 women who had a

Determinants of imbalanced sex ratio at birth in Nepal: evidence from secondary analysis of a large hospital-based study and nationally-representative survey data.

OBJECTIVES: To quantify sex ratios at births (SRBs) in hospital deliveries in Nepal, and understand the socio-demographic correlates of skewed SRB. Skewed SRBs in hospitals could be explained by sex selective abortion, and/or by decision to have a son delivered in a hospital-increased in -utero investments for male fetus. We use data on ultrasound use to quantify links between prenatal knowledge of sex, parity and skewed SRBs. DESIGN: Secondary analysis of: (1) de-identified data from a randomizedrandomised controlled trial, and (2) 2011 Nepal Demographic and Health Survey (NDHS). SETTING: N

The contribution of pain in determining the health status of cancer patients with bone metastases: A secondary analysis of data from three Phase III registration trials.

BACKGROUND: We aimed to provide a simple, descriptive health-status profile for cancer patients with bone metastases, based on the EuroQol EQ-5D, a tool commonly used to measure health utility scores, and to evaluate its association with the Brief Pain Inventory (BPI), a legacy pain-assessment tool. Although pain is one of five health-status dimensions measured by the EQ-5D, our understanding of how pain relates to the other EQ-5D dimensions is limited. METHODS: We derived data from 5500 patients with bone metastases who completed the EQ-5D and BPI. Regression analyses examined how BPI severi

Oral and injectable contraceptive use and HIV acquisition risk among women in four African countries: a secondary analysis of data from a microbicide trial.

OBJECTIVE: To assess the effect of oral and injectable contraceptive use compared to nonhormonal contraceptive use on HIV acquisition among Southern African women enrolled in a microbicide trial. STUDY DESIGN: This is a prospective cohort study using data from women enrolled in HIV Prevention Trials Network protocol 035. At each quarterly visit, participants were interviewed about self-reported contraceptive use and sexual behaviors and underwent HIV testing. Cox proportional hazards regression was used to assess the effect of injectable and oral hormonal contraceptive use on HIV acquisition.

Effect of dynamic humeral centring (DHC) treatment on painful active elevation of the arm in subacromial impingement syndrome. Secondary analysis of data from an RCT.

BACKGROUND: The physiotherapy dynamic humeral centring (DHC) aims to prevent subacromial impingement of rotator cuff tendons during elevation of the arm. The objective of the study was to determine whether DHC acts via an effect on subacromial impingement mechanism by assessing its effect on painful elevation of the arm in subacromial impingement syndrome. METHODS: This is a secondary analysis of results of a randomised controlled trial of the effectiveness of DHC. Sixty-nine patients with subacromial impingement syndrome were prospectively included. Patients and the assessor were blinded to

[Data on a study of the nature of secondary immunodeficient states. I. An immunophysiological analysis of the mechanisms of allergic reaction suppression in experimental lesion of the structures of the dorsal hippocampus].

Experiments on rabbits demonstrated that local electrocoagulation of the dorsal hyppocampus portions by means of the implanted electrodes caused reduction of the complementary and lysozyme activity of the blood serum, inhibited the development of Arthus' skin allergic-reaction, decreased the intensity of systemic anaphylaxis to the blood serum antigens, this being accompanied by a relative fall of the precipitating antibodies titres and a reduction of the vagus response of the heart to adrenaline.

Associations between reproductive health factors and sociodemographic characteristics and the severity of moderate to severe postmenopausal depression: a secondary analysis of randomized controlled trial data.

OBJECTIVES: The cessation of the menstrual cycle is associated with numerous physiological changes and symptoms, with depression being common during perimenopause and postmenopause, causing significant impacts on one's life. The objective of this study was to explore the relationship between the severity of moderate to severe postmenopausal depression and reproductive health factors, as well as sociodemographic characteristics. METHODS: This secondary analysis is based on data from a randomized controlled trial conducted at both a psychiatric hospital (Beijing Anding Hospital) and a general h

Factors associated with generalized anxiety disorder in Korean older adults: A secondary data analysis of the 2022 Korea National Health and Nutrition Examination Survey.

PURPOSE: The purpose of this study is to identify the factors influencing generalized anxiety disorder (GAD) in older adults and to provide effective health management directions for GAD patients. METHODS: This study used data from the 9th National Health and Nutrition Survey (2022) and selected 1,666 older adults. The analysis was conducted using the SPSS 26.0 program. A complex sample chi-square test was performed to identify factors related to GAD. Complex sample logistic regression was conducted to determine the factors influencing GAD in the participants. RESULTS: The study results indi

Exploring dropout in internet-delivered cognitive behavioral therapy for insomnia: A secondary analysis of prevalence, self-reported reasons, and baseline and intervention data as predictors.

INTRODUCTION: Internet-delivered cognitive behavioral therapy for insomnia (iCBT-I) is an effective treatment. However, dropout is a common challenge in digital therapeutics. This study examines dropout in iCBT-I by analyzing reported reasons for dropout and investigating whether baseline variables and intervention usage data can predict dropout. METHODS: This is an exploratory secondary analysis of a clinical trial investigating a stepped care model for insomnia featuring an eight-module iCBT-I. Reasons for dropout from the iCBT-I were assessed via self-developed items in follow-up surveys,

Characterising life-space mobility and its relationship to physical capacity and outdoor walking in older adults with difficulty walking outdoors: a secondary data analysis.

PURPOSE: To describe life-space mobility (LSM) and its relationship with physical capacity (PC) (walking endurance, walking speed, leg strength, balance), and outdoor walking in older adults with difficulty walking outdoors. METHODS: A secondary analysis of baseline data from 173 adults aged ≥ 65 years with mobility limitations in the Getting Older Adults Outdoors (GO-OUT) study was conducted. LSM was measured using the Life-space Assessment (LSA), and PC was assessed using the 6-minute walk test (6MWT), 10-meter walk test (10mWT) at a comfortable and fast pace, 30-second sit-to-stand (30sSTS

The Palliative Care Needs of Patients with Multiple Sclerosis, Parkinson's Related Diseases, and Motor Neurone Disease: A Secondary Analysis of the OPTCARE Neuro Trial Data.

Background: Long-term neurological conditions include multiple sclerosis, Parkinson's-related diseases, and motor neurone disease. National and international guidelines recommend a palliative approach for advancing neurological disease, but there is little research describing and comparing the palliative care needs of these patients side by side. Objective: The aim of this study was to describe and compare the symptom burden and psychological distress of patients with multiple sclerosis, Parkinson's-related diseases, and motor neurone disease. Design: A cross-sectional secondary analysis of th

Predictive factors of substance misuse and abuse in South Korean adolescents: a secondary data analysis of the 2021 Youth Risk Behavior Web-based Survey.

PURPOSE: This study aimed to identify the general characteristics and health behaviors of students with non-therapeutic substance use. METHODS: This secondary data analysis used data from the 17th Korea Youth Risk Behavior Web-based Survey (2021). Analyses of the 54,848 adolescents used descriptive statistics, the Rao-Scott χ2 test, and logistic regression. RESULTS: The risk factors for substance use among students were anxiety, loneliness, living separately from family, suicidal ideation, e-cigarette use, and high stress. CONCLUSION: The findings help identify the risk factors for non-ther…

Impact of Visceral Obesity on Clinical Outcome and Quality of Life for Patients with Multiple Myeloma: A Secondary Data Analysis of STaMINA (BMT CTN 0702) Trial.

Obesity is a common health problem in patients with multiple myeloma (MM) that has been linked to poor clinical outcomes and quality of life (QoL). We conducted a secondary analysis of the BMT CTN 0702, a randomized, controlled trial comparing outcomes of 3 treatment interventions after a single hematopoietic cell transplantation (HCT) (n = 758), to investigate the impact of visceral obesity, as measured by waist-to-hip ratio (WHR), on clinical outcomes and QoL in MM patients. A total of 549 MM patients, median age 55.5 years, were enrolled in the study. The majority of patients received tripl

Association between consumption of non-nutritive sweeteners and gestational diabetes mellitus in Chilean pregnant women: A secondary data analysis of the CHiMINCs-II cohort.

OBJECTIVE: To evaluate the association between consumed non-nutritive sweeteners (NNS) and gestational diabetes mellitus (GDM) in a cohort of pregnant women from Santiago, Chile. METHODS: This secondary data analysis of a cohort.involved 1,472 pregnant women from the Chilean Maternal-Infant Cohort Study-II (CHiMINCs-II). These women received care at primary health care centers in Puente Alto county, South-Eastern Metropolitan Health Service of Santiago, Chile. NNS consumption was estimated using 24-h dietary recalls and linked to the packaged foods nutrition facts panel. Plasma glucose values…

Воздействие вицеральной ожирения на клинический исход и качество жизни пациентов с множественной миеломой: вторичный анализ данных о СТАМИНЕ (BMT CTN) 0702) Судебное разбирательство

Краткое изложение проблемы ожирения является общей проблемой для здоровья многих пациентов, страдающих миеломой (ММ), и она связана с плохими клиническими результатами и качеством жизни (КОЛ). Мы провели вторичный анализ БМТ CTN 0702, выборочное, контролируемое испытание с сопоставлением результатов three :: лечение после одной пересадки гематополиетических клеток (ГХТ) для изучения воздействия висцерального ожирения, измеряемого соотношением талии и голени (ВПЧ), на клинические результаты и QOL у пациентов с MM. 549 Пациенты ММ, средний возраст 55.5 Годы, были зачислены в исследование. Больши

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… First, although our data were collected prospectively, this approach was a secondary data analysis of the BMT CTN 0702 trial, which was not designed specifically to assess the impact of obesity on MM outcomes. …

Prevalence and predictors of spontaneous preterm births in Nepal: findings from a prospective, population-based pregnancy cohort in rural Nepal-a secondary data analysis.

OBJECTIVE: Preterm birth can have short-term and long-term complications for a child. Socioeconomic factors and pregnancy-related morbidities may be important to predict and prevent preterm births in low-resource settings. The objective of our study was to find prevalence and predictors of spontaneous preterm birth in rural Nepal. DESIGN: This is a secondary observational analysis of trial data (registration number NCT01177111). SETTING: Rural Sarlahi district, Nepal. PARTICIPANTS: 40 119 pregnant women enrolled from 9 September 2010 to 16 January 2017. OUTCOME MEASURES: The outcome variab

Seasonal patterns of malaria, genital infection, nutritional and iron status in non-pregnant and pregnant adolescents in Burkina Faso: a secondary analysis of trial data.

BACKGROUND: Adolescents are considered at high risk of developing iron deficiency. Studies in children indicate that the prevalence of iron deficiency increased with malaria transmission, suggesting malaria seasonally may drive iron deficiency. This paper examines monthly seasonal infection patterns of malaria, abnormal vaginal flora, chorioamnionitis, antibiotic and antimalarial prescriptions, in relation to changes in iron biomarkers and nutritional indices in adolescents living in a rural area of Burkina Faso, in order to assess the requirement for seasonal infection control and nutrition i

Blood pressure thresholds in pregnancy for identifying maternal and infant risk: a secondary analysis of Community-Level Interventions for Pre-eclampsia (CLIP) trial data.

BACKGROUND: Blood pressure measurement is a marker of antenatal care quality. In well resourced settings, lower blood pressure cutoffs for hypertension are associated with adverse pregnancy outcomes. We aimed to study the associations between blood pressure thresholds and adverse outcomes and the diagnostic test properties of these blood pressure cutoffs in low-resource settings. METHODS: We did a secondary analysis of data from 22 intervention clusters in the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials (NCT01911494) in India (n=6), Mozambique (n=6), and P

Factors associated with HIV testing among the general male population in Cambodia: A secondary data analysis of the Demographic Health Survey in 2005, 2010, and 2014.

In Cambodia, the human immunodeficiency virus (HIV) is predominantly transmitted between spouses and casual partners, with men having higher mortality and morbidity from HIV infection than women due to lesser access to healthcare services and antiretroviral therapy. This study aimed to identify the rate of HIV testing and barriers to HIV testing among the general male population in Cambodia. We analyzed secondary data of men who underwent HIV testing at Voluntary Confidential Counseling and Testing (VCCT) sites in 2006-2017 and of male participants in the Cambodia Demographic and Health Survey