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Expert consensus on the clinical application of antibody-drug conjugates in the treatment of malignant tumors (2021 edition).

Antibody-drug conjugates (ADCs) are targeted biological agents composed of a cytotoxic drug linked to a monoclonal antibody through a linker. The monoclonal antibody targets tumor cells and transports small-molecule cytotoxic drugs for specific delivery and minimal off-target side effects. It is necessary for clinicians to understand the molecular characteristics and mechanisms of ADCs. Patients' survival mainly depends on the appropriate dose and course of treatment and also on proper management of adverse reactions. This consensus provides a systematic review of commercially available ADCs a

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… The main symptoms include fever, chills, occasional nausea, vomiting, pain, headache, vertigo, dyspnea, hypotension, rashes, and fatigue. … After administration Fever, chills, or other IRRs of the patient are observed for at least 90 min after the initial dose, and at least 30 min after the subsequent dose. …

Recent advances in management of COVID-19: A review.

The coronavirus disease 2019 (COVID-19) pandemic caused and is still causing significant mortality and economic consequences all over the globe. As of today, there are three U.S Food and Drug administration (FDA) approved vaccines, Pfizer-BioNTech, Moderna and Janssen COVID-19 vaccine. Also, the antiviral drug remdesivir and two combinations of monoclonal antibodies are authorized for Emergency use (EUA) in certain patients. Furthermore, baricitinib was approved in Japan (April 23, 2021). Despite available vaccines and EUA, pharmacological therapy for the prevention and treatment of COVID-19 i

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… Finally, patients could experience nonspecific symptoms such as fever, chills, fatigue, muscle ache, loss of taste and/or smell, headaches and confusion [3] . The Coronavirus enters the host cell via a trimeric spike glycoprotein, or peplomers, which give the viruses their corona-like appearance. … Less commonly patients might also present with sore throat, arthralgia, chills, rhinorrhoea, nausea and vomiting or loss of taste and/or smell. During this phase, the virus is replicating in the upper respiratory tract, mainly the nasal passages. …

Livedoid vasculopathy: A multidisciplinary clinical approach to diagnosis and management.

Livedoid vasculopathy (LV) is a rare, chronic, and occlusive disease of the veins supplying the upper parts of the skin. The pathogenesis of the disease is not precisely understood, and its attacks are often unpredictable but tend to worsen during the summer. LV affects women more often. This increased risk for LV in women might be related to sex-specific physiological conditions, such as pregnancy, or a higher incidence of LV-associated conditions, such as connective tissue diseases, hypercoagulable states, and venous stasis in women. The typical clinical appearance of LV consists of three ma

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… macrophages, T cells, and B cells, leading to decreased cytokine production; reduces immune complex deposition in small vessels; inhibits thromboxane synthetase; decreases vasoconstriction Monthly infusions in the dose of 0.4–2 g/kg over 2–3 consecutive days Allergic reactions, headache, flushing, chills … macrophages, T cells, and B cells, leading to decreased cytokine production; reduces immune complex deposition in small vessels; inhibits thromboxane synthetase; decreases vasoconstriction | Monthly infusions in the dose of 0.4–2 g/kg over 2–3 consecutive days | Allergic reactions, headache, flushing, chills …

Периоперативные соображения для пациентов с множественной миеломой.

Множественная миелома — неизлечимый рак, характеризующийся распространением клональных плазменных клеток, в основном в костном мозге, но вызывающий широкомасштабные системные осложнения. Кроме того, этот рак обычно встречается у пожилых пациентов, которые часто являются слабыми и страдают от многочисленных коморбидов. Общемировая распространенность множественной миеломы неуклонно возрастает, а терапевтические достижения способствуют повышению уровня выживания. Существует несколько осложнений миеломы, о которых анестезиолог должен знать в связи с самим заболеванием, конкретными и подкрепляющими

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… designed to bind two targets simultaneously: tumour-associated surface antigen and patient T cell CD3 antigen Cytolytic immune synapse formed activates the T cell and triggers degranulation, culminating in direct tumour cell lysis Cytokine release syndrome (CRS) - Symptoms: fever, rigor, malaise, fatigue chills …

Роль TP53 и FGFR2 в ходе лечения эндометического рака

Заболеваемость и смертность, вызываемые раком эндомеза, по-прежнему растут во всем мире. В последние годы была предложена новая система стратификации опухолей, основанная на статусе мутации POLE, TP53 и стабильности микроспутников. Цель этого исследования заключалась в анализе обширной группы по генам, которые потенциально могут быть связаны с геномомом эндомеального рака у польского населения. One hundred и three В исследование были зачислены белые пациентки с подтвержденным эндомеозным раком. Мы провели последовательность с использованием панели Hot Spot Illumin и стабильности микроспутников

The ZOTECT study: Effect of zoledronic acid on bone metabolism in patients with bone metastases from prostate or breast cancer.

PurposeThe ZOTECT study assesses the effect of zoledronic acid (ZOL) on bone-marker levels and potential correlations with disease outcomes in bisphosphonate-naive patients.MethodsThis prospective, single-arm, open-label study in bisphosphonate-naive (≥6 months) patients with bone metastases from prostate cancer (PC; n=301) or breast cancer (BC; n=99) enrolled at 98 German sites (May 2006 to July 2008) investigated the effect of ZOL (4 mg intravenously every 4 weeks×4 months, with a final follow-up at 12 months) on bone-marker levels. Secondary assessments: skeletal-related event (SRE) rate, p

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… SAEs | 75 (18.8) Death | 17 (4.3) SAEs with suspected relationship to study drug | 4 (1.0) SAEs leading to discontinuation | 10 (2.5) Frequent AEs (≥ 2.8%; by preferred term) | Bone pain | 45 (11.3) Nausea | 33 (8.3) Fatigue | 25 (6.3) Back pain | 19 (4.8) Constipation | 18 (4.5) Vomiting | 18 (4.5) Chills …

Мультиорганическая неисправность 5 Синдром цитокина у пациента с множественной миеломой после вливания карфилзомиба: доклад о деле.

Фон: Синдром высвобождения цитокина (CRS) представляет собой опасное для жизни системное воспалительное состояние, характеризующееся чрезмерным производством цитокина, что ведет к многоорганической дисфункции. Она обычно связана с Т-комплексными терапиями, такими, как химериковые антигенные рецепторы (CAR) Т клетки, Т-клекторные двуэлементные молекулы и моноклонные антитела. Известно, что карфилзомиб, протеиновый ингибитор, вызывает целый ряд негативных последствий, в первую очередь гематологическое и сердечно-сосудистое. Тем не менее, многоорганический уровень отказа 5 (Смертельная), аналогич

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… Clinical trials have described mild “flu-like” symptoms, such as fever and chills, however, severe CRS-like reactions are exceedingly rare [ 5 ]. Fatal CRS directly attributed to Carfilzomib has not been reported to date. …

Patient Perceptions of CAR-T Therapy in the USA: Findings from In-Depth Interviews.

INTRODUCTION: Chimeric antigen receptor-T cell (CAR-T) therapy has revolutionized advanced blood cancer treatment. However, preparation, administration, and recovery from these therapies can be complex and burdensome to patients and their care partners. Utilization of an outpatient setting for CAR-T therapy administration could help improve convenience and quality of life. METHODS: In-depth qualitative interviews were conducted with 18 patients in the USA with relapsed/refractory multiple myeloma or relapsed/refractory diffuse large B-cell lymphoma, 10 of whom had completed investigational or

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… The most common side effect of CAR-T therapy is cytokine release syndrome (CRS) [ 5 ], an immune response characterized by symptoms ranging from mild (fever, chills, fatigue, etc.) to severe (alterations in blood pressure and heart rate, organ damage, and possible death). …

SARS-CoV-2/COVID-19 and its relationship with NOD2 and ubiquitination.

COVID-19 infection activates the immune system to cause autoimmune and autoinflammatory diseases. We provide a comprehensive review of the relationship between SARS-CoV-2, NOD2 and ubiquitination. COVID-19 infection partly results from host inborn errors and genetic factors and can lead to autoinflammatory disease. The interaction between defective NOD2 and viral infection may trigger NOD2-associated disease. SARS-CoV-2 can alter UBA1 and abnormal ubiquitination leading to VEXAS syndrome. Both NOD2 and ubiquitination play important roles in controlling inflammatory process. Receptor interactin

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… With steroid taper, he developed high fever, chills, sore throat, nonproductive cough, and abdominal cramping with transient non-bloody diarrhea. Subsequently, he had another episode of high fevers and right periorbital cellulitis unresponsive to antibiotics. …

Practical Considerations for the Daratumumab Management in Portuguese Routine Clinical Practice: Recommendations From an Expert Panel of Hematologists.

The recent therapeutic progress in multiple myeloma (MM) has led to the introduction of novel and highly potent drug classes. Daratumumab was the first CD38-targeting antibody showing to be effective and safe in MM patients as monotherapy and in combination regimens, which led to its rapid implementation in clinical practice. Considering that treatment discontinuation for drug-related adverse events can impact patients' quality of life and outcomes, the treatment decision should consider different factors and be weighted for each patient individually. Here, we aimed to guide clinicians using d

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… From a pooled analysis of two daratumumab trials, IRRs were observed in 48% of the patients and consisted mainly of nasal congestion, cough, allergic rhinitis, throat irritation, chills, vomiting, and nausea ( 18 , 25 , 26 ). …

EMA Review of Daratumumab for the Treatment of Adult Patients with Multiple Myeloma.

On May 20, 2016, a conditional marketing authorization valid through the European Union (EU) was issued for daratumumab as monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma, whose prior therapy included a proteasome inhibitor (PI) and an immunomodulatory drug (IMiD) and who had demonstrated disease progression on the last therapy. The review of daratumumab was conducted under the EMA's accelerated assessment program for drugs that are of major interest for public health, especially from the point of view of therapeutic innovation.Daratumumab monother

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… Symptoms predominantly included nasal congestion, cough, throat irritation, chills, vomiting, and nausea. Severe IRRs included bronchospasm, dyspnea, laryngeal edema, pulmonary edema, hypoxia, and hypertension. …

Utility of blood procalcitonin concentration in the management of cancer patients with infections.

Diagnosis of infections in cancer patients is usually problematic since differentiating between infection and fever of unknown origin is often a considerable clinical challenge. In general, increase concentration of blood procalcitonin (PCT) is associated with severe bacterial infection. PCT with an optimal cutoff level of 0.5 ng/mL seems to be the most helpful biochemical parameter in detecting severe infections, mainly bloodstream infection, in patients with hematological cancers. In all clinical situations, the elevated level of PCT should be carefully analyzed, always with a thorough physi

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… This finding indicates that not only is PCT specific for bacterial infection but that it also may be a predictor of metastasis and advanced cancer in patients with no suspicion of BSI (no fever or chills). …

Cannabis, One Health, and Veterinary Medicine: Cannabinoids' Role in Public Health, Food Safety, and Translational Medicine.

Public health is connected to cannabis with regard to food, animal feed (feed), and pharmaceuticals. Therefore, the use of phytocannabinoids should be examined from a One Health perspective. Current knowledge on medical cannabis treatment (MCT) does not address sufficiently diseases which are of epidemiological and of zoonotic concern. The use of cannabinoids in veterinary medicine is illegal in most countries, mostly due to lack of evidence-based medicine. To answer the growing need of scientific evidence-based applicable medicine in both human and veterinary medicine, a new approach for the

Oxyphenbutazone ameliorates carfilzomib induced cardiotoxicity in rats via inhibition of oxidative free radical burst and NF-κB/IκB-α pathway.

Carfilzomib (CFZ), a chemotherapeutic agent used for multiple myeloma treatments reported to cause high incidence of cardiac events either new onset and/or exacerbate formerly diagnosed heart failure with ventricular and myocardial dysfunction. Purpose: Current research designed to explore and examine the preventive effect of oxyphenbutazone in the CFZ -instigated cardiotoxicity. Methodology: Female Wistar Rats weighing 200-250 g selected randomly and grouped as follows: Group 1 designated as the Normal control and receive normal saline only. Group 2 served toxic control and exposed to CFZ (4

Unleashing the Impact of Exosomes Derived from Human Placental Mesenchymal Stem Cells (hPMSCs) on U-266 Myeloma Cell Line.

Multiple myeloma (MM) is a malignancy of plasma cells, terminally differentiated B cells, with complications like hypercalcemia, renal failure, anemia, and bone disease, which are also known as CRAB criteria. MM develops from monoclonal gammopathy of unknown significance (MGUS), a pre-malignant plasma cell dyscrasia. Over some time, MGUS has the potential to progress into smoldering multiple myeloma (SMM), which can evolve into MM. MM rarely progresses into plasma cell leukemia (PCL), a condition in which malignant plasma cells no longer stay in the bone marrow niche and circulate in the perip

The Use of Imaging in Management of Patients with Low Back Pain.

Lower back pain (LBP) is one of the most common chief complaints encountered in primary care. Advanced imaging studies, including computerized tomography (CT) and magnetic resonance imaging (MRI), are frequently ordered in the setting of LBP. Structural abnormalities are commonly identified by CT and MRI in patients complaining of low back pain, however, these findings are also found in asymptomatic patients. In the past decade, multiple guidelines have been published to help providers identify patients in whom the use of advanced imaging is appropriate. In this article, we review common condi

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… Constitutional symptoms such as chills, night sweats, and weight loss may not be consistently present, but raise suspicion for infection when present.[ 32 ] White blood cell count may be normal, while erythrocyte sedimentation rate and C-reactive protein are usually, but not always, elevated.[ 32 33 …

Concurrent whole brain radiotherapy and bortezomib for brain metastasis.

BackgroundSurvival of patients with brain metastasis particularly from historically more radio-resistant malignancies remains dismal. A phase I study of concurrent bortezomib and whole brain radiotherapy was conducted to determine the tolerance and safety of this approach in patients with previously untreated brain metastasis.MethodsA phase I dose escalation study evaluated the safety of bortezomib (0.9, 1.1, 1.3, 1.5, and 1.7 mg/m2) given on days 1, 4, 8 and 11 of whole brain radiotherapy. Patients with confirmed brain metastasis were recruited for participation. The primary endpoint was the

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… Hyponatremia | | 1 # | Other | | | | | | | | | | Fatigue | 3 | | 2 | | 3 | | 1 | | 4 | Alopecia | 3 | | | | 1 | | 1 | | Sweating | 1 | | | | | | | | Edema | 1 Mucositis | | | 1 | 1 Pain (scalp) | | | | | | | 1 | | 1 Pain (extremity) | | | | | | | | | 1 Chills …

Plesiomonas shigelloides Bacteremia: A Scoping Review of Epidemiology, Clinical Characteristics, Outcomes, and Implications of Antimicrobial Stewardship.

Plesiomonas shigelloides, an aquatic Gram-negative bacillus often associated with self-limiting gastroenteritis, has been reported worldwide. However, to date, no reviews have specifically investigated P. shigelloides bacteremia, which is rare and potentially fatal. This scoping review aimed to examine the existing literature to identify the epidemiology, clinical characteristics, antimicrobial susceptibility, and outcomes of P. shigelloides bacteremia. A PRISMA-ScR-guided search of PubMed, Scopus, Web of Science, and Embase identified 22 published cases, all reported as single-patient case re

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… Fever was the most frequently reported symptom, occurring in the majority of cases [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 18 , 19 , 20 , 21 , 24 , 30 , 31 ], and was often accompanied by other systemic inflammatory signs such as chills [ 10 , 11 , 15 , 20 , 24 ]. …

Treatment of relapsed or refractory Hodgkin's lymphoma with lenalidomide combined with PD-1 monoclonal antibody: a case report and literature review.

The current standard treatment for relapsed or refractory Hodgkin's lymphoma involves salvage chemotherapy followed by high-dose chemotherapy and sequential autologous stem cell transplantation. However, for patients who cannot tolerate intense chemotherapy or do not meet the conditions for autologous stem cell transplantation, there is a need to explore new treatment options. We report a case of an elderly patient with multiple relapses of classical Hodgkin's lymphoma who experienced repeated disease progression despite undergoing multiple lines of treatment including novel agents such as CD3

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… On June 2nd, 2020, the patient developed fever again in the afternoon, with a temperature of up to 39.3°C, not accompanied by chills, cough, or other discomfort. Infection indicators were negative, and a whole-body PET/CT scan ( Figure 2 ) suggested progression of the primary disease. …

Framework for integrating electronic patient-reported data in routine cancer care: an Oncology Intake Questionnaire.

ObjectiveAs part of ongoing implementation of electronic patient-reported outcome tools at the Dana-Farber Cancer Institute, here we describe the development of the electronic New Patient Intake Questionnaire.Materials and methodsThe original New Patient Intake Questionnaire includes a review of symptoms, oncology history, family history, health behaviors, health and social status, health literacy and numeracy, which was modified for integration into the EHR using content determination, build and configuration, implementation, analytics, and interventions. The engagement of key stakeholders, i

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… | Symptom | Answer | Fever | Yes | No | Chills | Yes | No | Night sweats | Yes | No | Fatigue | Yes | No | Loss of appetite | Yes | No | Irregular heartbeats | Yes | No | Shortness of breath or difficulty breathing | Yes | No | Cough | Yes | No | Wheeze | Yes | No | Headaches | Yes | No | …