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Doxorubicin-induced cardiac dysfunction in unselected patients with a history of early-stage breast cancer.

Cardiomyopathy is a known complication of anthracycline-based adjuvant chemotherapy and is more commonly reported in population-based studies of breast cancer survivors than in clinical trials. This study prospectively evaluated the prevalence of elevated cardiac biomarkers in unselected patients who had been treated with doxorubicin for early-stage breast cancer and the prevalence of reduced LVEF in patients with an elevated biomarker. All participants underwent an examination, symptom inventory, medical record review, and biomarker analysis for BNP, troponin, and plasma and urine NT-proBNP.

Study on the potential role of KIF23 in doxorubicin-induced cardiomyopathy through multi-omics integration and AI-based screening.

OBJECTIVE: Doxorubicin-induced cardiomyopathy (DIC) is a common and severe cardiotoxic effect of doxorubicin (DOX)-based chemotherapy. This study aimed to identify core genes associated with DIC and investigate their immunoregulatory mechanisms. METHODS: Core genes were identified based on GEO datasets by integrating differential expression analysis, WGCNA, and machine learning algorithms. Functional enrichment analysis, immune infiltration analysis, and single-cell RNA sequencing analysis were subsequently performed. In addition, AI-based drug screening, molecular docking, molecular dynamics

Hit-Identification to Novel Antileishmanial Agents from a β‑Pinene Scaffold: from Synthesis to In Vitro Evaluation and In Silico SAR/ADMET Profiling.

β-Pinene, a low-cost natural product derived from agricultural waste, has shown in vitro activity against Leishmania amazonensis, but its use is hindered by unfavorable pharmacokinetic properties. Herein, we report a straightforward two-step synthesis of β-pinene-derived hydroxysulfides followed by an in vitro evaluation of their antileishmanial activity, cytotoxicity profile in mammalian cells, and in silico studies of structure-activity relationship (SAR) and ADMET properties. Initially, β-pinene was converted into its epoxide, the key intermediate of the series, through both chemoenzymatic

Moving geroscience forward in China: proceedings of the first international exchange forum of the Chinese Geriatrics Society.

Held on August 17, 2025 in Guangzhou, the inaugural International Exchange Forum of the Chinese Geriatrics Society marked a significant mile … penia and osteoporosis), cardiovascular aging (tyrosine kinase inhibitor- and anthracycline-induced cardiotoxicity), metabolic regulation (sarcopenic obesity and the gut-muscle axis), neurodegenerative interfaces (androgen-mediated monocyte-microglia interactions in Alzheimer's disease), and geriatric assessment (muscle-specific strength, intrinsic capacity, and …

General structure of scorpion venom and its influence on morphological parameters of the mammalian liver.

OBJECTIVE: Aim: To determine the general patterns of the structure of scorpion venom and its influence on the morphological parameters of the mammalian liver. PATIENTS AND METHODS: Materials and Methods: A thorough literature analysis was conducted on the basis of PubMed, Google Scholar, Web of Science, and Scopus databases. When searching for information of the general patterns of the structure of scorpion venom and its influence on the morphological parameters of the mammalian liver, we used the following combinations of keywords: "scorpions", "toxins", "liver", "hepatotoxicity", "hepatocyt

Feasibility and safety of 30-minute Trastuzumab reloading infusion in patients with HER2-positive solid tumors.

IntroductionTrastuzumab is a humanized HER2 targeting monoclonal antibody, and it is indicated for the treatment of various HER-2-positive c … b reloading doses can be safely administered as a 30-min infusion, without increased risk of IRR or cardiotoxicity.

Metabolic and nutritional stress-associated dilated cardiomyopathy in the setting of semaglutide use and long-term nicotine replacement therapy: a case report and literature review.

Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac transplantation worldwide. It is a multifactorial condition with diverse aetiologies, in which metabolic and nutritional factors are increasingly recognised, whereas pharmacological contributors remain comparatively underexplored. We describe a 57-year-old man presenting with acute heart failure and cardiogenic shock after a 12-h prodrome of chest pain and dyspnoea. He had intentionally lost 26 kg over 2 months through 0.25 mg semaglutide therapy, and reports >25 years of chronic nicotine replacement therapy (NRT: 30-

Interplay of oxidative stress and inflammatory mechanisms in doxorubicin-induced cardiomyopathy.

Doxorubicin (DOX) is a potent chemotherapeutic drug used to treat a variety of cancer types, but its usage is limited due to major cardiovascular side effects. According to World Health Organization reports, by 2050, new cancer cases are projected to increase to >35 million, implying an enhanced risk of DOX-induced cardiomyopathy (DIC). Despite its cardiotoxic side effects, DOX has remained an effective therapeutic choice for cancer treatment. Current evidence suggests that multiple pathophysiological mechanisms are involved in DIC, including oxidative stress, mitochondrial dysfunction, endopl

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7-Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues.

The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA-intercalating property. The synthetic analogue, 2,7-dibromocryptolepine, (2) does not intercalate into DNA and is markedly more active than the parent against Plasmodium sp. in vitro and in vivo. The aim of this study was to carry out a pre-clinical assessment of 1 and 2, and if appropriate, carry out in vivo pharm

Prevention of cancer-therapy related cardiac dysfunction.

PURPOSE OF REVIEW: Introduction of modern cancer therapies has led to increased survival of affected patients. With this advantage, the incidence of cancer therapy-related cardiac dysfunction (CTRCD) has increased and reasonable prevention strategies become necessary. This review outlines the major approaches to limit development and progression of CTRCD. RECENT FINDINGS: A broad range of cancer therapies can provoke CTRCD ranging from mild asymptomatic forms to severe heart failure. Profound cardiological assessment of cardiovascular comorbidities before initiation of cancer therapy allows i

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… Michel L Rassaf T Totzeck M Cardiotoxicity from immune checkpoint inhibitors Int J Cardiol Heart Vasc 2019 25 100420 31517036 10.1016/j.ijcha.2019.100420 PMC6736791 Michel L, Rassaf T, Totzeck M. Cardiotoxicity from immune checkpoint inhibitors. … Trastuzumab-induced cardiotoxicity: a review of clinical risk factors, pharmacologic prevention, and cardiotoxicity of other HER2-directed therapies. Breast Cancer Res Treat. 2021;188(1):21–36. 34115243 10.1007/s10549-021-06280-x 22. …

Syntheses, Biological and Preclinical Evaluations, and Nanoparticle Formulations of the ROS-Activatable Prodrugs of Doxazolidine for Drug-Resistant Cancer Therapy.

Doxorubicin (dox) has been used for the treatments of many cancers for more than 50 years since its discovery. Currently, the treatment with dox is often limited by cardiotoxicity and the development of drug resistance. Doxazolidine (doxaz) is a dox-formaldehyde conjugate discovered in the 1990s. It bears an extra carbon, linking its daunosamine hydroxyl to that adjacent amino substituent to create an oxazolidine ring. In contrast to dox, which is a topoisomerase inhibitor, doxaz cross-links DNA to nonspecifically inhibit cell growth. Doxaz is significantly more cytotoxic than dox, even agains…

Mechanism of myocardial damage induced by doxorubicin via calumenin-regulated mitochondrial dynamics and the calcium-Cx43 pathway.

BACKGROUND: The clinical application of doxorubicin (DOX) is limited by its potential to cause cardiac cardiotoxicity. AIM: To investigate the correlation between calumenin (CALU) and mitochondrial kinetic-related proteins in rats with DOX cardiomyopathy. METHODS: A rat model of DOX-induced cardiomyopathy was used to evaluate the effects of DOX. We observed the effect of DOX on electrical conduction in cardiomyocytes using the electromapping technique. Masson staining was performed to evaluate myocardium fibrosis. Electron microscopy was used to observe the changes in pathological ultrastruc…

Investigation of ponatinib metabolism and drug-drug interactions with lycopene and shikonin in vitro and invivo.

Ponatinib is approved for use in patients with chronic myeloid leukemia (CML) who are resistant to or intolerant to prior tyrosine kinase inhibitor (TKI) therapy. Given that ponatinib can induce significant cardiotoxicity when taken, and that most Chinese medicines have cardioprotective effects, it is possible to administer them in combination in clinic to alleviate adverse effects. The quantitative determination of ponatinib and its metabolite N-desmethyl ponatinib was optimized and fully verified by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). And the drug-d…

Fatal aconite poisoning in a rural Nepali traditional healer: clinical challenges and management strategies.

INTRODUCTION AND IMPORTANCE: Aconite, also known as Aconitum spp., is a group of highly toxic flowering plants used historically in traditional medicine despite their potent neurotoxic and cardiotoxic effects. In rural Nepal, where traditional healing practices are prevalent, accidental ingestion of Aconite remains a significant public health concern due to its resemblance to medicinal herbs. CASE PRESENTATION: The authors present a case of severe Aconite poisoning in a 45-year-old male traditional healer from rural Nepal. Following ingestion of a homemade herbal tea containing Aconitum speci

Second Generation Antipsychotics and Cardiovascular Adverse Effects: Developing Evidence-Based Recommendations for Primary Care Medicine.

BACKGROUND: Second-generation antipsychotic medications (SGAs) are often used by primary care physicians (PCPs) to treat multiple psychiatric diagnoses. SGAs have been connected to a number of adverse effects, including cardiovascular disease. Currently, there are no published evidence-based recommendations addressing SGAs and cardiotoxicity that are directed toward PCPs. This project aims to fill this gap. METHODS: Relevant search terms related to SGAs and cardiovascular disease were identified and then used to search databases (PubMed, PubMed Central, and AccessMedicine). Research studies o…

A Review of the Dual Role of MicroRNA-21 in Cardiovascular Diseases: Risk Factor or a Potential Therapeutic Target.

Cardiovascular diseases [CVD] are the number one reason for morbidity and mortality in the modern world, and their incidence is increasing a … we summarized recent research progress regarding the significant role of miR-21 in CVD, focusing on cardiotoxicity, heart arrhythmias, cardiomyopathies, and hypertension. Several signaling pathways [TGF-β1/Smad2 signaling, FGFR1/FGF21/PPARγ, NF-κB/miR-21/SMAD7, miR-21/SPRY1/ERK/mTOR …] and molecular targets [BTG2, PDCD4, PTEN, STAT3…] were reported to be control …

Narrative Review of Heart Failure Related to Cocaine Consumption and Its Therapeutic Management.

Background: Cocaine use can cause multiple cardiovascular complications, including heart failure. Aim: This general review of the literature delivers data on the relationship between cocaine consumption and the development of heart failure, as well as the elements of its diagnosis and management. Methods: A literature search was carried out using the PubMed, Web Of Science, and Google Scholar bibliographic databases over the period of 2007-2022 using the following keywords: "cocaine" AND "heart failure" NOT "acute heart disease". The exclusion criteria exempted studies carried out on animals,

Exercise Therapy in Oncology—the Impact on Quality of Life and Side Effects.

BACKGROUND: The diagnosis and treatment of cancer are highly stressful. Exercise therapy is often used to mitigate the adverse effects of tr … -mastectomy pain syndrome in breast cancer) and may also have a beneficial effect on sleep quality, cardiotoxicity, and cognitive function. Less conclusive studies are currently available with respect to chemotherapy-induced polyneuropathy, nausea/vomiting, and bone health. There is currently insufficient data to suggest any benefit with respect to sexual functi …

Development of doxorubicin-encapsulated magnetic liposome@PEG for treatment of breast cancer in BALB/c mice.

The magnetic doxorubicin-encapsulated liposome/PEG/Fe3O4 (called as DOX@m-Lip/PEG) was synthesized and studied as a novel nanocarrier for the treatment of breast cancer in BALB/c mice. Nanocarrier was characterized by FT-IR, zeta-potential sizer, EDX elemental analysis, EDX mapping, TEM, and DLS techniques. The results showed that the size of the nanocarrier was determined around 128 nm by TEM. EDX study confirmed PEG-conjugation in the magnetic liposomes and was homogenously distributed in the nanosize range (100-200 nm) with a negative surface charge (-61.7 mV). The kinetic studies indicated

Triple Combination with Direct Acting Antivirals in the Treatment of Hepatitis C Does not Prolong the QT Interval.

AIMS: Antiviral drugs are considered as potentially cardiotoxic, due to prolongation of QT interval which may affect incidence of severe ventricular arrhythmias. The main aim of this retrospective study was to assess the influence of treatment by three antiviral drugs on QT interval and to find patients who are at an increased risk of developing malignant ventricular arrhythmias. METHODS: The study included 23 patients (14 men, 9 women) who were treated with a combination of interferon alpha, ribavirin, and an NS3/4A protease inhibitor. The parameters from the 12 leads electrocardiograms were