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Posttransplant complications: molecular mechanisms and therapeutic interventions.

Posttransplantation complications pose a major challenge to the long-term survival and quality of life of organ transplant recipients. These complications encompass immune-mediated complications, infectious complications, metabolic complications, and malignancies, with each type influenced by various risk factors and pathological mechanisms. The molecular mechanisms underlying posttransplantation complications involve a complex interplay of immunological, metabolic, and oncogenic processes, including innate and adaptive immune activation, immunosuppressant side effects, and viral reactivation.

Osteoimmunopathology in HIV/AIDS: A Translational Evidence-Based Perspective.

Infection with the human immunodeficiency virus-1 (HIV) and the resulting acquired immune deficiency syndrome (AIDS) alter not only cellular immune regulation but also the bone metabolism. Since cellular immunity and bone metabolism are intimately intertwined in the osteoimmune network, it is to be expected that bone metabolism is also affected in patients with HIV/AIDS. The concerted evidence points convincingly toward impaired activity of osteoblasts and increased activity of osteoclasts in patients with HIV/AIDS, leading to a significant increase in the prevalence of osteoporosis. Research

SARS-CoV-2 Persistent Viral Shedding in the Context of Hydroxychloroquine-Azithromycin Treatment.

SARS-CoV-2 nasopharyngeal shedding contributes to the spread of the COVID-19 epidemic. Among 3271 COVID-19 patients treated at the Hospital University Institute Méditerranée Infection, Marseille, France from 3 March to 27 April 2020, tested at least twice by qRT-PCR, the median SARS-CoV-2 nasopharyngeal shedding duration was 6 days (range 2-54 days). Compared with short shedders (qRT-PCR positivity < 10 days), 34 (1.04%) persistent shedders (qRT-PCR positivity ≥ 17 days; mean ± SD: 23.3 ± 3.8 days) were significantly older, with associated comorbidities, exhibiting lymphopenia, eosinopenia, in

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… . | Common variable immunodeficiency | 40 days | No | No | Lopinavir/ritonavir, broad-spectrum antibiotics | No genome sequencing reported | Death on day 40 [ 26 ] | Female, 70-79 y. …

Diagnosis and treatment of cystic lung disease.

Cystic lung disease (CLD) is a group of lung disorders characterized by the presence of multiple cysts, defined as air-filled lucencies or low-attenuating areas, bordered by a thin wall (usually < 2 mm). The recognition of CLDs has increased with the widespread use of computed tomography. This article addresses the mechanisms of cyst formation and the diagnostic approaches to CLDs. A number of assessment methods that can be used to confirm CLDs are discussed, including high-resolution computed tomography, pathologic approaches, and genetic/ serologic markers, together with treatment modalities

Multiple myeloma in Niger Delta, Nigeria: complications and the outcome of palliative interventions.

BACKGROUND: Multiple myeloma (MM) is one of the hematological malignancies that require palliative care. This is because of the life-threatening nature and the suffering associated with the illness. The aim of this study is to bring to the fore the complications experienced by people living with MM in the Niger-Delta region of Nigeria and the outcome of various palliative interventions. METHODS: This was a 10-year multi-center retrospective study of 26 patients diagnosed and managed in three major centers in the Niger-Delta region of Nigeria from January 2003 to December 2012. Information on

NAPCON 2025 – Best Original Research Abstracts

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Unraveling the association between chronic inflammatory demyelinating polyradiculoneuropathy and peritoneal Dialysis.

BackgroundChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare disease seen in the general population and has been reported as showing an increased incidence in the peritoneal dialysis (PD) population, as documented in case reports.MethodsWe conducted a case-control study using data from the Taichung Veterans General Hospital electric medical record database from the years 2010 to 2023. We defined cases as CIDP with End-stage kidney disease (ESKD) and controls as without CIDP. A logistic regression analysis was used to investigate the association between CIDP and dialysis

Sarcopenia does not predict outcome in patients with CNS lymphoma undergoing systemic therapy.

Low skeletal muscle mass as a proxy parameter for sarcopenia acts as a non-invasive imaging marker that is associated with poor prognosis in numerous types of cancer. The present study aimed to assess the influence of body composition parameters on overall survival (OS) and progression free survival (PFS) in patients diagnosed with primary central nervous system lymphoma (PCNSL). A total of 98 patients with PCNSL treated at University Hospital Magdeburg (Magdeburg, Germany) from 2013-2019 were retrospectively studied. Patients with a pre-treatment staging computed tomography (CT) scan that inc

Clinical characteristics and outcomes of Castleman disease: A multicenter study of 185 Chinese patients.

Castleman disease (CD) is a rare lymphoproliferative disorder. To assess the clinical features, outcomes, and prognostic factors of this disease, we retrospectively analyzed 185 HIV-negative CD patients from four medical centers in southern China. The median age was 37 years. One hundred and twenty-one patients (65.4%) were classified as unicentric CD (UCD) and 64 patients (34.6%) were classified as multicentric CD (MCD). The histology subtype was hyaline-vascular for 132 patients (71.4%), plasma cell for 50 patients (27%), and mixed type for 3 patients (1.6%). The 5-year overall survival (OS)

Neuropathic cancer pain: What we are dealing with? How to manage it?

Cancer pain is a serious health problem, and imposes a great burden on the lives of patients and their families. Pain can be associated with delay in treatment, denial of treatment, or failure of treatment. If the pain is not treated properly it may impair the quality of life. Neuropathic cancer pain (NCP) is one of the most complex phenomena among cancer pain syndromes. NCP may result from direct damage to nerves due to acute diagnostic/therapeutic interventions. Chronic NCP is the result of treatment complications or malignancy itself. Although the reason for pain is different in NCP and non

Recommendations for influenza and Streptococcus pneumoniae vaccination in elderly people in China.

Influenza and pneumonia can be prevented by vaccination, but they remain major causes of morbidity and mortality in age-related diseases. In most areas of China, the rates of influenza and pneumococcal vaccination are relatively low and public awareness of vaccination remains insufficient. Thus, it is essential to recommend influenza and Streptococcus pneumoniae vaccination to elderly people in clinical practice. Based on recently published studies and related documents issued by several vaccination authorities, such as the World Health Organization, the National Health and Wellness Committee,

Acute and Chronic Respiratory Failure in Cancer Patients

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Immune effector cell-associated enterocolitis post-BCMA directed CAR T-cell therapy: insights from a multicenter case series.

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… The pathophysiology of IEC-EC remains incompletely defined but likely involves dysregulated T-cell activity, with clinical and histopathologic features overlapping graft-versus-host disease (GVHD) and common variable immunodeficiency (CVID) [ 1 , 2 ]. …

Улучшить пересадку аутологической гематопоиетической трансплантации стволовых клеток: сравнить педифилграстим с фугастимом в амбулаторной среде.

КОЛИЧЕСТВО: &lt; &lt; Нейтропенция фебрилов &gt; &gt; -- частое осложнение для пациентов, проходящих аутологическую трансплантацию стволовых клеток, увеличение заболеваемости и расходов на госпитализацию. ЦЕЛЬ: Цель настоящего исследования заключалась в сопоставлении эффективности two Составы пегилированного филграстима с филграстимом у пациентов, которые получили аутлогическую трансплантацию стволовых клеток в качестве амбулаторных для лимфомы или миэломы. МЕТОДЫ: Thirty пациенты были случайными, чтобы получить одноразовый 6 мг эталонного или биоаналогичного пегфилграстима в день +1. Группа р

Liver disease during and after hematopoietic stem cell transplantation in adults: a single-center Egyptian experience.

BACKGROUND: Hepatic complications are a well-known cause of both early and late mortality and morbidity in hematopoietic stem cell transplant (HSCT) recipients. Early diagnosis and management of hepatic complications is important in order to commence appropriate therapy. Conditioning regimens, acute and chronic graft versus host disease, sinusoidal obstruction syndrome, and infections among others represent major hepatic complications for the transplant recipient. We assessed liver function tests, viral markers, polymerase chain reaction, abdominal ultrasound, portal, and hepatic venous duplex

Emerging trends and disparities in mortality due to coexisting non-Hodgkin's lymphoma and respiratory infections: A U.S. nationwide retrospective analysis from 1999 to 2020.

Non-Hodgkin lymphoma (NHL) patients are highly susceptible to respiratory infections due to immunosuppression from both the disease and its treatments. Understanding mortality trends and disparities in this population is crucial for improving care and reducing the burden of coexisting conditions. This study analyzed death certificates from the Center of Disease Control Wide-Ranging Online Data for Epidemiologic Research database for individuals aged ≥ 25 years who died between 1999 and 2020 with both NHL and respiratory infections. Age-adjusted mortality rates (AAMRs) and annual percent change

Распределение основных HLA-A, -B, -DR и -DQ Loci потенциально ассоциируется с множественным склерозом в здоровом населении Южного Марокко.

Справочная информация: Многие факторы способствуют развитию и развитию молекулы Множественного склероза (MS), включая молекулы лейкоцита (HLA). Некоторые из них считаются предрасположенными, например DRB1*15, DRB1*13, DRB1*03, DQB1*04, DQB1*06, DQB1*02, в то время как HLA A2, HLA B44, DRB1*11 и DRB1*12 считаются скорее защитными. Данные о таких ассоциациях марокканского населения остаются неизвестными. Цель этого исследования состояла в том, чтобы определить частотность использования классов I (A и B) и II (DR и DQ) HLA, связанных с множественным склерозом (MS) в здоровом населении на юге Маро

Клинические характеристики и прогнозный анализ three hundred и nineteen - случаи первичного желудочно-кишечного диффузного большого лимфомы B-клеток.

С января были ретроспективно проанализированы клинические данные пациентов, диагностированных с помощью ПГИ-ДЛБКЛ в больнице, аффилированной с Ксинцзянским медицинским университетом. 2010 по апрель 2022A. Общее число 319 Пациенты с PGI-DLBCL были включены и разделены на тренировки (n = 223) и подтверждение (n = 96) группы. Средний возраст жителей составил 55 лет, с 48.9% мужчины и мужчины 51.1% Женщины-больные. К числу ключевых клинических особенностей относится положение дел с деятельностью Восточнокооперативной онкологической группы ≥ 2 (В тыс.40.8%), продвинутое заболевание (этап IV: 27.6%)

Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022.

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Metronomic chemotherapy: changing the paradigm that more is better.

The introduction of the "maximum tolerated dose" in usual treatment protocols (and its concomitant overt toxicity) made necessary the imposition of rest periods between cycles of therapy-a practice that not only involves re-growth of tumour cells, but also growth of selected clones resistant to the therapy. To avoid the problems caused by traditional chemotherapeutic regimens, a new modality of drug administration called "metronomic chemotherapy" has been proposed. This name makes reference to the chronic, equally spaced administration of (generally) low doses of various chemotherapeutic drugs