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A Randomized Assessor-Blinded Wait-List-Controlled Trial to Assess the Effectiveness of Acupuncture in the Management of Chemotherapy-Induced Peripheral Neuropathy.

PurposeChemotherapy-induced peripheral neuropathy is a complex side effect with few available treatment options. The aim of the study was to test the effectiveness of an 8-week course of acupuncture in the management of chemotherapy-induced peripheral neuropathy in cancer patients who were receiving or had received neurotoxic chemotherapy.MethodsRandomized assessor-blinded controlled trial with 2 arms; one arm received acupuncture twice weekly for 8 weeks, while the other arm was a wait-list control group receiving only standard care. Primary outcome was pain intensity and interference over th

Проект для самостоятельной мотивации: Качественное собеседование по вопросам предприимчивости выживших жертв рака к программам изменения цифрового здоровья.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Несмотря на повышенный риск рецидива, связанный с изменением образа жизни, многие лица, пережившие рак, не соблюдают рекомендации по укреплению здоровья. Цифровое медико-санитарное вмешательство открывает перспективы для поддержки изменений в поведении, однако лишь немногие исследования предусматривают участие выживших жертв в разработке мер вмешательства, что потенциально ограничивает эффективность реального мира. Понимание предпочтений и потребностей в поддержке выживших жертв рака имеет решающее значение для разработки эффективных мер по изменению поведения в цифровой

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… Maybe something like with massage therapy. [Participant 12] This preference highlighted participants’ holistic understanding of health and wellness that extended beyond medical interventions to include therapies that could address pain, stress, and overall quality of life. … to trigger proactive screening Health care integration: comprehensive service access Partner with existing clinical dietitians, mental health professionals, tobacco treatment specialists, and fitness specialists If resources permit, provide connections to mind-body services (yoga, meditation, and massage …

Real-world evidence from Germany: representativeness analysis and mortality endpoint validation in electronic health record-derived oncology cohorts.

BackgroundHigh-quality real-world data (RWD) for oncology research remains limited in Germany despite significant clinical need. Electronic health record (EHR)-derived datasets offer potential to capture longitudinal clinical information, but their value depends on representativeness and data quality. We characterized EHR-derived oncology cohorts from Germany, evaluating alignment with national benchmarks and validating mortality endpoints for real-world evidence generation.MethodsWe analyzed deidentified EHR data from the Germany Flatiron Health Research Database comprising adult patients dia

Prevalence and prognostic value of baseline sarcopenia in hematologic malignancies: a systematic review.

BackgroundThe correlation between sarcopenia and hematological malignancy prognosis is still controversial. Design: A systematic review and meta-analysis. Objectives: To explore sarcopenia's prevalence and prognostic value in hematologic malignancies.Data sources and methodsWe searched Embase, MEDLINE, and Cochrane Library through Ovid SP using an appropriate search strategy on August 28, 2022, and updated the search results on January 9, 2023. Study quality was assessed using the Newcastle-Ottawa scale. The pooled prevalence of sarcopenia was calculated with a 95% confidence interval (CI). Re

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… Although CT is available for most clinical settings and could be used to obtain healthy massages, cut-offs to judge LMM are not yet well determined ( 13 ). EWGSOP2 has provided recommendations for cut-off points focusing on European populations and using normative references. …

Clinical and Demographic Factors Associated With Follow-Up in a Hospital-Based Exercise Oncology Program.

OBJECTIVE: Despite the numerous benefits of regular exercise participation for cancer survivors, nearly 60% of survivors do not meet current guidelines. Hospital-based exercise oncology programs may be one strategy to promote exercise engagement as survivors have expressed a preference for exercise programs associated with a cancer hospital. However, follow-up rates in hospital-based exercise oncology programs can be low. Follow-up assessments are a critical component of exercise oncology programs as they determine survivor progress, allow for revision of exercise prescriptions, and demonstrat

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… Additionally, other wellness services such as physical therapy, occupational therapy, massage therapy, and nutrition counseling, may address survivors’ unmet needs and help them stick with their exercise program. …

The effect of exercise and nutrition interventions on physical functioning in patients undergoing haematopoietic stem cell transplantation: a systematic review and meta-analysis.

PurposeHaematopoietic stem cell transplantation (HSCT) is potentially lifesaving. However, it comes with negative consequences such as impaired physical functioning, fatigue and poor quality of life. The aim of this systematic review and meta-analysis is to determine the effect of exercise and nutrition interventions to counteract negative consequences of treatment and improve physical functioning in patients receiving HSCT.MethodsThis systematic review and meta-analysis included randomised controlled trials from three electronic databases between 2009 and 2020. The trials included adult patie

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… During aplasia twice daily, after engraftment once daily | Yes | Supervised low intensity passive and active mobilization consisting of gymnastics, massages, extensions and coordination training, 5 days a week | | ADL training | | | Other components: ADL training consisting of walking, stepping and …

Emergency Care

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PBMC-Humanized Mouse Model for Multical Sclerosis: Изучение неуменные изменения и участие CNS.

Гуманизированная иммунная система (HIS) мыши являются мощными инструментами для изучения функций и дисфункций иммунной системы человека и разработки иммунотерапевтической системы человека. Наличие изощренных штаммов супериммунодефицитной мыши позволило гуманизировать иммунную систему, используя трансплантацию человеческих периферийных моноядерных клеток крови (PBMC) или гематополиетических стволовых клеток. Его мыши широко используются в иммунной онкологии, в то время как проводится меньше исследований в области автономного иммунитета, особенно в области множественного склероза (MS). Используя

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… Massage the tail to facilitate blood flow. 10. Repeat steps F7–8 until you collect at least 50–80 μL of blood. 11. Gently press the tail with a cotton swab to stop bleeding and place the mouse back in the cage. 12. …

Управление неблагоприятными событиями, связанными с комбинациями на основе помалидомида у пациентов с повторной/редактируемой множественной миеломой.

Многоагентные режимы с иммуномодуляционными (IMID) агентами, такими, как палидомид, линалидомид и помалидомид, стали предпочтительным стандартом лечения пациентов с множественной миеломой (MM), что позволило улучшить показатели выживания. В настоящее время существуют three Агенты IMID, утвержденные для лечения MM: талидомид, линалидомид и помалидомид. Леналидомид обычно используется для лечения пациентов с недавно поставленным диагнозом MM, а также для лечения после пересадки стволовых клеток или после рецидива заболевания. Помалидомид, в центре внимания которого находится данный обзор, утверж

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… For mild cases, pain management through gentle massage, warm baths, and cold/heat packs can be used. …

Managing treatment-related peripheral neuropathy in patients with multiple myeloma.

Peripheral neuropathy is one of the most important complications of multiple myeloma treatment. Neurological damage can be observed at the onset of the disease, due to the effect of monoclonal protein or radicular compression, but more often is treatment related. Vinca alkaloids in the past era, and more recently, thalidomide and bortezomib are mainly responsible. Degeneration of dorsal root ganglion is common, prevalently related to angiogenesis inhibition and cytokine modulation in the case of thalidomide and inhibition of the ubiquitin proteasome system in the case of bortezomib. Sensory ne

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… pain; oral oxycodone or alternatively morphine for chronic moderate–severe pain; and SC opioid therapy (oxycodone or morphine injection) for acute severe pain. 104 , 105 Moreover, patients should be advised to: wear loose-fitting shoes, roomy socks, and padded slippers; soak feet in icy water and massage …

Symptom Clusters and Symptom Burden in Cancer Survivors.

ContextLimited information is available on the symptom burden and symptom clusters in cancer survivors.ObjectivesDescribe the occurrence, severity, and distress of 44 symptoms; determine risk factors associated with a higher symptom burden; and evaluate for symptom clusters using symptom occurrence rates.MethodsSurvivors (n = 1147) were recruited using an online survey. Symptom burden and symptom clusters were assessed using the Memorial Symptom Assessment Scale that included 44 symptoms and evaluated occurrence, severity, and distress. Simultaneous multivariable linear regression analysis was

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… Treatments for this symptom include gentle exercise, non‐opioid analgesics, and complementary therapies (e.g., massage, application of heat or cold). …

Sjögren Disease-B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell-Targeted Therapies.

Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)-approved disease-modifying therapies for SjD. In this review, we explore the expanding field of SjD endotyping as a tool to enhance patient stratification, prognostication, and clinical decision-making. SjD endotypes driven by heightened B cell activity are linked to increased lymphoma risk. B cells play a ce

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… She treated her parotid gland swelling with massage, warm compresses, and sugar‐free lozenges. She also had mild arthralgias of her metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints associated with one hour of morning stiffness. …

Продуктирует ли анальгезия в тригеминальной невралгии? Обновленный системный обзор и метаанализ.

Предыстория/цели: Тригеминальная нейронгия (ТН) представляет собой излучающееся состояние, которое в основном регулируется в рамках первичной медико-санитарной помощи, где карбамазепин остается единственной рекомендуемой терапией первой линии. Предварительные метаанализы сообщают о сокращении боли в конце лечения с помощью иглоукалывания, но не приводят к стратифицированным результатам в силу риска предвзятости, проверяют качество отчетности о результатах боли или изучают вопрос о том, сохраняются ли последствия анальгезии после периода лечения. В рамках этого обновленного систематического обз

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… Clinical Curative Effect Observation of Acupuncture for Primary Trigeminal Neuralgia Massage Rehabil. Med. 2018 9 19 20 47. Yang D. Effect Analysis of Traditional Chinese Medicine Acupuncture in Treating Primary Trigeminal Neuralgia Chin. J. Integr. Med. Cardiovasc. Dis. Electron. …

Нейрогенная желудочно-кишечная, мочевая и сексуальная дисфункция при множественном склерозе: многодисциплинарная основа для клинической практики.

Нейрогенные желудочно-кишечные, мочевые и сексуальные симптомы широко распространены у людей с множественным склерозом и существенно ухудшают качество жизни, повседневное функционирование и психосоциальное благополучие. Несмотря на их частотность и клиническую актуальность, управление по-прежнему носит разрозненный характер по различным специальностям, тесная взаимосвязь между этими симптомами зачастую игнорируется, а у клинических работников отсутствует прагматическая основа, адаптированная к различным условиям здравоохранения. Этот обзор преобразует нынешние данные в прагматичную модель уход

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… Patients with spinal cord lesions who lose sacral parasympathetic control of defecation with constipation and FI are dependent on the reflex rectal stimulation for defecation (abdominal massage and perianal manual stimulation). …

Global research trends of acupuncture therapy on cancer pain: A bibliometric and visualized study.

BackgroundThe number of publications on acupuncture for cancer pain is increasing rapidly with an upward tendency. Considering that no bibliometric articles related to this topic have been published yet. It is necessary to evaluate the global scientific output of research in this field, and shed light on the direction of clinical cancer pain management in the future.MethodsResearch publications regarding acupuncture on cancer pain from inception to 2022 were downloaded from the Web of Science Core Collection. Bibliometric analyses were performed using CiteSpace software, the bibliometrix R pac

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… Therefore, he proposed an integrative medicine (TCIM) including acupuncture and massage, to alleviate cancer symptoms or treatment-related adverse reactions such as pain, insomnia and fatigue ( 19 ). …

Cannabinoids: an Effective Treatment for Chemotherapy-Induced Peripheral Neurotoxicity?

Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most frequent side effects of antineoplastic treatment, particularly of lung, breast, prostate, gastrointestinal, and germinal cancers, as well as of different forms of leukemia, lymphoma, and multiple myeloma. Currently, no effective therapies are available for CIPN prevention, and symptomatic treatment is frequently ineffective; thus, several clinical trials are addressing this unmet clinical need. Among possible pharmacological treatments of CIPN, modulation of the endocannabinoid system might be particularly promising, espe

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… hands and feet | Recruiting Breast/evaluation of cryotherapy and TRPA1 receptors in chemotherapy induced neuropathy | Recruiting Exercise, rehabilitation and nutrition interventions ( n = 7) | Preventing chemotherapy-induced peripheral neuropathy using PRESIONA exercise program | Not yet recruiting Massage …

Investigating the Analgesic Mechanisms of Acupuncture for Cancer Pain: Insights From Multimodal Bioelectrical Signal Analysis.

PurposeCancer pain management remains a significant clinical challenge. While acupuncture has shown potential in alleviating cancer pain, its underlying mechanisms are not yet fully understood. This study investigates the neurophysiological mechanisms underlying acupuncture's analgesic effects using multimodal bioelectrical signal analysis.Patients and methodsFifteen cancer pain patients underwent acupuncture while wearing portable, multi-sensor devices to capture bioelectrical signals. Pain levels were assessed using the Numerical Rating Scale (NRS) before and during needle retention. Neuroph

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… Acupuncture vs massage for pain in patients living with advanced cancer: the IMPACT randomized clinical trial . JAMA Network Open . 2023 ; 6 ( 11 ): e2342482 – e2342482 . doi: 10.1001/jamanetworkopen.2023.42482 37962891 PMC10646731 12. He Y , Guo X , May BH , Zhang AL , Liu Y , Xue CC . …

A Multi-step Approach to Adapting a Mind-Body Resiliency Intervention for Fear of Cancer Recurrence and Uncertainty in Survivorship (IN FOCUS).

BackgroundFor cancer survivors, there is a paucity of fear of recurrence (FOR) interventions that integrate empirically supported mind-body and psychological skills for managing FOR and are delivered in scalable formats.ObjectiveTo adapt an evidence-based resiliency intervention to address FOR among cancer survivors.MethodsA multidisciplinary team of researchers, clinicians, and patient stakeholders followed an iterative intervention adaptation process (ORBIT). In Step 1, we sought to define key FOR management skills through a literature review and feedback from stakeholders. In Step 2, we int

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… Survivors in both the clinical and non-clinical FOR groups highlighted using breathing techniques, massage, and various types of meditation (imagery, mantra/personal prayer, meditative movement, mindfulness) as ways to induce relaxation. (2) Stress Awareness and Cognitive-Behavioral Techniques. …

Use of Immunoglobulin Replacement Therapy in Clinical Practice: A Review.

Immunoglobulins (Igs) are produced by B lymphocytes and play a key role in humoral immunity. Igs are classified into five isotypes (IgG, IgA, IgM, IgE, and IgD). Their primary function is to recognize and bind to foreign antigens. When Igs bind to antigens, they facilitate phagocytosis and promote clearance mediated by other immune cells. It is an essential component in protecting the host from outside pathogens. Hypogammaglobulinemia predisposes an individual to severe and recurrent infections. Therefore, replacement therapy is recommended to maintain optimal Ig level. In addition, Igs can mo

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… Warm compresses and gentle massage post-infusion are additional measures that may provide relief. Both IVIG and SCIG require a proactive approach to prevent adverse events. …

Intervention and application of drawing therapy in cancer patients: a scoping review.

BACKGROUND: Cancer itself and its treatment process cause a range of physical and psychological discomforts to patients. Drawing therapy, as a form of complementary alternative medicine, has been proven to be effective in alleviating the physical and psychological discomforts of cancer patients, such as chemotherapy-associated nausea and vomiting, and negative emotions such as anxiety and depression. OBJECTIVE: This scoping review aims to organize and describe the literature on drawing therapy in cancer patients, including implementers, intervention methods, and effects. It strives to provide

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… Associations between psychological symptoms and treatment outcomes of a massage therapy intervention: secondary analyses of a randomized controlled trial. Complement Ther Med. 2019;46:116–22. 10. Zhao C, Lai L, Zhang L, et al. …