Результаты поиска

Воздействие систем телемониторинга на лечение раковых заболеваний: систематический обзор.

В рамках этого систематического обзора оценивается воздействие, пригодность для использования, техническая эффективность и применение систем телемониторинга при лечении рака у взрослых. Этот систематический обзор проводился в соответствии с предпочтительными принципами отчетности для системных обзоров и мета-анализов и коллегиального обзора стратегий электронного поиска. Пубмед, МЕДЛИНА и КИНАХЛ были обысканы с июня 2013 по март 2025. Термины " поиск " охватывают лечение раковых заболеваний, системы телемониторинга, мобильное медицинское обслуживание (медицинское здоровье), электронн

Prices and Clinical Benefit of National Price-Negotiated Anticancer Medicines in China.

BackgroundHigh prices of anticancer medicines have increased the economic burden for both patients and health insurance systems. Since 2017, China has implemented national price negotiations for medicines, relying on evidence from health technology assessments. We aim to assess the relation between negotiated price and value of anticancer medicines listed in China's National Reimbursement Drug List (NRDL).MethodsFor all price-negotiated anticancer medicines and corresponding indications listed in the latest NRDL between 2017 and 2020, we collected their clinical outcomes data, including overal

Design and development of the Australian and New Zealand (ANZ) myeloma and related diseases registry.

BACKGROUND: Plasma cell dyscrasias (PCD) are a spectrum of disorders resulting from the clonal expansion of plasma cells, ranging from the pre-malignant condition monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM). MM generates a significant burden of disease on the community and it is predicted that it will increase in both incidence and prevalence owing to an ageing population and longer survival secondary to new therapeutic options. Robust and comprehensive clinical data are currently lacking but are required to define current diagnostic, investigational and

Concise Review: The High Cost of High Tech Medicine: Planning Ahead for Market Access.

Cellular therapies and other regenerative medicines are emerging as potentially transformative additions to modern medicine, but likely at a staggering financial cost. Public health care systems' budgets are already strained by growing and aging populations, and many private insurer's budgets are equally stretched. The current systems that most payers employ to manage their cash flow are not structured to absorb a sudden onslaught of very expensive prescriptions for a large portion of their covered population. Despite this, developers of new regenerative medicines tend to focus on the demands

Национальное обследование использования медицинских ресурсов для лечения раковых заболеваний с использованием данных о состоянии здоровья населения Японии 2011 в адрес 2022.

Многодисциплинарное лечение рака значительно продвинулось вперед, особенно в том, что касается молекулярной целевой терапии, способствующей прогнозированию. Хотя эти расходы являются дорогостоящими, их финансовые последствия остаются непроверенными. Цель этого исследования заключалась в изучении общего использования ресурсов здравоохранения и выявлении факторов, определяющих стоимость лечения рака в Японии. В этом ретроспективном когортном исследовании пациенты диагностировали недуги в период с апреля 2011 и март 2022 были классифицированы по типам раковых заболеваний, и были проанализированы

Robot-assisted Sistrunk's operation, total thyroidectomy, and neck dissection via a transaxillary and retroauricular (TARA) approach in papillary carcinoma arising in thyroglossal duct cyst and thyroid gland.

BACKGROUND: Carcinomas arising in the thyroglossal duct cysts are rare, accounting only for about 0.7-1.5 % of all thyroglossal duct cysts. Synchronous occurrence of thyroglossal duct carcinoma and thyroid carcinoma is reported to be even rarer. Traditionally, surgical treatments of such coexisting thyroglossal duct cyst carcinoma (TGDCa) and papillary thyroid carcinoma (PTC) were typically performed through a single transverse or double incisions on the overlying skin. A longer, extended cervical incision might be required if neck dissection is necessary. Though this method provides the opera

Ретроспективное, многоцентральное исследование наблюдений, направленное на создание возможностей для разработки основанных на искусственном интеллекте прогнозирующих моделей для развития заболеваний в множестве склерозов.

Множественный склероз (МС) характеризуется постепенным ухудшением состояния инвалидов с течением времени. С учетом того, что в настоящее время имеется большое число методов лечения, позволяющих замедлить этот прогресс, с помощью соответствующего регулирования, очевидно, что существует потребность в индивидуализированном и основывающемся на данных подходе к оптимизации лечения, с тем чтобы более эффективно замедлять прогресс в развитии заболеваний и, в конечном итоге, постепенно усугублять инвалидность. Это в значительной степени зависит от наличия биомаркеров, которые могут обнаруживать и пров

Experiences with health care and health-related quality of life of patients with hematologic malignancies in Mexico.

BACKGROUND: In Mexico, patients with hematologic malignancies (HMs) are characterized by being at high risk and advanced stages at diagnosis and by having a low cure rate; yet information on their experiences with health care and health-related quality of life (HRQL) is scarce. We aimed to evaluate experiences with health care and HRQL of patients with HMs and the association between these patient-reported measures. METHODS: We conducted a cross-sectional survey in two public oncology hospitals in Mexico City. The study included outpatient cancer patients aged ≥18 years with a diagnosis of le

The use of smart technologies for enhancing palliative care: A systematic review.

IntroductionWith the rapid advancement of technology, smart technologies have permeated various sectors, including palliative care in healthcare. Based on the available literature, similar studies have elucidated the application of individual and isolated smart technologies in palliative care, with their benefits, and limitations. This research, therefore, focuses on the conceptualisation of various smart technologies and makes holistic recommendations on the effective and efficient use of smart technologies in healthcare to enhance palliative care.PurposeThe purpose of this study is to system

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… It is imperative to note that these privacy and security measures need to be contextualised as a one-size-fits-all mechanism cannot be used. …

A tailored maturity model for REDCap-based patient-facing technology: revealing development stages and guiding future evolution.

ObjectivesThis integrative review aims to analyze the REDCap-based patient-facing technologies (PFTs) and propose a tailored maturity model to characterize their development stages, challenges, and future evolution toward intelligent, proactive care.Materials and methodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a focused search of PubMed, Web of Science, and Embase identified relevant studies. Data were analyzed using aggregate and thematic synthesis. Combining literature evidence with pilot case insights, a tailored maturity model wa

Ca2+ involvement in the action potential generation of myenteric neurones in the rat oesophagus.

OBJECTIVE: Arterial aneurysms are life-threatening but usually asymptomatic before requiring hospitalization. Oculomics of retinal vascular features (RVFs) extracted from retinal fundus images can reflect systemic vascular properties and therefore were hypothesized to provide valuable information on detecting the risk of aneurysms. By integrating oculomics with genomics, this study aimed to (i) identify predictive RVFs as imaging biomarkers for aneurysms and (ii) evaluate the value of these RVFs in supporting early detection of aneurysms in the context of predictive, preventive and personalize

Цифровые биомаркеры и АИ для дистанционного мониторинга утомительного прогресса в области неврологических расстройств: подключение механизмов к клиническому применению.

Цифровые биомаркеры для мониторинга усталости в неврологических расстройствах представляют собой новаторский подход к преодолению разрыва между механистическим пониманием и клиническим применением. В настоящем перспективном документе рассматривается вопрос о том, каким образом меры, разработанные с помощью смартфонов и проанализированные с помощью искусственных методов интеллекта, могут трансформировать оценку усталости из субъективной, эпизодической отчетности в непрерывный, объективный мониторинг. Предлагаемые рамки для цифровой фенотификации на основе смартфонов содержат пассивные данные (о

The GIMEMA-ALLIANCE Digital Health Platform for Patients With Hematologic Malignancies in the COVID-19 Pandemic and Postpandemic Era: Protocol for a Multicenter, Prospective, Observational Study.

BACKGROUND: The COVID-19 pandemic has raised unprecedented challenges in the management of patients with cancer and has increased the demands for digital health tools that, for example, could facilitate remote monitoring of patients. Based on this, the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) has recently developed a digital health tool dedicated to patients with hematologic malignancies: the GIMEMA-ALLIANCE platform. OBJECTIVE: The main objectives of this web-based platform are to generate relevant data to better understand quality of life, symptoms, and medication adherenc

Digital therapeutics from bench to bedside.

As a new therapeutic technique based on digital technology, the commercialization and clinical application of digital therapeutics (DTx) are increasing, and the demand for expansion to new clinical fields is remarkably high. However, the use of DTx as a general medical component is still ambiguous, and this ambiguity may be owing to a lack of consensus on a definition, in addition to insufficiencies in research and development, clinical trials, standardization of regulatory frameworks, and technological maturity. In this study, we conduct an in-depth investigation and analysis of definitions,

SiMON-PRO-Hematology®: Digital techology for pharmacotherapeutic and patient reported outcomes monitoring in patients with hematologic malignancies.

INTRODUCTION: Advances in hematologic malignancy treatment have improved survival, but patients often experience treatment-related toxicities. Traditional clinical follow-up often overlooks the patient's subjective experience, highlighting the need for integrated patient-reported outcome measures (PROMs). The primary objective of this study was to describe the design and implementation of the SiMON-PRO-Hematology® system, a comprehensive information tool supporting the pharmacotherapeutic follow-up of patients with hematological malignancies. A secondary objective was to detail the process for

A study protocol for a double-blinded, randomised, placebo-controlled trial on the use of encapsulated FMT for reducing the side effects of HSCT: the HSCT-BIOME study.

BackgroundThe composition of the gut microbiota both prior to and after haematopoietic stem cell transplantation (HSCT) is increasingly implicated in the outcomes of HSCT, including infections, poor immune reconstitution and disease relapse. Faecal microbiota transplantation (FMT) offers a potential strategy of supporting the gut microbiota and improve HSCT outcomes. Although FMT has been investigated in HSCT recipients, it has largely been evaluated therapeutically for indications such as infection, or once immunocompetency is regained.MethodsPeri-HSCT FMT (i.e. before and after HSCT) will be

Clinical Innovation Poster Abstracts

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Cancer Prevalence Projections in Japan and Decomposition Analysis of Changes in Cancer Burden, 2020-2050: A Statistical Modeling Study.

BACKGROUND: We provide comprehensive sex-stratified projections of cancer prevalence for 22 cancer sites in Japan from 2020 to 2050. METHODS: Using a scenario-based approach, we projected cancer prevalence by combining projected incidence cases and survival probabilities. Age-specific incidences were forecasted using age-period-cohort models, while survival rates were estimated using a period-analysis approach and multiple parametric survival models. To understand changes in cancer prevalence, decomposition analysis was conducted, assessing the contributions of incidence, survival, and popula

Health-Related Challenges and Programs Among Agriculture Workers: A Narrative Review.

Agriculture is one of the most hazardous occupations, with many workers experiencing occupational accidents and ill health. The misuse of toxic substances, often due to inadequate protective measures, raises concerns about both individual and nature safety. However, the strenuous tasks done by the agricultural workers, especially those related to pesticide exposure and some challenges affect the farmer's health and well-being. This review paper used databases like PubMed and Google Scholar to elaborate this. English language studies are included and other languages are excluded. The health sys

Federated Computing in Orthopaedic Surgery: A Paradigm Shift in Collaborative Multicenter Research.

➢ Multicenter studies remain rare in orthopaedics (9.9% of recent publications) due to regulatory complexity, restrictive data-sharing policies, and administrative delays, despite their proven value in generating robust, generalizable evidence. ➢ Federated computing (FC) brings analytic code to each institution's data and returns only encrypted, aggregated results. This preserves patient privacy, maintains institutional control, and streamlines compliance by reducing or eliminating the need for complex data-use agreements. ➢ Extensive applications in other medical fields show that FC can match