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Risk factors for prolonged hospitalization and disease course in osteomyelitis: a single-centre cohort study.

OBJECTIVE: To investigate pathogen epidemiology and clinical characteristics in osteomyelitis patients for optimizing clinical management strategies. METHODS: Confirmed osteomyelitis cases required pathogen isolation with radiological correlation. The cohort included both confirmed (culture-positive) and probable (culture-negative but meeting clinical and radiological criteria) cases, Radiation-induced osteomyelitis, sclerosing osteomyelitis and drug-associated osteomyelitis. Clinical specimens underwent standardized culture and VITEK Compact II or MALDI-TOF MS identification. SPSS 22.0 analy

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… Confirmed osteomyelitis: Patients who met at least two of the following three criteria: Clinical evidence: Localized pain, swelling, erythema, purulent discharge, or sinus tract formation, with or without systemic signs (fever, chills). …

A review of immunotherapy for bone tumors.

This article reviews the latest research progress in immunotherapy for bone tumors. Bone tumors are a serious threat to human health, and traditional treatments have limitations. Recently, immunotherapy, as an emerging treatment method, has shown great potential in the treatment of bone tumors. This article systematically introduces the pathological features, traditional treatment methods and limitations of bone tumors, and focuses on the principles, application status and challenges of immune checkpoint inhibitors, CAR-T cell therapy, tumor vaccines and other immunotherapies. At the same time

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… . | Most common: Flu-like symptoms (fever, chills, fatigue), injection site reactions. Less common: Transient liver enzyme elevations, neuralgia (e.g., facial paralysis). …

Терапия химическая антигенная терапия у пациентов, страдающих диабетом, с множественными миеломами: 5-Case Серия.

Цимерная антигенная рецепторная (CAR) T-клетотерапия стала трансформативным лечением множественных гематологовых магнентов, включая множественные миеломы. Однако пациенты с хроническими заболеваниями почек, особенно больные, страдающие диализом, как правило, исключаются из клинических испытаний, что оставляет значительный пробел в доказательствах, касающихся безопасности и целесообразности лечения этих пациентов с помощью ЦАР-Т-клеток. К числу проблем, вызывающих озабоченность у этой группы пациентов, относятся потенциальная токсичность лимфоразрушающих химиотерапий и повышенная подверженность

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… However, on day −4, the patient developed fevers and chills during her chemotherapy infusion. It was stopped, and she was treated with acetaminophen. On chest x-ray, she was found to have pleural effusions most consistent with volume overload and thus was given 4 mg of bumetanide. …

Safety Profile and Predictors of Adverse Events of Incadronate Disodium in Treating Breast Cancer Patients with Bone Metastases: A Retrospective Study.

PURPOSE: Bone metastasis is a common complication in advanced breast cancer. Bisphosphonates like incadronate disodium have shown potential in reducing bone resorption and skeletal-related events. We therefore performed a retrospective study to evaluate the safety profile of incadronate disodium in breast cancer patients with bone metastases. PATIENTS AND METHODS: This retrospective study was conducted involving 84 breast cancer patients with bone metastases who received incadronate disodium treatment between February 2022 and August 2024 in our center. The primary endpoint was the incidence

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… Acute phase reactions (APRs) were defined as flu-like symptoms (fever, chills, fatigue, and musculoskeletal pain) occurring within the first week of treatment. …

Varicella-Zoster Virus Infection and Varicella-Zoster Virus Vaccine-Related Ocular Complications.

The varicella-zoster virus is a human herpesvirus that causes varicella as the primary infection and HZ as the reactivation of a latent infection. Ten to twenty percent of cases of herpes zoster ophthalmicus (HZO) involve the ophthalmic branch of the fifth cranial nerve. Any area of the eye may be affected by the condition. HZ has a lifetime risk of more than 30%. Complications from herpes zoster can significantly lower quality of life. The goal of HZ vaccinations is to stop HZ activation and PHN formation. Despite the uncommon possibility of side effects such as eye problems, the majority of

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… leukemia | 2 days after vaccination | io foscarnet, iv/po/iv antiviral drugs, iv/po steroids | left eye visual acuity dropped to perception only Richards et al. [ 63 ] | Recurrent bilateral multifocal choroiditis | SHINGRIX | Recombinant zoster vaccine | 57 | F | arm swelling at the injection site, chills …

Оптимизация COVID-19 Записи вакцин для иммунокомпромиссированных групп населения (BOOST-IC): протокол исследования для адаптационного случайного контролируемого клинического испытания.

КОЛИЧЕСТВО: Иммунокомпромированные носители (МГХ) сталкиваются с более интенсивными инфекциями и более тяжелыми клиническими результатами после заражения COVID-19 чем иммунокомпетентные люди. Профилактическая моноклональная терапия антител может быть труднодоступной, и быстро появляются варианты выхода. Иммунитет, предоставляемый путем вакцинации, по-прежнему является одной из центральных стратегий профилактики COVID-19. COVID-19 Прививки не обеспечивают оптимальный иммунитет в ICH, а повышаются благодаря дополнительным дозам вакцины, что улучшает юморальную и клеточную иммунную реакцию. Этот

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… Solicited AEs are those events specifically captured in the diary card up to 7 days after each vaccination and for this study include pain, induration, erythema, temperature, headache, fatigue, chills, myalgia, joint pain, nausea, diarrhoea, chest pain. …

Subcutaneous immunoglobulins replacement therapy in secondary antibody deficiencies: Real life evidence as compared to primary antibody deficiencies.

Secondary antibody deficiencies (SAD) may require immunoglobulin replacement therapy (IgRT). While the intravenous route (IVIG) is broadly considered effective in SAD, the use of subcutaneous immunoglobulins (SCIG) is mainly adopted from the experience in primary antibody deficiencies (PAD), where SCIG have been shown to perform as effective as IVIG. However, evidence-based data on SCIG administration in SAD patients are still insufficient. Herein we retrospectively evaluated the efficacy and safety profile of SCIG treatment in 131 SAD patients as compared to a group of 102 PAD patients. We fo

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… Adverse events and local reactions A total of 14 PAD patients and 6 SAD patients reported mild side effects during SCIG treatment, defined as local cutaneous rash (10 patients) and pain at infusion site (3 patients), headache (3 patients), mild nausea (3 patients) and chills (2 patients), delayed fever …

The incidence and relative risk of adverse events in patients treated with bisphosphonate therapy for breast cancer: a systematic review and meta-analysis.

BACKGROUND: Adjuvant bisphosphonates reduce the rate of breast cancer recurrence in the bone and improve breast cancer survival. However, the risk of adverse events associated with bisphosphonate therapy for breast cancer remains poorly defined. METHODS: A literature search was conducted using the PubMed, EMBASE, Cochrane and Web of Science libraries. Risk ratio (RR) was calculated to evaluate the adverse events of the meta-analytic results. Osteonecrosis of the jaw (ONJ) incidence was calculated using the random effect model (D+L pooled) for meta-analysis. RESULTS: A total of 47 studies com

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… Studies have reported that nephrotoxicity, including toxic acute tubular necrosis and focal segmental glomerulosclerosis, is a potential limiting factor for intravenous bisphosphonates. 67 , 68 Adverse events such as influenza-like illness and chills were more common in the zoledronate group compared …

Diagnosis and Management of Chronic Pruritus: An Expert Consensus Review.

The aim of this study is to formulate the best clinical practice in the diagnosis and management of chronic pruritus (CP). We searched PubMed, EMBASE, Scopus, Web of Science, and the WHO's regional databases, for studies on "Diagnosis and management of chronic pruritus" from January 1, 2014, to July 31, 2015. We included programmatic reports and hand-searched references of published reviews and articles. Two independent reviewers screened articles and extracted data. We screened 87 of 95 studies that contained qualitative data. Avoid: Dry climate, heat, alcohol compress, ice packs, frequent ba

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… Pruritus during physical activity: Cholinergic pruritus, which is often reported to be atopic Aquagenic pruritus provoked by skin cooling/bathing, Nocturnal pruritus with chills, fatigue, sweating, weight loss reported in lymphoma, sleep disturbance are rare with psychogenic pruritus, whereas most types …

Importance of antiresorptive therapies for patients with bone metastases from solid tumors.

Patients with bone metastases are at risk of skeletal-related events such as pathologic fractures, spinal cord compression, the need for orthopedic surgery to bone, and palliative radiotherapy for severe bone pain. Antiresorptive therapies have demonstrated efficacy for reducing the risk of skeletal-related events and ameliorating bone pain. Despite the well documented clinical benefits of antiresorptive therapies, patient benefits can be limited or compromised by nonadherence with scheduled therapy. Potential reasons for poor compliance include lack of understanding of how antiresorptive ther

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… 3400) and D-CARE (n = 4500), both in patients with breast cancer. 67 , 68 Safety and managing adverse events with antiresorptive therapies Acute-phase responses Acute-phase responses have been reported in patients receiving antiresorptive therapy and consist of flu-like symptoms including fever, chills …

Role of phytoconstituents in the management of COVID-19.

BackgroundCOVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas.Scope and approachThis review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry

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… Camel Not known Transmission Through close contacts between human to human Touching infected camels or consuming their milk or meat Human to human transmission through close contacts Symptoms (major) Fever, dry cough, headache, difficulty in breathing, muscle aches, loss of appetite, diarrhoea Fever, chills … known Transmission | Through close contacts between human to human | Touching infected camels or consuming their milk or meat | Human to human transmission through close contacts Symptoms (major) | Fever, dry cough, headache, difficulty in breathing, muscle aches, loss of appetite, diarrhoea | Fever, chills …

A review of potential suggested drugs for coronavirus disease (COVID-19) treatment.

The latest pandemic, coronavirus disease-2019 (COVID-19), is associated with high prevalence and easy transmission, which is expanding globally with no conventional treatment or vaccine. The new virus revealed 79% and 50% genomic similarities with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively. Accordingly, since the disease resists testing and adopting new therapeutics, repositioning pre-existing drugs may present a fast and attractive strategy with known safety, characteristics, and dosage used. However, they

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… Remarkably, COVID-19 is clinically manifested as fever accompanied by chills or headache, fatigue, myalgia, shortness of breath, and dry coughing. Gastrointestinal disorders and lymphopenia have also been reported in severe cases. … inhibitor | In vitro dosage: EC50 = 1.13, EC90 = 1.76 | Upset stomach, Diarrhea | HIV | – | Co-administration with drugs that are highly dependent on CYP3A | In vitro effectiveness with the IC50 of 1.3 μM Teicoplanin (Targocid) | Antibiotic | Cathepsin L blocker | In vitro dosage: IC50 = 1.66 | Fever, Chills …

Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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Review Article: Immune Effector Cell-Mediated Enterocolitis Following CAR-T Cell Therapy-Clinical Features, Pathophysiology and Management.

BACKGROUND: Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionised the treatment of hematologic malignancies, and its use is expanding rapidly into numerous other disease states including autoimmune diseases. However, CAR-T therapy is associated with a spectrum of immune-related toxicities. In addition to the already well characterized cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, it has become apparent that rarely, CAR-T can cause gastrointestinal mucosal inflammation, termed immune effector cell-mediated enterocolitis (IEC-EC). AIMS: This

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… Manifestations include fever, hypotension, tachycardia, hypoxia, and chills, with serious events including cardiac dysfunction, renal insufficiency, and capillary leak syndrome, and treatments may include corticosteroids, IL‐6 receptor antagonist tocilizumab, or sometimes IL‐1 receptor antagonist anakinra …

Antibiotic lock therapy for the treatment of peripherally inserted central venous catheter-related bloodstream infection in patients with hematological malignancies: a single center retrospective study.

Catheter-related bloodstream infections represent one of the most prevalent complications in patients with peripherally inserted central venous catheters (PICCs). The application of antibiotic lock therapy (ALT), particularly in patients with hematological malignancies, has not been well documented. We aim to share our experience on ALT for these patients and to evaluate its effectiveness and safety. All cases of patients with hematological malignancies who had PICC from January 2018 to October 2024 were retrospectively reviewed. Microbiologic data of PICC-related bloodstream infections (PRBSI

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… PRBSI management and ALT When symptoms of infections such as fever, chills, rigors, hypotension, or other signs of sepsis occurred and PRBSI was suspected, paired blood cultures were obtained simultaneously from the PICC lumen and peripheral blood. …

Combined Topography-Guided Trans-Epithelial PRK and PTK for Treatment of Calcific Band Keratopathy Unresponsive to EDTA Chelation Therapy.

Patients with indolent B-cell non-Hodgkin lymphoma (iNHL) generally require treatment but experience normal survival, emphasizing the need for simpler, safer therapies. Proteasome inhibitors target aberrant signaling pathways within iNHL and have manageable toxicities. We evaluated the oral proteasome inhibitor ixazomib as initial monotherapy, and combined with rituximab, for first-line treatment of iNHL. Treatment-naïve patients with iNHL needing therapy received oral ixazomib 4 mg weekly until progressive disease or unacceptable adverse events. A 4-week course of rituximab was added during m

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… Headache | 30 | 0 | Vomiting | 30 | 0 | Infection | 27 | 0 | 1 (3) Fatigue | 24 | 0 | Fall | 24 | 1 (3) | Anorexia/decreased appetite | 24 | 0 | Thrombocytopenia | 21 | 0 | Constipation | 21 | 0 | Cough | 21 | 0 | Fever | 15 | 0 | Extremity pain | 15 | 0 | PN | 15 | 0 | Arthralgia | 15 | 0 | Chills …

Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences.

Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently the only therapy approved by the FDA and EMA for idiopathic multicentric CD and is recommended as first-line therapy in treatment guidelines. Despite the extensive characterization of siltuximab treatment in clinical trials, available evidence from real-world practice is still scant. This collection of clinical experiences focuses on patients tre

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… Case 7 In June 2018, a 54-year-old female patient presented with systemic symptoms, including fever associated with shaking chills, headache, vomiting and arthromyalgia. …

Placental expanded mesenchymal-like cells (PLX-R18) for poor graft function after hematopoietic cell transplantation: A phase I study.

Persistent cytopenia in the post-hematopoietic cell transplantation (HCT) setting can occur despite adequate engraftment of donor cells. PLX-R18, a placental-derived mesenchymal-like cell product, is expanded ex vivo in a 3-dimensional environment. PLX-R18 cells secrete a large array of hematopoietic factors, which promote regeneration, maturation, and differentiation of hematopoietic cells and stimulate their migration to peripheral blood. This phase 1, first-in-human study (NCT03002519), included 21 patients with incomplete hematopoietic recovery post-HCT. Patients were treated with escalati

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… These include tachycardia (1 patient, Cohort 3), hypotension (2 patients, Cohort 3), chills (2 patients, Cohort 3), peripheral edema (1 patient in Cohort 2, 1 patient in Cohort 3), pyrexia (4 patient, Cohort 3), and confusional state (1 patient, Cohort 3). …

Are the Physical Environments of Treatment Centres Meeting Recommendations for Patient-Centred Care? Perceptions of Haematological Cancer Patients.

The physical environment of a treatment centre may impact the well-being of patients and their perceptions of care. Outpatients with haematological cancer may be in contact with the treatment centre over long periods and could be particularly affected. This study aimed to identify haematological cancer patients' perceptions of supportive design elements in the hospital they attended and associations with self-reported mood or well-being. Outpatients from three large metropolitan hospitals in Australia were mailed a self-report questionnaire and responded to statements about the treatment centr

Novel Therapies for Relapsed or Refractory Diffuse Large B-Cell Lymphoma.

The most common type of non-Hodgkin lymphoma in adults is diffuse large B-cell (DLBCL). There is a historical unmet need for more effective therapies in the 2nd and 3rd line setting. Emerging immunochemotherapies have shown activity in small studies of heavily pre-treated patients with prolonged remissions achieved in some patients. Anti-CD19 CAR (chimeric antigen receptor) T cells are potentially curative in the 3rd line and beyond setting and are under investigation in earlier lines of therapy. Antibody-drug conjugates (ADC's) such as polatuzumab vedotin targeting the pan-B-cell marker CD79b

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… The most common AEs were infusion reaction, fever and chills. Immune checkpoint inhibitors have gained recognition in multiple solid tumors and demonstrated durable responses. PD-1 and PDL-1 are expressed in many hematologic malignancies and have recently been approved for second line HL. …