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Приемлемость и пригодность ассистивных средств и технологий для лиц с множественным склерозом: качественное исследование с участием профессиональных терапевтов.

ВВЕДЕНИЕ: Вспомогательное оборудование и технология (АЭ и Т) часто являются частью практики профессиональной терапии для лиц с множественным склерозом (МС). Мы стремимся изучить приемлемость и удобство использования ЭИ и Т людьми, имеющими НР, с точки зрения профессиональных терапевтов. МЕТОДЫ: В нашем исследовании использовался качественный описательный дизайн с использованием полуструктурированных опросов, проведенных с пятью квалифицированными профессиональными терапевтами, имеющими по меньшей мере 6-месячный опыт в деле обеспечения профессиональной терапии взрослых, имеющих MS. Для анализа

Survey of MaineHealth Cancer Care Network Providers on Cannabis Use: Preparation for Studies Sponsored by the National Cancer Institute.

IntroductionCannabis and cannabinoid use in patients with cancer has rapidly scaled up over the past decade and is a topic of considerable clinical, research, and public health interest.MethodsWe conducted a cannabis landscape survey among front-line providers in the MaineHealth Cancer Care Network (MHCCN) before applying and participating in National Cancer Institute (NCI)-sponsored studies on cannabis use in patients with cancer. The results of the survey can better inform participation in national studies and provide a departure point for provider educational activities focused on cannabis

Сочетание виртуальной реальности и гипноза? Исследование опыта работы с пациентами с множественной миеломой после трансплантации стволовых клеток.

Множественная миелома (ММ) и трансплантация стволовых клеток (ЦТ) оказывают значительное влияние на качество жизни пациентов. Виртуальная реальность с гипнозом (ОВГ) стала многообещающим нефармакологическим вмешательством для решения этих проблем, однако данных о ее приемлемости и опыте пользователей по-прежнему недостаточно. В ходе этого исследования была проведена оценка приемлемости и опыта использования ОВЗ среди взрослых пациентов с МИ, прошедших аллогенный СХТ. Участники использовали прикладную программу VRH и оценили свой опыт с помощью стандартизированных вопросников и полуструктуриров

Навигация потерь и рост хронических заболеваний: исследование по вопросу о физической активности и благополучии.

В этом исследовании изучается живой опыт пациентов с хроническими заболеваниями, с тем чтобы понять, каким образом значения, приписываемые хроническим заболеваниям, физической активности и благополучию, переплетаются. Это понимание имеет решающее значение для практики ухода, направленной на поддержку и повышение благосостояния. МЕТОДОЛОГИЧЕСКАЯ ДЕСИГН: Мы провели качественное исследование, основанное на герменевическо-феноменологии, с тем чтобы отразить жизненный опыт участников в описательной форме. В качестве руководящего принципа отчетности используется COREQ. ЭТИЧЕСКИЕ ВОПРОСЫ И УТВЕРЖДЕНИ

Patients' and family members' dyadic experience of post-operative delirium in the intensive care unit: A qualitative study.

BACKGROUND: Post-operative delirium is a complication with long-lasting consequences for both patients and their families. This is particularly true for those transferred to the intensive care unit after surgery, where the incidence of post-operative delirium is high, and patient outcomes are often poor. Despite the acknowledged role of family engagement in delirium management, previous research has mainly focused on patients, with limited exploration of the shared experiences between patients and family members. AIM: This study aims to explore the experiences of patients and family members d

Potential role of immunotherapy and targeted therapy in the treatment of cancer: A contemporary nursing practice.

Immunotherapy and targeted therapy have emerged as promising therapeutic options for cancer patients. Immunotherapies induce a host immune response that mediates long-lived tumor destruction, while targeted therapies suppress molecular mechanisms that are important for tumor maintenance and growth. In addition, cytotoxic agents and targeted therapies regulate immune responses, which increases the chances that these therapeutic approaches may be efficiently combined with immunotherapy to ameliorate clinical outcomes. Various studies have suggested that combinations of therapies that target diff

Amyloidosis: a case series and review of the literature.

BackgroundSystemic amyloidosis is group of disorders characterized by the accumulation of insoluble proteins in tissues. The most common form of systemic amyloidosis is light chain amyloidosis, which results from the accumulation of misfolded immunoglobulins. The disease is progressive, with treatment targeted at the underlying plasma cell dyscrasia. Since essentially any organ system can be affected, the presentation is variable and delays in diagnosis are common. Given this diagnostic difficulty, we discuss four different manifestations of light chain amyloidosis.Case presentationsIn this ca

Deciphering transcriptomic changes in chemobrain: a comprehensive review.

Chemotherapy-induced cognitive impairments (CICI), colloquially known as "chemobrain," represents a profound and debilitating side effect experienced by a significant number of cancer survivors, impacting their memory, multitasking, and quality of life. This review critically evaluates the molecular mechanisms underlying CICI, with a particular focus on the insights gained from transcriptomic analyses. As cancer incidence rises globally, understanding the complex interplay between chemotherapy agents and their cognitive repercussions becomes increasingly vital. Key mechanisms implicated in CIC

Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-κB Signaling Pathways.

BACKGROUND: Epstein-Barr virus (EBV) is detected in 40% of patients with Hodgkin lymphoma (HL). During latency, EBV induces epigenetic alterations to the host genome and decreases the expression of pro-apoptotic proteins. The present study aimed to evaluate the expression levels of mRNA molecules and the end product of proteins for the JAK/STAT and NF-κB pathways, and their association with clinicopathological and prognostic parameters in patients with EBV-positive and -negative classical Hodgkin lymphoma (CHL). METHODS: A prospective cohort study was conducted from 2017 to 2022 at the Facult

The PRO-CAR-T™ study: achieving excellence in patient and public involvement and engagement.

BackgroundPatient and Public Involvement and Engagement (PPIE) is advocated in Patient Reported Outcome (PRO) research, but implementation remains inconsistent and often suboptimal. Many barriers exist, including a lack of understanding about how to apply the principles of PPIE in practice. This paper offers an example of how PPIE can be meaningfully integrated into the development of a digital PRO system within the complex and rapidly evolving field of advanced therapies. The aims are to offer practical insights about how PPIE was conceptualised and operationalised in the context of this stud

Изучение терапевтической роли видеоконференцсвязи тренера-руководителя с экспресс-конференцией в многоразовом склерозе: качественное исследование.

Справочная информация/цели: Эмоциональные изменения оказывают значительное воздействие на людей с множественным склерозом (PwMS), что часто приводит к негативным психологическим симптомам, включая горе. Эффективное управление этими симптомами может способствовать развитию личности, укрепить доверие и возродить надежду. Хотя экспрессивное письмо продемонстрировало психологические преимущества при обработке травм и хронических заболеваний, его воздействие на PwMS по-прежнему недостаточно изучено. Цель этого исследования заключалась в устранении этого пробела путем изучения опыта ПВМС, которые уч

Clinical context and communication in shared decision-making about major surgery: Findings from a qualitative study with colorectal, orthopaedic and cardiac patients.

Increasing numbers of older people undergo major surgery in the United Kingdom (UK), with many at high risk of complications due to age, co-morbidities or frailty. This article reports on a study of such patients and their clinicians engaged in shared decision-making. Shared decision-making is a collaborative approach that seeks to value and centre patients' preferences, potentially addressing asymmetries of knowledge and power between clinicians and patients by countering medical authority with greater patient empowerment. We studied shared decision-making practices in the context of major su

Intervention and application of drawing therapy in cancer patients: a scoping review.

BACKGROUND: Cancer itself and its treatment process cause a range of physical and psychological discomforts to patients. Drawing therapy, as a form of complementary alternative medicine, has been proven to be effective in alleviating the physical and psychological discomforts of cancer patients, such as chemotherapy-associated nausea and vomiting, and negative emotions such as anxiety and depression. OBJECTIVE: This scoping review aims to organize and describe the literature on drawing therapy in cancer patients, including implementers, intervention methods, and effects. It strives to provide

Euthanasia and physician-assisted suicide not meeting due care criteria in the Netherlands: a qualitative review of review committee judgements.

UNLABELLED: ObjectivesTo assess how Dutch regional euthanasia review committees (RTE) apply the euthanasia and physician-assisted suicide (EAS) due care criteria in cases where the criteria are judged not to have been met ('due care not met' (DCNM)) and to evaluate how the criteria function to set limits in Dutch EAS practice. DESIGN: A qualitative review using directed content analysis of DCNM cases in the Netherlands from 2012 to 2016 published on the RTE website (https://www.euthanasiecommissie.nl/) as of 31 January 2017. RESULTS: Of 33 DCNM cases identified (occurring 2012-2016), 32 case

The Role of Transcranial Magnetic Stimulation and Peripheral Magnetic Field Therapy in Chemotherapy-Induced Peripheral Neuropathy: A Narrative Review.

Chemotherapy-induced peripheral neuropathy (CIPN) impairs quality of life and may result in discontinuation of anti-neoplastic therapy. In older patients, CIPN is associated with reduced executive function, more severe pain, comorbidities and polypharmacy. The use of magnetic fields to modulate central and peripheral neurons may offer some benefit for relieving neuropathic pain, with few adverse effects. The evidence of the benefits of using transcranial magnetic stimulation (TMS) or peripheral magnetic stimulation (PMS) in patients with CIPN is evaluated in this narrative review. Improved pat

Strategies for promoting exercise adherence within a cancer exercise recovery program: a qualitative case study.

BACKGROUND: Physical activity (PA) plays an important role in physical health and well-being for cancer survivors. However, cancer survivors demonstrate low adherence to cancer PA guidelines. Research is needed to understand how to optimize delivery of cancer PA programs to enhance participation and adherence. In this study, we conducted an instrumental qualitative case study of a clinical cancer exercise recovery program (CERP) demonstrating high adherence (over 90% session completion), with the goal of understanding implementation strategies that patients link to higher program adherence. ME

Therapies in Stiff-Person Syndrome: Advances and Future Prospects Based on Disease Pathophysiology.

Among the glutamic acid decarboxylase (GAD)-antibody-spectrum disorders, the most common phenotypic subset is the stiff-person syndrome (SPS), caused by impaired GABAergic inhibitory neurotransmission and autoimmunity characterized by very high titers of GAD antibodies and increased GAD-IgG intrathecal synthesis. If not properly treated or untreated because of delayed diagnosis, SPS progresses leading to disability; it is therefore fundamental to apply the best therapeutic schemes from the outset. This article is focused on the rationale of specific therapeutic strategies based on the SPS path

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… A recent report that SPS-SD patients have impaired verbal learning and recall fluency, attention, and processing speed 33 should be viewed with caution because it was based on a retrospective chart review of patients with SPS-SD, most of which did not have pure SPS but other comorbidities or neurologic …

Виртуальная физиотерапия на основе нейропрофилактики в множестве склероза: протокол для двойного беспорядочного теста с двойным проверочным склерозом на функцию верхней конечности, почту и качество жизни с молекулярной и функциональной оценкой МРТ.

ВВЕДЕНИЕ: У людей с множественным склерозом (pwMS) широко распространено нарушение конечности (UL), а функциональное восстановление UL является ключевой целью реабилитации. Технологические подходы, как и виртуальная реальность, все более перспективны. В то время как большинство VR-клиентов ориентированы на конкретные задачи, наш клинический подход включает в себя принципы нейропрофилактичности "содействия и сдерживания" (NFI). Чтобы продвинуться вперед, мы разработали погруженное VR программное обеспечение, основанное на принципах NFI, которое ориентировано на функцию UL и способность стоять н

Intrathecal idursulfase-IT in patients with neuronopathic mucopolysaccharidosis II: Results from a phase 2/3 randomized study.

Two-thirds of patients with mucopolysaccharidosis II (MPS II; Hunter syndrome) have cognitive impairment. This phase 2/3, randomized, controlled, open-label, multicenter study (NCT02055118) investigated the effects of intrathecally administered idursulfase-IT on cognitive function in patients with MPS II. Children older than 3 years with MPS II and mild-to-moderate cognitive impairment (assessed by Differential Ability Scales-II [DAS-II], General Conceptual Ability [GCA] score) who had tolerated intravenous idursulfase for at least 4 months were randomly assigned (2:1) to monthly idursulfase-I

Facial expression deep learning algorithms in the detection of neurological disorders: a systematic review and meta-analysis.

BackgroundNeurological disorders, ranging from common conditions like Alzheimer's disease that is a progressive neurodegenerative disorder and remains the most common cause of dementia worldwide to rare disorders such as Angelman syndrome, impose a significant global health burden. Altered facial expressions are a common symptom across these disorders, potentially serving as a diagnostic indicator. Deep learning algorithms, especially convolutional neural networks (CNNs), have shown promise in detecting these facial expression changes, aiding in diagnosing and monitoring neurological condition