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New Treatment Options in Advanced Stage Follicular Lymphoma.

Follicular lymphoma is one of the most common non-Hodgkin's lymphomas with an expected survival of more than 20 years for the majority of patients. This impressive outcome has been achieved with the introduction of immunochemotherapy, as first line treatment with remissions lasting over 8 years, followed by other treatment options at first or subsequent relapse. However, certain groups of patients still have a poor prognosis. In recent years the efficacy of chemotherapy regimens has been augmented by new compounds selectively targeting the cell surface, intracellular pathways, and/or the micro

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… The most common adverse events reported were fatigue, diarrhea, nausea, rash, chills, and pyrexia, whereas the most frequent grade 3 and grade 4 adverse events were diarrhea, pneumonitis, and elevation of liver enzymes. 48 Reports of deaths because of opportunistic infections with Pneumocystis jirovecii …

A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia.

BackgroundHepcidin plays a central role in iron homeostasis and erythropoiesis. Neutralizing hepcidin with a monoclonal antibody (mAb) may prevent ferroportin internalization, restore iron efflux from cells, and allow transferrin-mediated iron transport to the bone marrow. This multicenter, phase 1 study evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of a fully humanized mAb (LY2787106) with high affinity for hepcidin in cancer patients with anemia.MethodsThirty-three patients with hepcidin levels ≥5 ng/mL received LY2787106 either every 3 weeks (19 patients,

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… 0 | 1 (14.3) | 0 | 2 (28.6) | 2 (28.6) | 6 (18.2) Arthralgia | 0 | 0 | 1 (14.3) | 0 | 2 (28.6) | 2 (28.6) | 5 (15.2) Bone pain | 0 | 0 | 0 | 0 | 2 (28.6) | 3 (42.9) | 5 (15.2) Diarrhea | 0 | 0 | 0 | 0 | 2 (28.6) | 3 (42.9) | 5 (15.2) Vomiting | 0 | 0 | 0 | 1 (20.0) | 2 (28.6) | 2 (28.6) | 5 (15.2) Chills …

Immune Therapies for Myelodysplastic Syndromes and Acute Myeloid Leukemia.

Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are hematologic malignancies arising from the bone marrow. Despite recent advances in treating these diseases, patients with higher-risk MDS and AML continue to have a poor prognosis with limited survival. It has long been recognized that there is an immune component to the pathogenesis of MDS and AML, but until recently, immune therapies have played a limited role in treating these diseases. Immune suppressive therapy exhibits durable clinical responses in selected patients with MDS, but the question of which patients are most s

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… Side effects of GO included treatment-related infusion reactions such as fever, chills, hypotension, hematological toxicity, and infection. … Adverse effects included infusion toxicities, chills, nausea, vomiting, respiratory symptoms such as throat or chest tightness, and hypotension [ 108 ]. …

Clinical practice guidelines on addressing cognitive impairment in treatable dementias.

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… Lethargy Fever (may not be present sometimes) Neck stiffness Immunocompromised host (esp in HIV, cryptococcal meningitis) HIV-associated dementia/AID-dementia complex (later stages of HIV infection) Toxoplasmosis | Immunocompromised host Focal neurological signs Cerebral Malaria | Stupor Fever and chills …

Иммунозащитное воздействие жидкости Кангфуксина на систематическую токсичность, связанную с аутологической трансплантацией стволовых клеток в множестве миеломы.

Цель Это исследование позволило оценить эффективность жидкости Канфуксина с точки зрения аутологической токсичности трансплантации стволовых клеток у пациентов с множественной миеломой. 82 участников, разделенных на простую группу по криотерапии (контрольная группа), в состав которой входили: 43 пациентов с множественными миэломами, перенесших аутлогическую трансплантацию стволовых клеток до мая 2023, и жидкость Канфуксина + пероральная криотерапия (экспериментальная группа), включая 39 пациенты с множественными миэломами, которые после июня прошли автологическую трансплантацию стволовых клето

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… Bloodstream infection (BSI): Defined as at least one positive blood culture for a recognized pathogen accompanied by compatible clinical manifestations (e.g., fever ≥ 38 °C, chills, or hypotension). …

PEX11B Palmitoilation пары пероксисомальная дисфункция с клетками Шванна не работают в диабетической нейропатии.

Диабетическая нейропатия (ДН) является распространенным и болезненным осложнением диабета; однако механизмы, лежащие в основе ее патогенеза, остаются неясными, а эффективные клинические методы лечения отсутствуют. Цель этого исследования заключается в изучении роли пероксисома в клетках Шванна в DN. МЕТОДЫ: Изобилие пероксисома в акустических нервах мышей или клеток Шванна анализировалось с помощью лазерной суперразрешительной съемки и западного пятна. Пробоотборник RPF-GPF-SKL (Ser-Lys-Leu) использовался для оценки уровней пексафагии (пероксисомы-автофагика). Для оценки пальмитоилирования PEX

Sheng-Jiang Powder Alleviates Th17/Treg Immune Imadium of Experimental Autoimune Encephalomyelitis путем регулирования метаболизма жирных кислот.

Множественный склероз (MS) является одной из главных причин инвалидности среди молодежи, и иммунный дисбаланс между клеткой Т 17 (Th17) и клетками регулирования Т (Tregs) играет решающую роль в ее патогенезе. В настоящее время лечение MS в значительной степени зависит от иммунодепрессивных препаратов или глюкокортикоидов, которые часто имеют побочные эффекты и недостатки в эффективности. Порошок Шэн Цзян (SJP) — традиционная китайская медицина — продемонстрировал антивоспалительные эффекты и может предложить новый терапевтический вариант для MS.АИМ: Цель этого исследования заключалась в изучен

Health-related quality of life in patients with hematologic malignancies treated with chimeric antigen receptor T-cell therapy: review and current progress.

Chimeric antigen receptor (CAR) T-cell therapy has transformed the care of patients with relapsed/refractory B-cell-derived hematologic malignancies. To date, six CAR T-cell therapies, targeting either CD19 or B-cell maturation antigen, have received regulatory approval. Along with the promising survival benefit, CAR T-cell therapy is associated with potentially life-threatening adverse events, including cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. While clinical trials evaluating CAR T-cell therapy consistently report the incidence of these adverse eve

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… The patients reported the following as the most common symptoms associated with treatment: fatigue, lack of appetite, headache, chills/cold, and confusion. 15 This qualitative study was useful in generating a CAR T-cell specific tool, the MDASI-CAR, which was later validated by Wang and colleagues. 13 …

A Focus on CAR T-Cell Therapy and Bispecific Antibodies in Multiple Myeloma.

Significant strides have been made in the management of patients living with myeloma. However, patients with multiply relapsed or refractory multiple myeloma (MM) have a shorter overall survival; therefore, new treatments with novel mechanisms of action are needed in this patient population. Patients with relapsing disease require a full restaging workup, including whole body imaging to evaluate for extramedullary disease and lytic bone lesions, as well as bone marrow biopsy with fluorescence in situ hybridization to determine if the patient has any new chromosomal changes that are present. Th

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… Cytokine Release Syndrome The main symptoms observed with CRS include fever, hypotension, chills, and hypoxia. Other symptoms that may be observed with CRS include renal insufficiency, ventricular tachycardia, and atrial fibrillation. …

Symptom Prevalence in Spanish and Colombian Oncology Patients Measured with the MSAS.

Cancer patients experience several symptoms throughout their illness and the treatments they receive. While this pathology represents a worldwide health problem, knowing the symptom prevalence in oncology patients remains a challenge; validated tools to obtain this information are essential. Furthermore, this prevalence information would help health professionals to establish appropriate treatments. The objective of this study was to ascertain the symptom prevalence in cancer patients from Spain and Colombia to improve future approaches. The frequency, severity, and distress of 32 symptoms fro

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… considered in this scale such as menstrual alteration, amenorrhea, burning eyes, dry eyes, increased appetite, increased olfactory sensitivity, change in nail color, severe headache, moderate headache, nasal congestion, joint weakness, decreased visual acuity, abdominal pain, headache, waist pain, chills …

Update on elotuzumab for the treatment of relapsed/refractory multiple myeloma: patients' selection and perspective.

Monoclonal antibodies (mAbs) targeting antigens expressed by plasma cells demonstrated major clinical activity in multiple myeloma patients and therefore became a new major class of drug for these patients. Elotuzumab is a humanized mAb targeting the cell surface signaling lymphocytic activation molecule family member 7, a glycoprotein highly expressed on plasma cells, that is the second mAb approved for the treatment of myeloma patients. The mechanism of action of elotuzumab includes natural killer cell (NK) mediated antibody-dependent cellular cytotoxicity and direct activation of NK-cells.

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… IRR consisted mostly on chills, fatigue, pyrexia, nausea and back pain. 18 In the Phase III trial ELOQUENT-2 (Elo-Rd), IRR were reported in 33 (10%) of patients in the elotuzumab arm. Again, IRR were mostly grade 1/2 with only 4 patients with grade 3 reactions (no grade 4 or 5). …

Tolerability of obinutuzumab therapy in patients with rituximab-relapsed/refractory B-cell malignancies - a retrospective single center cohort study.

Background & aimIn randomised clinical trials, the type II anti-CD20 antibody obinutuzumab has been shown to be more effective than rituximab for therapy of chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL). However, this enhanced efficacy was linked with elevated rates of high-grade adverse events. The aim of this study was to assess the tolerability and toxicity profile of obinutuzumab treatment in routine patients with CLL and FL, of whom the majority had experienced toxicity or resistance to rituximab.MethodsThis retrospective cohort study investigated fifteen obinutuzumab-tr

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… The most frequent infusion related reactions (IRRs) are flu-like syndromes (fever, chills and rigor) [ 33 ]. Additional hypersensitivity reactions like tumor lysis syndrome (TLS), can be observed [ 33 ]. …

Synthetic nickel-containing superoxide dismutase attenuates para-phenylenediamine-induced bladder dysfunction in rats.

Para (p)-phenylenediamine and its toxic metabolites induce excess reactive oxygen species formation that results in bladder voiding dysfunction. We determined the effects of synthetic Ni-containing superoxide dismutase mimics and the role of oxidative stress in p-phenylenediamine-induced urinary bladder dysfunction. P-phenylenediamine (60 μg/kg/day) was intraperitoneally administered for 4 weeks to induce bladder injury in female Wistar rats. Synthetic Ni-containing superoxide dismutase mimics, WCT003 (1.5 mg/kg) and WCT006 (1.5 mg/kg), were then intraperitoneally administered for 2 weeks. Tra

Emerging markers of cachexia predict survival in cancer patients.

BACKGROUND: Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic and predictive markers of cachexia in oncologic patients. Their impact on patient survival was also evaluated. METHODS: 140 adults with different cancer diagnoses were recruited. Thirty healthy volunteers served as control. Serum ghrelin, obestatin and leptin were tested at baseline and after a follow-up period of 18 months. RESULTS: Ghrelin levels were significantly higher in

Quality of life and supportive care in multiple myeloma.

UnlabelledMultiple myeloma is the second most common haematological malignancy. Novel therapies have led to improvement in survival. Current myeloma management is matching the progress made in improved survival through disease control while optimising quality of life with effective supportive care. Supportive treatment is an essential part of the therapeutic management of myeloma patients because it is directed towards improving the patient's quality of life and also can improve survival. The aim of this review is to highlight the relationship among life of quality, supportive care, and improv

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… During the first year of treatment the patients on interferon reported significantly more fever, chills, dry skin, fatigue, pain, nausea/vomiting, and appetite loss than the control patients. …

Immunotherapy in chronic lymphocytic leukemia: advances and challenges.

Chronic lymphocytic leukemia (CLL) is characterized as a clonal proliferation of mature B lymphocytes with distinct immunophenotypic traits, predominantly affecting the middle-aged and elderly population. This condition is marked by an accumulation of lymphocytes within the peripheral blood, bone marrow, spleen, and lymph nodes. The associated immune dysregulation predisposes CLL patients to a higher risk of secondary malignancies and infections, which significantly contribute to morbidity and mortality rates. The advent of immunotherapy has revolutionized the prognosis of CLL, advancing treat

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… The administration of CD20 mAbs can be accompanied by several adverse effects, which are primarily categorized as follows: The first is acute anaphylaxis, which is characterized by fever, chills, nausea, vomiting, rash, and other symptoms. … The clinical manifestations of CRS include fever, chills, hypotension, tachycardia, and in severe cases, can escalate to multi-organ dysfunction and even mortality [ 84 ]. Management strategies for CRS primarily involve pharmacological interventions and supportive care. …

High-Dose Vitamin C in Advanced-Stage Cancer Patients.

High-dose intravenously administered vitamin C (IVC) is widely used in cancer patients by complementary and alternative medicine practitioners. The most frequent indications for IVC therapy result from the belief in its effectiveness as a potent anti-cancer agent which additionally enhances chemosensitivity of cancer cells and reduces chemotherapy-related toxicities and fatigue intensity. In this narrative review, we decided to deal with this issue, trying to answer the question whether there is any scientific evidence supporting the rationale for application of high-dose IVC therapy in advanc

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… Some patients experienced unpleasant fluttering sensation in the upper abdomen and chills during the IVC infusion and increased leg edema for a few days after each infusion [ 26 ]. … 14 patients with advanced cancer | IVC 1.5 g/kg body weight 2 or 3 times a week in combination with chemotherapy | Frequently reported mild adverse events: thirst, increased urinary flow Others: nausea and occasional vomiting ( n = 1), thirst and unpleasant sensation in the upper abdomen ( n = 1), chills …

Poster Abstracts

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Нетуберкулезные микобактерные инфекции в Центре комплексного рака Национального института рака во Флориде.

Нетуберкулезная микобактерия (НТМ) - это экологические организмы, которые становятся оппортунистическими патогенами в некоторых популяциях. Показатель распространенности НТМ возрос во всем мире, что, вероятно, объясняется расширением диагностических тестов и наличием демографических исследований. Нынешняя литература по онкологическим пациентам минимальна и представляет собой уникальную область исследований. Здесь мы представляем эпидемиологию и лечение случаев заражения НТМ в созданном Национальным институтом раковых заболеваний Центре комплексного лечения раковых заболеваний. Мы провели ретро

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… Symptoms (which for pulmonary infections included chills, fever, night sweats, weight loss, cough, shortness of breath, and hemoptysis) not only had to be present but also had to fit the appropriate time course to be deemed attributable to NTM infection (along with other possible causes being excluded …

COVID-19 Vaccination in Cancer Patients: A Review Article.

Coronavirus disease 2019 (COVID-19) infection is caused by severe acute respiratory syndrome coronavirus 2. Adults with cancer are immunocompromised due to several causes including cancer itself and immunosuppressive therapy. Thus, cancer patients are more susceptible to develop COVID-19 infection. As COVID-19 vaccines became available, patients with cancer would benefit from receiving the vaccine. This article aims to review the recent evidences and recommendations about COVID-19 vaccination in cancer patients.Current guidelines recommend that patients with cancer should have the priority to

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… The most commonly reported acute side effects of the COVID-19 vaccines are injection site pain, muscle pain, fatigue, headache, fever, and chills. …