Результаты поиска

Minimally Invasive Surgical Techniques for Management of Painful Metastatic and Primary Spinal Tumors.

Patients with metastatic spinal disease are affected by disabling pain. The treatment of spinal metastases is focused on pain reduction and improvement in quality of life. Until recently, many patients with metastatic spinal disease did not qualify as surgical candidates due to the risks of surgery and length of recovery period. However, recent advances in minimally invasive surgery such as kyphoplasty and vertebroplasty allow patients to safely undergo surgery for pain relief with a short recovery period. The studies reviewed here suggest that vertebral augmentation is successful in reducing

The ZOTECT study: Effect of zoledronic acid on bone metabolism in patients with bone metastases from prostate or breast cancer.

PurposeThe ZOTECT study assesses the effect of zoledronic acid (ZOL) on bone-marker levels and potential correlations with disease outcomes in bisphosphonate-naive patients.MethodsThis prospective, single-arm, open-label study in bisphosphonate-naive (≥6 months) patients with bone metastases from prostate cancer (PC; n=301) or breast cancer (BC; n=99) enrolled at 98 German sites (May 2006 to July 2008) investigated the effect of ZOL (4 mg intravenously every 4 weeks×4 months, with a final follow-up at 12 months) on bone-marker levels. Secondary assessments: skeletal-related event (SRE) rate, p

Effectiveness of Erector Spinae Muscle Block in Vertebral Oncologic Fracture.

Objectives An observational, retrospective, longitudinal, and analytical study aimed to evaluate the effectiveness of the erector spinae plane (ESP) block in managing pain in patients with vertebral fractures secondary to tumoral activity. This study included patients treated at the Pain Clinic who underwent ESP block. The objectives were to describe demographic characteristics, oncological diagnosis, vertebral fracture features, imaging techniques, medications used, and the level of ESP block. Additionally, pain levels were assessed using a numerical analog scale, and the consumption of opioi

Совпадение в полном тексте источника
… Combination of the T7 unilateral Erector spinae plane block and T10 bilateral Retrolaminar blocks in a patient with multiple rib fractures on the right and T10-12 vertebral compression fractures: a case report. Gluncic V, Bonasera L, Gonzalez S, Lukić IK, Candido K. …

Редкое дерматологическое проявление фолликулярных смешений у пациента с множественной миеломой и конечной стадией почечной болезни при гемодиализе: отчет по делу.

Множественная миелома (ММ) — гематологическая порча, характеризующаяся клональным расширением злокачественных плазменных клеток в костном мозге, что приводит к различным системным осложнениям. Хотя резкие проявления MM редки, фолликулы представляют собой весьма специфический, но редкий дерматологический вывод, связанный с MM. В настоящем исследовании представлен пример 59-year-old Человек с MM, который демонстрировал фолликулярный акантоз и гиперкератоз в качестве скромных индикаторов злодеяний. Пациент с историей сцены 5 В ходе клинической оценки и лабораторных исследований был диагностирован

Совпадение в полном тексте источника
… of bilateral maxillary and ethmoid sinusitis. ii) Skeletal lesions, multiple hypodense lesions were identified in the skull, several vertebrae, bilateral ribs, scapulae and pelvic bones, which are findings consistent with lytic lesions of MM. iii) Fractures and spinal changes, bilateral pathological rib … (C) An axial pelvic CT revealed lytic bone lesions, bilateral pathological rib fractures and pelvic effusion. …

Hypophosphatasia: Clinical Clues and Management Considerations.

This case report identifies typical manifestations of a patient with hypophosphatasia, a rare genetic condition in which mutations in tissue-non-specific alkaline phosphatase (TNSALP) enzymes cause low levels of alkaline phosphatase and defective bone mineralization. It explores common diagnostic clues from the history and laboratory evaluation, which can help clinicians identify the disorder. This case introduces a 49-year-old patient with a long history of fractures and dental abnormalities who was referred to endocrinology for evaluation of osteopenia. Further review of her laboratory data

Secondary fracture prevention in primary care: a narrative review.

The global burden of osteoporosis continues to rise with an ageing population. Untreated osteoporotic fractures not only heighten the risk of subsequent fractures but are associated with excess mortality. Although primary care guidelines consistently stress the importance of secondary fracture prevention, fewer than 20% of patients are appropriately treated for osteoporosis following an initial osteoporotic fracture. This worldwide phenomenon is known as the osteoporosis care gap. This literature review examines the barriers to secondary fracture prevention in primary care and evaluates the ef

A case report of metastatic hepatocellular carcinoma in the mandible and coracoid process: A rare presentation.

RationaleWe report a rare case of hepatocellular carcinoma (HCC) with metastases to the mandible and coracoid process of scapula without evidence of lung involvement.Patients concernsThe patient was diagnosed with HCC, presented 5 months later with right lower tooth pain, swelling over the right mandible area and right shoulder pain.DiagnosesHistopathological examination of mandible showed findings suggestive of metastatic HCC. Magnetic resonance imaging (MRI) of the right shoulder revealed findings of irregular enhancing lesion at the right coracoid process causing erosion of the coracoid pro

A new prediction model for overall survival of elderly patients with solitary bone plasmacytoma: A population-based study.

BackgroundComprehensive studies on the prognosis of solitary bone plasmacytoma (SPB) are lacking, especially in elderly patients with SPB. This study aims to establish a novel nomogram and risk stratification system to predict the overall survival (OS) of elderly patients with SPB.MethodsThe data of elderly patients with SPB from 2000 to 2017 were identified in the SEER database. SPB patients were randomly assigned to the training set (n = 825) and validation set (n = 354). The Cox regression analysis was used to determine the independent risk factors for OS in elderly SPB patients. The nomogr

A quantitative method for the characterization of lytic metastases of the bone from radiographic images.

The aim of our study was to assess the diagnostic usefulness of the gray level parameters to distinguish osteolytic lesions using radiological images. Materials and Methods. A retrospective study was carried out. A total of 76 skeletal radiographs of osteolytic metastases and 67 radiographs of multiple myeloma were used. The cases were classified into nonflat (MM1 and OL1) and flat bones (MM2 and OL2). These radiological images were analyzed by using a computerized method. The parameters calculated were mean, standard deviation, and coefficient of variation (MGL, SDGL, and CVGL) based on gray

Какие факторы связаны с неблагоприятным прогнозом у нескольких пациентов с миеломой после операции?

Для изучения прогнозов пациентов с множественной миеломой (ММ) после операции, анализа факторов риска, ведущих к неблагоприятным результатам послеоперационного лечения, и создания номограммы. МЕТОДЫ: Клинические данные 154 пациентов с MM, которые прошли операцию в нашем учреждении между 2007 и 2019 был ретроспективно проанализирован. Оценка и сопоставление уровней боли, качества жизни и функционального состояния пациентов до и после операции (Р) < 0.05) были признаны статистически значимыми. Кривая выживания Каплана-Мейера использовалась для оценки средней продолжительности выживаемости. Отриц

Совпадение в полном тексте источника
… Thirty-three (21.4%) patients experienced limb fractures, and 3 (1.9%) patients had rib fractures, for which fracture reduction and fixation combined with bone cement filling were performed. …

A review of spontaneous bone metastases in domestic and laboratory animals.

Bone metastases cause significant morbidity and ultimately death in some human cancer patients. Although experimental animal models of skeletal metastases have been invaluable for investigating the molecular mechanisms of cancer progression and growth in bones, few of these models recapitulate the heterogeneous nature of bone metastases observed in humans. Animals with naturally occurring cancers have been proposed as ideal and unique models for human cancer research. From this, understanding the incidence, histologic features, clinical presentation, and response to therapy of spontaneous bone

Роль радиотерапии для пациентов с множественной миеломой в современную эпоху: реальный мировой опыт работы в одном центре.

Рентгенотерапия (RT) является хорошо зарекомендовавшей себя формой лечения в нескольких миеломах (ММ), особенно при событиях, связанных со скелетом. Однако его роль, по всей видимости, меняется с внедрением современных системных методов. MethodsWe провел ретроспективный анализ большой, одноцентровой группы MM, обработанной современными протоколами, для описания нынешних моделей использования RT.RecondsRT продолжает приносить клиническую пользу, при этом наблюдались изменения в моделях использования по сравнению с историческими группами. ConcernRT сохраняет свою актуальность в современном ландш

A Tailored Approach for Appendicular Impending and Pathologic Fractures in Solid Cancer Metastases.

Advances in medical and surgical treatment have played a major role in increasing the survival rates of cancer patients with metastatic bone disease. The clinical course of patients with bone metastases is often impaired by bone complications, such as bone fractures, which have a substantial negative impact on clinical outcomes. To optimize clinical results and prevent a detrimental impact on patients' health, a tailored approach should be defined for any given patient. The optimal management of impending or pathologic fractures is unknown and relies on a multidisciplinary approach to tailor c

Abstracts

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Isolated Lesser Trochanter Fractures in Adults: A Systematic Review of Malignant, Infectious, and Benign Etiologies.

Isolated lesser trochanter (LT) fractures are uncommon in adults and may be the first clue to an underlying pathologic process. In contrast to adolescent apophyseal avulsions, the same finding in a skeletally mature patient has been linked to metastatic disease, primary bone tumors, hematologic malignancy, infection, and, less often, benign traumatic, stress-related, osteoporotic, or metabolic causes. This review examined the malignant, infectious, and benign etiologies, diagnostic pathways, treatments, and outcomes that have been reported in adults aged 18 years or older presenting with a rad

Cytology and clinical features of myelomatous pleural effusion: Three case reports and a review of the literature.

The purpose of this study was to report the clinical features, laboratory findings, and cytomorphology, and prognosis of three patients with myelomatous pleural effusion (MPE). The literature pertaining to MPE was reviewed. The three cases and literature review suggest that MPE is rare and often associated with a poor prognosis. The correct diagnosis depends on the aggressive clinical characteristics, laboratory findings, and chromosomal abnormalities, but routine pathological examination of the pleural effusion has low sensitivity. Cell blocks stained with hematoxylin & eosin and by immunohis

Совпадение в полном тексте источника
… Multiple pathological rib fractures were seen (Figure 1 B). Bone marrow aspiration revealed 90% of dystrophic PC. Thoracocentesis yielded exudative effusion with multiple atypical PC. …

Анапластическая лимфатическая киназа-положительная анапластическая большая клеточная лимфома с первичным участием костей: отчет по делу.

КОЛИЧЕСТВО: Лимфомы, происходящие из костей, но не связанные с висцеральными или региональными лимфатическими узлами, диагностируются как первичная костная лимфома (PBL). Поступило мало сообщений об анапластической крупноклеточной лимфоме (ALCL), исходящей из кости. Цель настоящего доклада состоит в том, чтобы описать трудности, связанные с диагностированием и полным лечением этого редкого вида лимфомы кости. Мы описываем случай положительной анапластической лимфатической киназы (ALK+) ALCL пациента с первичными множественными повреждениями костей. Сначала пациент был в местной больнице из-за

The use of cortical heterologous sheets for sinus lift bone grafting: a modification of Tulasne's technique with 7-year follow-up.

PLAIN ENGLISH SUMMARY: (Please see www.Toolsfortalking.co.uk for an easy read summary of the project.) The Tools for Talking are a set of resources that were developed through collaboration between Black, Asian and minority ethnic people with learning disabilities and researchers at the University of Birmingham. The resources were designed to be used by people with learning disabilities and service providers to facilitate culturally-sensitive communication and information sharing, service planning and delivery. They comprise illustrative videos and exploratory activities relating to five topic

Множественная миелома: личный отчет о моем путешествии с болезнью и о реакции на теклистамб.

Множественная миелома (ММ) остается неизлечимым гематологическим раком, приводящим к повреждению костного мозга, что, помимо многих других последствий, приводит к разрушительным повреждениям костей. Я пациент с MM, который прошел курс лечения с момента диагностики этой болезни в декабре. 2019. В настоящем документе рассматриваются методы лечения и замечания, сделанные в течение этого периода. Основные результаты такого лечения обсуждаются в хронологическом порядке. В этот период у меня случился рецидив MM, а потом меня познакомили с лечением теклистамб. Результаты лечения теклистамбов весьма м

A systematic review of microsurgical reconstruction of the jaws using vascularized fibula flap technique in patients with bisphosphonate-related osteonecrosis.

ObjectiveThe aim of this systematic review was to assess the role of microsurgical reconstruction of the jaws in patients with bisphosphonate-related osteonecrosis, and biological complications after an observation period of at least 12 months.Material and methodsAn electronic MEDLINE search supplemented by manual searching was conducted to identify studies reporting data of at least 12 months observation on the microsurgical reconstruction of the jaws in patients with bisphosphonate-related osteonecrosis.ResultsFour studies resulted eligible for the analysis yielded. Three out of five studies