Результаты поиска

Mechanisms of Chemotherapy-Induced Neurotoxicity.

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been extensively used in the clinic as the main cancer treatment either alone or as an adjuvant therapy before and after surgery. Although the use of chemotherapeutic drugs improved the survival of cancer patients, these drugs are notorious for causing many severe side effects that significantly reduce the efficacy of anti-cancer treatment and patients' quality of life. Many widely used chemotherapy drugs including platinum-based agents, taxanes, vinca alkaloids, proteasome inhibitors, and thalidomide ana

The unseen symptom: A longitudinal qualitative interview study exploring mobility loss in people with advanced cancer.

BACKGROUND: Mobility loss is a common symptom in people with advanced cancer and is associated with reduced function and quality of life. While its physical consequences are well documented, less is known about how individuals and their families experience and adapt to these changes over time. AIM: To explore how individuals with advanced cancer and their caregivers experience and respond to mobility loss. DESIGN: A qualitative longitudinal study using Interpretative Phenomenological Analysis. Participants completed two semi-structured interviews, with follow-ups prompted by changes in mobil

Визуальное расстройство при множественном склерозе, связанном с постгенифицированной серой и белой материей: выше и выше.

Визуальное расстройство является одним из наиболее распространенных и нетрудоспособных проявлений множественного склероза (МС). Несмотря на то, что зрительная дисфункция, связанная с оптическим невритом и участием в работе мозговой системы, хорошо известна, зрительные нарушения, связанные с постгенетическими визуальными путями, включая оптические излучение и зрительные коры коры, относительно недостаточно изучены и недостаточно признаны в клинической практике. Увеличение числа свидетельств, полученных в результате продвинутого нейроимации, оптической томографии и нейропсихологического тестиров

New approaches to divorce with children: A problem of public health.

This broad review elaborates on the most up-to-date knowledge on biochemical and psychobiological aspects of parental loss and other childhood adversities during divorce involving minor children. So far, divorce involving minor children was unfortunately considered by authorities only as a purely juridical problem, and this approach has often allowed a completely different approach according to the Courts. Now, scientific research, also making use of animal models, is demonstrating the biological basis of the problem and the indisputable consequences on the well-being and health of children. T

Результаты беременности у пациентов с множественным склерозом: ретроспективное исследование из одного центра в Бенгази, Ливия.

Предыстория: широко распространены ошибочные представления о множественном склерозе (СМС), беременности и лечении заболеваний, которые часто обусловлены опасениями о том, что ДМТ представляют опасность для плода или что беременность усугубит это заболевание. Цель этого исследования заключалась в оценке и документировании местных клинических приемов и процессов принятия решений в области управления женщинами с НР в отношении использования ДЗ во время беременности. Методы: Ретроспективный обзор был проведен в клинике MS медицинского центра Бенгази, Бенгази, Ливия, с января 1, 2016 по декабрь 31,

Adaptation of digital integration of PROMs and PREMs in oncology during implementation: a scoping review.

PurposeDigital tools facilitate the timely collection of patient-reported outcome and experience measures (ePROMs/PREMs), but there is no consistent reporting on the technical and content adaptations made essential to implementing these digital tools in a specific context. Adaptations made to ePROMs/ePREMs can improve data quality, clinical management, and patient outcomes. We explored how studies report on adaptations and the reasons and types of these during an implementation process of ePROMs/ePREMs systems in routine cancer care.MethodsWe conducted a systematic scoping review. We searched

Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review.

COVID-19 affects brain function, as deduced by the "brain fog" that is often encountered in COVID-19 patients and some cognitive impairment that is observed in many a patient in the post-COVID-19 period. Approximately one-third of patients, even when they have recovered from the acute somatic disease, continue to show posttraumatic stress disorder (PTSD) symptoms. We hypothesized that the persistent changes induced by COVID-19 on brain structure would overlap with those associated with PTSD. We performed a thorough PubMed search on 25 April 2023 using the following strategy: ((posttraumatic OR

Воздействие непрерывного лечения леналидомидома на людей, живущих с множественным исследованием по оценке качества услуг в одном центре миэломы.

PMOPSE: Непрерывное лечение линалидомида после аутологической трансплантации стволовых клеток способствует повышению уровня свободного развития и общей выживаемости вновь диагностированных пациентов с множественными миеломами и является стандартом ухода в Соединенном Королевстве с марта 2021. Однако имеется мало информации о ее воздействии на повседневную жизнь пациентов. Эта оценка услуг была направлена на качественную оценку пациентов, проходящих курс лечения линалидомидом в раковом центре в Лондоне, с тем чтобы эта служба могла лучше соответствовать потребностям и ожиданиям пациентов.МЕТОДЫ

Teledentistry as a Supportive Tool for Dentists in Diagnosing MRONJ in Northern Cyprus.

OBJECTIVE: This web-based survey, as a tool of teledentistry, is aimed at assessing the level of knowledge, attitudes, and awareness regarding MRONJ among dental professionals in Northern Cyprus. METHODS: An online self-administered questionnaire about MRONJ was sent to all dentists in Northern Cyprus through Google Forms. The first part of the questionnaire consists of demographic and professional information, and the second part included questions about knowledge and awareness questions about MRONJ. The SPSS software was used for statistical data analysis. A Chi-square test was performed to

Communicating Health Literacy on Prescription Medications on Social Media: In-depth Interviews With "Patient Influencers".

BackgroundHistorically, pharmaceutical companies have struggled with trust and brand reputation among key stakeholders and have adopted innovative marketing strategies to reach patients directly and rebuild those relationships. Social media influencers are a popular strategy to influence younger demographics, including Generation Z and millennials. It is common for social media influencers to work in paid partnerships with brands; this is a multibillion-dollar industry. Long have patients been active in online health communities and social media platforms such as Twitter and Instagram, but in

Exploring Barriers and Facilitators to Engagement of an Online Acceptance and Commitment Therapy Intervention for Cancer Survivors With Chronic Painful Chemotherapy-Induced Peripheral Neuropathy: Qualitative Interview Study.

BackgroundOnline self-management interventions for cancer survivors are increasingly being used, but engagement is often difficult for patients. Given the importance of engagement for intervention effectiveness, identifying patient-reported barriers and facilitators is essential.ObjectiveThe aim of this study was to qualitatively examine barriers and facilitators influencing engagement with an online self-management intervention, offered with or without guidance, for cancer survivors experiencing chronic painful chemotherapy-induced peripheral neuropathy (CIPN).MethodsPatients who took part in

Characteristics and Components of Self-Management Interventions for Improving Quality of Life in Cancer Survivors: A Systematic Review.

Self-management can improve clinical and psychosocial outcomes in cancer survivors. Which intervention characteristics and components are beneficial is unclear, hindering implementation into practice. We systematically searched six databases from inception to 17 November 2021 for studies evaluating self-management interventions for adult cancer survivors post-treatment. Independent reviewers screened for eligibility. Data extraction included population and study characteristics, intervention characteristics (TIDieR) and components (PRISMS), (associations with) quality of life (QoL), self-effic

Дифференциация по признаку расы и места в области многоразового склерозового лечения: качественное исследование опыта пациентов.

Множественный склероз - это нейродегенеративное и нейро-воспалительное заболевание, вызывающее различные симптомы, включая физические и когнитивные области. Предыдущие исследования показали, что расовые диспропорции характерны для многочисленных неврологических результатов склероза, при этом чернокожие люди сталкиваются с более тяжелыми последствиями, чем их белые коллеги. ЦЕЛЬ: Изучение различий по признаку расы и места в опыте оказания многочисленных услуг по склерозу среди чернокожих и белых участников. МЕТОДЫ: Качественные данные были собраны у 20 взрослых с множественным склерозом в ходе

Cancer Research in the Time of COVID-19: A Colombian Narrative.

Cancer research is deficient in Colombia and efforts and resources diverted due to the COVID-19 pandemic could worsen the situation. We explore the impact of the pandemic on cancer research funding, output, and conduct. We sought information at national level and used the experience of an academic reference center to contrast the impact at institutional level. We searched databases and official documents of national governmental institutions, trial registries, hospital registries, and the Web of Science. We interviewed principal investigators (PIs) to retrieve information on the conduct of can

Естественные соединения серы в состоянии психического здоровья и неврологических расстройств: наблюдения и исследования.

За прошедшие годы глобальное бремя неврологических и психических расстройств значительно возросло, в результате чего они стали одной из наиболее серьезных проблем и вызовов для здоровья человека. В рамках новых методов лечения от болезней и болезней все больше внимания уделяется вопросам питания и здравоохранения. Питание серы, главным образом полученное из различных природных источников, играет решающую роль в многочисленных физиологических процессах, включая функцию мозга. В настоящем обзоре содержится обзор химического состава ряда естественных источников таких богатых серой веществ, как из

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… Even though they did not demonstrate an improvement in the MATRICS Composite score, other tests concluded that spatial working memory and verbal learning have improved ( p  = 0.004 and p  = 0.031). …

Exploring the characteristics of conversational agents in chronic disease management interventions: A scoping review.

ObjectiveWith the increasing global burden of chronic diseases, there is the potential for conversational agents (CAs) to assist people in actively managing their conditions. This paper reviews different types of CAs used for chronic condition management, delving into their characteristics and the chosen study designs. This paper also discusses the potential of these CAs to enhance the health and well-being of people with chronic conditions.MethodsA search was performed in February 2023 on PubMed, ACM Digital Library, Scopus, and IEEE Xplore. Studies were included if they focused on chronic di

Longitudinal Collection of Patient-Reported Outcomes and Activity Data during CAR-T Therapy: Feasibility, Acceptability, and Data Visualization.

Background: Clinicians must closely monitor patients for toxicities after chimeric antigen receptor T-cell therapy (CAR-T). Patient-reported outcomes (PROs) (e.g., toxicities, quality of life) and activity data (e.g., steps, sleep) may complement clinicians’ observations. This study tested the feasibility and acceptability of collecting PROs and activity data from patients with hematologic malignancies during CAR-T and explored preliminary data patterns. Methods: Participants wore a Fitbit tracker and completed PROs at several timepoints through 90-days post-infusion. Feasibility was assessed

Exercise Intervention on Insomnia in Patients with a Cancer: A Systematic Review of the Literature.

Cancer is associated with increased muscle weakness, reduced physical functioning, increased fatigue, but also sleep disturbances, including insomnia, that affect quality of life (QoL). Physical activity demonstrated benefits on functional capacity, resilience and cancer-related fatigue, but there is a paucity of available data regarding its effects on insomnia in patients with cancer. This systematic review aims to examine the efficacy of exercise levels with insomnia in cancer patients. A systematic search was performed for articles published in PubMed and Cochrane Library databases from Dec

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… A Twelve-Week Moderate Exercise Programme Improved Symptoms of Depression, Insomnia, and Verbal Learning in Post-Aneurysmal Subarachnoid Haemorrhage Patients: A Comparison with Meningioma Patients and Healthy Controls. Neuropsychobiology. 2018;76:59–71. doi: 10.1159/000486903. 33. …

The role of social networks in prognostic understanding of older adults with advanced cancer.

ObjectivesExplore how older patients utilize their social networks to inform prognostic understanding.MethodsIn a pilot study of adults (≥65 years old) with advanced cancer, 16 patients completed surveys, social network maps, and semi-structured interviews exploring with whom they preferred to communicate about their illness. Interviews were analyzed using open-coding, and codes were categorized into emergent themes. Social network maps and themes were analyzed via mixed-methods social network analysis (MMSNA). Three case examples with diverse network characteristics and communication patterns

Оценка киберзаболевания в бессмертных виртуальных средах: систематический обзор с последствиями для неврологической реабилитации.

Введение. Распространение виртуальных технологий виртуальной реальности (ВР) изменило характер взаимодействия людей с цифровой средой, открывая беспрецедентные возможности в различных областях: от развлечений и образования до здравоохранения и лечения психических заболеваний. Велосипедный VR все чаще внедряется в моторные и когнитивные программы в нейро-абилитации, где крайне важно обеспечить безопасность пациентов и соблюдение курса лечения. Несмотря на свою актуальность, концептуализация и измерение киберболезни (КШ) остаются фрагментированными в разных дисциплинах, при этом различные инстру