Результаты поиска

Cancer-related cognitive impairment in patients with hematologic malignancies after CAR T cell therapy: a systematic review and meta-analysis of prevalence.

PURPOSE: Cancer-related cognitive impairment is one of the symptoms of neurotoxicity among patients receiving chimeric antigen receptor (CAR) T cell therapy. Evidence of the overall estimated prevalence of cancer-related cognitive impairment following CAR T-cell therapy among patients with hematologic malignancies at short-term and long-term follow-ups is lacking. This review aimed to summarize the cognitive functioning status and estimate the prevalence of cancer-related cognitive impairment at follow-up within 1 month, 1 to 12 months, and > 12 months after CAR T cell therapy. METHODS: PubMe

The challenge of pharmacotherapy for musculoskeletal pain: an overview of unmet needs.

Musculoskeletal disorders are characterized by several impairments, including pain, affecting muscles, bones, joints and adjacent connective tissue, resulting in temporary or permanent functional limitations and disability. Musculoskeletal pain is particularly prevalent worldwide and greatly impacts the quality of life, social participation and economic burden. To date, several issues persist about the classification of musculoskeletal pain and its management strategies and resources. The treatment of musculoskeletal pain conditions is complex and often requires a multimodal approach, includin

The impact of myelosuppression on quality of life of patients treated with chemotherapy.

Side effects from chemotherapy-induced myelosuppression can negatively affect patients' quality of life (QoL). Neutropenia increases infection risk, and anemia frequently results in debilitating fatigue. Additionally, the bleeding risk associated with thrombocytopenia can lead to fear and anxiety. However, traditional interventions for myelosuppression fall short of the ideal. Granulocyte colony-stimulating factors reduce the risk of severe neutropenia but commonly lead to bone pain. Erythropoiesis-stimulating agents are not always effective and may cause thromboembolic events, while transfusi

Integrated palliative nursing interventions for older adults with cancer: Effects on quality of life, psychological outcomes, and symptom burden.

OBJECTIVES: Older adults with cancer frequently experience high symptom burden, psychological distress, and reduced quality of life. Integrating palliative nursing interventions into routine oncology care has the potential to improve these outcomes, yet evidence examining their measurable effects remains limited. This study aimed to examine the effects of integrated palliative nursing interventions on quality of life, psychological outcomes, and symptom burden among older adults with cancer. METHODS: A quasi-experimental one-group pre-test-post-test design was conducted at King Khaled Hospita

Complementing clinical cancer registry data with patient reported outcomes: A feasibility study on routine electronic patient-reported outcome assessment for the Austrian Myelome Registry.

OBJECTIVES: Routinely assessed patient-reported outcomes (PROs), such as quality of life (QOL), are important to supplement clinical cancer data but requires rigorous implementation. This study aims at depicting the implementation procedure and evaluating the feasibility of routine electronic PRO monitoring (ePRO) for collecting data supplementing the Austrian Myeloma Registry (AMR). METHODS: Integration of ePRO monitoring into clinical routine was planned according to the Replicating Effective Programs framework. QOL data were assessed regularly during treatment and aftercare at the hematoon

Mechanisms of chemotherapy-induced behavioral toxicities.

While chemotherapeutic agents have yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side-effects from the treatment which can lead to dose reduction or even cessation of treatment. Common side effects (symptoms) of chemotherapy include (i) cognitive deficiencies such as problems with attention, memory and executive functioning; (ii) fatigue and motivational deficit; and (iii) neuropathy. These symptoms often develop during treatment but can remain even after cessation of chemotherapy, severely impacting long-term quality of lif

Совпадение в полном тексте источника
… Kesler et al. ( 2013 ) reported an interaction between IL-6 and TNF-α on performance on a verbal learning test in chemotherapy-treated breast cancer survivors. …

PROMIS® Health Organization (PHO) 2021 Conference Abstracts.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Turkish validity and reliability study of Self-Blame Attributions for Cancer Scale: A methodological study.

PurposeThis study aimed to culturally adapt the Self-Blame Attributions for Cancer Scale (SBAC) into Turkish and evaluate its psychometric properties, including validity and reliability.MethodThis methodological study enrolled 161 patients from both inpatient and outpatient oncology departments of a university hospital during a 1-year observation period (March 2024-March 2025). Participant data were obtained by using 2 instruments: a demographic questionnaire and the adapted Turkish version of "the SBAC."ResultsConfirmatory factor analysis revealed strong factor loadings ranging from 0.670 to

Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

The epigenetic potential of vitamin K2 in brain health.

Vitamin K2 refers to a subfamily of vitamin K isoforms known as Menaquinones and, therefore, indicated as MK-n, the "n" indicating the number of isoprene units present in the side chain. Like the other members of the Vitamin K family, K2 is an enzymatic cofactor for the γ-glutamyl carboxylase (GGCX). This enzyme's substrates, which carboxylate glutamic acid residues, are known as Vitamin K-dependent proteins (VKDPs). Besides being involved in bone homeostasis, vitamin K exerts its primary function in the coagulation process. More recently, a function of Vitamin K also in brain homeostasis has

'I think it affects every aspect of my life, really': Cancer survivors' experience of living with chronic pain after curative cancer treatment in England, UK.

AimTo explore cancer survivors' experiences of living with chronic pain after curative cancer treatment in England, UK.MethodsA qualitative study using telephone interviews with adult cancer survivors experiencing chronic pain after curative cancer treatment. Interview data was analysed using a reflexive thematic approach [1-3].FindingsNineteen participants: 14 female, 5 male, mean age 62.4 years, 1.5-48 years since cancer diagnosis, eight tumour groups represented. Six participants (31.6%) developed chronic pain more than ten years after completing cancer treatment (range 0-25 years). Five th

Experiences of Cancer-Related Cognitive Impairment Across Cancer Types: Qualitative Systematic Review.

BackgroundCancer-related cognitive impairment (CRCI) is frequently reported during cancer treatment, with 35% of patients experiencing cognitive issues even after treatment completion. Commonly reported impairments include difficulties with memory, attention, executive function, and processing speed, which often reduce daily functioning and quality of life (QoL). Despite its prevalence, CRCI remains underresearched across various cancer types, limiting understanding of the patient experience.ObjectiveThis study aims to synthesize the qualitative evidence regarding the lived experience of CRCI

Disease-Modifying Therapies for Multiple System Atrophy: Where Are We in 2022?

Multiple system atrophy is a rapidly progressive and fatal neurodegenerative disorder. While numerous preclinical studies suggested efficacy of potentially disease modifying agents, none of those were proven to be effective in large-scale clinical trials. Three major strategies are currently pursued in preclinical and clinical studies attempting to slow down disease progression. These target α-synuclein, neuroinflammation, and restoration of neurotrophic support. This review provides a comprehensive overview on ongoing preclinical and clinical developments of disease modifying therapies. Furth

ESMO/ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2023.

The European Society for Medical Oncology (ESMO) and ASCO are publishing a new edition of the ESMO/ASCO Global Curriculum (GC) with contributions from more than 150 authors. The purpose of the GC is to provide recommendations for the training of physicians in medical oncology and to establish a set of educational standards for trainees to qualify as medical oncologists. This edition builds on prior ones in 2004, 2010, and 2016 and incorporates scientific advances and input from an ESMO/ASCO survey on GC adoption conducted in 2019, which revealed that GC has been adopted or adapted in as many a

Moments of deep connection between clinicians and patients in oncology: a mixed-methods study of sacred moments.

PurposeSacred moments are periods of deep connection between clinicians and patients, associated with increased clinician career fulfillment and stronger therapeutic alliances in radiation oncology and internal medicine. Our study is the first to investigate sacred moments in medical oncology.MethodsWe conducted semi-structured qualitative interviews with clinicians and patients at an NCI-designated Comprehensive Cancer Center. Interviews were recorded, transcribed, and analyzed using inductive coding. Participants completed a closed-ended (Likert-style) questionnaire that assessed demographic

Специальный выпуск: резюме 11th Конгресс Европейской академии неврологии, Хельсинки, Финляндия.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Эффективность транскраниальной непосредственной стимуляции тока на двигательных и когнитивных функциях у пациентов с множественным склерозом: систематический обзор и метаанализ.

Множественный склероз (MS) представляет собой хроническое неврологическое расстройство, затрагивающее 2.8 million :: люди во всем мире, характеризующиеся дисфункцией двигателя и когнитивными нарушениями, которые по-прежнему плохо решаются только с помощью фармакологических средств. Транскраниальное прямое стимулирование течения (tDCS) стало многообещающей неинвазивной нейромодуляцией для лечения симптомов у пациентов с синдромом MS. ЦЕЛИ: Этот систематический обзор и метаанализ были направлены на оценку эффективности ТДСЦ в деле совершенствования двигательных и когнитивных функций у пациентов

Cancer: a looming public health crisis in Africa-a call to accelerate equitable access to medicines.

The global incidence of cancer is on the rise, with Africa experiencing a particularly steep increase in both cancer incidence and mortality. This upward trend is driven by a combination of factors, including population growth, poverty, aging, urbanization, and the adoption of lifestyles that increase the risk of cancer. It is projected that from 2022 to 2045, the incidence of cancer in Africa will increase by 106.8%, while cancer mortality will rise by 111.7% if no action is taken. In contrast, Europe is expected to see increases of only 22.5% in incidence and 32.2% in mortality. Despite glob

Топография инфонтенторных повреждений в депрессии и тревоге при множественном склерозе.

БОЛЕЕ: Депрессия и тревога широко распространены при множественном склерозе и оказывают значительное воздействие на результаты лечения пациентов. Однако их связь с конкретными областями обезвоживания остается неясной. ЗАДАЧИ: В настоящем исследовании рассматривается связь между инфантентными повреждениями и депрессией или тревогой с уделением особого внимания трем областям, представляющим интерес: рэфе-нуклей, колокольчик коэулеус и мозговой лобуле VIIА. В клинике когнитивной нейроиммунологии Королевской мельбурнской больницы были приняты на работу пациенты. Участники были отнесены к группам "

Совпадение в полном тексте источника
… Cognitive performance was screened using the validated Brief International Cognitive Assessment for MS (BICAMS) [ 16 ], consisting of the Symbol Digit Modality Test (SDMT) [ 17 ], the second edition of the California Verbal Learning Test [ 18 ], and the revised Brief Visuospatial Memory Test [ 19 ]. …

Nursing care for chimeric antigen receptor T cell therapy survivors: A literature review.

Chimeric antigen receptor T cell (CAR-T) therapy is an immunotherapy that involves genetically modifying the patient's own T cells to express a chimeric antigen receptor, enabling them to recognize and destroy cancer cells. This treatment has revolutionized the prognosis and management of hematological malignancies, leading to a significant increase in long-term survivors. However, there is limited evidence regarding late sequelae and post-treatment care due to the recent emergence of this therapy. The rapid advancement of CAR-T therapies has created opportunities for advanced practice nurses