Результаты поиска

Diffuse large B cell lymphoma originating from the maxillary sinus with skin metastases: A case report and review of literature.

BackgroundDiffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma (ML), accounting for 30%-40% of cases of non-Hodgkin's lymphoma (NHL) in adults. Primary paranasal sinus lymphoma is a rare presentation of extranodal NHL that accounts for only 0.17% of all lymphomas. ML from the maxillary sinus (MS) is a particularly rare presentation, and is thus often difficult to diagnose. We have reported the first known case of DLBCL originating from the MS with rapidly occurrent multiple skin metastasis.Case summaryAn 81-year-old Japanese man visited our hospital due to contin

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review.

Haematological malignancies induce important alterations of the immune system, which account for the high frequency of autoimmune complications observed in patients. Cutaneous immune-mediated diseases associated with haematological malignancies encompass a heterogeneous group of dermatoses, including, among others, neutrophilic and eosinophilic dermatoses, autoantibody-mediated skin diseases, vasculitis and granulomatous dermatoses. Some of these diseases, such as paraneoplastic pemphigus, are associated with an increased risk of death; others, such as eosinophilic dermatoses of haematological

Совпадение в полном тексте источника
… One hypothesis suggests that leukaemic cells infiltrate the skin and drive either Th2 cells or eosinophil and basophil activation, e.g. by releasing antibodies against the high-affinity immunoglobulin E receptor (FceRI) [ 123 , 124 ]. … Serum from a subset of patients with chronic lymphocytic leukemia and large local reactions to mosquito bites induces upregulation of CD63 surface expression on basophils in atopic donors. Leuk Lymphoma. 2016;57:2417–2420. doi: 10.3109/10428194.2016.1173208. 124. …

Болезнь Альцгеймера (AD) в множестве склерозов (MS): систематический обзор опубликованных случаев, механистические связи между AD и MS и возможная клиническая оценка AD в MS.

Фон: Болезнь Альцгеймера (AD) и множественный склероз (MS) являются двумя неврологическими расстройствами, которые могут создавать огромное бремя для качества жизни человека. В связи с появлением новых методов лечения, которые существенно увеличивают продолжительность жизни, возможно, наблюдается рост распространенности АД среди пожилых пациентов с НР. Цель: На основе предыдущего обзора, посвященного сосуществованию MS-AD, этот обзор был направлен не только на расширение круга поиска литературы, но и на изучение возможных механистических связей между клиническими маркерами MS и AD. Методы: мы

Совпадение в полном тексте источника
… Similarly, Saccharomyces and Aspergillus were found in higher concentrations in MS patients; the former was positively correlated with circulating basophils but negatively correlated with regulatory B cells, while the latter was positively correlated with activated CD16+ dendritic cells. 120 Additionally …

Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia.

Suppressor of cytokine signaling 1 (SOCS1) protein, which encodes a member of signal transducers and activators of transcription-induced inhibitors, takes part in a negative regulation of cytokine signaling. The mechanism of SOCS1 in tumor carcinogenesis is complex and there have been no studies concerning the clinic-biologic implication of SOCS1 expression in acute myeloid leukemia (AML). Here, we first identified that higher bone marrow (BM) SOCS1 expression was closely associated with older age, FLT3-ITD, NPM1 and DNMT3A mutations, but negatively correlated with CEBPA mutation in patients w

A Novel Approach to Prognostic Factors and Risk Stratification in Pediatric AML: Case Report and Literature Review.

Acute myeloid leukemia (AML), the second most common type of leukemia in children, is a heterogeneous disease known to be caused by genetic, epigenetic, and transcriptional changes, predominantly somatic and germline abnormalities. Despite significant improvement of overall survival rates, the prognosis of pediatric AML remains unfavorable in comparison with acute lymphoblastic leukemia (ALL), especially in relapsed or refractory settings. The current status and future directions are focused on establishing an accurate diagnosis and treatment strategies based on the genomic background. Next-ge

Совпадение в полном тексте источника
… This aberration is typically associated with a reduced white blood cell count and the presence of large blast cells characterized by basophilic cytoplasm, numerous azurophilic granules, and Auer rods [ 123 , 124 ]. … Approach to Acute Myeloid Leukemia with Increased Eosinophils and Basophils J. Clin. Med. 2024 13 876 10.3390/jcm13030876 38337573 PMC10856720 129. Ustun C. Marcucci G. Emerging Diagnostic and Therapeutic Approaches in Core Binding Factor Acute Myeloid Leukaemia Curr. Opin. …

Evolving Paradigms in the Management of Primary Immune Thrombocytopenia in Adults: From Corticosteroids to Targeted Therapies.

Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia (platelet count <100 × 109/L) in the absence of another explanatory cause. Bleeding risk has traditionally anchored clinical management, yet patient-reported data show that fatigue and impaired quality of life represent an equally prominent burden of the disease and are increasingly proposed as a practical, patient-centered axis for personalizing treatment rather than as a secondary consideration. For decades, treatment relied on corticosteroids as first-line therapy, followed by a limit

Transferrin-Bound Doxorubicin Enhances Apoptosis and DNA Damage through the Generation of Pro-Inflammatory Responses in Human Leukemia Cells.

Doxorubicin (DOX) is an effective antineoplastic drug against many solid tumors and hematological malignancies. However, the clinical use of DOX is limited, because of its unspecific mode of action. Since leukemia cells overexpress transferrin (Tf) receptors on their surface, we proposed doxorubicin-transferrin (DOX-Tf) conjugate as a new vehicle to increase drug concentration directly in cancer cells. The data obtained after experiments performed on K562 and CCRF-CEM human leukemia cell lines clearly indicate severe cytotoxic and genotoxic properties of the conjugate drug. On the other hand,

Activin Receptor-Ligand Trap for the Treatment of β-thalassemia: A Serendipitous Discovery.

β-thalassemia is a hereditary disorder caused by defective production of β-globin chains of hemoglobin (Hb) that leads to an increased α/β globins ratio with subsequent free α-globins. Alpha globin excess causes oxidative stress, red blood cells membrane damage, premature death of late-stage erythroid precursors, resulting in ineffective erythropoiesis. The transforming growth factor β (TGF-β) superfamily signaling acts on biological processes, such as cell quiescence, apoptosis, proliferation, differentiation, and migration, and plays an essential role in regulating the hematopoiesis. This pa

New generation sequencing of targeted genes in the classical and the variant form of hairy cell leukemia highlights mutations in epigenetic regulation genes.

Classical hairy cell leukemia (HCL-c) is a rare lymphoid neoplasm. BRAFV600E mutation, detected in more than 80% of the cases, is described as a driver mutation, but additional genetic abnormalities appear to be necessary for the disease progression. For cases of HCL-c harboring a wild-type BRAF gene, the differential diagnosis of the variant form of HCL (HCL-v) or splenic diffuse red pulp lymphoma (SDRPL) is complex. We selected a panel of 21 relevant genes based on a literature review of whole exome sequencing studies (BRAF, MAP2K1, DUSP2, MAPK15, ARID1A, ARID1B, EZH2, KDM6A, CREBBP, TP53, C

Toxicology and carcinogenesis studies of androstenedione (CAS No. 63-05-8) in F344/N rats and B6C3F1 mice (gavage studies).

UNLABELLED: Androstenedione is an androgen steroid that is normally synthesized within men and women and may be metabolized to a more potent androgen or estrogen hormone. It was nominated to the National Toxicology Program for study due to concern for adverse health effects associated with its chronic use as a dietary supplement by athletes (prior to the banning of its over the counter sales). In order to evaluate its subchronic and chronic toxicity, male and female F344/N rats and B6C3F1 mice were administered androstenedione (98% pure) by gavage for 2 weeks, 3 months, or 2 years. Genetic tox

Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy.

Chemokines are a large family of small chemotactic cytokines that coordinates immune cell trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the tumor, thereby shaping the tumor microenvironment immune profile, often towards a pro-tumorigenic state. Furthermore, chemokines can directly target non-immune cells in the tumor microenvironment, including cancer, stromal and vascular endothelial cells. As such, chemokines participate in several cancer development processes such as angiogenesis, metastasis, cancer cell proliferation, stemness and invasivene

Совпадение в полном тексте источника
… CCR2 | CCL2, CCL7, CCL8, CCL13, CCL16 | It mediates monocyte chemotaxis and can be found on the surface of monocytes, basophils, B cells and activated memory T cells. … CCR3 | CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL15, CCL16, CCL23, CCL24, CCL26, CCL28 | Expressed in eosinophils, basophils, T H 2 cells, CD34 + hematopoietic progenitors, keratinocytes and mast cells present in several tissues. …

Тип 1 Диабет и многоразовый склероз делятся общей генной переменой автономного иммунитета.

Справочная информация/цели: тип 1 диабет (T1D) и множественный склероз (MS) являются аутоиммунными, многофакторными, специфическими для органов расстройствами, обусловленными иммунными клетками. Их соучастие отчасти объясняется общими генетическими и экологическими факторами. Мы стремились расчленить общую генетическую архитектуру между T1D и MS с использованием крупномасштабных исследований по общегеномной ассоциации (GWAS) и анализа совместной локализации. Методы: Мы применили Байесовскую систему совместной локализации к two Крупномасштабные наборы данных GWAS: исследование T1D, включающее 1

Совпадение в полном тексте источника
… Patients with immunodeficiency caused by pathogenic mutations in IRF8 present a lack of circulating monocytes, dendritic cells, and basophils, but also present severe neutrophilia and eosinophilia [ 42 ]. …

Promising immunotherapeutic approaches for primary effusion lymphoma.

Primary effusion lymphoma (PEL) is a large B-cell neoplasm usually presenting as a serious effusion in body cavities without detectable tumor masses. It is an AIDS-related non-Hodgkin's lymphoma (HL) with human herpes virus 8 (HHV8)/Kaposi sarcoma-associated herpes virus (KSHV) infection. A combination antiretroviral therapy (cART) prolongs the lifespan of AIDS and AIDS-related malignant lymphoma patients, but PEL continues to have a dismal prognosis. PEL showed disappointing outcomes with standard chemotherapy such as CHOP or CHOP-like regimens. A PEL status highlights the urgent need for new

A Pathology Experience of Posttransplant Lymphoproliferative Disorder From One Tertiary Hospital: Pathology Concepts and Diagnostic Approach.

BACKGROUND: Solid organ transplantation and bone marrow/hematologic stem cell transplantation recipients face a heightened risk of developing malignancies or cancer as a result of immunosuppression. Posttransplant lymphoproliferative disorders (PTLD) are a range of disorders from benign lymphoid growth to lymphoma found post-transplant. Risk factors for PTLD include high immunosuppressive use and oncogenic effects of Epstein-Barr virus (EBV). There is a lack of comprehensive clinical and pathological documentation of PTLD cases among Saudi patients, and the available data are limited to a few

Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors.

BACKGROUND: Bone marrow fibrosis (BMF) severely impacts both the quality of life and the efficacy of diagnostic procedures. However, the correlation between BMF and clinicopathological features, cytogenetic changes, and prognosis of newly diagnosed multiple myeloma (NDMM) remains unclear. This study determined the incidence, patient characteristics, and clinical outcomes of patients with NDMM with BMF. METHODS: The clinical data, histological features, and clinical outcomes of patients with NDMM were collected. Reticular fiber staining was performed on the enrolled cases, and the degree of re

Supporting the gastrointestinal microenvironment during high-dose chemotherapy and stem cell transplantation by inhibiting IL-1 signaling with anakinra.

High-dose chemotherapy causes intestinal inflammation and subsequent breakdown of the mucosal barrier, permitting translocation of enteric pathogens, clinically manifesting as fever. Antibiotics are mainstay for controlling these complications, however, they are increasingly recognized for their detrimental effects, including antimicrobial resistance and dysbiosis. Here, we show that mucosal barrier injury induced by the mucotoxic chemotherapeutic agent, high-dose melphalan (HDM), is characterized by hyper-active IL-1b/CXCL1/neutrophil signaling. Inhibition of this pathway with IL-1RA, anakinr

Совпадение в полном тексте источника
… RDW-SD/-CV, fL/%), mean platelet volume (fL), mean platelet volume (MPV, fL), platelet large cell ratio (P-LCR, %), procalcitonin (PCT, %), nucleated red blood cell (NRBC, 10 9 /L and %), neutrophils (10 9 /L and %), lymphocytes (10 9 /L and %), monocytes (10 9 /L and %), eosinophils (10 9 /L and %), basophils …

Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications.

HHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was condu

Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy.

Vitamin C is a water-soluble vitamin introduced through the diet with anti-inflammatory, immunoregulatory, and antioxidant activities. Today, this vitamin is integrated into the treatment of many inflammatory pathologies. However, there is increasing evidence of possible use in treating autoimmune and neoplastic diseases. We reviewed the literature to delve deeper into the rationale for using vitamin C in treating this type of pathology. There is much evidence in the literature regarding the beneficial effects of vitamin C supplementation for treating autoimmune diseases such as Systemic Lupus

Совпадение в полном тексте источника
… This vitamin is also essential to ensure physiological natural killer (NK) cell development and function and acts on basophils, eosinophils, and mast cells by modulating cytokine production and reducing histamine levels [ 6 ]. … It promotes the immunosuppressive action of T-reg lymphocytes and modulates the cytokine microenvironment, also regulating the function of NK cells, eosinophils, mast cells, and basophils [ 6 ]. It also enhances the cytotoxic action of CD8+ T cells and regulates NETosis processes [ 23 , 24 ]. …

Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance.

Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption. Post-translational modifications (PTMs) are covalent and enzymatic modifications of proteins after their translation, which have been reported to play roles in inflammatory and allergic diseases. However, less attention has been paid to the effect of PTMs on AD. This review summarized the knowledge of six major classes (including phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, o-glycosylation, and glycati

Совпадение в полном тексте источника
… In the acute phase, T H 2 cells secreted cytokines (primarily IL-4, IL-5, and IL-13) that stimulate B cells to produce IgE antibodies and activate eosinophils, basophils, and mast cells in allergic responses; IL-5 is responsible for the trafficking and production of eosinophils in vivo ( Gandhi et al … Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin. J. I. 193, 3717–3725. 10.4049/jimmunol.1401307 Kim J., Kim J., Cho D., Park H. (2016). Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis. IJMS 17, 1234. 10.3390/ijms17081234 Kim T.-H., Jung J.-A., Kim G. …

High-Dose Intravenous Immunoglobulins in the Treatment of Severe Acute Viral Pneumonia: The Known Mechanisms and Clinical Effects.

The current outbreak of viral pneumonia, caused by novel coronavirus SARS-CoV-2, is the focus of worldwide attention. The WHO declared the COVID-19 outbreak a pandemic event on Mar 12, 2020, and the number of confirmed cases is still on the rise worldwide. While most infected individuals only experience mild symptoms or may even be asymptomatic, some patients rapidly progress to severe acute respiratory failure with substantial mortality, making it imperative to develop an efficient treatment for severe SARS-CoV-2 pneumonia alongside supportive care. So far, the optimal treatment strategy for

Совпадение в полном тексте источника
… Subsequent research revealed that administration of sialylated IgG resulted in the production of IL-33 from hDC-SIGN + macrophages or dendritic cells and ensuing expansion of IL-4-producing basophils, and these cytokines led to FcγRIIB expression on effector cells ( 64 , 65 ). … Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils. J Immunol. (2014) 192:5031–8. 10.4049/jimmunol.1301611 71. Nagelkerke SQ, Dekkers G, Kustiawan I, van de Bovenkamp FS, Geissler J, Plomp R, et al. …