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Updating Disability Weights for Measurement of Healthy Life Expectancy and Disability-adjusted Life Year in Korea.

BackgroundThe present study aimed to update the methodology to estimate cause-specific disability weight (DW) for the calculation of disability adjusted life year (DALY) and health-adjusted life expectancy (HALE) based on the opinion of medical professional experts. Furthermore, the study also aimed to compare and assess the size of DW according to two analytical methods and estimate the most valid DW from the perspective of years lost due to disability and HALE estimation.MethodsA self-administered web-based survey was conducted ranking five causes of disease. A total of 901 participants star

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… object | 0.226 | 0.270 | 0.258 | 0.339 304 | Sexual violence | 0.503 | 0.362 | 0.594 | 0.481 305 | Assault by other means | 0.238 | 0.274 | 0.365 | 0.376 306 | Exposure to forces of nature | 0.244 | 0.275 | 0.339 | 0.367 307 | Conflict and terrorism | 0.500 | 0.361 | 0.520 | 0.443 308 | Executions and police …

CAR T-Cells in Multiple Myeloma Are Ready for Prime Time.

The survival of patients with multiple myeloma (MM) has been dramatically improved in the last decade thanks to the incorporation of second-generation proteasome inhibitors (PI), immunomodulatory drugs (IMID), and, more recently, anti-CD38 monoclonal antibodies (MoAb). Nevertheless, still, a major proportion of MM patients will relapse, underscoring the need for new therapies in this disease. Moreover, survival in patients failing the current standard of care regimens (including PI, IMIDs, and anti-CD38 MoAb), which is now defined as triple-class refractory, remains dismal, and new drugs with

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… Dar H., Henderson D., Padalia Z., Porras A., Mu D., Kyungah M., Police S., Kalaitzidis D., Terrett J., Sagert J. Preclinical Development of CTX120, an Allogeneic CAR-T Cell Targeting Bcma. Blood. 2018;132:1921. doi: 10.1182/blood-2018-99-116443. 48. …

The Challenges of Outcomes-Based Contract Implementation for Medicines in Europe.

ObjectivesThe aim was to outline the challenges of implementing outcomes-based contracts (OBCs) in Europe.MethodsA scoping review was conducted, building on the searches of a previous systematic review and updating them for December 2017 until May 2021. The combined results were screened, based on inclusion and exclusion criteria. All identified studies published in the English language that described specific OBC schemes for medicines in European countries were included. Insights into the challenges of OBCs were extracted and analysed to develop a conceptual framework.ResultsTen articles from

Состояние и тенденции распространения рака в раннем возрасте и связанные с ним факторы риска в Китае: демографическое исследование.

ИСТОРИЯ ВОПРОСА: Данное исследование было направлено на оценку масштабов распространения рака в раннем возрасте в Китае и тенденций изменения связанных с ним факторов риска на основе последних статистических данных о раке. МЕТОДЫ: Мы интегрировали и проанализировали данные 34 в Китае от глобального бремени болезней 2021 Исследование и Глобальная обсерватория по раковым заболеваниям 2022 проект. Первичные результаты включают в себя стандартизованные по возрасту показатели заболеваемости (АСИР), смертность (СЗМС) и скорректированные на инвалидность показатели продолжительности жизни (ССО) и сред

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… The GBD 2021 cause-of-death database included data from various sources, including vital registration, cause-of-death inference, cancer registries, police records, sibling history, monitoring, and surveys or census data collected since 1980. …

Second-Class Care: How Immigration Law Transforms Clinical Practice in the Safety Net.

This article examines how U.S. immigration law extends into the health care safety net, enacting medical legal violence that diminishes noncitizens' health chances and transforms clinical practices. Drawing on interviews with health care workers in three U.S. states from 2015 to 2020, I ask how federal citizenship-based exclusions within an already stratified health care system shape the clinical trajectories of noncitizens in safety-net institutions. Focusing specifically on cancer care, I find that increasingly anti-immigrant federal policies often reshape clinical practices toward noncitize

Assessment of Psychiatric Disorders in Consultation-Liaison Setting.

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… In MHTS, the behavioral problems are arranged in five categories of urgency for psychiatric assessment Immediate (red) – Immediate need of mental health response along with referral to security or police-due to violent aggression/possessing weapon/self-destruction attempt Emergency (orange) – Very …

Stem cell revolution: bridging the gap between research and clinical application.

Stem cells are characterized by their capacity for self-renewal and their potential for multi-directional differentiation, enabling them to develop into various functional tissues and organs under specific conditions. Their applications hold considerable promise, and the market for stem cell products is progressively expanding. Internationally, several stem cell products have received approval for market release; however, in China, the field remains largely undeveloped, presenting substantial opportunities for growth. Recent years have witnessed significant advancements in stem cell research,

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… Currently, the hospitals engaged in stem cell treatment are mainly military hospitals, such as Beijing 302 Hospital, Navy General Hospital, Armed Police General Hospital, etc. In the field of consumer applications, stem cells are mostly used in medical beauty and anti-aging health care. …

Abstracts 12th PCNE working conference 'Partnering for better patient outcomes: challenges and opportunities 3-6 February 2021, University of Basel, Switzerland (was held online).

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Combination therapy with novel agents for acute myeloid leukaemia: Insights into treatment of a heterogenous disease.

The treatment landscape of acute myeloid leukaemia (AML) is evolving rapidly. Venetoclax in combination with intensive chemotherapy or doublets or triplets with targeted or immune therapies is the focus of numerous ongoing trials. The development of mutation-targeted therapies has greatly enhanced the treatment armamentarium, with FLT3 inhibitors and isocitrate dehydrogenase inhibitors improving outcomes in frontline and relapsed/refractory (RR) AML, and menin inhibitors showing efficacy in RR NPM1mut and KMT2A-rearranged AML. With so many new drugs approved, the number of potential combinator

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… Niparuck P , Police P , Noikongdee P , Siriputtanapong K , Limsuwanachot N , Rerkamnuaychoke B , TP53 mutation in newly diagnosed acute myeloid leukemia and myelodysplastic syndrome . Diagn Pathol . 2021 ; 16 : 100 . 34717674 10.1186/s13000-021-01162-8 PMC8557522 119. …

Преодоление препятствий: развитие клеточной терапии в области аутоиммунной борьбы с заболеваниями.

Аутоиммунные заболевания возникают в результате дисрегламента в иммунной системе, что приводит к агрессивному нападению на ткани самого организма. Патогенез этих условий является многофакторным, охватывающим сложные взаимосвязи между генетическими предрасположениями, экологическими детерминантами и гормональными колебаниями. Диапазон аутоиммунных заболеваний является широким и оказывает воздействие на множество систем органов, при этом можно привести такие примечательные примеры, как ревматуидный артрит (RA), системный волчан (SLE), множественный склероз (MS), псориаз и витилиго. Несмотря на з

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… Antigen-specific regulatory T cells: are police CARs the answer ? Trans research: J Lab Clin Med . ( 2017 ) 187 : 53–8 . doi: 10.1016/j.trsl.2017.06.009 28688236 63 Eggenhuizen PJ Ng BH Ooi JD . Treg enhancing therapies to treat autoimmune diseases . …

CD70-targeted CAR-T/NK therapy: Rationale, advances, and future directions.

Chimeric antigen receptor T and natural killer (CAR-T/NK) cells is a rapidly evolving cellular immunotherapy technology that has made great achievements in the treatment of hematologic diseases. CD70, as a surface antigen expressed on tumor cells in a variety of hematologic malignancies, including acute myeloid leukemia, non-Hodgkin lymphoma, multiple myeloma, etc., and solid tumors such as renal cell carcinoma, osteosarcoma, and glioma, is a potential target for CAR-T/NK cells. Several preclinical studies and clinical trials on CAR-T/NK cells targeting CD70 are currently underway, bringing ne

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… Police S. Mu D. Maeng K. Huang E. Spencer S. Lorson N. Gonzales P. Holmquist C. Hirschfeld G. Terrett J.A. Kalaitzidis D. …

Chimeric Antigen Receptor T Cells as Living Therapeutics Targeting Senescence and Age-Related Diseases.

The aging of the global population exacerbates the burden of age-related diseases; however, therapies that can intervene in fundamental aging processes are lacking. Senescent cells drive chronic inflammation and multitissue dysfunction through the secretion of proinflammatory and profibrotic senescence-associated secretory phenotype cells, making them emerging therapeutic targets. Although first-generation senolytic drugs have entered clinical trials, they face limitations such as insufficient targeting specificity and transient efficacy. The success of chimeric antigen receptor T cell (CAR T

Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors.

The field of immuno-oncology has revolutionized cancer patient care and improved survival and quality of life for patients. Much of the focus in the field has been on exploiting the power of the adaptive immune response through therapeutic targeting of T cells. While these approaches have markedly advanced the field, some challenges remain, and the clinical benefit of T cell therapies does not extend to all patients or tumor indications. Alternative strategies, such as engaging the innate immune system, have become an intense area of focus in the field. In particular, the engagement of natural

AllergoOncology - the impact of allergy in oncology: EAACI position paper.

Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveill

Natural killer cell engagers for cancer immunotherapy.

This review article explores the rapidly evolving field of bi-, tri-, and multi-specific NK cell engagers (NKCEs), highlighting their potential as a cutting-edge approach in cancer immunotherapy. NKCEs offer a significant advancement over conventional monoclonal antibodies (mAbs) by enhancing Antibody-Dependent Cellular Cytotoxicity (ADCC). They achieve this by stably and selectively binding to both NK cell activating receptors and tumor-associated antigens (TAAs). Unlike traditional mAbs, which depend on the relatively transient interaction between their Fc region and CD16a, NKCEs establish m

The contribution of Cyprus to non-communicable diseases and biomedical research from 2002 to 2013: implications for evidence-based health policy.

BackgroundNon-communicable diseases (NCDs) are the leading causes of disease burden and mortality at the European level and in Cyprus. This research was conducted to map the research activities of Cypriot institutions in five NCDs, namely oncology, cardiovascular diseases, diabetes, mental health and respiratory conditions.MethodsFor the period 2002-2013, research in Cyprus was assessed on its biomedical outputs and compared to the rest of Europe relative to their GDP. The research output in the five NCDs was obtained and contrasted to their respective disease burdens. The results from each of

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… Additionally, this previous study demonstrated that the Government of the Republic of Cyprus, including the MoH and the other 10 Ministries, and several other private and government organisations, including the Fire Brigade and the Traffic Branch of the Police Force, administer various public health …

The State of Cancer Care in the United Arab Emirates in 2022.

Cancer is the third-leading cause of death in the United Arab Emirates (UAE); cancer care in the UAE has evolved dramatically over the last 40 years, from a single center in Al Ain in 1981 to more than 30 cancer centers and clinics across the UAE, with at least four comprehensive cancer centers in the UAE nowadays. Despite the significant progress in medical care, cancer quality control across the UAE is still lacking, with significant variations in cancer care across the cancer centers. Access to clinical trials is still hampered by a lack of expertise and research infrastructure and a small

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… There are multiple independent sponsoring agencies for cancer care abroad in the UAE, including all the health authorities (DOH, DHA, and Ministry of Health and Prevention), Presidential Affairs offices, armed forces, police, charity organizations, and self-paying [ 2 ]. …

Green Tea Catechins for Prostate Cancer Prevention: Present Achievements and Future Challenges.

Green tea catechins (GTCs) are a family of chemically related compounds usually classified as antioxidant molecules. Epidemiological evidences, supported by interventional studies, highlighted a more than promising role for GTCs in human prostate cancer (PCa) chemoprevention. In the last decades, many efforts have been made to gain new insights into the mechanism of action of GTCs. Now it is clear that GTCs' anticancer action can no longer be simplistically limited to their direct antioxidant/pro-oxidant properties. Recent contributions to the advancement of knowledge in this field have shown

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… Reactive oxygen species, ageing and the hormesis police FEMS Yeast Res. 2014 14 33 39 10.1111/1567-1364.12070 23965186 PMC4332618 24. Oh B. Figtree G. Costa D. Eade T. Hruby G. Lim S. Elfiky A. Martine N. Rosenthal D. Clarke S. …

Metal-on-Metal Total Hip Resurfacing Arthroplasty: An Evidence-Based Analysis.

OBJECTIVE: The objective of this review was to assess the safety and effectiveness of metal on metal (MOM) hip resurfacing arthroplasty for … rectorate of Ottawa, toxicologists, biomedical researchers, pathologists, and members of provincial police. Epidemiological studies were carried out by the Provincial Ministry of Health and the Quebec City Health Department. The association between the development of myocardiopathy and the consumption of the particular brand of beer was proven. The morta …

Recent advances in biomimetic nanodelivery systems for cancer Immunotherapy.

Tumor immunotherapy is a developing and promising therapeutic method. However, the mechanism of tumor immune microenvironment and individual differences of patients make the clinical application of immunotherapy still very limited. The resulting targeting of the tumor environment and immune system is a suitable strategy for tumor therapy. Biomimetic nanodelivery systems (BNDS) coated with nanoparticles has brought new hope for tumor immunotherapy. Due to its high targeting, maximum drug delivery efficiency and immune escape, BNDS has become one of the options for tumor immunotherapy in the fut

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… In the field of medical research, tumor immunotherapy is considered to be a promising cancer treatment method, playing the role of "police" within the human body, using the body's own immune system to identify and destroy cancer cells. …