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The combined effects of cardiometabolic index and high sensitivity C-reactive protein on cardiometabolic multimorbidity risk: a prospective analysis based on CHARLS.

BACKGROUND: Both the cardiometabolic index (CMI), which integrates measures of body fat and lipids, and high sensitivity C-reactive protein … ese demographic. METHODS: This research consisted of 6522 adults selected from the China Health and Retirement Longitudinal Study (CHARLS) cohort. Then, cox regression assessed how CMI and hs-CRP, separately and jointly, relate to CMM risk. Additive and multiplicative interactions were examined to evaluate potential synergy. Reclassification and discriminati …

Development and validation of a nomogram for identifying pre-frailty risk in middle-aged and elderly maintenance hemodialysis patients: a cross-sectional study.

AIM: This study aimed to develop a nomogram for screening the risk of pre-frailty in middle-aged and elderly patients on maintenance hemodia … and elderly MHD patients was 71.27%. Logistic regression analysis revealed that employment status (retirement), weekly exercise frequency (≤ 2 times/week), presence of hyposomnia, high activities of daily living (ADL) score, presence of multiple complications, and low albumin (ALB) levels were independently associated with increased risk of pre-frailty. Fur …

Edentulism and incident hip fracture among middle-aged and older adults in China: evidence from the CHARLS.

BACKGROUND: Hip fractures are a major cause of disability and mortality in aging populations, yet risk prediction based solely on traditiona … frailty might represent a potential pathway. METHODS: Data were obtained from the China Health and Retirement Longitudinal Study, a nationally representative cohort of Chinese adults. A total of 7,385 community-dwelling participants aged ≥ 45 years without prior hip fracture at baseline (2011) were followed through 2020. Baseline edentulism was self-reporte …

Integrating inflammation, insulin resistance, and visceral adiposity: the C-reactive protein-triglyceride-glucose-Chinese visceral adiposity (CTI-CVAI) index is associated with cardiovascular disease risk across CKM stages 0-3 in a nationwide prospective cohort.

BACKGROUND: Early-stage (0-3) cardiovascular-kidney-metabolic (CKM) syndrome populations require urgent cardiovascular disease (CVD) prevention. Chronic inflammation, insulin resistance, and visceral adiposity are three core interactive CVD pathogenic pathways, while current biomarkers fail to integrate all three. This study aimed to explore the association of the novel three-dimensional composite index CTI-CVAI with incident CVD and its predictive value in Chinese adults with CKM stages 0-3. METHODS: This nationwide prospective cohort study used data from the China Health and Retirement Long…

Optimizing early triage for subclinical cardiovascular-kidney-metabolic syndrome: longitudinal associations, incremental value, and clinical utility of nine insulin resistance surrogates.

BACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome stage 3 represents a critical, yet highly insidious, window of subclinical target organ damage. We aimed to comprehensively compare nine baseline non-insulin-based surrogate indices of insulin resistance to predict progression to CKM stage 3 and determine their scenario-specific clinical utility. METHODS: This longitudinal study included 2958 adults initially at CKM stages 0-2 from the China Health and Retirement Longitudinal Study. Independent associations were assessed using multivariable logistic regression and restricted cubic spl…

The Relationship between Sarcopenia and All-Cause and Cardiovascular Mortality Risk among Middle-Aged and Older Adults across Stages 0-3 of Cardiovascular-Kidney-Metabolic Syndrome: Evidence from NHANES and CHARLS.

INTRODUCTION: Sarcopenia has been proved to be associated with cardiovascular diseases (CVD), chronic kidney disease, and metabolic disorder … 3 of CKM syndrome based on Nutrition Examination Survey (NHANES) 2011-2018 and the China Health and Retirement Longitudinal Study (CHARLS) 2011-2020. METHODS: Multivariable Cox regression analysis was performed to analyze the association of sarcopenia with all-cause and CVD mortality. Restricted cubic spline (RCS) analysis was conducted to explore the non-l …

Associations of "weekend warrior" and other physical activity patterns with sarcopenia among older adults in China: a cross-sectional study.

BACKGROUND: Moderate-to-vigorous physical activity (MVPA) is effective in preventing sarcopenia. Current physical activity guidelines recomm … This cross-sectional study was based on 3,579 participants aged ≥ 60 years in the China Health and Retirement Longitudinal Study (CHARLS). MVPA patterns were self-reported through questionnaires and categorized into four groups: inactive (no MVPA), insufficiently active (IA) (< 150 min of MVPA /week), weekend warrior (WW) (≥ 150 min of MVPA with ≤ 2 session …

The association between greenness exposure and arthritis in middle-aged and older Chinese adults, mediated by climate factors.

BACKGROUND: Arthritis is a common health issue among middle-aged and older adults, significantly impacting their quality of life. While prev … oach. METHODS: Data for the present study were extracted from the 2015 wave of the China Health and Retirement Longitudinal Study (CHARLS), focusing specifically on middle-aged and older adults aged 45 years and above. Greenness exposure was quantified using the NDVI. Generalized linear models were used to assess the association between NDVI and arthritis. C …

The impact of different combinations of body mass index and depressive status on the incidence of sarcopenia in middle-aged and older adults ≥45 years: A retrospective cohort study based on CHARLS follow-up data from 2011 to 2015.

Sarcopenia is a major public health concern among middle-aged and older adults. Although abnormal body mass index (BMI) and depression are recognized as independent risk factors for sarcopenia, longitudinal evidence regarding their combined impact remains limited. This retrospective cohort study utilized data from the China Health and Retirement Longitudinal Study, including the 2011 baseline survey and 2013 and 2015 follow-up surveys. Participants aged ≥ 45 years without baseline sarcopenia were categorized by BMI (overweight: ≥25 kg/m2; non-overweight: <25 kg/m2) and depressive status (Cente…

Association of longitudinal changes in depressive symptoms and handgrip strength with cardiovascular disease in middle-aged and elderly populations.

BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death among the elderly population. While handgrip strength and depressive sy … or future prevention research in this population. METHODS: Based on data from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2018, we used Cox proportional hazards regression models to analyze the independent and joint associations of longitudinal changes in handgrip strength and depressive symptoms with incident CVD. Longitudi …

Associations Between Metabolic Obesity Phenotypes and Sarcopenia in Middle-Aged and Older Chinese Adults:Age- and Sex-Dependent Interaction Trends.

Objective To investigate the associations between metabolic obesity phenotypes and the risk of developing sarcopenia among middle-aged and older Chinese adults,and further examine the potential moderating roles of age and sex in the associations. Methods On the basis of the data from the China Health and Retirement Longitudinal Study conducted in 2011-2012,a total of 7 421 participants aged 45 years and older were enrolled in this study.Sarcopenia was diagnosed according to the 2019 criteria established by the Asian Working Group for Sarcopenia.According to the body mass index and overall meta…

Reciprocal risks of diabetes and sarcopenia in aging Chinese adults: A prospective cohort study using a semi-Markov multi-state framework.

Type 2 diabetes mellitus and sarcopenia are increasingly recognized as interrelated syndromes sharing pathophysiological pathways, yet empirical evidence for their reciprocal, time-dependent relationship in aging populations remains limited. Conventional analytical approaches fail to capture the dynamic, trajectory-based nature of their coprogression because of restrictive assumptions regarding state transitions and sojourn time. We conducted a prospective cohort study using harmonized data from 2 nationally representative Chinese longitudinal surveys: the China Health and Retirement Longitudi…

Time to first cigarette after waking and risk of incident chronic respiratory diseases in males: A prospective national cohort study.

INTRODUCTION: While cumulative smoking exposure is a well-established risk factor of chronic respiratory disease (CRD), a behavioral indicat … uded 5198 Chinese men aged ≥45 years without baseline CRD who were enrolled in the China Health and Retirement Longitudinal Study (CHARLS). TTFC was categorized as >60, 31-60, 6-30, and <6 minutes after waking, with never smokers as the reference group. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CI …

High-Altitude Residence, Blood Biomarkers, and Chronic Disease Risk in Middle-Aged and Older Chinese Adults.

Background/Objectives: The goal of the study is to examine associations of baseline residential elevation with blood biomarkers and newly reported multisystem chronic diseases among middle-aged and older adults, and to explore whether routine blood indicators may lie on these pathways. Methods: We analyzed 2011, 2015, and 2018 data from the China Health and Retirement Longitudinal Study (CHARLS). Wave 1 provided residential elevation, covariates, and 14 biomarkers; Wave 3 provided intermediate biomarkers; and Wave 4 identified 13 chronic disease outcomes based on participants' reports of havin…

Longitudinal bidirectional associations among sarcopenia risk, social isolation, and frailty in Chinese older adults using an item response theory-derived frailty index.

INTRODUCTION: Frailty is a common geriatric syndrome characterized by multisystem decline and increased vulnerability in older adults, and m … idual deficits. METHODS: This longitudinal observational study used data from the China Health and Retirement Longitudinal Study from 2011 to 2015. A total of 3,159 adults aged 60 years and older with repeated measures of sarcopenia risk, social isolation, and frailty were included. Frailty was assessed using a 40-item item response theory-derived frailty i …

Кардиометаболическая многомерность увеличивает риск разлома гипса: продольное коотертное исследование на основе CHARLS.

В качестве сопутствующего явления Cardiometabolic Multimbidity (CMM) two или более заболеваний сердца, сахарного диабета, инсульта и гипертонии. Предыдущие исследования показали связь между кардиометаболическими заболеваниями и хрупкими трещинами; однако связь между ШМ и переломами бедра у китайского населения остается неясной. Таким образом, цель данного исследования заключается в изучении этой ассоциации в китайской когорте в целях информирования о стратегиях предотвращения переломов. 2011 в адрес 2020. Участники от 2011 Первоначально была включена группа базовых обследований. Впоследствии о

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BackgroundCardiometabolic Multimorbidity (CMM) is defined as the co-occurrence of two or more conditions among heart disease, diabetes melli … ture prevention strategies.MethodsThis prospective cohort study used data from the China Health and Retirement Longitudinal Study (CHARLS) collected from 2011 to 2020. Participants from the 2011 baseline survey cohort were initially included. Subsequently, individuals were sequentially excluded if they were under 45 years of age, had incomplete baseline CMM …

Divergent mortality associations of TyG-BMI in middle-aged and older adults: Parallel analyses of Chinese and US populations.

BACKGROUND: To compare the association between TyG-BMI and all-cause mortality in Chinese and US middle-aged and older adults using parallel, dataset-specific analytical approaches. METHODS: A comparative analysis was conducted using data from the China Health and Retirement Longitudinal Study (CHARLS) and the US National Health and Nutrition Examination Survey (NHANES) linked to mortality records. A total of 7478 participants from CHARLS and 8363 from NHANES were included after excluding those aged <45 years and with missing data. Multivariable Cox proportional hazards models, restricted cub…

Prediction of depression risk in chronic kidney disease using PSO-optimized random forest: a web-based application based on CHARLS data.

BACKGROUND: Depression is a prevalent psychological issue among chronic kidney disease (CKD) patients. Such symptoms can greatly affect the physical and mental health and life expectancy of middle-aged and older persons with CKD. OBJECTIVE: The aim of this study is to develop a depression risk prediction model for CKD patients, laying the scientific groundwork for early intervention. METHODS: This research utilized data from the 2015 China Health and Retirement Longitudinal Study (CHARLS), a dataset representative of the Chinese population. The study examined 52 indicators, encompassing soci…

Normalized creatinine-to-cystatin C ratio and cardiovascular disease risk in populations with cardiovascular-kidney-metabolic syndrome stages 0-3: findings from a national and prospective cohort study.

BACKGROUND: The normalized creatinine-to-cystatin C ratio (NCCR) has been identified as a viable metric for assessing skeletal muscle mass and diabetes risk. However, the relationship between NCCR and cardiovascular disease (CVD) remains insufficiently understood. This study aims to clarify this association within a national, longitudinal, and prospective cohort. METHODS: Participants were selected from the China Health and Retirement Longitudinal Study to form the study cohort. Baseline NCCR was designated as the exposure variable, while the primary outcome was the incidence of newly diagnos…

Data retrieval and harmonisation for individual participant data meta-analysis in the context of a neglected tropical disease: challenges and lessons from the Infectious Diseases Data Observatory visceral leishmaniasis data platform.

INTRODUCTION: Individual participant data meta-analysis (IPD-MA) is the gold-standard approach for evidence synthesis. Poverty-related infec … DDO platform from 31 (21.1%). Reasons for data non-retrievability of 116 studies included: authors' retirement (n=42, 36.2%), data were lost (n=30, 25.9%), authors' non-response (n=22, 19.0%), authors were no longer contactable (n=17, 14.7%) and a lack of clarity over data ownership (n=5, 4.3%). The median sample size was 226 (IQR: 120-542, range: 30-1,143) …