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[Biomarkers for the prognosis of severe dengue].

INTRODUCTION: There are very few strategies for the early detection of the patients who might develop the severe form of the illness. OBJECTIVE: To evaluate the utility of serum levels of some immune response mediators as early biomarkers for the severe dengue prognosis during the early phase of the illness. MATERIALS AND METHODS: Using a case-control design nested in a multicenter cohort from the AEDES network (a Colombian multicenter study), we compared TNF a, ST2, TRAIL and IDO levels in samples which were obtained during the early phase of the illness. RESULTS: ST2, TRAIL and TNF a leve…

Dengue: a new challenge for neurology.

Dengue infection is a leading cause of illness and death in tropical and subtropical regions of the world. Forty percent of the world's population currently lives in these areas. The clinical picture resulting from dengue infection can range from relatively minor to catastrophic hemorrhagic fever. Recently, reports have increased of neurological manifestations. Neuropathogenesis seems to be related to direct nervous system viral invasion, autoimmune reaction, metabolic and hemorrhagic disturbance. Neurological manifestations include encephalitis, encephalopathy, meningitis, Guillain-Barré synd…

[Psychiatric manifestation of a dengue-encephalopathy].

Psychiatric manifestation of dengue virus infections is seldom reported. Here a case is presented of a 21-year-old man who developed mainly neuropsychiatric symptoms which he caught one week after a feverish infection during his stay in India: troubles with concentration and memory, confusion, as well as depressive delusions and agoraphobia. Liquor diagnosis as well as CCT and MRI was mainly inconspicuous. The FDG-PET showed a diffuse lack of activity. IgM and IgG antibodies of dengue virus were positive. We interpreted these psychiatric symptoms as a result of a dengue virus infection.

Dengue hemorrhage in a mouse model.

Here we summarized our findings in the mouse model of the events that lead to dengue hemorrhage. Immunocompetent mice inoculated intradermally with DENV-2 strain 16681 develop hemorrhage locally or systemically. The incidence and the severity of hemorrhage development are dependent on the size of viral inoculum. The hemorrhage mice exhibit severe thrombocytopenia, prolonged bleeding time, and increased numbers of circulating endothelial cells. In the hemorrhage tissues, there is endothelial damage accompanied by infiltrating macrophages that secret TNF-alpha. The endothelial cells express iNOS…

[Hematological abnormalities in patients with dengue].

Dengue is a neglected disease with high morbidity and mortality among children and adults that occurs mainly in tropical and subtropical regions. The objective of this study was to evaluate hematological changes in patients with clinical manifestations of dengue. Medical records relating to 543 cases of dengue virus 3 that occurred during the 2007 epidemic in Campo Grande, Mato Grosso do Sul, were studied. Cases of classic dengue predominated (90.2%), with mild clinical manifestations lacking complications. The main hematological findings were leukopenia (68.3%), thrombocytopenia (66.5%), lymp…

Dengue in travellers is still underestimated.

BACKGROUND: Dengue fever (DF), one of the main emerging virus diseases, also increases in German travellers, due to the increasing number of travellers to tropical regions. METHODS: We determined antibodies against DF virus in a group (n = 149) of long-distance travellers in order to evaluate the risk of acquiring DF. Serum samples were collected at the travel vaccination centre in Frankfurt/Main and DF seroprevalence in serum samples was determined using different antibody assays with particular attention to flavivirus cross-reactivity. So, antibodies against tick-borne encephalitis and prev…

Role of ultrasound in dengue fever.

This study was performed to find out whether ultrasound is an important adjunct to clinical and laboratory profile in diagnosing dengue fever or dengue haemorrhagic fever and to further determine whether ultrasound is useful in predicting the severity of the disease. Ultrasound was performed on 128 patients (2-9 years) with clinical suspicion of dengue fever. Serological tests were performed to confirm the diagnosis. 40 patients were serologically negative for dengue fever and later excluded from the study. Of the remaining 88 serologically positive cases, 32 patients underwent ultrasound on s…

[Hepatic alterations in patients with dengue].

Clinical features of Dengue are very variable due to multiple alterations induced by the virus in the organism. Increased levels of transaminases similar to those produced by the Hepatitis virus have been reported in patients with Dengue from hiperendemic zones in Asia. The objectives of this study were to determine alterations in the liver tests in patients with Dengue and to relate them to the disease, clinically and serologically. Clinical history, hemathological tests serum transaminases (ALT y AST) and bilirubin assays were performed in 62 patients with clinical and serological diagnosis …

Dengue fever in the Western Hemisphere.

Dengue virus, an arthropod-borne viral agent, causes two distinct diseases: classic dengue fever (DF) and dengue hemorrhagic fever (DHF). There are four dengue virus serotypes: DEN-1, DEN-2, DEN-3, and DEN-4. Although infection with dengue stimulates immunologic response to a serotype, there is no cross-immunity conferred. Hence, a person can potentially be infected with each serotype during his or her lifetime. An infected female Aedes mosquito transmits the virus from person to person while feeding. The disease, now endemic in more than 100 countries in Africa, the Americas, the Eastern Medi…

Microevolution and virulence of dengue viruses.

The evolution of dengue viruses has had a major impact on their virulence for humans and on the epidemiology of dengue disease around the world. Although antigenic and genetic differences in virus strains had become evident, it is mainly due to the lack of animal models of disease that has made it difficult to detect differences in virulence of dengue viruses. However, phylogenetic studies of many different dengue virus samples have led to the association between specific genotypes (within serotypes) and the presentation of more or less severe disease. Currently, dengue viruses can be classifi…

[Dengue in Martinique in 1995-1996].

The incidence of dengue increased sharply in Martinique from the end of 1995 into 1996. Virological tests performed jointly on 36 serum samples by the Pasteur Institute in French Guyana and the Center for Disease Control in Puerto Rico led to identification of serogroups 1, 2, and 4 for six dengue virus. Between January 1995 and December 1996, the Departmental Hygiene Laboratory of Martinique carried out screening tests to detect specific IgM by the immunocapture method (MAC ELISA) in patients with suspected dengue. Results were positive in 701 of the 2,143 patients tested (32.7%). Symptoms we…

Вирус Dengue M содержит проапоптотическая последовательность, называемая Apoptom.

Инкорпорация апоптотической смертности в клетках является важным цитопатическим эффектом вирусов денге (DEN). Один из ключевых вопросов, подлежащих рассмотрению, заключается в том, какие вирусные компоненты вызывают апоптоз в клетках, инфицированных вирусом DEN. В ходе этого исследования был изучен вопрос о том, был ли маленький мембранный белок связан с апоптозом вируса ДЕН. Для решения этой проблемы использовался ряд усовершенствованных зеленых люминесцентных белков DEN. Имеются данные, свидетельствующие о том, что внутриклеточное производство эктодомена M (остатки M-1-M-40) из всех четырех

Совпадение в аннотации оригинала
The induction of apoptotic cell death is a prominent cytopathic effect of dengue (DEN) viruses. One of the key questions to be addressed is which viral components induce apoptosis in DEN virus-infected cells. This study investigated whether the small membrane (M) protein was involved in the induction of apoptosis by DEN virus. This was addressed by using a s…

The Evolution of Dengue Virus in India.

The evolution of dengue virus (DENV) is highly modulated by pathogen transmission bottlenecks and immunological pressures. These evolutionary events lead to mutations that cause antigenic changes and the replacement of DENV genotypes, which are directly correlated with epidemic magnitude and severe disease. India bears a disproportionately high dengue burden, accounting for nearly one-third of global cases, making it a persistent public health challenge. The periodic recurrence of outbreaks and cocirculation of all four serotypes pose challenges in disease control efforts. Nearly half of the c…

Dengue and Typhoid: A Duet of Choreoathetosis.

Choreoathetoid movements can be caused by a range of conditions. Here, we discuss the case of a 16-year-old male with a history of acute febrile illness who presented with features typical of paroxysmal dystonic choreoathetosis. He arrived at the hospital complaining of a fever that had been present for four days, suggesting a viral etiology, but he did not exhibit any involuntary movements. The routine panel suggests both dengue and typhoid as potential culprits. Consequently, during the ward stay, the patient developed involuntary movements in bilateral upper limbs, lower limbs, and face. Co…

The early history of dengue in Australia.

Although reports of outbreaks of dengue-like diseases in the Asia Pacific region were frequent from about 1870, the disease probably did not become endemic in Australia until about 1885. Several seminal discoveries about this disease were made in Queensland and later in Sydney. These included a refined case definition for dengue, identification of the mosquito vector, demonstration of a viraemia and its duration, quantification of the incubation time, demonstration of immunity after experimental infection and recognition that the virus could cause a fatal haemorrhagic fever, and this was more …

Role of Gut Microbiota in Dengue.

Dengue is a disease caused by a flavivirus (DENV) and transmitted by the bite of a mosquito, primarily the Aedes aegypti and Aedes albopictus species. Previous studies have demonstrated a relationship between the host gut microbiota and the evolution of dengue. It seems to be a bidirectional relationship, in which the DENV can affect the microbiota by inducing alterations related to intestinal permeability, leading to the release of molecules from microbiota dysbiosis that can influence the evolution of dengue. The role of angiotensin II (Ang II) in the microbiota/dengue relationship is not we…

Neutrophils - an understudied bystander in dengue?

Dengue is a mosquito-borne viral disease which causes significant morbidity and mortality each year. Previous research has proposed several mechanisms of pathogenicity that mainly involve the dengue virus and host humoral immunity. However, innate immune cells, such as neutrophils, may also play an important role in dengue, albeit a much less defined role. In this review, we discuss the emerging roles of neutrophils in dengue and their involvement in pathologies associated with severe dengue. We also describe the potential use of several neutrophil proteins as biomarkers for severe dengue. The…

[Dengue vaccination: when and for whom?].

Dengue is the most common mosquito-borne tropical disease. Infections are no longer confined to (sub)tropical regions of the world, as vectors are rapidly spreading to new areas, including Europe. In Southern Europe, autochthonous cases are increasingly reported, whereas in the Netherlands, all reported dengue cases are still imported by travellers. In this article, we present a patient who developed dengue haemorrhagic fever following a reinfection with dengue virus, highlighting the potential for severe outcomes, such as dengue haemorrhagic fever and dengue shock syndrome. We discuss the ava…