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Mapping the "Depression Switch" During Intraoperative Testing of Subcallosal Cingulate Deep Brain Stimulation.

IMPORTANCE: The clinical utility of monitoring behavioral changes during intraoperative testing of subcallosal cingulate deep brain stimulat … d a pattern of connections to the bilateral ventromedial frontal cortex (via forceps minor and left uncinate fasciculus) and to the cingulate cortex (via left cingulum bundle), whereas behaviorally salient but nonbest contacts had only cingulate involvement. The involvement of the 3 white matter bundles during stimulation of the best contacts suggests a mechanism for …

Brain white matter development in 8-year-old children is associated with maternal mental health during pregnancy.

BACKGROUND: Maternal mental health during pregnancy can influence fetal brain development, yet its long-term effects remain unclear. This st … tion) were extracted from the limbic system white matter structures including cingulum, fornix, and uncinate fasciculus, which are closely associated with emotional and motivational processes. RESULTS: Higher maternal depression symptom scores were associated with lower FA (R = -0.3126, p = 0.0305, in CGH.R; R = -0.3025, p = 0.0366, in FXC.R) and MK (R = -0.3284, p …

Predicting recovery in patients with mild traumatic brain injury and a normal CT using serum biomarkers and diffusion tensor imaging (CENTER-TBI): an observational cohort study.

BACKGROUND: Even patients with normal computed tomography (CT) head imaging may experience persistent symptoms for months to years after mil … stic tracts were the left posterior thalamic radiation, left superior cerebellar peduncle and right uncinate fasciculus. Serum biomarkers could have avoided 1 in 5 DTI scans, with GFAP <12 h and NFL 12-24 h from injury performing best. INTERPRETATION: DTI substantially improved existing prognostic models for functional outcome in patients with mTBI and a normal CT, …

Microstructural Alterations in Tract Development in College Football and Volleyball Players: A Longitudinal Diffusion MRI Study.

BACKGROUND AND OBJECTIVES: Repeated impacts in high-contact sports such as American football can affect the brain's microstructure, which can be studied using diffusion MRI. Most imaging studies are cross-sectional, do not include low-contact players as controls, or lack advanced tract-specific microstructural metrics. We aimed to investigate longitudinal changes in high-contact collegiate athletes compared with low-contact controls using advanced diffusion MRI and automated fiber quantification. METHODS: We examined brain microstructure in high-contact (football) and low-contact (volleyball)

Regional associations of white matter integrity and neurological, post-traumatic stress disorder and autonomic symptoms in Veterans with and without history of loss of consciousness in mild TBI.

BACKGROUND: Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) share overlapping symptom presentations and are high … d that global symptom severity was associated with FA in the cingulum angular bundle (positive) and uncinate fasciculus (negative) only, without variability by symptom domain. We also found regional specificity in the relationship between FA and autonomic function, such that FA was positively associated with autonomic function in all tracts except the cingulum angula …

White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease.

BACKGROUND AND OBJECTIVES: The dynamics of white matter (WM) changes are understudied in Alzheimer disease (AD). Our goal was to study the a … racts NDI decreased with increasing regional Braak tau SUVRs. Of all the significant WM tracts, the uncinate fasciculus (r = -0.274 for Braak I, -0.311 for Braak III/IV, and -0.292 for Braak V/VI, p < 0.05) and cingulum adjoining hippocampus (r = -0.274, -0.288, -0.233, p < 0.05), both tracts anatomically connected to areas of early tau deposition, were consistently …

Structuro-functional surrogates of response to subcallosal cingulate deep brain stimulation for depression.

Subcallosal cingulate deep brain stimulation produces long-term clinical improvement in approximately half of patients with severe treatment … seline and longitudinally-largely overlapped with depression-implicated white matter tracts, namely uncinate fasciculus, cingulum bundle and forceps minor/rostrum of corpus callosum. The extent of patient-specific engagement of these same tracts (according to electrode location and stimulation parameters) also served as an independent predictor of treatment-resistant …

Association Between Microstructural Asymmetry of Temporal Lobe White Matter and Memory Decline After Anterior Temporal Lobectomy.

BACKGROUND AND OBJECTIVES: Risk for memory decline is a substantial concern in patients with temporal lobe epilepsy (TLE) undergoing anterio … sociated with decline on prose and associative recall in LTLE, whereas leftward FA asymmetry of the uncinate fasciculus (UNC) was associated with decline on prose recall only. After controlling for preoperative memory score and hippocampal volume, leftward FA asymmetry of the entorhinal SWM uniquely contributed to decline in both prose and associative recall (β = -0. …

Episodic memory and the self in a case of isolated retrograde amnesia.

Isolated retrograde amnesia is defined as impaired recollection of experiences pre-dating brain injury with relatively preserved anterograde … 's MRI showed damage to the right ventral frontal cortex and underlying white matter, including the uncinate fasciculus, a frontotemporal band of fibres previously hypothesized to mediate retrieval of specific events from one's personal past. Recent functional neuroimaging evidence of an association between right frontal lobe functioning and episodic retrieval demand …

Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life.

Maternal inflammation during pregnancy can alter the trajectory of fetal brain development and increase risk for offspring psychiatric disor … n Tensor Imaging (DTI) was used to characterize fractional anisotropy (FA) along the left and right uncinate fasciculus (UF), representing the main frontolimbic fiber tract. In N = 30 of the infants with serial MRI data at birth and 12-mo age, cognitive and socioemotional developmental status was characterized using the Bayley Scales of Infant Development. All analys …

Distinguishing persistent post-traumatic headache from migraine: Classification based on clinical symptoms and brain structural MRI data.

BACKGROUND: Persistent post-traumatic headache most commonly has symptoms that overlap those of migraine. In some cases, it can be clinically difficult to differentiate persistent post-traumatic headache with a migraine phenotype from migraine. The objective of this study was to develop a classification model based on questionnaire data and structural neuroimaging data that distinguishes individuals with migraine from those with persistent post-traumatic headache. METHODS: Questionnaires assessing headache characteristics, sensory hypersensitivities, cognitive functioning, and mood, as well a

Prenatal Adversity and Neonatal Brain Connectivity Relate to Emerging Executive Function at Age 2 Years.

OBJECTIVE: Early life adversity alters the structure and function of higher-order brain networks that subserve executive function (EF). The extent that prenatal exposure to adversity and neonatal white matter (WM) microstructure and resting-state functional connectivity (rs-fc) underlie problems in emerging EF remains unclear. METHOD: This prospective study includes 164 infants (45% female, 85% term-born) who were recruited prenatally and underwent neonatal diffusion and rs-fc magnetic resonance imaging scans. Social disadvantage and maternal psychosocial stress were assessed in the prenatal

МРТ корреляции депрессии и тревоги при множественном склерозе.

Множественный склероз (MS) является нейродегенеративным и хроническим воспалительным заболеванием, которое часто ассоциируется с психиатрической коморбидией, особенно депрессией и тревогой, которые играют важную роль в инвалидности, когнитивной дисфункции и качестве жизни. Растущие данные свидетельствуют о том, что симптомы воздействия в MS связаны не только с психосоциальным бременем, но и со структурными и функциональными аномалиями в мозге, которые могут быть выявлены с помощью магнитного резонансного изображения (MRI). МЕТОДЫ: Был проведен систематический поиск базы данных в целях выявлени

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… Disease duration, fractional anisotropy of the left uncinate fasciculus, and functional connectivity of the right amygdala accounted for 48% of the variance in depression severity [ 48 ]. 3.2. Anxiety 3.2.1. … Decreased fractional anisotropy and increased diffusivity were reported in the uncinate fasciculus, cingulum, fornix, and superior longitudinal fasciculus [ 44 , 48 , 49 ]. …

Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review.

COVID-19 affects brain function, as deduced by the "brain fog" that is often encountered in COVID-19 patients and some cognitive impairment that is observed in many a patient in the post-COVID-19 period. Approximately one-third of patients, even when they have recovered from the acute somatic disease, continue to show posttraumatic stress disorder (PTSD) symptoms. We hypothesized that the persistent changes induced by COVID-19 on brain structure would overlap with those associated with PTSD. We performed a thorough PubMed search on 25 April 2023 using the following strategy: ((posttraumatic OR

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… On the basis of their answers during the clinical interview, pts. were subdivided into cognitive noncomplainers ( n = 29) and cognitive complainers ( n = 29) | ↑ MD bilaterally affecting the inferior FOF, uncinated fasciculus, and corona radiata as well as several CC sections. ↑ RD in several WM tracts … located in the left hemisphere (corona radiata, ILS, inferior FOF, SLF, and uncinate fasciculus). ↑ AD in some inter-hemispheric associative tracts. ↑ FC in bilateral insular cortex, bilateral supramarginal and operular cortex, ACC, bilateral precentral gyrus, and inferior lateral occipital cortex; …

Корреляция когнитивных дисфункций и мер по диффузионному измерению МРТ в предметах, имеющих ОРД.

КОЛИЧЕСТВО: Когнитивная дисфункция - это обычное нарушение, наблюдаемое у лиц с множественным склерозом (MS), затрагивающее такие ключевые области, как внимание, скорость обработки информации, память и исполнительные функции. Этот дефицит, как правило, выявляется на основе всеобъемлющих нейропсихологических оценок, которые представляют собой золотой стандарт для когнитивной оценки. В последние годы были активизированы усилия по интеграции нейропсихологических результатов с передовыми методами нейроимации, с тем чтобы лучше понять нейронные субстраты когнитивной дисфункции. Среди них Difsusion

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… WM damage at specific fasciculi was related to episodic memory impairment, with significant correlations observed between M@T episodic memory scores and streamlines in the left uncinate fasciculus ( r = 0.57, p = 0.001), left inferior longitudinal fasciculus ( r = 0.477, p = 0.009), and right cingulum … Increased IIV on the SRT subtest was associated with reduced integrity in multiple WM tracts, including the corpus callosum (body, genu, splenium), posterior thalamic radiation, corona radiata, uncinate fasciculus, external capsule, and superior fronto-occipital fasciculus. …

Несоразмерный небольшой форник с модифицированной микроструктурой в педиатрическом множественном склерозе, показываемом с высокой разрешающей жидкостной диффузионной трактографией.

ОКРУЖАЮЩАЯ СРЕДА: У взрослых с множественным склерозом (MS) диффузионно-тензорная съемка (DTI) выявила явные аномалии объема и диффузии форникса, основного выходного участка гиппокампа (WM). ЦЕЛЬ: Определение того, затрагивает ли форник в педиатрическом плане MS (POMS), используя те же протоколы DTI, что и для взрослых MS (AOMS), что предполагает его участие в курсе болезни на раннем этапе. МЕТОДЫ: Для выявления форников в 11 пациентах в возрасте 13-19 лет и 26 контролерах с высоким разрешением была использована инфекционная трактография с использованием флюидов. Показатели объема и диффузии с

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… DTI metrics are altered in POMS in most NAWM, including major tracts like the corpus callosum, posterior limb of the internal capsule, cerebral peduncle, and long association fibers (superior longitudinal, inferior fronto-occipital, and uncinate fasciculus). 16 Relative to controls, DTI metrics …

Редактор специального выпуска : Множественный склероз: от диагностических биомаркеров до воображаемых и клинических прогнозов

Множественный склероз (MS) представляет собой хроническое, нейро-воспалительное и нейродегенеративное заболевание центральной нервной системы (CNS), которое может вызывать множество физических и когнитивных расстройств [...]

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… Lastly, streamlines of the uncinate fasciculus, inferior longitudinal fasciculus and corpus callosum were associated with verbal episodic and semantic memory performance [ 5 ]. …

Advances in Neuroimaging of Breast Cancer Pain: An Overview.

Breast cancer is currently the most common malignant tumor, primarily affecting women, and it frequently leads to chronic pain that significantly impairs physical and mental health. Neuroimaging studies have demonstrated that breast cancer-related pain is associated with specific brain alterations, including changes in activation, connectivity, and structure of pain-processing regions. This review synthesizes findings on functional and structural brain changes related to chronic pain in breast cancer and compares them with non-cancer chronic pain patterns. By integrating recent evidence, it pr

Иммунитет в нейромодуляции: исследование нейронных и иммунных путей в расстройствах мозга.

Иммунитет четко регулирует функцию мозга. Она непосредственно участвует в патологических процессах таких нейродегенеративных заболеваний, как болезнь Паркинсона и Альцгеймера, посттравматические заболевания, множественный склероз, травма головного мозга и психические расстройства (большое расстройство организма, серьезное депрессивное расстройство (МДС), расстройства тревожности, расстройства психоза и шизофрения, а также расстройства нервного развития (НРД). Нейромодулирование в настоящее время является одной из ведущих терапевтических стратегий лечения этих расстройств, однако пока мало что

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… A number of correlations have been observed in the left cingulum II and the left uncinate fasciculus [ 127 ]. ECT modulates the immune system and improves neurotrophin production. …

Питание N-6 Полиненасыщенное содержание жира в кислоте и здоровье мозга у взрослых людей среднего и старшего возраста.

ПАФА играет важную роль в возникновении и развитии нейродегенеративных заболеваний. С тех пор, как нейрозащитные эффекты n-3 ПУФА получил широкую поддержку, роль n-6 ПУФА по-прежнему обсуждается, а их основополагающие механизмы до сих пор не в полной мере понятны. В этом исследовании 169,295 Участники из Биобанка Соединенного Королевства были включены для анализа связей между питанием n-6 Поступление ПУФА и нейродегенеративные заболевания с использованием моделей коксовой регрессии с полной корректировкой для потенциальных сомнителей. Кроме того, для оценки воздействия различных моделей линейн

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… Additionally, a significant negative association for ICVF was also found with estimated β s of (−0.040 [−0.078, −0.003]) for tract superior thalamic radiation, (−0.044 [−0.081, −0.006]) for tract uncinate fasciculus, reflecting decreased intracellular volume and tissue density ( Figure 4 . …