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Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications.

Omega-3 polyunsaturated fatty acids (PUFAs) are considered immunonutrients and are commonly used in the nutritional therapy of cancer patients due to their ample biological effects. Omega-3 PUFAs play essential roles in cell signaling and in the cell structure and fluidity of membranes. They participate in the resolution of inflammation and have anti-inflammatory and antinociceptive effects. Additionally, they can act as agonists of G protein-coupled receptors, namely, GPR40/FFA1 and GPR120/FFA4. Cancer patients undergo complications, such as anorexia-cachexia syndrome, pain, depression, and p

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… On the other hand, other complications, such as non-islet cell tumor hypoglycemia, gynecomastia, acromegaly, hypertension, ovarian hyperstimulation syndrome, hyperprolactinemia, hyperthyroidism, and secretory diarrhea, are considered rare endocrine paraneoplastic syndromes [ 145 ]. …

Treating Primary Aldosteronism-Induced Hypertension: Novel Approaches and Future Outlooks.

Primary aldosteronism (PA) is the most common cause of secondary hypertension and is associated with increased morbidity and mortality when compared with blood pressure-matched cases of primary hypertension. Current limitations in patient care stem from delayed recognition of the condition, limited access to key diagnostic procedures, and lack of a definitive therapy option for nonsurgical candidates. However, several recent advances have the potential to address these barriers to optimal care. From a diagnostic perspective, machine-learning algorithms have shown promise in the prediction of P

Bioactivity of the Genus Turnera: A Review of the Last 10 Years.

Turnera is a genus of plants whose biological activity has been widely studied. The importance of this genus, particularly Turnera diffusa, as a source of treatment for various conditions is evidenced by the large number of new studies that have evaluated its biological activity. Accordingly, the objective of this review was to compile the information published in the last ten years concerning the biological activities reported for Turnera spp. The present work includes 92 publications that evaluate 29 bioactivities and toxicological and genotoxic information on five species of this genus. Amo

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… The use of inhibitors of this enzyme has been explored for the treatment of breast cancer, gynecomastia, and infertility, among other diseases [ 78 , 79 ]. Zava et al. determined the binding capacity of plant extracts on estrogen and progesterone receptors in breast cancer cell lines. …

Evaluation and Treatment of Obesity and Its Comorbidities: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity.

The goal of the 8th edition of the Clinical Practice Guidelines for Obesity is to help primary care physician provide safe, effective care to patients with obesity by offering evidence-based recommendations to improve the quality of treatment. The Committee for Clinical Practice Guidelines comprised individuals with multidisciplinary expertise in obesity management. A steering board of seven experts oversaw the entire project. Recommendations were developed as the answers to key questions formulated in patient/problem, intervention, comparison, outcomes (PICO) format. Guidelines underwent mult

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… Urogenital | Hypogonadism, menstrual abnormalities, polycystic ovary syndrome, infertility, subfertility, precocious puberty, gynecomastia, erectile disorder, adverse maternal outcomes (gestational diabetes, preeclampsia, eclampsia, miscarriage, dystocia, elevated risk of cesarean sections), congenital …

Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments.

Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of bone remodeling. It affects postmenopausal women but also significantly impacts older men. Estrogen can promote the production of osteoprotegerin, a decoy receptor for RANKL, thereby preventing RANKL from activating osteoclasts. Furthermore, estrogen promotes osteoblast survival and function via activation of the Wnt signaling pathway. Likewise, androgens play a critical role in bone metabolism, primarily through their conversion to estrogen in men. Estrogen deficiency accelerates bone resorption throug

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… Enlarged breast tissue (gynecomastia) | Decreased in bone mass in 25–48% of KS cases A deficiency associated with a significant decrease in BMD leads to the risk for premature osteopenia and osteoporosis A meta-analysis of testosterone replacement therapy in KS patients confirmed its limited impact on …

The Continuum of Thyroid Disorders Related to Immune Checkpoint Inhibitors: Still Many Pending Queries.

BackgroundUntil more data are available to shed light on the thyroid disorders related to immune checkpoint inhibitors (ICPi) implemented for the treatment of hematological malignancies, the decision-making is guided by pertinent data derived mostly from solid tumors.MethodsThe present review provides a comprehensive and updated overview of the thyroid disorders related to ICPi, namely to inhibitors of cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed cell death (PD) 1 (PD-1), and the ligand of the latter (PD-L1).ResultsWith the increasing recognition of ir thyroid disorders, many outstand

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… Additional symptoms and signs that raise suspicion of thyrotoxicosis are new onset atrial fibrillation, myopathy, hyperdefecation (not diarrhea), urinary frequency, oligomenorrhea or amenorrhea in women, and gynecomastia and erectile dysfunction in men [ 62 ]. …

Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials.

Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. These comorbidities include type 2 diabetes, hypertension, ventilatory dysfunction, arthrosis, venous and lymphatic circulation diseases, depression, and others, which have a negative impact on health and increase morbidity and mortality. GLP-1 agonists, used to treat type 2 diabetes, have been shown to be effective in promoting weight loss in preclinical and clinical studies. This review summarizes numerous studies conducted on the main drugs in the GLP-1 agonists class, outlini

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… Genitourinary complications such as menstrual disorders, reduced fertility, obstetric complications, polycystic ovary [ 32 , 33 ], gynecomastia, urinary incontinence, and impaired renal function [ 34 ] have also been associated with obesity ( Figure 2 ). …

Hematology

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… clubbing, Dupuytren’s contractures, palmar erythema, asterixis, cool and dry skin, vitiligo, hair thinning, alopecia areata, periorbital edema, scleral icterus, conjunctival pallor, altered mental status, anemia, macroglossia, parotid enlargement, fetor hepaticus, goiter, lymphadenopathy, spider angiomas, gynecomastia …

Hematology

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… clubbing, Dupuytren’s contractures, palmar erythema, asterixis, cool and dry skin, vitiligo, hair thinning, alopecia areata, periorbital edema, scleral icterus, conjunctival pallor, altered mental status, macroglossia, parotid enlargement, fetor hepaticus, goiter, lymphadenopathy, spider angiomas, gynecomastia …

DNA Damaging Drugs

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… Gynecomastia and impotence are possible estrogenic effects. Careful monitoring of treatment is required in specific risk groups: There is an increased risk of thrombosis, including fatal or non-fatal myocardial infarction, in men receiving estrogens for prostatic cancer. …

The prince and the pauper. A tale of anticancer targeted agents.

Cancer rates are set to increase at an alarming rate, from 10 million new cases globally in 2000 to 15 million in 2020. Regarding the pharmacological treatment of cancer, we currently are in the interphase of two treatment eras. The so-called pregenomic therapy which names the traditional cancer drugs, mainly cytotoxic drug types, and post-genomic era-type drugs referring to rationally-based designed. Although there are successful examples of this newer drug discovery approach, most target-specific agents only provide small gains in symptom control and/or survival, whereas others have consiste

Cancer Metabolism as a Therapeutic Target and Review of Interventions.

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of glucose. In addition to dietary and lifestyle modifications which work on tumors metabolically, there are a panoply of nutritional supplements and repurposed drugs associated with cancer prevention and

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… The standard dosing of cimetidine is 400 mg twice daily, and it is generally well-tolerated, with the most common side effect being gynecomastia [ 134 ]. 3.12. …

Abstracts - IANCON 2025

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Abstracts - IANCON 2024

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33rd Европейский конгресс патологии - резюме.

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Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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Резюме ЭСП 2013.

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters.

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Integumentary System

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