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A REVIEW OF SALIVARY BIOMARKERS OF PERIODONTAL DISEASE.

BackgroundPeriodontal disease is a complex multifactorial disease resulting from the interplay amongst microbiota, host immune response (influenced by genetic make-up) and lifestyle factors. The chronic inflammatory nature of the disease results in the destruction of the component of the periodontium. The process of the disease is associated with inflammation, collagen degradation and, bone loss which correlate with clinical features of periodontal disease. The clinical diagnosis of periodontal disease entails clinical examination involving the evaluation of probing depth, bleeding on probing,

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… Examples are: IL-1β, TNFα, IgA, Aspartate aminotransferase, Metalloproteinase-8, 9, 13, C-reactive protein, Cathepsin-B, Osteocalcin, ICTP, etc. 11 . … Osteocalcin Osteocalcin: It has been found that the level of osteocalcin increases in conditions where there is increased bone metabolism 21 as seen in osteoporosis, multiple myeloma, and during fracture repairs 22 . …

Wubi Shanyao Pills ameliorate glucocorticoid-induced osteoporosis by regulating bone marrow T cell homing as an immune intermediate to restore bone metabolism.

BACKGROUND: The disruption of bone immune function and bone metabolism homeostasis is intricately linked to the onset and progression of glu … ing bone-specific alkaline phosphatase (BALP), procollagen type I N-terminal propeptide (PINP), and osteocalcin (BGP). CONCLUSIONS: In summary, this study suggests that WBSY exerts anti-GIOP effects via an indirect pharmacological mechanism. WBSY may modulate the CXCL10-CXCR3 axis to inhibit aberrant T cell homing to the bone marrow, thereby reducing the exc …

Is Use of BMP-2 Associated with Tumor Growth and Osteoblastic Differentiation in Murine Models of Osteosarcoma?

BACKGROUND: The putative benefit of rhBMP-2 is in the setting of limb reconstruction using structural allografts, whether it be allograft-pr … the osteoblastic markers connective tissue growth factor, Runx-2, Osterix, alkaline phosphatase and osteocalcin. Experimental and control cell lines were injected into the proximal tibia of either NOD-SCID (143b and SaOS-2 xenograft model), or C3H (DLM8-M1 syngeneic model) mice. Local tumor burden was quantitatively assessed using tumor volume caliper measure …

Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects.

BACKGROUND: Bone loss, in malignant or non-malignant diseases, is caused by increased osteoclast resorption and/or reduced osteoblast bone formation, and is commonly associated with skeletal complications. Thus, there is a need to identify new agents capable of influencing bone remodeling. We aimed to further pre-clinically evaluate the effects of dasatinib (BMS-354825), a multitargeted tyrosine kinase inhibitor, on osteoblast and osteoclast differentiation and function. METHODS: For studies on osteoblasts, primary human bone marrow mensenchymal stem cells (hMSCs) together with the hMSC-TERT

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… For statistical analysis, values for a determined serum marker (e. g. osteocalcin) at each point (control, 3 and 7 weeks of treatment) were normalized for every individual animal to its own osteocalcin level at the beginning of the experiment, and plotted as fold change. … Minimal differences were found in osteocalcin serum levels between the 2.5 mg/kg BID and 10 mg/kg BID doses, neither after 3 weeks nor after 7 weeks of treatment, which probably reflects a near to plateau-effect on osteocalcin induction with the doses in our study. …

Novel_circ_003686 regulates the osteogenic differentiation of MSCs in patients with myeloma bone disease through miR-142-5p/IGF1 axis.

ObjectivesCirc_003686 is a novel_circRNA with abnormally low expression found in the samples of multiple myeloma bone disease (MBD) patients. The current research intended to investigate the effects of novel_circ_003686 in osteogenesis-induced differentiation of bone marrow mesenchymal stem cells (BMSCs) in MBD.MethodsBMSCs were extracted from MBD patients and normal participants, the pcDNA3.1 encoding the circ_003686 (ov-circ_003686), miR-142-5p-mimic/inhibitor and siRNA oligonucleotides targeting insulin like growth factor 1 (IGF1, si-IGF1) were applied to intervene circ_003686, miR-142-5p a

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… Note: IGF1, insulin-like growth factors-1; ALP, alkaline phosphatase; OPN, osteopontin; OC, osteocalcin. … The mRNA expressions of alkaline phosphatase (ALP) (B), osteopontin (OPN) (C) and osteocalcin (OC) (D) were detected by RT-PCR, and ACTIN was applied as the normalization standard. …

Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis.

INTRODUCTION: This systematic review and meta-analysis aimed to evaluate the effects of exercise interventions on bone mineral density (BMD), bone mineral content (BMC), and bone turnover markers in patients with cancer and compromised bone health. MATERIALS AND METHODS: A comprehensive search of four electronic databases was conducted to identify randomized controlled trials evaluating the effect of exercise intervention compared to supplementation or bone-targeted agents only on BMD, BMC and bone turnover markers. Meta-analyses were performed using random-effects models to calculate effect

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… Ex: osteocalcin ↔ Ex vs. … Bone turnover markers were assessed in two investigations, reporting conflicting results for CTX-I, osteocalcin, PINP, bone ALP, NTX-I, deoxypyridinoline, and pyridinoline [ 25 , 26 , 40 ]. …

Прогнозирующие биомаркеры для общего выживания пациентов, проходящих операцию на метастазах костей: исследование пан-ракера.

Быстрое диагностирование и прогнозируемая оценка метастаза костей (БМ) по-прежнему сопряжены с трудностями, поскольку большинство исследований и перспективных моделей концентрируются на одной первичной опухоли и пренебрегают биомаркерами, связанными с принимающей страной. Таким образом, это панраковое исследование было направлено на оценку метаболизма костей, провокационных и гематологических биомаркеров у пациентов, проходящих хирургическую операцию для БМ, выявление факторов риска для развития БМ и создание прогнозной номограммы. Потенциальная группа взрослых пациентов с гистологическим подт

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… P1NP, CTX, Osteocalcin, 1,25(OH)2D, and PTH levels were evaluated by using chemiluminescent immunoassay with the following assays: IDS-iSYS lntact P1NP and IDS-iSYS CTX-I (CrossLaps ® ) (Immunodiagnostic Systems, Boldon Colliery, United Kingdom), DiaSorin LIAISON ® Osteocalcin, DiaSorin LIAISON ® XL … Osteocalcin: beyond bones. Endocrinol Metab. (2024) 39:399–406. doi: 10.3803/EnM.2023.1895 21. Hu C, Wu J, Duan Z, Qian J, Zhu J. Risk factor analysis and predictive model construction for bone metastasis in newly diagnosed malignant tumor patients. …

Vitamin D control of osteoblast function and bone extracellular matrix mineralization.

Vitamin D is the major regulator of calcium homeostasis and protects the organism from calcium deficiency via effects on the intestine, kidney, parathyroid gland, and bone. Disturbances in the vitamin D endocrine system (e.g., vitamin D-dependent rickets type I and type II), result in profound effects on the mineralization of bone. Recent studies with vitamin D receptor knockout mice also show effects on bone. It is questioned whether vitamin D has a direct effect on bone formation and mineralization. In rickets and particular vitamin D receptor knockout mice, calcium supplementation restores

Osteoporosis and the Potential of Cell-Based Therapeutic Strategies.

Osteoporosis, the most common chronic metabolic bone disease, is characterized by low bone mass and increased bone fragility. Nowadays more than 200 million individuals are suffering from osteoporosis and still the number of affected people is dramatically increasing due to an aging population and longer life, representing a major public health problem. Current osteoporosis treatments are mainly designed to decrease bone resorption, presenting serious adverse effects that limit their safety for long-term use. Numerous studies with mesenchymal stem cells (MSCs) have helped to increase the knowl

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… The possible roles of osteocalcin, osteonectin, osteopontin and bone sialoprotein in bone mineralisation and resorption Cell Biol. Int. 1994 18 617 628 10.1006/cbir.1994.1088 8075622 68. Neve A. Corrado A. Cantatore F.P. Osteocalcin: Skeletal and extra-skeletal effects J. … Increased bone formation in osteocalcin-deficient mice Nature 1996 382 448 452 10.1038/382448a0 8684484 71. Tsao Y.T. Huang Y.J. Wu H.H. Liu Y.A. Liu Y.S. Lee O.K. Osteocalcin Mediates Biomineralization during Osteogenic Maturation in Human Mesenchymal Stromal Cells Int. J. Mol. …

Cellular and Molecular Mechanisms Associating Obesity to Bone Loss.

Obesity is an alarming disease that favors the upset of other illnesses and enhances mortality. It is spreading fast worldwide may affect more than 1 billion people by 2030. The imbalance between excessive food ingestion and less energy expenditure leads to pathological adipose tissue expansion, characterized by increased production of proinflammatory mediators with harmful interferences in the whole organism. Bone tissue is one of those target tissues in obesity. Bone is a mineralized connective tissue that is constantly renewed to maintain its mechanical properties. Osteoblasts are responsib

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… The endocrine function of bones was recently discovered, and the three main osteokines produced are FGF23, osteocalcin (OCN), and lipocalin-2 [ 170 ]. … Uncarboxilated osteocalcin (UnOC), released after osteoclast’s bone resorption, works as a hormone and promotes glucose tolerance [ 173 ]. …

Medication for bone loss in female patients with anorexia nervosa: a systematic review and management algorithm.

PURPOSE: Anorexia Nervosa can have a major impact on bone health through low bone mass and bone loss. Considering the lack of consensual guidelines for the prevention and treatment of bone loss in this condition, a systematic review was performed to provide practical treatment guidance for clinicians. METHODS: We systematically searched Medline, Cochrane, Psychinfo, and the Web of Science for anorexia nervosa AND (osteopenia OR osteoporosis OR bone density OR bone loss) AND (prevention OR treatment OR medication OR therapeutic) in clinical studies from March 1st, 2017, to October 31st, 2024,

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… NS for osteocalcin ( p = 0.469). … 0.05) for osteocalcin and PICP. …

The osteoblast in regulation of tumor cell dormancy and bone metastasis.

Breast and prostate cancer are among the most common malignancies worldwide. After treatment of the primary tumor, distant metastases often occur after a long disease-free interval. Bone is a major site for breast and prostate cancer metastasis and approximately 70% of patients with advanced disese suffer from osteolytic or osteoblastic bone metastases, a stage at which the disease is incurable. In bone, the disseminated tumor cells (DTCs) can become quiescent or "dormant", a state where they are alive but not actively dividing. Alternatively, the cancer cells can proliferate, disturb the bone

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… These “educated” osteoblasts were shown to express Runx2, osteocalcin and osteopontin. … Osx-TD+ osteoprogenitor cells and osteocalcin-GFP+ osteoblasts significantly expanded at early stages of primary tumor growth (<0.2 cm 3 ) and even more once the tumor reached a volume of >1 cm 3 . …

Potential diagnostic value of PD-1 in peripheral blood mononuclear cells of postmenopausal osteoporosis patients.

BACKGROUND: Postmenopausal osteoporosis (PMOP) is an estrogen deficiency-induced skeletal disorder. Bone mineral density (BMD) testing is the gold standard for diagnosing osteoporosis. However, its sensitivity for fracture risk assessment is low. Programmed cell death protein 1 (PD-1) is a key immune checkpoint molecule implicated in the pathophysiology of bone remodeling, but its role in osteoporosis has not yet been explored. Thus, this study aimed to assess the expression and diagnostic utility of PD-1 in PMOP. METHODS: A total of 56 patients with PMOP and 37 postmenopausal healthy control

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… The levels of procollagen type 1 N‐terminal propeptide (PINP), osteocalcin (OSTEOC), and β‐crosslaps (CROSSL) were higher in patients with PMOP than in controls (Table 3 ). … Table 3 Levels of bone turnover markers in patients with PMOP and healthy controls Abbreviations: BMD, bone mineral density; CROSSL, β‐crosslaps; OSTEOC, osteocalcin; PINP, procollagen type 1 N‐terminal propeptide; PMOP, postmenopausal osteoporosis. …

Changes in osteoblastic activity in patient who received bortezomib as second line treatment for plasma cell myeloma: a prospective multicenter study.

We conducted a prospective multicenter study identifying the role of bortezomib in patients with relapsed or refractory plasma cell myeloma (PCM) in bone resorption and formation via bone turnover markers. A total of 104 patients received at least 1 cycle of bortezomib. Most of them had advanced disease (n = 89). Among them, 75 patients completed 4 cycles of treatment. Most of the patients (81.7%) were treated in combination with steroid. After the 4th cycle treatment, 47 of 75 patients achieved CR, nCR, VGPR, and PR (64.4%), while 26 patients achieved less than PR (35.6%). The proportion of p

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… Bone-specific alkaline phosphatase (bALP) and osteocalcin (OC) were measured as bone formation indices. … Low serum osteocalcin levels in glucocorticoid-treated asthmatics. Journal of Clinical Endocrinology and Metabolism. 1986;62(2):379–383. doi: 10.1210/jcem-62-2-379. …

Sclerostin induced tumor growth, bone metastasis and osteolysis in breast cancer.

Breast cancer is the second leading cause of cancer-related deaths among women worldwide. Many patients suffer from bone metastasis. Sclerostin, a key regulator of normal bone remodeling, is critically involved in osteolytic bone diseases. However, its role in breast cancer bone metastasis remains unknown. Here, we found that sclerostin was overexpressed in breast cancer tumor tissues and cell lines. Inhibition of sclerostin by antibody (Scl-Ab) significantly reduced migration and invasion of MDA-MB-231 and MCF-7 cells in a time- and dose-dependent manner. In xenograft model, sclerostin inhibi

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… Compared with controls, a higher level of osteocalcin (Fig. 5B ) and a lower level of OPG (Fig. 5C ) were identified in Scl-Ab treated group. … Consistent with precious reports 32 – 34 , a lower level of OPG (p < 0.01) and a higher level of osteocalcin (p < 0.01) were detected in Scl-Ab treated group compared with controls. …

Advances in the research on myokine-driven regulation of bone metabolism.

The traditional view posits that bones and muscles interact primarily through mechanical coupling. However, recent studies have revealed that myokines, proteins secreted by skeletal muscle cells, play a crucial role in the regulation of bone metabolism. Myokines are widely involved in bone metabolism, influencing bone resorption and formation by interacting with factors related to bone cell secretion or influencing bone metabolic pathways. Here, we review the research progress on the myokine regulation of bone metabolism, discuss the mechanism of myokine regulation of bone metabolism, explore

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… Osteocalcin receptor Gprc6a knockout mice exhibit a phenotype of reduced muscle mass, whereas ESP (a phosphatase that inhibits osteocalcin function) knockout mice exhibit increased muscle mass. Osteocalcin supplementation increased muscle mass and restored exercise capacity in mice [ 98 ]. … Oxytocin/Osteocalcin/IL-6 and NGF/BDNF mRNA levels in response to cold stress challenge in mice: possible oxytonic brain-bone-muscle-interaction Front. …

[Role of R-spondin 2 on osteogenic differentiation of bone marrow mesenchymal stem cells and bone metabolism in ovariectomized mice].

OBJECTIVE: To investigate the effects of R-spondin 2 (Rspo2) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) … ogenesis-related genes [RUNX family transcription factor 2 (Runx2), collagen type Ⅰ alpha 1 (Col1), osteocalcin (OCN)] were detected by real-time fluorescence quantitative PCR (RT-qPCR). In addition, 18 10-week-old female C57BL/6 mice were randomly divided into sham operation group (sham group), ovariectomy group (OVX group), and OVX+Rspo2-intervention group …

[Mechanical properties and effect on osteodifferentiation of induced pluripotent stem cells of chitosan/whisker/calcium phosphate cement composite biomaterial].

OBJECTIVE: To investigate the mechanical properties of the novel compound calcium phosphate cement (CPC) biological material as well as the … ) activity, Live/Dead fluorescence staining and quantitative detection, ALP, Runx2, collagen typeⅠ, osteocalcin (OC), and bone morphogenetic protein 2 (BMP-2) gene expressions by RT-PCR were detected at 1, 7, and 14 days; and the alizarin red staining were detected at 1, 7, 14, and 21 days. Twenty-four 3-month-old male Sprague Dawley rats were used to establi …

P919: SIGNIFICANCE OF IHC AND BIOCHEMICAL MARKERS OF BONE METABOLISM FOR PREDICTING OSTEODESTRUCTIVE SYNDROME IN PLASMA CELL PROLIFERATION

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… At the stage of MGUS, 25.3% of patients (according to the level of osteocalcin) and 16.1% (according to the level of VAR) had disorders in the processes of bone tissue formation. … Summary/Conclusion: At the stage of MGUS, disturbances in the processes of bone tissue remodeling occur, which is accompanied by the appearance of deviations in the level of biochemical markers (osteocalcin, β CrossLaps). …

Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+/-) mice.

Mesenchymal stem cell commitment to an osteoprogenitor lineage requires the activity of Runx2, a molecule implicated in the etiopathology of multiple congenital craniofacial anomalies. Through promoter analyses, we have recently identified a new direct transcriptional target of Runx2, Nell-1, a craniosynostosis (CS)-associated molecule with potent osteogenic properties. This study investigated the mechanistic and functional relationship between Nell-1 and Runx2 in regulating osteoblast differentiation. The results showed that spatiotemporal distribution and expression levels of Nell-1 correlat