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Managing bisphosphonate-related osteonecrosis of the jaws with xenografts: a case report.

It is possible to manage large bone destruction induced by BRONJ using xenograft grafting to promote a bone formation.

Small RNA Sequencing Identifies PIWI-Interacting RNAs Deregulated in Glioblastoma-piR-9491 and piR-12488 Reduce Tumor Cell Colonies In Vitro.

Glioblastoma (GBM) is the most frequently occurring primary malignant brain tumor of astrocytic origin. To change poor prognosis, it is necessary to deeply understand the molecular mechanisms of gliomagenesis and identify new potential biomarkers and therapeutic targets. PIWI-interacting RNAs (piRNAs) help in maintaining genome stability, and their deregulation has already been observed in many tumors. Recent studies suggest that these molecules could also play an important role in the glioma biology. To determine GBM-associated piRNAs, we performed small RNA sequencing analysis in the discove

The efficiency of risedronate in reducing bone resorption after total hip arthroplasty: a meta-analysis of randomized control trials at a minimum of 6 months' follow-up.

BackgroundRecently risedronate is suggested to be effective for the prevention and treatment of for osteoporosis in total hip arthroplasty. This meta-analysis aimes to evaluate the efficacy of risedronate in reducing femoral periprosthetic bone mineral density loss in patients undergoing primary total hip arthroplasty.MethodsA systematic search was performed in Medline (1966-31 October 2017), PubMed (1966-31 October 2017), Embase (1980-31 October 2017), ScienceDirect (1985-31 October 2017) and the Cochrane Library. Only randomized controlled trial (RCT) were included. Fixed/random effect model

Study of a novel Ca/P/S-based cement implanted in the osteoporotic goat spine and its clinical application in preventing adjacent vertebral fractures.

Osteoporotic vertebral compression fracture (OVCF) has been increasing over the last decades. In addition to primary OVCF, the adjacent vertebral fracture (AVF) is a frequent serious complication in OVCF patients receiving percutaneous vertebroplasty or kyphoplasty, resulting in poor long-term outcome and recurrent symptoms. The aim of the present study is to investigate the bone regeneration behavior of a novel Ca/P/S-based resorbable cement (Ezechbone® Cement CBC-400) implanted into surgically created vertebral defects of ovariectomized (OVX) goats. Furthermore, the present study provides a

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… Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics. Int. J. Nanomed. 1 (3), 317–332. 10.2147/DIJN.1.S627 Blouin S., Moreau M. F., Weiss P., Daculsi G., Baslé M. F., Chappard D. (2006). … Relationships between endothelial cells, pericytes, and osteoblasts during bone formation in the sheep femur following implantation of tricalciumphosphate‐ceramic. Anat. Rec. 242 (3), 310–320. 10.1002/ar.1092420304 Demontiero O., Vidal C., Duque G. (2012). …

Количественная оценка холестерина в мозговой и спинной кордах во время развития, обезвоживания и ремиелинации.

Хлестерин в центральной нервной системе (КНС) в значительной степени неэстерифицирован (>99%) и присутствует главным образом в миелинской оболочке (~70% от общего количества холестерина CNS). Однако во время неврологических заболеваний наблюдалось накопление холестерина. В этом поперечном исследовании мы измерили уровень свободного холестерина и холестерина эстера в мозгу и спинные мозги модели мыши Plp1-iCKO-Myrf во время послеродовой миелиации, демиелинации и ремиелиции с использованием газовой хроматографии-массы спектрометрии с одним ионным мониторингом (GC-MS-SIM) и жидкой хроматографии-м

Innovative Biomaterials for the Treatment of Bone Cancer.

Bone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions developing within the bone. To date, available treatments are rarely curative and are primarily aimed at prolonging patients' survival and ameliorating their quality of life. Furthermore, both pharmacological and surgical therapies are aggravated by a consistent burden of adverse events and subsequent disability due to the loss of healthy bone structural and functional properties. Therefore, great research efforts are being made to develop

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… Photothermal effect of 3D printed hydroxyapatite composite scaffolds incorporated with graphene nanoplatelets Ceram. Int. 2020 47 6336 6340 10.1016/j.ceramint.2020.10.212 99. Ma H. Jiang C. Zhai D. Luo Y. Chen Y. Lv F. Yi Z. Deng Y. Wang J. Chang J. … Salinas A.J. 6—Ceramics as bone repair materials Bone Repair Biomaterials 2nd ed. Pawelec K.M. Planell J.A. Woodhead Publishing Cambridge, UK 2019 141 178 10.1016/B978-0-08-102451-5.00006-8 121. Raucci M.G. D’Amora U. Ronca A. Ambrosio L. …

A Review of 3D-Printed Medical Devices for Cancer Radiation Therapy.

This review explores the transformative role of three-dimensional (3D) printing in radiation therapy for cancer treatment, emphasizing its potential to deliver patient-specific, cost-effective, and sustainable medical devices. The integration of 3D printing enables rapid fabrication of customized boluses, compensators, immobilization devices, and GRID collimators tailored to individual anatomical and clinical requirements. Comparative analysis reveals that additive manufacturing surpasses conventional machining in design flexibility, lead time reduction, and material efficiency, while offering

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… While the range of materials available for 3D printing has expanded to include metals, ceramics, polymers, and biocompatible options, 3D-printed materials often exhibit lower strength, heat resistance, and longevity compared to their conventionally produced counterparts [ 112 , 118 ]. … Other composite materials for radiation shielding include thermoplastics filled with tungsten powder, highly absorbent ceramic powders, and gadolinium oxysulfide [ 168 ]. …

Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice.

Over the past few decades, there has been growing interest in understanding the molecular mechanisms of cancer pathogenesis and progression, as it is still associated with high morbidity and mortality. Current management of large bone sarcomas typically includes the complex therapeutic approach of limb salvage or sacrifice combined with pre- and postoperative multidrug chemotherapy and/or radiotherapy, and is still associated with high recurrence rates. The development of cellular strategies against specific characteristics of tumour cells appears to be promising, as they can target cancer cel

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… In vitro differentiation on scaffolds and re-implantation Morishita et al. used tissue-engineered osteogenic ceramics to fill BDs after bone tumour curettage. … They isolated BMMSCs that were osteogenic differentiated to osteoblasts after culture on porous hydroxyapatite ceramics [178] , shaped based on specific patient needs and implanted in three patients suffering from a bone tumour. …

Biomaterials from the sea: Future building blocks for biomedical applications.

Marine resources have tremendous potential for developing high-value biomaterials. The last decade has seen an increasing number of biomaterials that originate from marine organisms. This field is rapidly evolving. Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials. The latter are represented by chitin and chitosan, marine-derived collagen, and composites of different organisms of marine origin. The diversity of marine natural products, their properties and applications are discussed thoroughly in t

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… Many natural materials (e.g. gelatin, chitosan) and synthetic materials (e.g. bioactive ceramics and synthetic polymers) have been used for construction of scaffolds. … The mechanical properties, bioactivity and osteogenic potential of chitosan-based scaffolds are improved when chitosan is combined with other polymers and biomaterials such as hydroxyapatite, bioglass ceramic and silicon dioxide [ 300 ]. …

An Overview of Polymeric Nanoparticles-Based Drug Delivery System in Cancer Treatment.

Cancer is recognized as one of the world's deadliest diseases, with more than 10 million new cases each year. Over the past 2 decades, several studies have been performed on cancer to pursue solutions for effective treatment. One of the vital benefits of utilizing nanoparticles (NPs) in cancer treatment is their high adaptability for modification and amalgamation of different physicochemical properties to boost their anti-cancer activity. Various nanomaterials have been designed as nanocarriers attributing nontoxic and biocompatible drug delivery systems with improved bioactivity. The present

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… Inorganic NPs: NPs, such as gold NPs (AuNPs), magnetic NPs, quantum dots, carbon NPs, and ceramics NPs, having a central core made up of inorganic materials are responsible for their electronic, magnetic, optical, and fluorescent properties. 36 Hybrid NPs: These NPs are fabricated by combining different … complex. | https://bioinfo3d.cs.tau.ac.il/PatchDock/php.php 13. | Hex | Hex is an interactive protein docking and molecular superposition program. | hex.loria.fr/licence-8.0.0.html Application in Cancer Treatment As discussed in the above sections, NPs of various materials such as polymers, metals, and ceramics …

Disappearance of femoral head shortly after femoral neck fracture: a case report and literature review.

This case report describes a woman in her 70s who presented with a 3-month history of hip pain and inability to walk. Upon admission, she was diagnosed with the extremely rare condition of complete femoral head disappearance. A comprehensive examination was conducted to determine the cause and devise an effective treatment strategy, taking the patient's medical history into account. Through interdisciplinary discussions, occult infection and other potential causes were ruled out. The femoral head disappearance was ultimately determined to be due to wear, ischemia, and absorption following a fr

Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions.

Percutaneous-reinforced osteoplasty is currently being investigated as a possible therapeutic procedure for fracture stabilization in high-risk patients, primarily in patients with bone metastases or osteoporosis. For these patients, a percutaneous approach, if structurally sound, can provide a viable method for treating bone fractures without the physiologic stress of anesthesia and open surgery. However, the low strength of fixation is a common limitation that requires further refinement in scaffold design and selection of materials, and may potentially benefit from tissue-engineering-based

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… In one study, chitosan fiber and calcium phosphate ceramic (CF/CPC) scaffolds were examined for comminuted fracture repair of weight-bearing bones in a canine model [ 61 ]. … Figure 4 Chitosan fiber and calcium phosphate ceramics (CF/CPC) scaffold for fracture repair in weight-bearing long bones (radiuses) [ 61 ]. Upper panel: ( a ) X-ray images of both radii in adult dogs, right radius received CF/CPC scaffold, left radius were untreated (blank control). …

The Role of 3D-Printed Custom-Made Vertebral Body Implants in the Treatment of Spinal Tumors: A Systematic Review.

In spinal surgery, 3D prothesis represents a useful instrument for spinal reconstruction after the removal of spinal tumors that require an "en bloc" resection. This represents a complex and demanding procedure, aiming to restore spinal length, alignment and weight-bearing capacity and to provide immediate stability. Thus, in this systematic review the authors searched the literature to investigate and discuss the advantages and limitations of using 3D-printed custom-made vertebral bodies in the treatment of spinal tumors. A systematic literature review was conducted following the PRISMA (Pref

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… In spinal surgery, the most used are Selective Laser Sintering (SLS), where several materials as metal alloys or ceramics can be used, and Stereolithography (SLA) [ 30 , 31 ]. 4.2. …

Несбалансированность строения и cholesterol-24-hydroxylase dys Регулирование связано с развитием множественного склероза.

Инвалидность, усугубляющаяся множественным склерозом (MS), связана с нейродегенерацией. Холестерин гомеостазис необходим для нормального функционирования мозга. CYP46A1, что имеет решающее значение для оборота холестерина мозга и уменьшается в некоторых нейродегенеративных заболеваниях, является потенциальной целью нейрозащиты. Мы предположили, что CYP46A1 понижается в мозгах MS и связан с холестерином дисбалансом. Масс-спектрометрический анализ стеролов был проведен на основе совпадающей плазмы и цереброспинной жидкости (CSF) в женской группе MS (n = 32Средний возраст = 33). Инвалидность реги

Nanogel-Based Precision Bone Regeneration: Rational Design, Biological Barrier Penetration, and Osteoporotic Microenvironment Remodeling.

The pathogenesis of osteoporosis is primarily associated with impaired communication between osteoblasts and osteoclasts, leading to disrupted bone homeostasis. Conventional biomaterials mainly rely on macroscopic structural support and are limited in their ability to precisely regulate the complex bone microenvironment and overcome biological barriers. As representative soft matter nanoplatforms, nanogels possess unique viscoelastic mechanical properties and adaptive biointerfacial properties, offering new opportunities to overcome physical barriers within bone tissues. Moving beyond previous

Центральная ингибиция TYK2 идентифицирует TYK2 как ключевой нейроиммунный модулятор.

GWAS выявила тирозиновую киназу 2 (TYK2) в многочисленных провокационных расстройствах, в частности защитную гипоморфическую аллею TYK2 (P1104A) в множественных склерозах (MS). Поврежденный TYK2 сигнал в центральной нервной системе (CNS) может вызывать защитное воздействие аллеля TYK2 P1104A в MS. Мы использовали ингибиторы TYK2 (cTYK2i) в дополнение к периферически ограниченному ингибитору TYK2 (pTYK2i; BMS-986165) для того, чтобы рассеять влияние центрального ингибитора TYK2 в различных моделях нейроинфламмации. В то время как PTYK2i не оказывал существенного воздействия, cTYK2i уменьшили кл

Silencing of SPARC represses heterotopic ossification via inhibition of the MAPK signaling pathway.

Heterotopic ossification (HO), the pathologic formation of extraskeletal bone, can be disabling and lethal. However, the underlying molecular mechanisms were largely unknown. The present study aimed to clarify the involvement of secreted protein acidic and rich in cysteine (SPARC) and the underlying mechanism in rat model of HO. The mechanistic investigation on roles of SPARC in HO was examined through gain- and loss-of-function approaches of SPARC, with alkaline-phosphatase (ALP) activity, mineralized nodules, and osteocalcin (OCN) content measured. To further confirm the regulatory role of S

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… Kim J.A. et al. (2016) Extracellular calcium-binding peptide-modified ceramics stimulate regeneration of calvarial bone defects. Tissue Eng. Regen. Med. 13, 57–65 10.1007/s13770-015-9066-x 29. …

Токсичность тяжелых металлов в клиническом и экологическом здравоохранении: источники, механизмы, диагностика и научно обоснованное управление ртутью, свинцом, кадмием и арсеником.

Тяжелые металлы, включая ртуть (Hg), свинец (Pb), кадмий (Cd) и мышьяк (As), по-прежнему остаются значительными глобальными токсинами в силу их экологической стойкости, широкомасштабного антропогенного высвобождения и серьезного биологического воздействия. Этот обзор укрепляет нынешнее понимание их природных и промышленных источников, круговорота окружающей среды, маршрутов воздействия на человека и факторов уязвимости на уровне населения. Она охватывает их токсикокинетику и токсикодинамику, делая акцент на специфических для каждого вида механизмах поглощения, распределения и травмирования, вк

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… In developed countries, the use of lead is limited, but it remains in lead-containing products, such as gasoline, pigments, ceramics, and batteries [ 7 ]. Despite its beneficial contribution in many applications, lead is highly toxic and is one of the most widespread environmental health hazards. … high-efficiency particulate air [HEPA] vacuuming, interim controls, professional abatement when indicated), flushing stagnant plumbing and replacing lead service lines or leaded brass fixtures where feasible, using certified point-of-use filters for drinking and cooking water, and addressing imported ceramics …

Влияние лечения рака на оральные структуры и лицо черепа - последствия для протезирования и онкологического риска.

ЦЕЛЬ ОБЗОРА: Настоящее исследование направлено на выявление осложнений и трудностей при проведении остеоинтеграции имплантатов в онкологических пациентах, учитывая влияние лечения на микроархитектуру краниофасциальной области, микробиомо рта и воспаление полости рта. НОВЫЕ ДАННЫЕ: Хирургическая резекция, радиотерапия, химиотерапия и таргетная терапия значительно влияют на состояние костей, слизистых оболочек и мягких тканей, а также на возможности и ограничения протезирования. Химиотерапия значительно влияет на метаболизм кальция и фосфора. Было замечено, что существует увеличенный риск перел

A 3D engineered multiple myeloma niche for evaluating CAR T cell therapy.

Chimeric antigen receptor (CAR) T cell therapies targeting B cell maturation antigen (BCMA) have shown unprecedented success in treating multiple myeloma (MM), yet long-term relapse remains a critical challenge, possible due to the protective influence of the bone marrow (BM) microenvironment. Current in vitro models often rely on simplistic 2D cocultures of CAR T and MM cells, and fail to recapitulate the 3D structural and cellular complexity of the osteogenic niche, which is known to facilitate immune evasion. In this study, we aimed to develop a physiologically relevant 3D in vitro MM model