Результаты поиска

Noninvasive detection of sleep/wake changes and cataplexy-like behaviors in orexin/ataxin-3 transgenic narcoleptic mice across the disease onset.

Sleep and behavioral monitoring of young mice is necessary for understating the progress of symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep patterns of newborn mice using a simple piezoelectric transducer (PZT). Using this system, we have succeeded in detecting age-dependent occurrences and changes in sleep fragmentation of orexin/ataxin-3 narcoleptic mice (a narcoleptic mouse model with postnatal hypocretin/orexin cell death) across the disea

Modafinil ameliorates excessive daytime sleepiness after traumatic brain injury.

BACKGROUND: Excessive daytime sleepiness (EDS) and fatigue are common symptoms after traumatic brain injury (TBI), but there is no specific treatment for affected patients. With this pilot study, we aimed at studying the effect of daily modafinil on posttraumatic EDS and fatigue. METHODS: We conducted a prospective, double-blind, randomized, placebo-controlled pilot study in 20 patients with TBI who had fatigue or EDS or both. After baseline examinations (questionnaires including the Epworth Sleepiness Scale to assess EDS and the Fatigue Severity Scale to assess fatigue, actigraphy, polysomno

Предлагаемые причинно-следственные связи между 17 аутоиммунные заболевания и панкреатит: A two- Выбрать менделианское исследование случайности.

В ходе эпидемиологических исследований сообщалось о взаимосвязи между различными аутоиммунными заболеваниями (АД) и панкреатитом. В ходе этого исследования систематически проводилось изучение причинно-следственного воздействия факторов АД на панкреатит с использованием менделийской случайности (МС). Мы выбрали 17 Обычные АД как воздействие из самого крупного набора данных исследований в рамках всей ассоциации геномов в Европе. К числу результирующих переменных относятся острый панкреатит (АП), хронический панкреатит (CP), острый панкреатит, вызванный алкоголем, и хронический панкреатит, вызван

Совпадение в полном тексте источника
… In addition, datasets for each AD were obtained from the GWAS and Finngen datasets open to IEU as exposures, including RA, systemic lupus erythematosus (SLE), Eczema, Psoriasis, Vitiligo, multiple sclerosis (MS), myasthenia gravis (MG), narcolepsy, type 1 diabetes (T1D), graves’ disease (GD), hashimoto … Other results were that 7 ADs increased the risk of AAP (Psoriasis: OR = 1.020, P  = .7351; Narcolepsy: OR = 1.321, P  = .1283; PSC: OR = 1.033, P  = .6065; PBC: OR = 1.091, P  = .0535; UC: OR = 1.152, P  = .0867; CD: OR = 5.699, P  = .8850; AH: OR = 1.031, P  = .7069), and the presence of 12 …

Effect of Disease-Associated Germline Mutations on Structure Function Relationship of DNA Methyltransferases.

Despite a large body of evidence supporting the role of aberrant DNA methylation in etiology of several human diseases, the fundamental mechanisms that regulate the activity of mammalian DNA methyltransferases (DNMTs) are not fully understood. Recent advances in whole genome association studies have helped identify mutations and genetic alterations of DNMTs in various diseases that have a potential to affect the biological function and activity of these enzymes. Several of these mutations are germline-transmitted and associated with a number of hereditary disorders, which are potentially cause

The hypocretin neuron system: an arousal system in the human brain.

Hypocretins are recently discovered neuropeptides produced by a small group of posterior hypothalamic neurons which project widely over the neuroaxis. In this study, we note that hypocretin neuron perikarya in the human brain are localized to the perifornical region of the posterior hypothalamus, extending into the lateral hypothalamus. These neurons lightly innervate all areas of cerebral cortex studied in a variable pattern with denser innervation of association cortex than primary motor or sensory cortex. There is a dense innervation of hypothalamus, locus coeruleus, raphe nuclei, midline t

Sleep and sex: what can go wrong? A review of the literature on sleep related disorders and abnormal sexual behaviors and experiences.

STUDY OBJECTIVES: To formulate the first classification of sleep related disorders and abnormal sexual behaviors and experiences. DESIGN: A computerized literature search was conducted, and other sources, such as textbooks, were searched. RESULTS: Many categories of sleep related disorders were represented in the classification: parasomnias (confusional arousals/sleepwalking, with or without obstructive sleep apnea; REM sleep behavior disorder); sleep related seizures; Kleine-Levin syndrome (KLS); severe chronic insomnia; restless legs syndrome; narcolepsy; sleep exacerbation of persistent s…

Clinical analysis of anti-Ma2-associated encephalitis.

Increasing experience indicates that anti-Ma2-associated encephalitis differs from classical paraneoplastic limbic or brainstem encephalitis … ical limbic encephalitis. Excessive daytime sleepiness affected 32% of the patients, sometimes with narcolepsy-cataplexy and low CSF hypocretin. Additional hormonal or MRI abnormalities indicated diencephalic-hypothalamic involvement in 34% of the patients. Eye movement abnormalities were prominent in 92% of the patients with brainstem dysfunction, but those …

Patient-reported outcomes as a source of evidence in off-label prescribing: analysis of data from PatientsLikeMe.

BACKGROUND: Evaluating a new use for an existing drug can be expensive and time consuming. Providers and patients must all too often rely up … off-label uses. Only 34 of the 1755 (1%) reporting purpose used modafinil for an approved purpose (narcolepsy or sleep apnea). Only 104 out of 1197 members (9%) reported taking amitriptyline for its approved indication, depression. Members taking amitriptyline for off-label purposes rated the drug as more effective than those who were taking it for its appr …

Vivid dreams, hallucinations, psychosis and REM sleep in Guillain-Barré syndrome.

We conducted a prospective controlled study of the clinical and biological determinants of the mental status abnormalities in 139 patients w … abnormal mental status in GBS patients. CSF hypocretin-1 (a hypothalamic neuropeptide deficient in narcolepsy) levels, measured in 20 patients, were lower in GBS patients with hallucinations (555 +/- 132 pg/ml) than in those without (664 +/- 71 pg/ml, P = 0.03). Since the mental status abnormalities had dream-like aspects, we examined their association with …

The mutual impacts of stem cells and sleep: opportunities for improved stem cell therapy.

Sleep is an indispensable physiological function regulated by circadian rhythms, which influence the biological pathways and overall health of the body. Sleep is crucial for the maintenance and restoration of bodily systems, and disturbances can lead to various sleep disorders, which can impair both mental and physical health. Treatment options for these disorders encompass lifestyle modifications, psychotherapy, medications, and therapies such as light therapy and surgery. Not only sleep deprivation has a significant impact on essential organs, but it also influences various types of stem cel

Совпадение в полном тексте источника
… The primary disorders within this category include narcolepsy (types 1 and 2), idiopathic hypersomnia, and Kleine-Levin syndrome [ 16 ]. Narcolepsy is a neurological condition marked by EDS and frequent, uncontrollable sleep attacks. … There are two types of narcolepsy: narcolepsy type 1 involves a significant loss of neurons that produce the neurotransmitter orexin (hypocretin), which is involved in regulating sleep and wakefulness. …