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Incidence and survival of lymphoid neoplasms in Spain, 2002-2013: A population-based study from the Spanish Network of Cancer Registries (REDECAN).

IntroductionThe aim of this study was to describe incidence, incidence trends and survival patterns of lymphoid neoplasms (LNs) and its subtypes in Spain in the period 2002-2013 using data from the Spanish Network of Cancer Registries (REDECAN).Materials and methodsData were extracted from 13 Spanish population-based cancer registries. LNs incident cases were codified using the International Classification of Diseases for Oncology, third edition (ICD-O-3) and grouped according to the WHO 2008 classification. Age-standardized incidence rates to the 2013 European standard population (ASIRe) were

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… 1,142 | 2.92 | 63 | 0.91 (0.86-0.96) | 0.98 (0.92-1.03) | 1.63 4.2.1 Peripheral T-cell lymphoma, NOS | 9702 | 492 | 1.26 | 66 | 0.39 (0.36-0.43) | 0.42 (0.39-0.46) | 1.83 4.2.2 Angioimmunoblastic T-cell lymphoma | 9705 | 177 | 0.45 | 69 | 0.14 (0.12-0.16) | 0.16 (0.13-0.18) | 1.72 4.2.3 Subcutaneous panniculitis-like …

Abstracts from the ISSAID 2021 Periodic Congress : Virtual. May - Dec 2021

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… The most common clinical features in NEMO-NDAS pts were panniculitis with systemic inflammation (100%), ectodermal dysplasia (83%), hepatosplenomegaly (77%) and B-cell lymphopenia (80%). … Compared to CANDLE pts (n=5), NEMO-NDAS pts’ skin biopsies (n=7) showed histiocytic panniculitis, vacuolar interface changes and dyskeratosis. Liver biopsies (n=3) showed granulomatous hepatitis; 2 other pts had portal hypertension. …

Histopathological Markers for Target Therapies in Primary Cutaneous Lymphomas.

In recent years, targeted (biological) therapies have become available also for primary cutaneous T-cell lymphomas (PCTCLs) including anti-CD30 (brentuximab vedotin) in mycosis fungoides, primary cutaneous anaplastic large T-cell lymphoma, lymphomatoid papulosis; anti-CCR4 (mogamulizumab) in Sezary syndrome; anti-CD123 (tagraxofusp) in blastic plasmocytoid cell neoplasm. Moreover, anti-PD1 (nivolumab), anti-PDL1 (pembrolizumab, atezolizumab), anti-CD52 (alemtuzumab), anti-KIR3DL2-CD158k (lacutamab), and anti-CD70 (cusatuzumab) have been tested or are under investigations in phase II trials. Th

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… Subcutaneous panniculitis-like T-cell lymphoma: Definition, classification, and prognostic factors: An EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood. 2008;111:838–845. doi: 10.1182/blood-2007-04-087288. 3. Willemze R. …

Targeted Therapy for Idiopathic Inflammatory Myopathy.

BACKGROUND: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by chronic muscle inflammation and significant extramuscular involvement. A substantial proportion of patients exhibit refractory or relapsing disease despite conventional immunosuppressive therapies, necessitating the development of novel targeted treatments. Recent immunological advances have identified novel therapeutic targets-including B cells, T cells, cytokines and intracellular signalling pathways-paving the way for personalized treatment. Targeted therapies represent pr

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… Kang , “ Ruxolitinib for Refractory PL‐12 Antisynthetase Syndrome‐Associated Angioedema‐Like Panniculitis With Clonal T‐Cell Receptor Gene Rearrangement ,” JAMA Dermatology 160 , no. 3 ( 2024 ): 363 – 366 . 38117485 10.1001/jamadermatol.2023.4940 85 L. Ladislau , X. Suárez‐Calvet , S. …

Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 1.

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Proceedings of the 27th European Paediatric Rheumatology Congress (PReS 2021) : Virtual. 19-21 September 2021

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Dabrafenib plus trametinib in BRAFV600E-mutated rare cancers: the phase 2 ROAR trial.

BRAFV600E alterations are prevalent across multiple tumors. Here we present final efficacy and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus trametinib (MEK inhibitor) in eight cohorts of patients with BRAFV600E-mutated advanced rare cancers: anaplastic thyroid carcinoma (n = 36), biliary tract cancer (n = 43), gastrointestinal stromal tumor (n = 1), adenocarcinoma of the small intestine (n = 3), low-grade glioma (n = 13), high-grade glioma (n = 45), hairy cell leukemia (n = 55) and multiple myeloma (n = 19). The primary endpoint of investigator-assessed o

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… Panniculitis under successful targeted inhibition of the MAPK/ERK signaling pathway in a patient with BRAF V600E-mutated spindle cell oncocytoma of the pituitary gland. Anticancer Res. 39 , 3955–3959 (2019). 27. Brunet, M., Khalifa, E. & Italiano, A. …

The Clinical Application of Ozonetherapy

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Ход работы сессии 31st Европейский педиатрический конгресс по педиатрии: часть 2.

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Skin Telocytes Could Fundament the Cellular Mechanisms of Wound Healing in Platelet-Rich Plasma Administration.

For more than 40 years, autologous platelet concentrates have been used in clinical medicine. Since the first formula used, namely platelet-rich plasma (PRP), other platelet concentrates have been experimented with, including platelet-rich fibrin and concentrated growth factor. Platelet concentrates have three standard characteristics: they act as scaffolds, they serve as a source of growth factors and cytokines, and they contain live cells. PRP has become extensively used in regenerative medicine for the successful treatment of a variety of clinical (non-)dermatological conditions like alopec

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… Thus, the abnormal accumulation of dermal collagen (a structural feature of scleroderma), particularly collagen II and the reticular fibers (collagen III) along mucoid oedema and panniculitis (that are structurally also featuring scleroderma) produces separation of TCs in their networks, disarranging …

Hematology

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… primary sclerosing cholangitits genitourinary —acute interstitial nephritis, acute post-streptococcal glomerulonephritis, eosinophilic cystitis, eosinophilic prostatitis rheumatologic —eosinophilia–myalgia syndrome and idiopathic eosinophilic synovitis, Churg–Strauss syndrome dermatologic —eosinophilic panniculitis …

Immunotherapies for pediatric cancer: current landscape and future perspectives.

The advent of immunotherapy has revolutionized how we manage and treat cancer. While the majority of immunotherapy-related studies performed to date have focused on adult malignancies, a handful of these therapies have also recently found success within the pediatric space. In this review, we examine the immunotherapeutic agents that have achieved the approval of the US Food and Drug Administration for treating childhood cancers, highlighting their development, mechanisms of action, and the lessons learned from the seminal clinical trials that ultimately led to their approval. We also shine a

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… The vaccine was also well tolerated, with severe adverse events being limited to 5 incidences of reversible panniculitis and 1 incidence of bone pain. The current study, which was initiated in 2010, reached its primary completion date in 2012 and is expected to be completed in 2026 [ 91 ]. …

Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.

Nuclear receptors (NRs) are a large family of ligand-dependent transcription factors that regulate the expression of a wide range of target genes in response to endogenous and exogenous ligands, including steroid hormones, thyroid hormone, vitamin D, retinoic acid, fatty acids, and oxidative steroids. Upon ligand binding, nuclear receptors form dimer complexes with transcriptional cofactors, which interact with specific DNA sequences in the promoter or enhancer regions of target genes to modulate gene expression. This process plays a crucial role in many physiological processes such as reprodu

Ход работы сессии 25th Европейский конгресс педиатрической ремуматологии (ПСР) 2018) Лиссабон, Португалия. 5-8 сентябрь 2018

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Pathology Competencies in Medical Education and Educational Cases: Update 2023.

Pathology is a core component of medical school curricula because understanding the pathogenesis of the disease is foundational both for diagnostic efficiency and optimal use of ancillary resources in patient care. The Pathology Competencies for Medical Education (PCME) were developed as a national resource of expectations of pathology knowledge for medical students. The PCME are composed of three competencies: disease mechanisms and processes, organ system pathology, and diagnostic pathology and therapeutic pathology. The learning goals and learning objectives of the PCME that were first publ

Hematology

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… primary sclerosing cholangitits genitourinary —acute interstitial nephritis, acute post-streptococcal glomerulonephritis, eosinophilic cystitis, eosinophilic prostatitis rheumatologic —eosinophilia–myalgia syndrome and idiopathic eosinophilic synovitis, Churg–Strauss syndrome dermatologic —eosinophilic panniculitis …

Current State of Knowledge on Primary Sjögren's Syndrome, an Autoimmune Exocrinopathy.

Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most frequent connective tissue disease after rheumatoid arthritis, affecting 0.3-3% of the population. Women are more prone to develop pSS than men, with a sex ratio of 9:1. Considered in the past as innocent collateral passive victims of autoimmunity, the epithelial cells of the saliv

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… More rarely pSS can be responsible for cutaneous ulcer, livedo, erythema nodosum, panniculitis, amyloidosis or granuloma annulare [ 209 ]. 4.8. Cardiovascular Manifestations Raynaud phenomenon is the most frequent vascular manifestation, affecting 15% of patients [ 207 ]. …

Устные бесплатные бумажные сессии.

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Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

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… panniculitis inflammation of the subcutaneous fat. See also opportunistic mycobacterial infection. …