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Complete Remission of BCG-Refractory High-grade Bladder CIS with Pharmacologic Ascorbate and Mistletoe.

CONTEXT: Bladder cancer is the fourth-most-common cancer in males in the U.S., who develop about 90% of the high-grade, carcinoma in situ (C … ly adult life to several known carcinogens, including ultrafine particulate air pollution, benzene, toluene, and other organic solvents, aromatic amines and engine exhausts, and possibly arsenic in water. DESIGN: The research team performed an integrative oncology case study on pharmacologic ascorbate (PA) and mistletoe, both agents shown to activate NK …

Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNpc). Activation of the mixed lineage kinase and c-Jun N-terminal kinase (JNK) has been reported in models of PD. Our focus was to discern whether distinct pathways were activated in cell-specific manner within the SNpc. We now demonstrate the selective phosphorylation of p38 MAP kinase within the dopaminergic neurons, whereas JNK activation occurs predominantly in the microglia. p38 activation results in downstream phosphoryl

[Changes in murine skin odors following Plasmodium infections and their impact on mosquito attraction].

OBJECTIVE: To investigate the alterations in skin volatile odors in mice following Plasmodium infections and their effect on mosquito attrac … nonanal (62 215.11 ± 11 348.82 vs 24 040.15 ± 8 557.10; t = 4.35, P = 0.02), and lower contents of toluene (61 833.23 ± 2 755.23 vs. 152 906.21 ± 10 199.69; t = 14.93, P = 0.00), benzaldehyde (583 921.81 ± 39 764.63 vs. 1 071 368.84 ±254 069.28; t = 3.28, P = 0.00) and indole (10 991.89 ± 582.76 vs. 27 275.57 ± 3 995.59; t = 6.99, P = 0.00) relative to c …

Additive Manufacturing for Occupational Hygiene: A Comprehensive Review of Processes, Emissions, & Exposures.

This comprehensive review introduces occupational (industrial) hygienists and toxicologists to the seven basic additive manufacturing (AM) p … metallic feedstocks, released organic gases, including (but not limited to), respiratory irritants (toluene, xylenes), asthmagens (methyl methacrylate, styrene), and carcinogens (benzene, formaldehyde, acetaldehyde). Real-time photoionization detectors for total volatile organics provided useful information for processes that utilize polymer feedstock mat …

Concentrations of air toxics in motor vehicle-dominated environments.

We at the Desert Research Institute (DRI*) measured volatile organic compounds (VOCs), including several mobile-source air toxics (MSATs), p … BC and were between two and six times higher for PM2.5 mass. The on-road concentrations of benzene, toluene, ethylbenzene, and xylenes (BTEX) during the summer were 3.5 +/- 0.7 and 1.2 +/- 0.6 times higher during morning and afternoon commuting periods, respectively, compared to annual average 24-hour concentrations measured at air toxic monitoring networ …

Расширенный полиглутамин в ATAXIN1 приводит к потере функции, которая усугубляет остроту множественного склероза в модели мыши EAE.

Ataxin-1 (ATXN1) — белок, в котором расширение его полиглутаминового тракта вызывает нервно-дегенеративное расстройство спинномозговой системы 1 (SCA1) в результате повышения функциональности. Недавно было продемонстрировано, что АТXN1 дикая порода играет защитную роль в регулировании жесткости экспериментального аутоиммунного энцефаломиелита (EAE) — хорошо зарекомендовавшей себя модели мыши для мультиклероза (MS). В этом исследовании дополнительно изучается роль ATXN1 с расширенным полиглутаминым трактом в контексте MS с использованием модели мыши EAE.МЕТОДЫ: Гемизиговые атксны1 (Atxn1 2Q/-)

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… Finally, sections were mounted in ProLong Gold Antifade with 4′,6- diamidino-2-phenylindole (DAPI) to visualize nuclei (Thermo Fisher Scientific) for immunofluorescence and in toluene for 3,3’-Diaminobenzidine (DAB) (Vactor laboratories) staining. …

Real-World Vehicle Emissions Characterization for the Shing Mun Tunnel in Hong Kong and Fort McHenry Tunnel in the United States.

INTRODUCTION: Motor vehicle exhaust is an important source of air pollutants and greenhouse gases. Concerns over the health and climate effe … ssions for all pollutants: emission factors for naphthalene were reduced the most, by 98%; benzene, toluene, ethylbenzene, and xylene (BTEX), by 94%; CO, NMHCs, and NOx, by 87%; and aldehydes by about 71%. Smaller reductions were observed for HD emission factors: naphthalene emissions were reduced by 95%, carbonyl emissions decreased by about 75%, BTEX by …

[Recent advances in the use of graphene for sample preparation].

Sample preparation is playing an increasingly important role in sample analysis. The enrichment efficiency of the target and the removal eff … anic pollutants, including polychlorinated biphenyls, phthalates, polycyclic aromatic hydrocarbons, toluene, xylenes, organophosphorus pesticides, phenoxy acid herbicides, and antibiotics, in environmental or biological samples have been successfully determined. The extraction mechanism, including π-π, electrostatic, hydrophobic, hydrophilic, and hydrogen …

Регулирование Kynurenin Pathway в Relapping Rising Multial Sclerosis и его корреляции с прогрессивным нейродегенерацией.

Несмотря на отсутствие острых повреждений при многократном склерозе (MS), хроническое нейродегенерация продолжает развиваться, и потенциальным основополагающим механизмом может быть кинурайнский путь (КП). Как известно, продолжительная активация КП от хронического воспаления усугубляет прогресс нервно-дегенеративных заболеваний за счет производства нейротоксичных метаболитов. В числе 8 КП метаболиты, six из них, а именно: кинурень (КИН), 3- Гидроксилкилинин (3ГК), антраиличная кислота (АА), кинуриновая кислота (КИНА) и квинолинская кислота (QUIN) были связаны с нейродегенерацией.Чтобы получить

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… The fluorinated esters were extracted into toluene and washed with 5% sodium bicarbonate solution. The upper organic layer was collected, washed with ultra pure water type I, dried using sodium sulphate-packed pipette tips, and finally transferred to vials for gas chromatography analysis. …

Расширенный полиглутамин в ATAXIN1 приводит к потере функции, которая усугубляет остроту множественного склероза в модели мыши EAE.

Ataxin-1 (ATXN1) — белок, в котором расширение его полиглутаминового тракта вызывает нервно-дегенеративное расстройство спинномозговой системы 1 (SCA1) в результате повышения функциональности. Недавно было продемонстрировано, что АТXN1 дикая порода играет защитную роль в регулировании жесткости экспериментального аутоиммунного энцефаломиелита (EAE) — хорошо зарекомендовавшей себя модели мыши для мультиклероза (MS). В этом исследовании дополнительно изучается роль ATXN1 с расширенным полиглутаминым трактом в контексте MS с использованием модели мыши EAE.МЕТОДЫ: Гемизигиозные мыши Atxn1 (Atxn12Q

Совпадение в полном тексте источника
… Finally, sections were mounted in ProLong Gold Antifade with 4′,6- diamidino-2-phenylindole (DAPI) to visualize nuclei (Thermo Fisher Scientific) for immunofluorescence and in toluene for 3,3′-Diaminobenzidine (DAB) (Vactor laboratories) staining. …

Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.

Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity by inhibiting T-cell proliferation and altering glucose metabolism. The tumor suppressor p53 also alters these cellular processes with similar results. The effect of IDO on p53 and on glucose metabolism was evaluated in alloreactive T cells. Mixed-lymphocyte reactions (MLRs) were performed in the presence or not of the IDO inhibitor, 1-dl-methyl-tryptophan (1-MT) and/or the p53 inhibitor, pifithrin-α (PFT). Cell proliferation, glucose consumption and lactate production were assessed. 1-MT increased cell proliferation, glucose influ

Molecular Mechanisms of Bortezomib Action: Novel Evidence for the miRNA-mRNA Interaction Involvement.

Bortezomib is an anti-tumor agent, which inhibits 26S proteasome degrading ubiquitinated proteins. While apoptotic transcription-associated activation in response to bortezomib has been suggested, mechanisms related to its influence on post-transcriptional gene silencing mediated regulation by non-coding RNAs remain not fully elucidated. In the present study, we examined changes in global gene and miRNA expression and analyzed the identified miRNA-mRNA interactions after bortezomib exposure in human neuroblastoma cells to define pathways affected by this agent in this type of cells. Cell viabi

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… Induction of apoptosis in human leukemia cells through the production of reactive oxygen species and activation of hmox1 and noxa by benzene, toluene, and o-xylene Toxicology 2011 280 109 117 10.1016/j.tox.2010.11.017 21144877 40. Lamkanfi M. Kanneganti T.D. …

A review on gold nanoparticles as an innovative therapeutic cue in bone tissue engineering: Prospects and future clinical applications.

Bone damage is a complex orthopedic problem primarily caused by trauma, cancer, or bacterial infection of bone tissue. Clinical care management for bone damage remains a significant clinical challenge and there is a growing need for more advanced bone therapy options. Nanotechnology has been widely explored in the field of orthopedic therapy for the treatment of a severe bone disease. Among nanomaterials, gold nanoparticles (GNPs) along with other biomaterials are emerging as a new paradigm for treatment with excellent potential for bone tissue engineering and regenerative medicine application

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… In this method, a simple process based on rapid reduction of gold ions in water-toluene two-phase system is followed by spontaneous adsorption of alkanethiols. … GNPs made in this way are extremely stable and are also soluble in solvents such as toluene, pentane, and chloroform, meaning that they can be sedimented, redissolved, and stored in powder form [ 52 ]. …

The Development of Laboratory-made NTD Sensor Systems for the Analysis of Volatile Organic Compounds (VOCs) in Synthetic Breath Samples.

INTRODUCTION: In recent years, the analysis of volatile organic compounds (VOCs) has emerged as a highly attractive sample preparation metho … ared with polyaniline polymer in laboratory environment were used for the determination of benzene, toluene, ethylbenzene and and o-, p-xylene (BTEX) compounds, which are important for environmental exposure, in synthetic breath medium. MATERIAL AND METHODS: The NTD systems used in the study were made using four different conductive polymers. Surface and …

[Determination of atmospheric organochlorine pesticides using isotope dilution high-resolution gas chromatography/high-resolution mass spectrometry].

A method for the determination of 25 organochlorine pesticides (OCPs) in the atmosphere using isotope dilution high-resolution gas chromatog … the pigments. Thus, the combination of florisil and graphitized carbon black cartridges using 10 mL toluene for elution was determined as the final cleaning method in this study. A high-resolution mass spectrometer equipped with a gas chromatograph was used for quantification. A fused-silica capillary column (Rtx-CL Pesticides2, 30 m×0.25 mm×0.2 μm) was u …

A Preliminary Investigation towards the Risk Stratification of Allogeneic Stem Cell Recipients with Respect to the Potential for Development of GVHD via Their Pre-Transplant Plasma Lipid and Metabolic Signature.

The clinical outcome of allogeneic hematopoietic stem cell transplantation (SCT) may be influenced by the metabolic status of the recipient following conditioning, which in turn may enable risk stratification with respect to the development of transplant-associated complications such as graft vs. host disease (GVHD). To better understand the impact of the metabolic profile of transplant recipients on post-transplant alloreactivity, we investigated the metabolic signature of 14 patients undergoing myeloablative conditioning followed by either human leukocyte antigen (HLA)-matched related or unr

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… Dried extracts were resuspended using 110 µL of a methanol/toluene (9:1, v / v ) mixture containing CUDA (50 ng/mL; internal standard for quality control of injection) with support of vortexing (10 s), and centrifuged at 800 rpm for 5 min, followed by transferring 100 µL of the supernatant into auto-sampler …

Molecular Diversity of Lupane Hybrids in Drug Design and Materials Science.

The need for new, more effective drugs to treat cancer, infectious diseases, various parasitic infestations, and metabolic disorders requires innovative approaches to the design of promising molecules. One of these areas is the creation of hybrid structures. Lupane triterpenoids are of significant interest for such research due to their high abundance in natural sources and their renewable nature, their molecular architecture, presence of several easily modifiable functional groups, enantiomeric purity, broad spectrum of biological activity, and low toxicity. Active research into the biologica

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… The study determined that the 1,2,3-triazole derivative of allobetuline 149a with a 1,2-dihydroxybenzene spacer formed a stable gel exclusively in toluene. In contrast, the model compounds 150 , 151 did not exhibit gel formation in any of the solvents tested. … Molecular dynamics simulations conducted in six solvents (water, ethanol, cyclohexanol, acetonitrile, toluene) alongside quantum-chemical calculations demonstrate that intermolecular interactions of the tail substituents are the primary factor influencing the gelation of the synthesized compounds. …

Корреляция физико-химических свойств с антиоксидантной активностью в фенолах и тиофенолах.

Окисляющий стресс, связанный с чрезмерным производством реактивных видов кислорода и азота (ROS, RNS), способствует развитию и развитию многих заболеваний, таких, как старение, сердечно-сосудистые заболевания, болезнь Альцгеймера, болезнь Паркинсона, диабет, рак, предэклампсия или множественный склероз. В то время как фенолы и полифенолы являются наиболее изученными структурно схожими соединениями антиоксидантов, такими, как анилины или тиофенолины, периодически анализируются, несмотря на их радикальный потенциал сбора. В ходе этой работы проводится оценка воздействия структурных особенностей

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… Proton-coupled electron transfer versus hydrogen atom transfer in benzyl/toluene, methoxyl/methanol, and phenoxyl/phenol self-exchange reactions. J. Am. Chem. Soc. 124 , 11142–11147. 10.1021/ja012732c (2002). 43. Litwinienko, G. & Ingold, K. U. …

Структурное и механистическое профилирование модулятуры Hurr1 vidofludimus позволяет проектировать лиганд на основе структуры.

В центре биомедицинских исследований находится фактор нейрозащиты, связанный с ядерным рецептором 1 (Nurr1, NR4A2) для его многообещающей нейрозащитной роли в болезни Паркинсона, болезни Альцгеймера и множественном склерозе. Его деятельность может контролироваться лигандами, предлагающими доступ к фармакологической модуляции Hurr1. Вместе с тем связующие эпитопы и механизмы молекулярной активации синтетических активаторов Hurr1 по-прежнему остаются труднодостижимыми, но имеют важное значение для продвижения к новым лекарствам лигандов Hurr1. Здесь мы охарактеризовали диссоциацию Hurr1 димера и

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… A solvent mixture of toluene (2 mL), EtOH (1.33 mL), and H 2 O (0.66 mL) was degassed by the freeze-pump-thaw method (3x) and added under Ar. Then XPhos-Pd-G2 (16 mg, 0.02 mmol, 0.10 eq) was added, and the reaction was stirred at 100 °C for 18 h. …

An update review on Commiphora molmol and related species.

The origins of myrrh and frankincense are traced to the Arabian Peninsula. According to Herodotus (5th century BC): "Arabia is the only coun … squalene peroxidation by UV irradiation. The first type was free radical scavenger (Butyl hydroxyl toluene and an olive extract rich in hydroxytyrosol). The second type was the essential oil of C. myrrha, a singlet oxygen quencher. These properties were confirmed using the 2,2-diphenyl-1-picrylhydrazyl test for anti-radical capacity and 1,3-diphenylisobe …