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Comprehensive Review of Prevention and Management Strategies for Medication-related Osteonecrosis of the Jaw (MRONJ).

PURPOSE: To assess and classify the strategies employed in various dental specialities for the prevention and management of medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: A comprehensive literature review was conducted, acquiring studies sourced from Google Scholar and PubMed. The emphasis was on studies published in recent years, focusing on successful MRONJ prevention techniques across various dental specialties. RESULTS: Four types of prevention were identified. Primary prevention strategies include optimizing oral hygiene, managing dental caries, and extracti

Оценка терпимости к засухе на большом числе горных хлопковых заводов (Gosypium hirsutum L.) в рамках различных режимов ирригации на стадии селекции.

Завод по производству хлопка имеет важное значение, поскольку он обеспечивает сырьем различные отрасли промышленности. Несмотря на то, что хлопок, как правило, является устойчивым к засухе, на нем негативно сказывается долгосрочная засуха. Испытание проводилось в соответствии с прикладной экспериментальной конструкцией в качестве полностью произвольной конструкции (CRD) three тиражирование для определения группы экспертов 93 Генотипы хлопка в ответ на засуху в контролируемых условиях 2022. Все генотипы были покрыты водой 80 mL-1 Водные ресурсы100% ирригация, полевая мощность) three Появлялись

A head-to-head comparison of the EQ-5D-5L and 15D descriptive systems and index values in a general population sample.

BackgroundThe EQ-5D-5L and 15D are generic preference-accompanied health status measures with similar dimensions. In this study, we aim to compare the measurement properties of the EQ-5D-5L and 15D descriptive systems and index values in a general population sample.MethodsIn August 2021, an online cross-sectional survey was conducted in a representative adult general population sample (n = 1887). The EQ-5D-5L and 15D descriptive systems and index values were compared in terms of ceiling and floor, informativity (Shannon's Evenness index), agreement, convergent and known-groups validity for 41

The evolving role and utility of off-label drug use in multiple myeloma.

The treatment landscape for multiple myeloma (MM) has dramatically changed over the last three decades, moving from no US Food and Drug Administration approvals and two active drug classes to over 19 drug approvals and at least eight different active classes. The advances seen in MM therapy have relied on both a structured approach to obtaining new labels and cautious off-label drug use. Although there are country and regional differences in drug approval processes, many of the basic principles behind off-label drug use in MM can be summarized into four main categories: 1) use of a therapy pri

Cross-study safety analysis of risk factors in CAR T cell clinical trials: An FDA database pilot project.

The Chimeric Antigen Receptor (CAR) T Cell Safety Database Project explored the use of cross-study safety data to identify risk factors associated with severe cytokine release syndrome (sCRS) and severe neurological toxicities (sNTX) after CAR T cell administration. Sponsors voluntarily submitted data for 1,926 subjects from 17 phases 1 and 2 studies (six acute lymphocytic leukemia [ALL], five non-Hodgkin's lymphoma [NHL], and six multiple myeloma [MM] studies). Subjects with ALL had a higher risk for developing sCRS and sNTX compared with subjects with NHL or MM. Subjects who received CAR T c

Survival protection of patients undergoing hematopoietic stem cell transplantation: grounded theory.

PurposeFor patients with blood malignancies, hematopoietic stem cell transplantation (HSCT) is a significant challenge. These patients have hope to be completely cured after the transplantation, but deal with the dread of dying at the same time. This study presents a deep understanding of the psychological process of the treatment including perception, emotion, interactions, and its consequences in patients undergoing HSCT.MethodsThis study utilized a qualitative method based on the Strauss and Corbin Approach toward the grounded theory. The research population comprised all patients undergoin

Development of a quality indicator set for day hospices in Germany - a multi-stage, quality-assured review of German guidelines and quality indicator sets.

BackgroundDay hospices are an emerging component of outpatient palliative care in Germany. However, a standardized quality management system utilizing defined quality indicators has not yet been implemented. This study aimed to develop a new set of quality indicators for day hospices.MethodsThrough a multi-phase, quality-assured review, we screened validated quality indicators from German-language S3 guidelines and established quality indicator sets, including the Quality Indicator System for Outpatient Care (QISA) and Outpatient Quality Indicators and Key Figures (AQUIK) based on defined crit

Совпадение в полном тексте источника
… AQUIK consists of 65 quality indicators for outpatient care, addressing a range of medical conditions and medical office management. It is intended as a tool for quality management control [ 18 ]. AOK is one of the largest health insurance companies in Germany. …

Photobiomodulation therapy on chemo- and radiotherapy induced oral conditions: an umbrella review.

ObjectivesPhotobiomodulation (PBM) is a laser-based therapy used to promote tissue repair, reduce inflammation and pain, and has been extensively studied in chemo- and radiotherapy-induced oral mucositis (OM). This review examines the level of evidence of systematic reviews (SRs) that have investigated PBM in such cases of OM.Materials and methodsSRs evaluating PBM for both the treatment and prevention of OM in patients undergoing chemotherapy and/or radiotherapy and published before November 30, 2023, on PubMed, Cochrane, Embase, Web of Science, LILACS, TRIP and Open Grey databases were eligi

Развитие микробиотерапии: роль синтетической биологии в инженерных микробных сообществах для точной медицины.

В последние годы исследования в области микробиотических исследований и синтетической биологии были посвящены изучению новых подходов к микробным манипуляциям в терапевтических целях. Тем не менее, по этому аспекту имеется фрагментированная информация с ключевыми идеями, разбросанными по различным дисциплинам, таким, как молекулярная биология, генетика, биоинженерия и медицина. Цель этого обзора заключается в создании преобразующего потенциала синтетической биологии в плане развития исследований и лечения микробиоме, что имеет значительные последствия для здравоохранения, сельского хозяйства и

Poster Presentation

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Medication-Related Osteonecrosis of the Jaw: An Evidence-Based 2025 Position Statement from a Korean Multidisciplinary Task Force.

With a rapidly aging population and increasing use of antiresorptive agents, medication-related osteonecrosis of the jaw (MRONJ) represents a growing clinical challenge worldwide. To address the need for tailored clinical guidance, a multidisciplinary task force was convened. Five Korean academic societies-the Korean Society for Bone and Mineral Research, the Korean Association of Oral and Maxillofacial Surgeons, the Korean Society of Maxillofacial Plastic and Reconstructive Surgeons, the Korean Osteoporosis Society, and the Korean Endocrine Society-collaborated to develop this position statem

A comprehensive economic assessment of the burden of obesity in Kuwait.

BackgroundObesity is a complex public health issue that has risen to epidemic proportions globally. The aim of this study was to estimate the economic costs associated with obesity from governmental and societal perspectives in the State of Kuwait in 2024.MethodsA disease-specific prevalence-based cost-of-illness framework was applied. Key parameters include prevalence of obesity and its related comorbidities, relative risks, healthcare resources, income rate and growth, and lost workdays for patients and relatives, all were derived from literature. The outcomes measured were total healthcare

The Effects of Patient-Centered Communication on Patient Engagement, Health-Related Quality of Life, Service Quality Perception and Patient Satisfaction in Patients with Cancer: A Cross-Sectional Study in Türkiye.

IntroductionPatient-centered communication is a type of communication that takes place between the provider and the patient.ObjectivesIt is aimed to reveal the effects of patient-centered communication on patient engagement, health-related quality of life, perception of service quality and patient satisfaction.MethodThe study was conducted by applying multiple regression analysis to the data obtained from 312 patients with cancer treated in a training and research hospital affiliated to the Ministry of Health in Diyarbakır, Türkiye.ResultsMore than half of the patients were female and had stag

Management of patients with multiple myeloma beyond the clinical-trial setting: understanding the balance between efficacy, safety and tolerability, and quality of life.

Treatment options in multiple myeloma (MM) are increasing with the introduction of complex multi-novel-agent-based regimens investigated in randomized clinical trials. However, application in the real-world setting, including feasibility of and adherence to these regimens, may be limited due to varying patient-, treatment-, and disease-related factors. Furthermore, approximately 40% of real-world MM patients do not meet the criteria for phase 3 studies on which approvals are based, resulting in a lack of representative phase 3 data for these patients. Therefore, treatment decisions must be tai

Barriers to Treg therapy in Europe: From production to regulation.

There has been an increased interest in cell based therapies for a range of medical conditions in the last decade. This explosion in novel therapeutics research has led to the development of legislation specifically focused on cell and gene based therapies. In Europe, the European medicines agency (EMA) designates any medicines for human use which are based on genes, tissues, or cells as advanced therapy medicinal products or advanced therapy medicinal products (ATMPs). In this article we discuss the hurdles to widespread adoption of ATMPs in Europe, with a focus on regulatory T cells (Tregs).

Financial toxicity and employment status in cancer survivors. A systematic literature review.

BackgroundFinancial toxicity has traditionally been attributed to the rising costs of cancer care. As ability to work impacts one's financial situation, limited employment and reduced income may also contribute to financial toxicity. We examined evidence of the association between financial toxicity and employment status in cancer survivors.MethodsA systematic literature review was performed via PubMed, Web of Science, CINAHL, and PsycINFO with search terms including "Cancer," "Financial toxicity," and "Employment" on September 25, 2019.ResultsThirty-one papers met eligibility criteria. Thirte

Dysregulation of sphingolipid metabolism in pain.

Pain is a clinical condition that is currently of great concern and is often caused by tissue or nerve damage or occurs as a concomitant symptom of a variety of diseases such as cancer. Severe pain seriously affects the functional status of the body. However, existing pain management programs are not fully satisfactory. Therefore, there is a need to delve deeper into the pathological mechanisms underlying pain generation and to find new targets for drug therapy. Sphingolipids (SLs), as a major component of the bilayer structure of eukaryotic cell membranes, also have powerful signal transducti

Наблюдение за финансовыми трудностями пациентов с множественной миеломой и хронической лимфоцитической лейкемией, проходящих лечение в онкологических клиниках США (Alliance A231602CD).

ЦЕЛИ: Оценка доли и корреляции финансовых трудностей, о которых сообщают сами пациенты с множественной миеломой (ММ) или хронической лимфоцитической лейкемией (КЛ). Вечеринка: Sixty-six Общинная практика США и практики меньшинств в области онкологии связана с Программой общинных онкологических исследований Национального института раковых заболеваний (НКОРП). Участники: в целом 521 (больные)≥18 С согласия MM или CLL и 416 :: ответы на опрос (процент завершения)79.8%). Респонденты имели диагноз MM (MM-диагностика)74.0%), степень бакалавра или выше (53.4%), белые (или белые).89.2%), застрахованны

Moments of deep connection between clinicians and patients in oncology: a mixed-methods study of sacred moments.

PurposeSacred moments are periods of deep connection between clinicians and patients, associated with increased clinician career fulfillment and stronger therapeutic alliances in radiation oncology and internal medicine. Our study is the first to investigate sacred moments in medical oncology.MethodsWe conducted semi-structured qualitative interviews with clinicians and patients at an NCI-designated Comprehensive Cancer Center. Interviews were recorded, transcribed, and analyzed using inductive coding. Participants completed a closed-ended (Likert-style) questionnaire that assessed demographic

Телемедицина в искусстве для лечения нейроразвитых и неврологических расстройств: аналитическая оценка.

БАКГРУС: Искусственная терапия, охватывающая арттерапию, музыкальную терапию, драматическую терапию и танцевальную терапию с более широкой практикой экспрессивной терапии, продемонстрировала положительные результаты в лечении нейроразвитых и неврологических расстройств (ННД). Все более важное значение для улучшения доступа людей с нарушениями подвижности или людей, проживающих в отдаленных районах, к средствам телемедицины приобретает интеграция методов лечения искусств. Цель этого исследования состоит в том, чтобы составить карту существующей литературы, с тем чтобы дать углубленный обзор тел