Результаты поиска

Chemical and Cellular Formation of Reactive Oxygen Species from Secondary Organic Aerosols in Epithelial Lining Fluid.

INTRODUCTION: Oxidative stress mediated by reactive oxygen species (ROS) is a key process for adverse aerosol health effects. Secondary orga … were formed by mixtures of Fe2+ and SOA generated from photooxidation of isoprene, α-terpineol, and toluene. The molar yields of organic radicals by SOA were 5-10 times higher in ELF than in water. Fe2+ enhanced organic radical yields by a factor of 20-80. Ascorbate mediated redox cycling of iron ions and sustained organic peroxide decomposition, as suppo …

Air toxics exposure from vehicle emissions at a U.S. border crossing: Buffalo Peace Bridge Study.

The Peace Bridge in Buffalo, New York, which spans the Niagara River at the east end of Lake Erie, is one of the busiest U.S. border crossin … Peace Bridge plaza were responsible for elevated downwind concentrations of PM2.5, EC, and benzene, toluene, ethylbenzene, and xylenes (BTEX), as well as 1,3-butadiene and styrene. The chlorinated VOCs and aldehydes were not differentially higher at the downwind site. Several metals (aluminum, calcium, iron, copper, and antimony) were two times higher at …

Метод газовой хроматографии для количественного определения остаточных растворителей в наноформуляциях.

Описано разработку и проверку метода газовой хроматографии, который является чувствительным, быстрым и специфичным для оценки 19 распространенных растворителей класса 2 и класса 3, часто используемых в формулировке наномедицины. Проверка метода проводилась с использованием системы газовой хроматографии PerkinElmer с детектированием искровой ионизации и колонки Elite 624 Crossbond 6% цианопропилфенил-94% диметилполисилоксана или DB-Fatwax-Ultra Inert с гелием в качестве носителя. Оценены характеристики валидации, такие как линейность, восстановление при добавлении, точность метода, специфичност

Совпадение в полном тексте источника
… Class 2 solvents include acetonitrile, chlorobenzene, chloroform, cyclohexane, hexane, methanol, N-methyl-2-pyrrolidone, N,N-dimethylformamide (N,N-DMF), tetrahydrofuran (THF), xylene, toluene, pyridine, ethylene glycol, dichloromethane, 1,4-dioxane, and others. …

Polybasic nanogels for intracellular co-delivery of paclitaxel and carboplatin: a novel approach to ovarian cancer therapy.

Ovarian cancer is one of the leading causes of cancer-related deaths in women, with limited progress in treatments despite decades of research. Common treatment protocols rely on surgical removal of tumors and chemotherapy drugs, such as paclitaxel and carboplatin, which are capable of reaching cancer cells throughout the body. However, the effectiveness of these drugs is often limited due to toxic reactions in patients, nonspecific drug distribution affecting healthy cells, and the development of treatment resistance. In this study, we introduce a polybasic nanogel system composed of poly(die

Совпадение в полном тексте источника
… Afterward, 0.681 mL of a nitrogen-purged SnOct 2 solution in toluene (10 wt%) was added to the flask to achieve a molar ratio of 0.0012 mol SnOct 2 per mol d , l -lactide. …

Development and application of decatungstate catalyzed C-H 18F- and 19F-fluorination, fluoroalkylation and beyond.

Over the past few decades, photocatalytic C-H functionalization reactions have received increasing attention due to the often mild reaction conditions and complementary selectivities to conventional functionalization processes. Now, photocatalytic C-H functionalization is a widely employed tool, supporting activities ranging from complex molecule synthesis to late-stage structure-activity relationship studies. In this perspective, we will discuss our efforts in developing a photocatalytic decatungstate catalyzed C-H fluorination reaction as well as its practical application realized through co

Совпадение в полном тексте источника
… In addition, although electronically deactivated for HAT by the cationic ammonium group, in a competition reaction between toluene (56) and the TFA salt of o -toluidine 57, the major product was that derived from C(sp 3 )–H alkylation of 57 to afford 58b (selectivity ∼4 : 1) ( Scheme 14c ). …

NTP Toxicology and Carcinogenesis Studies of Ethylbenzene (CAS No. 100-41-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).

Ethylbenzene is mainly used in the manufacture of styrene. Ethylbenzene is also a major component of mixed xylenes used as solvents in agric … its potential for widespread human exposure and because of its structural similarity to benzene and toluene. Male and female F344/N rats and B6C3F1 mice were exposed to ethylbenzene (greater than 99% pure) by inhalation for 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, mouse lymphoma cells, cultured Chinese hamster ovary ce …

NTP technical report on the toxicity studies of a Chemical Mixture of 25 Groundwater Contaminants Administered in Drinking Water to F344/N Rats and B6C3F(1) Mice.

Toxicity studies were performed with a chemically defined mixture of 25 groundwater contaminants, using dose levels considered to have envir … l) phthalate, ethylbenzene, lead, mercury, methylene chloride, nickel, phenol, tetrachloroethylene, toluene, 1,1,1-trichloroethane, trichloroethylene, xylenes. In a 26-week study in which mice were exposed to the chemical mixture at concentrations of 0, 11, 38, 113, and 378 ppm in drinking water, there were no clear adverse effects noted in survival, weig …

Selective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell function.

Multiple myeloma is a plasma cell malignancy with a poor prognosis despite the recent development of new therapeutic options. Histone deacetylase 6 (HDAC6) is overexpressed in multiple myeloma cells and may be involved in the acquisition of resistance to conventional anti-proteasome treatments. In addition to displaying a deacetylase catalytic activity, HDAC6 plays an essential role in the regulation of autophagy and cell death by recognizing ubiquitinated motifs from misfolded proteins through its C-terminal ZnF-UBP binding domain. These defective proteins are sent to the aggresome to facilit

Совпадение в полном тексте источника
… Solvents for solution phase reactions: N,N’-dimethylformamide (DMF), acetone, acetonitrile (MeCN), methanol (MeOH), ethanol (EtOH), and toluene (PhMe) were purchased in anhydrous grade from Sigma-Aldrich and used without further purification. …

Вытяжка из листа EGb 761* в качестве образца продукта по концепции процесса.

Часто недооценивается тот факт, что экстракты, получаемые с одного и того же растения, могут существенно различаться по их фитохимическому составу, а также по их фармакокинетическим и фармакодинамическим свойствам, которые лежат в основе их клинической эффективности и безопасности. Специальная экстрактная EGb 761- Это... one из наиболее изученных выдержек растений в мире. В настоящем обзоре, используя этот экстракт в качестве парадигмы, мы рассказываем о том, как климат, район сбора урожая, обработка растительного материала, процесс сушки, экстракционные растворители и детали последующих этапо

Совпадение в полном тексте источника
… Secondly, a mixture of toluene and butanol instead of pure butanol may be used. …

Обобщение и оценка 6-ариламинобензамидов в качестве позитронных фотографических лигандов для рецептора фингозина-1-фосфата-5.

Спингосин-1-фосфат-5 (S1P5) является одним из пяти мембранных белковых рецепторов G, которые активируются лизофосфолипидом, фосфатом-1, что приводит к регулированию многих клеточных процессов. Рецепторы S1P5 расположены на олигодендроцитах и предлагаются для оказания влияния на физиологию олигодендроцитов. Понимание модуляции S1P5 в ходе таких процессов, как ремиелионация, может иметь потенциальные возможности для демиелионизации расстройств CNS, таких, как множественный склероз (MS). В этой связи мы сообщаем об обобщении и предварительной оценке серии фторированных 6-ариламинобензамидов в кач

Совпадение в полном тексте источника
… H 19 IN 2 NaO 2 433.0383; found 433.0385. 6-[(4′-(Trimethylstannyl)-2′-6′-dimethylphenyl)amino]-2-methoxy-3-methylbenzamide (23) An oven-dried microwave vial was flushed with argon and charged with 6-[(4′-iodo-2′,6′-dimethylphenyl)amino]-2-methoxy-3-methylbenzamide (22) (0.0800 g, 0.195 mmol) in toluene …

Abstracts

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Preclinical Evaluation of a Lentiviral Vector for Huntingtin Silencing.

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder resulting from a polyglutamine expansion in the huntingtin (HTT) protein. There is currently no cure for this disease, but recent studies suggest that RNAi to downregulate the expression of both normal and mutant HTT is a promising therapeutic approach. We previously developed a small hairpin RNA (shRNA), vectorized in an HIV-1-derived lentiviral vector (LV), that reduced pathology in an HD rodent model. Here, we modified this vector for preclinical development by using a tat-independent third-generation LV (pCCL) ba

Совпадение в полном тексте источника
… The sections were mounted, dehydrated by soaking twice in 100% ethanol/toluene, and coverslips applied in Eukitt (O. Kindler). …

[Report on health status of residents in areas with industrial, mining or military sites in Sardinia, Italy].

UNLABELLED: The work described in the present report has been requested by the Secretary of Hygiene, Health and Social Welfare of the Sardin … enim production. Porto Torres (168,000). Chemical industry: production of basic chemicals (benzene, toluene, ethylene, propylene and others), polyethylene, elastomers and vinyl chloride. Textile industry. First and second category landfills. Some plants have been classified "at high technological risk" (Norma Seveso Decree 334/1999). The area is a Nationa …

15th Report on Carcinogens.

BACKGROUND: The Report on Carcinogens (RoC) is a congressionally mandated, science-based public health document that the National Toxicology … ylonitrile; Adriamycin; Aflatoxins; Alcoholic Beverage Consumption; 2-Aminoanthraquinone; o-Aminoazotoluene; 4-Aminobiphenyl; 1-Amino-2,4-dibromoanthraquinone; 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (see Heterocyclic Amines [Selected]); 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (see Heterocyclic Amines [Selected]); 1-Amino-2-methylanthraquinone; …

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control.

ETHNOPHARMACOLOGICAL RELEVANCE: Herba Patriniae has been used for thousands of years in China as a traditional Chinese medicine with heat-clearing and detoxicating effects. It is applied widly for the treatment of rheumatoid arthritis, diarrhea, acute hepatitis, pelvic inflammatory disease and ulcerative colitis in clinic. Two species, namely Patrinia scabiosaefolia Fisch. (PS) and Patrinia villosa Juss. (PV) from the Caprifoliaceae family, are considered as Herba Patriniae in the pharmaceutical industry. AIM OF THE REVIEW: This paper aims to comprehensively outline the traditional uses, bota

Совпадение в полном тексте источника
… (2016a) 150 o-Cymene C 10 H 14 PS Xue et al. (2016) 151 Camphogen C 10 H 14 PV Liu et al. (2016a) 152 Isodurene C 10 H 14 PV Liu et al. (2016a) 153 4-Methyldecane C 11 H 24 PV Liu et al. (2016a) 154 n-Heptadecane C 17 H 36 PS Liu et al. (2016a) 155 n-Tetradecane C 14 H 30 PS Liu et al. (2016a) 156 Toluene … al. (2016) 151 | Camphogen | C 10 H 14 | PV | Liu et al. (2016a) 152 | Isodurene | C 10 H 14 | PV | Liu et al. (2016a) 153 | 4-Methyldecane | C 11 H 24 | PV | Liu et al. (2016a) 154 | n-Heptadecane | C 17 H 36 | PS | Liu et al. (2016a) 155 | n-Tetradecane | C 14 H 30 | PS | Liu et al. (2016a) 156 | Toluene …

NTP Toxicology and Carcinogenesis Studies of Benzene (CAS No. 71-43-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

Benzene ranks 16th in production volume for chemicals produced in the United States, with approximately 9.9 billion pounds being produced in … cticides, and plastics. Benzene, along with other light, high-octane aromatic hydrocarbons, such as toluene and xylenes, is a component of motor gasoline. Benzene is also used as a solvent, but for most applications, it has been replaced by less hazardous solvents. During the 17-week studies, groups of 10 or 15 male and female F344/N rats and B6C3F1 mice …

Advanced Technologies for Large Scale Supply of Marine Drugs.

Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translation into commercial drugs and other valuable products. From a structural point of view and with few exceptions, MNPs of pharmaceutical importance derive from the so-called secondary metabolism of marine organisms. When production strategies rely on marine macroorganisms, harvesting or culturing coupled with extraction procedures frequently remain t

Совпадение в полном тексте источника
… The microbial-mediated enzymatic cis -dihydroxylation of aromatic substrates facilitated by genetically engineered bacterial strains that overexpress the enzyme toluene dioxygenase represents a valuable biotransformation process for the production of chiral synthons with high optical purity, necessary …

Meeting abstracts from the 21st European Symposium on Radiopharmacy and Radiopharmaceuticals

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Резюме АОКНМБ и СНМИКС 2025

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Emergency Care

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.